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List of works by Chung-Hang Leung

20(S)-Protopanaxadiol, a metabolite of ginsenosides, induced cell apoptosis through endoplasmic reticulum stress in human hepatocarcinoma HepG2 cells

scientific article published on 17 June 2011

A G-quadruplex-selective luminescent iridium(III) complex and its application by long lifetime

scientific article

A Highly Selective and Non-Reaction Based Chemosensor for the Detection of Hg2+ Ions Using a Luminescent Iridium(III) Complex ⬇️

scientific article published on March 22, 2013

A Luminescent Cocaine Detection Platform Using a Split G-Quadruplex-Selective Iridium(III) Complex and a Three-Way DNA Junction Architecture

scientific article published on 18 August 2015

A Metal‐Based Inhibitor of Tumor Necrosis Factor‐α ⬇️

scientific article published on July 13, 2012

A MnO2 nanosheet-assisted GSH detection platform using an iridium(iii) complex as a switch-on luminescent probe

scientific article

A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- Pyridylmethyl)amine (tpa) As An Inhibitor Of Beta-amyloid Fibrillation

scientific article

A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease

scientific article

A Rhodium(III)-Based Inhibitor of Lysine-Specific Histone Demethylase 1 as an Epigenetic Modulator in Prostate Cancer Cells.

scientific article published on 20 February 2017

A colorimetric and luminescent dual-modal assay for Cu(II) ion detection using an iridium(III) complex

scientific article

A cyclometalated iridium(III) complex used as a conductor for the electrochemical sensing of IFN-γ.

scientific article published on 15 February 2017

A highly selective, label-free, homogenous luminescent switch-on probe for the detection of nanomolar transcription factor NF-kappaB ⬇️

scientific article published on March 11, 2011

A highly sensitive G-quadruplex-based luminescent switch-on probe for the detection of polymerase 3'-5' proofreading activity.

scientific article

A label-free luminescent switch-on assay for ATP using a G-quadruplex-selective iridium(III) complex

scientific article

A long-lived ferrocene-conjugated iridium(III) complex for sensitive turn-on luminescence detection of traces of DMSO in water and human serum

scientific article

A long-lived peptide-conjugated iridium(iii) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2

scientific article published on 01 October 2018

A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation

scientific article published on 23 March 2017

A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe.

scientific article

A luminescent G-quadruplex-selective iridium(iii) complex for the label-free detection of lysozyme

scientific article published on 17 March 2016

A metal-based inhibitor of NEDD8-activating enzyme

scientific article

A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells

scientific article

A natural product-like inhibitor of NEDD8-activating enzyme

scientific article published on 14 January 2011

A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α

scientific article published on 2 March 2016

A one-step strategy for ultra-fast and low-cost mass production of plastic membrane microfluidic chips

scientific article published in October 2016

A parallel G-quadruplex-selective luminescent probe for the detection of nanomolar calcium(II) ion.

scientific article published on 19 July 2013

A reaction-based luminescent switch-on sensor for the detection of OH- ions in simulated wastewater

scientific article published on 9 May 2017

A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo

scientific article

A rhodium(III)-based inhibitor of autotaxin with antiproliferative activity

scientific article published on 22 November 2016

A ruthenium(II) complex supported by trithiacyclononane and aromatic diimine ligand as luminescent switch-on probe for biomolecule detection and protein staining

scientific article

A small molecule Pin1 inhibitor blocks NF-κB signaling in prostate cancer cells

scientific article published on 30 December 2017

A versatile nanomachine for the sensitive detection of platelet-derived growth factor-BB utilizing a G-quadruplex-selective iridium(III) complex

scientific article

ATP modulates poly(ADP-ribose) polymerase-1-facilitated topoisomerase I-linked DNA religation in the presence of camptothecin

scientific article

An Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells

scientific article

An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex

scientific article published on 23 April 2016

An iridium(iii)-based irreversible protein-protein interaction inhibitor of BRD4 as a potent anticancer agent

scientific article published on 30 July 2015

An oligonucleotide-based label-free luminescent switch-on probe for RNA detection utilizing a G-quadruplex-selective iridium(III) complex

