Search filters

List of works by Ann F. Hubbs

A characterization of amiodarone-induced pulmonary toxicity in F344 rats and identification of surfactant protein-D as a potential biomarker for the development of the toxicity

journal article published in 2000

A new way to look at old questions of silica carcinogenicity

journal article published in 1997

Abrasive blasting agents: designing studies to evaluate relative risk

journal article published in 2005

Accumulation of ubiquitin and sequestosome-1 implicate protein damage in diacetyl-induced cytotoxicity

journal article published in 2016

Acute central neurotoxicity of inhaled alpha-diketone butter flavoring compounds in the rat brain

abstract published in 2010

Acute inflammatory reaction in rats after intratracheal instillation of material collected from a nylon flocking plant

journal article published in 1999

Acute inflammatory reaction in rats after intratracheal instillation of material collected from a nylon flocking plant

abstract published in 1999

Acute lung injury induced by a commercial leather conditioner

journal article published in 1997

Acute pulmonary dose-responses to inhaled multi-walled carbon nanotubes

journal article published in 2013

Acute response of rats to intratracheal instillation of airborne dust collected at a nylon flocking plant

conference proceedings item published in 1999

Adhesion molecule expression and cytotoxicity in diacetyl exposed rat lungs

abstract published in 2009

Adjuvant effect of respiratory irritation on pulmonary allergic sensitization: time and site dependency

journal article published in 1997

Airway epithelial toxicity of the flavoring agent, 2,3-pentanedione

abstract published in 2010

Airway responses in Brown Norway rats following inhalation sensitization and challenge with trimellitic anhydride

journal article published in 2006

Altered ubiquitin expression in the airways of diacetyl-exposed mice

abstract published in 2014

Amiodarone-induced pulmonary toxicity (AIPT) in F344 rats

abstract published in 1999

Amplification of mouse chromosome 4 in chemically induced and invasive mouse lung adenocarcinoma

abstract published in 2012

Analysis of real-time changes of rat dorsi-flexor forces during injurious stretch-shortening cycles in vivo

conference proceedings item published in 2002

Apoptosis and bax expression are increased by coal dust in the polycyclic aromatic hydrocarbon - exposed lung

journal article published in 2006

Application of intratracheal instillation exposure to the etiological determination of a pulmonary disease outbreak: nylon flock as an example

chapter published in 2005

Application of laser scanning confocal microscopy in the analysis of drug-induced lung fibrosis

abstract published in 2001

Assessment of autofluorescent alveolar macrophages and centriacinar emphysema as markers of smoking status in decreased coal miners

conference abstract published in 2003

Asthma progression to airway remodeling and bone marrow eosinophil responses in genetically distinct strains of mice

journal article published in 2008

Beryllium-induced sensitization and granulomatous lung disease in murine models

abstract published in 2008

Biological and statistical approaches to predicting human lung cancer risk from silica

journal article published in 2001

Biological effects of inhaled crude oil vapor. III. Pulmonary inflammation, cytotoxicity, and gene expression profile

journal article published in 2023

Biological effects of inhaled hydraulic fracturing sand dust. II. Particle characterization and pulmonary effects 30 d following intratracheal instillation

journal article published in 2020

Biological effects of inhaled hydraulic fracturing sand dust. IX. Summary and significance

journal article published in 2020

Changes in asthma-like responses after extended removal from exposure to trimellitic anhydride in the Brown Norway rat model

journal article published in 2009

Cis-4-[18F] fluoro-L-proline PET imaging of pulmonary fibrosis in a rabbit model

journal article published in 2002

Coal dust alters beta-naphthoflavone-induced aryl hydrocarbon receptor nuclear translocation in alveolar type II cells

journal article published in 2009

Coal dust increases bax expression, increases apoptosis, and supresses CYP1A1 induction in a rat model of mixed exposure to polycyclic aromatic hydrocarbons and respirable particles

abstract published in 2004

Coal dust is a modifier of pulmonary CYP1A1 induction in rats

abstract published in 2002

Comment on Farsalinos et al., "Evaluation of electronic cigarette liquids and aerosol for the presence of selected inhalation toxins."

