List of works - Guy P. Vigers

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

scientific article

Characterization of the microtubule movement produced by sea urchin egg kinesin

scientific article published on 01 February 1987

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

scientific article

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system

scientific article

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

scientific article published on 07 November 2018

Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease

scientific article

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

scientific article

Discovery of pyrrolopyrimidine inhibitors of Akt

scientific article

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA

scientific article

Electron microscopy of frozen-hydrated biological material

scientific article published in Nature

Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase

scientific article

Location of the 100 kd-50 kd accessory proteins in clathrin coats.

scientific article

Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta.

scientific article

Multiple active site corrections for docking and virtual screening.

scientific article published in January 2004

Non-charged thiamine analogs as inhibitors of enzyme transketolase.

scientific article published on 3 December 2007

Non-oxime inhibitors of B-Raf(V600E) kinase

scientific article

Potent selective nonpeptidic inhibitors of human lung tryptase.

scientific article published on July 1999

Regulation of nuclear envelope precursor functions during cell division

scientific article published on June 1, 1992

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species

scientific article

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

scientific article

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

scientific article published on 3 December 2007

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

scientific article

Three-dimensional structure of clathrin cages in ice.

scientific article published on March 1986

X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution

scientific article

List of works by Guy P. Vigers

8-Tetrahydropyran-2-yl chromans: highly selective beta-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors

Characterization of the microtubule movement produced by sea urchin egg kinesin

Crystal Structure of Human AKT1 with an Allosteric Inhibitor Reveals a New Mode of Kinase Inhibition

Discovery of 7-tetrahydropyran-2-yl chromans: β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors that reduce amyloid β-protein (Aβ) in the central nervous system

Discovery of Tetrahydropyridopyrimidines as Irreversible Covalent Inhibitors of KRAS-G12C with In Vivo Activity

Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease

Discovery of dihydrothieno- and dihydrofuropyrimidines as potent pan Akt inhibitors

Discovery of pyrrolopyrimidine inhibitors of Akt

Discovery of spirocyclic sulfonamides as potent Akt inhibitors with exquisite selectivity against PKA

Electron microscopy of frozen-hydrated biological material

Highly potent and selective 3-N-methylquinazoline-4(3H)-one based inhibitors of B-Raf(V600E) kinase

Location of the 100 kd-50 kd accessory proteins in clathrin coats.

Mapping receptor binding sites in interleukin (IL)-1 receptor antagonist and IL-1 beta by site-directed mutagenesis. Identification of a single site in IL-1ra and two sites in IL-1 beta.

Multiple active site corrections for docking and virtual screening.

Non-charged thiamine analogs as inhibitors of enzyme transketolase.

Non-oxime inhibitors of B-Raf(V600E) kinase

Potent selective nonpeptidic inhibitors of human lung tryptase.

Regulation of nuclear envelope precursor functions during cell division

Spirocyclic β-site amyloid precursor protein cleaving enzyme 1 (BACE1) inhibitors: from hit to lowering of cerebrospinal fluid (CSF) amyloid β in a higher species

Synthesis, characterization, and PK/PD studies of a series of spirocyclic pyranochromene BACE1 inhibitors

Synthesis, in vitro and in vivo activity of thiamine antagonist transketolase inhibitors.

The discovery of furo[2,3-c]pyridine-based indanone oximes as potent and selective B-Raf inhibitors

Three-dimensional structure of clathrin cages in ice.

X-ray structure of interleukin-1 receptor antagonist at 2.0-A resolution