scientific article published on August 2014

Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction

scientific article published on 22 February 2017

Antitumor agents 294. Novel E-ring-modified camptothecin–4β-anilino-4′-O-demethyl-epipodophyllotoxin conjugates as DNA topoisomerase I inhibitors and cytotoxic agents ⬇️

scientific article published on May 19, 2012

Application of iridium(III) complex in label-free and non-enzymatic electrochemical detection of hydrogen peroxide based on a novel "on-off-on" switch platform

scientific article published on 12 May 2016

Apurinic/apyrimidinic endonuclease-1 protein level is associated with the cytotoxicity of L-configuration deoxycytidine analogs (troxacitabine and beta-L-2',3'-dideoxy-2',3'-didehydro-5-fluorocytidine) but not D-configuration deoxycytidine analogs (

scientific article published on 15 February 2006

Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol

scientific article published on 3 August 2016

Baicalein Induces Beclin 1- and Extracellular Signal-Regulated Kinase-Dependent Autophagy in Ovarian Cancer Cells

scientific article published on 13 January 2017

Bioactive luminescent transition-metal complexes for biomedical applications

scientific article published on 13 June 2013

Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis

scientific article published on 15 June 2016

Butyrate mediates nucleotide-binding and oligomerisation domain (NOD) 2-dependent mucosal immune responses against peptidoglycan

scientific article published in December 2009

Cell imaging of dopamine receptor using agonist labeling iridium(iii) complex.

scientific article published on 19 December 2017

Comprehensive quantitative analysis of Shuang-Huang-Lian oral liquid using UHPLC-Q-TOF-MS and HPLC-ELSD.

scientific article published on 30 August 2014

Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior

scientific article

Construction of a Nano Biosensor for Cyanide Anion Detection and Its Application in Environmental and Biological Systems

scientific article published on 26 September 2017

Correction: Discovery of a Natural Product-Like c-myc G-Quadruplex DNA Groove-Binder by Molecular Docking.

scientific article published on 25 October 2012

Correction: Inhibition of TLR1/2 dimerization by enantiomers of metal complexes

scientific article published on 11 January 2017

Correction: Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library

scientific article published in January 2015

Crystal violet as a fluorescent switch-on probe for i-motif: label-free DNA-based logic gate ⬇️

scientific article published on May 13, 2011

Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells

scientific article published on 19 April 2016

Current Advancements in Aβ Luminescent Probes and Inhibitors of Aβ Aggregation ⬇️

scientific article published on September 1, 2012

Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons

scientific article published on 19 April 2010

Cyclometalated platinum(II) complexes as topoisomerase IIα poisons

scientific article published on 11 November 2010

DNA-binding small molecules as inhibitors of transcription factors

scientific article

Detection of 3'→5' exonuclease activity using a metal-based luminescent switch-on probe

scientific article published on 21 August 2013

Determination of cell metabolite VEGF₁₆₅ and dynamic analysis of protein-DNA interactions by combination of microfluidic technique and luminescent switch-on probe

scientific article published on 30 November 2015

Development of a Long-Lived Luminescence Probe for Visualizing β-Galactosidase in Ovarian Carcinoma Cells

scientific article

Development of a luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of adenosine

scientific article

Development of an Aptamer-Based Sensing Platform for Metal Ions, Proteins, and Small Molecules through Terminal Deoxynucleotidyl Transferase Induced G-Quadruplex Formation

scientific article published on 9 October 2015

Discovery of a Natural Product-Like c-myc G-Quadruplex DNA Groove-Binder by Molecular Docking ⬇️

scientific article published on August 17, 2012

Discovery of a natural product-like iNOS inhibitor by molecular docking with potential neuroprotective effects in vivo

scientific article

Discovery of a novel ROCK2 inhibitor with anti-migration effects via docking and high-content drug screening

scientific article

Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening

scientific article published on 24 August 2014

Drug repositioning by structure-based virtual screening ⬇️

scientific article published on January 4, 2013

Dual Inhibition And Monitoring Of Beta-amyloid Fibrillation By A Luminescent Iridium(III) Complex

scientific article

Editorial for "Recent advances in DNA-based biosensor".