publication published in 2015

Comparative in vivo assessment of alveolar fibrosis, histopathology, and systemic translocation induced by carbon nanotubes and nanofibers from US facilities

abstract published in 2019

Comparative pulmonary toxicity of 6 abrasive blasting agents

journal article published in 2001

Comparative pulmonary toxicity of blasting sand and five substitute abrasive blasting agents

journal article published in 2002

Comparative toxicity of nanomaterials in vitro and in vivo

conference abstract published in 2005

Complex profile of mechanical responses of guinea-pig isolated airways to the popcorn butter flavorings, diacetyl and 2,3-pentanedione

abstract published in May 2011

Complex profile of mechanical responses of guinea-pig isolated airways to the popcorn butter flavorings, diacetyl and 2,3-pentanedione

abstract published in 2011

Criteria for a recommended standard: occupational exposure to diacetyl and 2,3-pentanedione

NIOSH criteria document published in 2016

Crystalline silica is a negative modifier of pulmonary cytochrome P-4501A1 induction

journal article published in 2008

Current intelligence bulletin 63: occupational exposure to titanium dioxide

NIOSH current intelligence bulletin published in 2011

Current intelligence bulletin 70: health effects of occupational exposure to silver nanomaterials

NIOSH current intelligence bulletin published in 2021

Cytochrome P450 1A1 and 2B1 in the rat lung: exposure to silica and inducers of xenobiotic metabolism

abstract published in 1999

Cytochrome P4501A1 (CYP1A1) induction is suppressed by coal dust exposure in the ovine lung

conference abstract published in 2004

Designer mice: transgenic and knockout mice in toxicology research

journal article published in 1997

Developing a solution for nasal and olfactory transport of nanomaterials

journal article published in 2022

Developing a solution for nasal and olfactory transport of nanomaterials (dataset)

research dataset published in 2023

Diacetyl Increases Sensory Innervation and Substance P Production in Rat Trachea

scientific article published on July 11, 2013

Diacetyl causes age-enhanced ubiquitin aggregation in the neuroepithelium of the rat nose

abstract published in 2016

Diacetyl increases sensory innervation and substance P production in rat trachea

abstract published in 2010

Diacetyl-induced respiratory and olfactory toxicity in mice: influence of ubiquitination, gender, and dicarbonyl/L-xylulose reductase gene knockout

abstract published in 2013

Differential mouse pulmonary dose and time course responses to titanium dioxide nanospheres and nanobelts

journal article published in 2013

Distribution and fibrotic response following inhalation exposure to multi-walled carbon nanotubes

journal article published in 2013

Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes

abstract published in 2010

Distribution and persistence of pleural penetrations by multi-walled carbon nanotubes

scientific article published on October 4, 2010

Dose response of multi-walled carbon nanotube-induced lung tumors

abstract published in 2017

Dynamic force responses of skeletal muscle during stretch–shortening cycles

scientific article published on July 9, 2003

Effect of engineered titanium dioxide nanoparticle shape on toxicity in vivo

abstract published in 2011

Effect of inhaled crystalline silica in a rat model: time course of pulmonary reactions

journal article published in 2002

Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model

journal article published in 2014

Effect of ozone treatment on airway reactivity and epithelium-derived relaxing factor in guinea pigs

journal article published in 2000

Effects of diacetyl vapor inhalation on airway reactivity to methacholine (MCh) in vitro in rats

abstract published in 2010

Effects of ozone inhalation on reactivity to methacholine, epithelium-derived relaxing factor (EpDRF) release, and neurogenic responses in guinea-pig tracheal preparations in vitro

conference abstract published in 1996

Efficacy of a technique for exposing the mouse lung to particles aspirated from the pharynx

journal article published in 2003

Emerging issues in occupationally relevant zoonoses

journal article published in 2002

Enhanced nitric oxide and reactive oxygen species production and damage after inhalation of silica

journal article published in 2002

Enhanced nitric oxide production associated with silica-induced disease in rats

conference abstract published in 2002

Enhanced pulmonary response to the inhalation of freshly fractured silica as compared with aged dust exposure

journal article published in 1996

Evaluation of Furfuryl Alcohol Sensitization Potential Following Dermal and Pulmonary Exposure: Enhancement of Airway Responsiveness

scientific article published on October 14, 2011

Exposure to Triclosan Augments the Allergic Response to Ovalbumin in a Mouse Model of Asthma

scientific article published on November 28, 2012

Exposure to triclosan augments the allergic response to ovalbumin in a mouse model of asthma

abstract published in 2013

Extrapulmonary transport of MWCNT following inhalation exposure

journal article published in 2013

Feasibility study for PET imaging of pulmonary fibrosis with cis-4-[F-18]fluoro-L-proline (FP)

abstract published in 1998

Fission fragment relative biological effectiveness for liver tumor induction

journal article published in 1995

Flavorings-related lung disease: a brief review and new mechanistic data

journal article published in 2019

Freshly fractured quartz inhalation leads to enhanced lung injury and inflammation. Potential role of free radicals

scientific article published on September 1, 1995

GHS classifications for diacetyl, 2,3-pentanedione, and mixtures containing these chemicals

abstract published in 2015

Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses

journal article published in 2014

Genotoxicity of multi-walled carbon nanotubes at occupationally relevant doses

abstract published in 2012

Genotoxicity of multiwalled carbon nanotubes

abstract published in 2013

High-fat Western diet consumption exacerbates silica-induced pulmonary inflammation and fibrosis

journal article published in 2022

Histopathology of the broad class of carbon nanotubes and nanofibers used or produced in U.S. facilities in a murine model

journal article published in 2021

Historical shift in pathological type of progressive massive fibrosis among coal miners in the USA

journal article published in 2023

IGF-I, IGF-II, and IGF-receptor-1 transcript and IGF-II protein expression in myostatin knockout mice tissues

journal article published in 2002

IgG subclass responses in experimental silicosis

journal article published in 2001

Immune dysfunction in silicosis: a hypothesis

journal article published in 1996

Immunoglobulin responses to experimental silicosis

journal article published in 2001

Impaired clearance of pulmonary listeria monocytogenes infection in experimental silicosis

conference abstract published in 1999

Induction of CYP1A1 and NADPH quinone oxidoreductase (QR) with concomitant attenuation of CYP2B1 in the lung: effects of paving asphalt fume exposure

abstract published in 2002

Induction of aneuploidy by single walled carbon nanotubes

abstract published in 2009

Induction of aneuploidy by single-walled carbon nanotubes

journal article published in 2009

Induction of mitotic spindle aberrations by occupationally relevant doses of single-walled carbon nanotubes

abstract published in 2010

Inhalation dosimetry of diacetyl and butyric acid, two components of butter flavoring vapors

journal article published in 2009

Inhalation exposure of rats to asphalt fumes generated at paving temperatures alters pulmonary xenobiotic metabolism pathways without lung injury

journal article published in 2003

Inhalation of carbon nanotubes induces oxidative stress and cytokine response causing respiratory impairment and pulmonary fibrosis in mice

abstract published in 2008

Inhalation of ultrafine titanium dioxide augments particle-dependent microvascular dysfunction

abstract published in 2007

Inhalation toxicity of the flavoring agent, diacetyl (2,3-butanedione), in the upper respiratory tract of rats

abstract published in 2004

Inhalation vs. aspiration of single-walled carbon nanotubes in C57BL/6 mice: inflammation, fibrosis, oxidative stress, and mutagenesis

journal article published in 2008

Inhaled diacetyl vapors and in vivo airway reactivity to methacholine (MCh) in rats

abstract published in 2010

Inhaled silica dust increases nitric oxide and cytokine production associated with collagen synthesis and fibrosis in rats

journal article published in 1996

Inhibitory action of cytokine preservatives on chemiluminescence assays

journal article published in 1996

Intratracheal amiodarone administration to F344 rats causes acute damage to airway and parenchymal cells: the possible role of free radical generation