scientific article published in December 2013

Editorial: Small molecule therapeutics for Alzheimer's disease

scientific article

Eriocalyxin B inhibits nuclear factor-kappaB activation by interfering with the binding of both p65 and p50 to the response element in a noncompetitive manner

scientific article published on 29 August 2006

Evaluation of Cinnamomum osmophloeum Kanehira extracts on tyrosinase suppressor, wound repair promoter, and antioxidant

scientific article published on 9 March 2015

Expression of deoxynucleotide carrier is not associated with the mitochondrial DNA depletion caused by anti-HIV dideoxynucleoside analogs and mitochondrial dNTP uptake

scientific article

First Synthesis of an Oridonin-Conjugated Iridium(III) Complex for the Intracellular Tracking of NF-κB in Living Cells

scientific article published on 17 February 2017

G-quadruplexes for luminescent sensing and logic gates ⬇️

scientific article published on February 23, 2013

Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells

scientific article published on 3 November 2015

Gold-Catalyzed Cycloisomerization and Diels-Alder Reaction of 1,4,9-Dienyne Esters to 3 a,6-Methanoisoindole Esters with Pro-Inflammatory Cytokine Antagonist Activity

scientific article published on 15 May 2015

Group 9 metal-based inhibitors of β-amyloid (1–40) fibrillation as potential therapeutic agents for Alzheimer's disease

scholarly article by Bradley Yat-Wah Man et al published 2011 in Chemical Science

Group 9 organometallic compounds for therapeutic and bioanalytical applications.

scientific article published on 4 November 2014

Hit identification of IKKβ natural product inhibitor ⬇️

scientific article published on January 7, 2013

Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells

scientific article

Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α.

scientific article published on 14 April 2016

Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity

scientific article

In silico identification of natural product inhibitors of JAK2.

scientific article

In silico screening of quadruplex-binding ligands ⬇️

scientific article published on February 26, 2012

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound.

scientific article published on 16 May 2017

Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds ⬇️

scientific article published on 13 February 2016

Iridium(iii) complexes as reaction based chemosensors for medical diagnostics

scientific article published on 01 October 2018

Iridium-based probe for luminescent nitric oxide monitoring in live cells

scientific article published in Scientific Reports

Label-Free Luminescent Switch-On Probe for Ochratoxin A Detection Using a G-Quadruplex-Selective Iridium(III) Complex

scientific article published on 9 April 2015

Label-free detection of sub-nanomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe

scientific article

Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe.

scientific article

Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe

scientific article

Label-free luminescent detection of LMP1 gene deletion using an intermolecular G-quadruplex-based switch-on probe

scientific article

Label-free luminescent oligonucleotide-based probes ⬇️

scientific article published on April 21, 2013

Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex.

scientific article

Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes

scientific article published on 24 October 2019

Luminescence switch-on assay of interferon-gamma using a G-quadruplex-selective iridium(III) complex

scientific article published on 24 September 2015

Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe

scientific article published on 18 May 2015

Luminescent G-quadruplex Probes ⬇️

scientific article published on January 1, 2012

Luminescent Strategies for Label-free G-quadruplex-based Enzyme Activity Sensing

scientific article published on 3 May 2017

Luminescent and colorimetric strategies for the label-free DNA-based detection of enzyme activity ⬇️

scientific article published on 08 February 2013

Luminescent detection of DNA-binding proteins

scientific article published on 03 October 2011

Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells

scientific article

Luminescent turn-on detection of Hg(II) via the quenching of an iridium(III) complex by Hg(II)-mediated silver nanoparticles

scientific article

Metal complexes as potential modulators of inflammatory and autoimmune responses

scientific article

Molecular modeling of drug–DNA interactions: Virtual screening to structure-based design ⬇️

scientific article published on April 19, 2011

Novel mechanism of inhibition of nuclear factor-kappa B DNA-binding activity by diterpenoids isolated from Isodon rubescens

scientific article

Oligonucleotide‐Based Luminescent Detection of Metal Ions ⬇️

scientific article published on February 18, 2011

Organoplatinum(II) complexes with nucleobase motifs as inhibitors of human topoisomerase II catalytic activity

scientific article published on October 2010

PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells.

scientific article

Pharmacological Inhibition of LSD1 for Cancer Treatment

scholarly article by Guan-Jun Yang et al published 4 December 2018 in Molecules

Pharmacophore modeling for the identification of small-molecule inhibitors of TACE.

scientific article published on 26 September 2014

Phosphorescent imaging of living cells using a cyclometalated iridium (III) complex

scientific article

Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis

Purified Astaxanthin from Haematococcus pluvialis Promotes Tissue Regeneration by Reducing Oxidative Stress and the Secretion of Collagen In Vitro and In Vivo

scientific article published on 03 August 2020

Real-time detection of oxalyl chloride based on a long-lived iridium(iii) probe

scientific article published on 30 November 2017

Recent Developments in G-Quadruplex Probes

scientific article (publication date: 23 July 2015)

Recent development of transition metal complexes with in vivo antitumor activity

scientific article

Reversal of multidrug resistance in cancer cells by pyranocoumarins isolated from Radix Peucedani

scientific article published in July 2003

Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response

scientific article published on 30 October 2018

Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy

scientific article published on 19 July 2018

Simple and convenient G-quadruplex-based turn-on fluorescence assay for 3' → 5' exonuclease activity

scientific article

Simultaneous blocking of the pan-RAF and S100B pathways as a synergistic therapeutic strategy against malignant melanoma

scientific article published on 30 December 2020

Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes

scientific article published on 18 February 2011

Stabilization of G-quadruplex DNA with platinum(II) Schiff base complexes: luminescent probe and down-regulation of c-myc oncogene expression

scientific article published on December 2009

Stable anticancer gold(III)-porphyrin complexes: effects of porphyrin structure

scientific article

Structural analogs of tylophora alkaloids may not be functional analogs

scientific article

Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines

Structure-based design of platinum(II) complexes as c-myc oncogene down-regulators and luminescent probes for G-quadruplex DNA.

scientific article published on June 2010

Structure-based discovery of natural-product-like TNF-α inhibitors

scientific article published on 16 March 2010

Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing

scientific article published on 6 December 2017

Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer

scientific article published on 4 March 2011

Structure-based repurposing of FDA-approved drugs as inhibitors of NEDD8-activating enzyme

scientific article published on 19 March 2014

Structure‐Based Repurposing of FDA‐Approved Drugs as TNF‐α Inhibitors ⬇️

scientific article published on May 2, 2011

Synergistic Effects of Linderanolide B Combined with Arbutin, PTU or Kojic Acid on Tyrosinase Inhibition

scientific article published on 7 September 2015

The Development of G-Quadruplex-Based Assays for the Detection of Small Molecules and Toxic Substances

scientific article

The design and development of covalent protein-protein interaction inhibitors for cancer treatment

scientific article published on 30 March 2020

The impact of hypoxic treatment on the expression of phosphoglycerate kinase and the cytotoxicity of troxacitabine and gemcitabine

scientific article

The interaction of an iridium(III) complex with G-quadruplex DNA and its application in luminescent switch-on detection of Siglec-5.

scientific article published on 28 September 2016

Time-Resolved Luminescent High-Throughput Screening Platform for Lysosomotropic Compounds in Living Cells

scientific article published on 28 December 2020

Total Tanshinones-Induced Apoptosis and Autophagy Via Reactive Oxygen Species in Lung Cancer 95D Cells

scientific article published on 22 September 2015

Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases

scientific article published on 26 February 2020

Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex-Silver Nanoparticle Platform

scientific article published on 21 August 2017

UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids

scientific article published on 16 July 2018

Ultrasensitive electrochemical detection of miRNA-21 by using an iridium(III) complex as catalyst

scientific article published on 2 July 2016

Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library

scientific article

Visualization of Zn²⁺ ions in live zebrafish using a luminescent iridium(III) chemosensor

scientific article published in August 2014

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