abstract published in 2001

Intratracheal amiodarone administration to F344 rats directly damages lung airway and parenchymal cells

scientific article published on April 15, 2003

Letter to the editor. RE: Galbraith D and Weill D (2009), Popcorn lung and bronchiolitis obliterans: a critical appraisal 82:407- 416

publication published in 2010

Local and systemic toxicity in mice following subcutaneous implantation of latex penrose drains

journal article published in 2004

Local and systemic toxicity of implanted accelerator-free polychloroprene-type and latex surgical glove material

abstract published in 2011

Localization of inducible nitric oxide synthase in a rat model of silicosis

conference proceedings item published in 1999

Long-term effects of carbon containing engineered nanomaterials and asbestos in the lung: one year postexposure comparisons

journal article published in 2014

Mechanistic links between the lung and the systemic microcirculation after nanoparticle exposure

abstract published in 2009

Metabolic functions of alveolar type II cells in acute silicosis

abstract published in 1997

Mining tenure and job duties differ among contemporary and historic underground coal miners with progressive massive fibrosis

journal article published in 2023

Modification of pulmonary CYP2B1 and induced CYP1A1 activities by intravenous injection of iron dextran

abstract published in 2005

Mouse models of beryllium-induced sensitization and granulomatous lung disease

abstract published in 2007

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

journal article published in 2010

Multi-wall carbon nanotube (MWCNT)-induced gene expression in the mouse lung: implication of carcinogenesis risk

abstract published in 2011

Multiorgan autoimmune inflammation, enhanced lymphoproliferation, and impaired homeostasis of reactive oxygen species in mice lacking the antioxidant-activated transcription factor Nrf2

journal article published in 2006

Multiple emulsion-mediated enhancement of the therapeutic effect of tetrandrine against silicosis

journal article published in 1996

Multiwalled carbon nanotube-induced lung tumors

abstract published in 2013

Nanoparticle inhalation augments particle-dependent systemic microvascular dysfunction

journal article published in 2008

Nanoparticle inhalation increases microvascular oxidative stress and compromises nitric oxide bioavailability

abstract published in 2009

Nanoparticulate pathology

conference proceedings item published in 2011

Nanoparticulates

chapter published in 2013

Nanoparticulates

chapter published in 2023

Nanotechnology: toxicologic pathology

journal article published in 2013

Nanotoxicology—A Pathologist’s Perspective

scientific article published on December 14, 2010

Nasal uptake of diacetyl and butyric acid vapors

abstract published in 2008

Necrosis of nasal and airway epithelium in rats inhaling vapors of artificial butter flavoring

journal article published in 2002

Neoplastic potential of rat tracheal epithelial cell lines induced by 1-nitropyrene and dibenzo(a,i)pyrene

journal article published in 1999

Non-malignant respiratory disease among workers in industries using styrene - a review of the evidence

journal article published in 2017

Occupationally acquired infections of the lung

chapter published in 1998

Olfactory and central neurotoxicity of occupationally relevant inhaled aerosols

abstract published in 2023

One year pulmonary outcomes after exposure to carbonaceous nano-engineered materials and asbestos

abstract published in 2014

Ovalbumin aeroallergen exposure-response in brown Norway rats

journal article published in 2000

Oxidative stress and pulmonary toxicity of carbon nanotubes

abstract published in 2004

Particle-associated systemic microvascular dysfunction

abstract published in 2009

Pathology and mineralogy demonstrate respirable crystalline silica is a major cause of severe pneumoconiosis in U.S. coal miners

journal article published in 2022

Persistant pulmonary inflammation after intratracheal instillation of abrasive blasting agents

abstract published in 1999

Persistent Pulmonary Fibrosis, Migration to the Pleura, and Other Preliminary New Findings after Subchronic Exposure to Multi-Walled Carbon Nanotubes

NIOSH Science Blog post published in 2009

Persistent pulmonary inflammation, airway mucous metaplasia and migration of multiwalled carbon nanotubes from the lung after subchronic exposure

abstract published in 2009

Pharmaceutical considerations in the use of tetrandrine to treat silicosis

chapter published in 1995

Popcorn Flavoring Effects on Reactivity of Rat Airways in Vivo and in Vitro

scientific article published on January 1, 2013

Popcorn worker's lung: in vitro exposure to diacetyl (D), an ingredient in microwave popcorn butter flavoring, damages guinea-pig tracheal epithelium (E) and increases reactivity to methacholine (MCh)

conference abstract published in 2005

Popcorn worker's lung: in vitro exposure to diacetyl, an ingredient in microwave popcorn butter flavoring, increases reactivity to methacholine

journal article published in 2006

Positron emission tomographic (PET) imaging of silicosis in a rabbit model using an F-fluorinated proline amino acid analog tracer

conference abstract published in 2002

Potent lung tumor promotion by inhaled MWCNT

journal article published in 2024

Potential role of free radicals in acute silicosis

conference abstract published in 1994

Priorities for development of research methods in occupational cancer

journal article published in 2003

Promotion of lung adenocarcinoma following inhalation exposure to multi-walled carbon nanotubes

journal article published in 2014

Pulmonary carcinogenicity of relatively low doses of beta-particle radiation from inhaled 144CeO2 in rats

journal article published in 1996

Pulmonary effects of single-walled carbon nanotubes: inhalation vs aspiration

abstract published in 2009

Pulmonary exposure to dusts from grinding stone countertop products induces lung inflammation and fibrosis

abstract published in 2024

Pulmonary exposure to residual oil fly ash (ROFA) impairs systemic microvascular endothelium-dependent dilation

abstract published in 2005

Pulmonary fibrotic response from inhaled multiwalled carbon nanotube exposure in mice

abstract published in 2012

Pulmonary fibrotic response to aspiration of multi-walled carbon nanotubes

journal article published in 2011

Pulmonary fibrotic response to subchronic multi-walled carbon nanotube exposure

abstract published in 2011

Pulmonary inflammation after intratracheal instillation of abrasive blasting substitutes

abstract published in 2001

Pulmonary inflammation and fibrosis in rats after intratracheal instillation of adipic acid and adipic acid mixtures

abstract published in 1998

Pulmonary inflammation, epithelial hyperplasia, and lymph node translocation after multi-walled carbon nanotube inhalation

abstract published in 2011

Pulmonary nanoparticle exposure disrupts systemic microvascular nitric oxide signaling

journal article published in 2009

Pulmonary oxidative stress, inflammation, and fibrosis induced by carbon nanotubes

abstract published in 2005

Pulmonary toxicity of Expancel® microspheres in the rat

journal article published in 2007

Pulmonary toxicity of carbon nanotubes

abstract published in 2005

Pulmonary toxicity of inhaled multiwalled carbon nanotubes

abstract published in 2009

Pulmonary toxicity of multi-walled carbon nanotubes

abstract published in 2009

Pulsed and continuous patterns of diacetyl (2,3butanedione) inhalation cause rhinitis, laryngitis, tracheitis, and bronchitis in rats

abstract published in 2007

Quantifying cellular expression of cytochrome P450 1A1 (CYP1A1) in the pulmonary alveolus: a comparison of indirect enzymatic immunohistochemistry (IH) and indirect immunofluorescence (IF)

abstract published in 2001

Rat pulmonary CYP1A1 induction is inhibited by respirable coal dust exposure

abstract published in 2003

Regulation of eosinophilopoiesis in a murine model of asthma

journal article published in 2003

Relationship between in vivo carcinogenicity and human risk to carbon nanotubes

abstract published in 2014

Respirable coal dust particles modify cytochrome P4501A1 (CYP1A1) expression in rat alveolar cells

journal article published in 2004

Respiratory and Olfactory Cytotoxicity of Inhaled 2,3-Pentanedione in Sprague-Dawley Rats

scientific article published on August 13, 2012

Respiratory exposures from microwave popcorn packaging

abstract published in 2002

Respiratory toxicologic pathology of inhaled diacetyl in Sprague-Dawley rats

journal article published in 2008

Role of cytokines in oxygen radical generation during phagocytosis

abstract published in 1994

Role of inducible nitric oxide synthase-deried nitric oxide in silica-induced pulmonary inflammation and fibrosis

journal article published in 2004

Role of inducible nitric oxide-derived nitric oxide in silica-induced pulmonary inflammation and injury

abstract published in 2004

Role of p53 in the chronic pulmonary immune response to tangled or rod-like multi-walled carbon nanotubes

journal article published in 2018

Silica carcinogenicity analysis in a susceptible mouse model

conference abstract published in 2006

Silica carcinogenicity in a susceptible mouse model

abstract published in 2007

Single-walled carbon nanotube-induced mitotic disruption

scientific article published on December 8, 2011

Systemic effects of chronic asthma on bone marrow eosinophil development

conference abstract published in 2006

Systemic microvascular dysfunction after pulmonary particulate matter exposure

abstract published in 2005

Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure

journal article published in 2006

Temporal relationships between biochemical mediators of lung damage and fibrosis after silica inhalation in rats

abstract published in 1999

The fate of inhaled nanoparticles: detection and measurement by enhanced dark-field microscopy

journal article published in 2018

The use of e-cadherin immunofluorescence in pulmonary toxicologic pathology studies

abstract published in 2011

Thinking small: new approaches for evaluating the toxicologic pathology of nanotechnology products

conference proceedings item published in 2013

Time course of pulmonary response of rats to inhalation of crystalline silica: histological results and biochemical indices of damage, lipidosis, and fibrosis

journal article published in 2001

Time course of pulmonary responses to inhalation of crystalline silica in the rat model: evidence for a threshold burden beyond which silicosis progresses without further exposure

conference abstract published in 2002

Time course of pulmonary responses to inhaled multiwalled carbon nanotubes

abstract published in 2013

Toxic Metals Stimulate Inflammatory Cytokines in Hepatocytes through Oxidative Stress Mechanisms

scientific article published on August 1, 1998

Toxic response following latex drain implantation

abstract published in 2001

Toxicity of Inhaled 91 YCl 3 in Dogs

scientific article published on August 1, 1998

Transforming and carcinogenic potential of cadmium chloride in BALB/c-3T3 cells

journal article published in 2000

Transport of inhaled MWCNT to the pleura, respiratory muscles and systemic organs

abstract published in 2013

Ultrafine particulate matter inhalation attenuates microvascular endothelial nitric oxide production

abstract published in 2008

Ultrafine particulate matter inhalation induces remote microvascular dysfunction

conference abstract published in 2006

Ultrastructural changes in the airways of rats inhaling butter flavoring vapors

abstract published in 2002

Understanding carbon nanotube genotoxicity

abstract published in 2011

Understanding nanotechnology: an emerging challenge for the toxicologic pathologist

abstract published in 2014

Understanding the variable drivers of toxicity for the broad class of carbon nanotubes and nanofibers from US facilities

abstract published in 2020

Unusual inflammatory and fibrogenic pulmonary responses to single-walled carbon nanotubes in mice

journal article published in 2005

Use of tetrandrine to differentiate between mechanisms involved in silica-versus bleomycin-induced fibrosis

journal article published in 1999

Vacuolar leukoencephalopathy with widespread astrogliosis in mice lacking transcription factor Nrf2

journal article published in 2007

Welding fume exposure and associated inflammatory and hyperplastic changes in the lungs of tumor susceptible A/J mice

journal article published in 2006

What's your diagnosis? Cachexia in a B6;129S2-Tnfsf5tm1lmx mouse

journal article published in 2004

Workplace safety and food ingredients: the example of butter flavoring

conference abstract published in 2002

mRNAs and miRNAs in whole blood associated with lung hyperplasia, fibrosis, and bronchiolo-alveolar adenoma and adenocarcinoma after multi-walled carbon nanotube inhalation exposure in mice

journal article published in 2016