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List of works by Francesco Lo-Coco

8p11 myeloproliferative syndrome with a novel t(7;8) translocation leading to fusion of the FGFR1 and TIF1 genes

scientific article published in March 2005

A Leukemia-Associated CD34/CD123/CD25/CD99+ Immunophenotype Identifies FLT3-Mutated Clones in Acute Myeloid Leukemia.

scientific article published on 8 May 2015

A monoclonal antibody against mutated nucleophosmin 1 for the molecular diagnosis of acute myeloid leukemias

scientific article published on 10 June 2010

A new complex rearrangement involving the ETV6, LOC115548, and MN1 genes in a case of acute myeloid leukemia

scientific article published in November 2004

A simple prognostic scoring system for newly diagnosed cytogenetically normal acute myeloid leukemia: retrospective analysis of 530 patients

scientific article published on 12 July 2011

AIDA 0493 protocol for newly diagnosed acute promyelocytic leukemia: very long-term results and role of maintenance

scientific article

ATRA + ATO: has a new standard of care been established in low-risk acute promyelocytic leukaemia?

scientific article published on March 2014

Active Pin1 is a key target of all-trans retinoic acid in acute promyelocytic leukemia and breast cancer

scientific article published on 13 April 2015

Acute leukemia in women

scientific article published on March 2010

Acute myeloid leukemia developing in patients with autoimmune diseases ⬇️

scientific article published on December 16, 2011

Acute promyelocytic leukemia: recent advances in diagnosis and management

scientific article published on August 2008

All-trans retinoic acid with daunorubicin or idarubicin for risk-adapted treatment of acute promyelocytic leukaemia: a matched-pair analysis of the PETHEMA LPA-2005 and IC-APL studies

scientific article published on 15 May 2015

An allele-specific rt-PCR assay to detect type A mutation of the nucleophosmin-1 gene in acute myeloid leukemia.

scientific article published on 10 April 2008

Analysis of t(15;17) chromosomal breakpoint sequences in therapy-related versus de novo acute promyelocytic leukemia: association of DNA breaks with specific DNA motifs at PML and RARA loci

scientific article published in August 2010

Arsenic trioxide for management of acute promyelocytic leukemia: current evidence on its role in front-line therapy and recurrent disease

scientific article published on 03 April 2012

BRCA1, PARP1 and γH2AX in acute myeloid leukemia: Role as biomarkers of response to the PARP inhibitor olaparib

article

Biology and management of therapy-related acute promyelocytic leukemia

scientific article

Body cavity lymphoma

scientific article

Budgetary impact of treating acute promyelocytic leukemia patients with first-line arsenic trioxide and retinoic acid from an Italian payer perspective

scientific article published on 12 August 2015

Central nervous system involvement in adult acute lymphoblastic leukemia: diagnostic tools, prophylaxis, and therapy.

scientific article

Characteristics and clinical correlates of MPL 515W>L/K mutation in essential thrombocythemia

scientific article published on 2 June 2008

Chromosomal Aberration of the 11q23 Locus in Acute Leukemia and Frequency of MLL Gene Translocation Results in 378 Adult Patients

article

Chromosomal aberration of the 11q23 locus in acute leukemia and frequency of MLL gene translocation: results in 378 adult patients

scientific article published on 01 August 2004

Clinical and biological features of acute promyelocytic leukemia patients developing retinoic acid syndrome during induction treatment with all-trans retinoic acid and idarubicin

scientific article

Clinical significance of ZAP-70 protein expression in B-cell chronic lymphocytic leukemia

scientific article published on 06 April 2006

Clustering of genomic breakpoints at the MLL locus in therapy-related acute leukemia with t(4;11)(q21;q23).

scientific article published on 5 December 2013

Comparative molecular analysis of therapy-related and de novo acute promyelocytic leukemia.

scientific article

Cost-Effectiveness Analysis of Treating Acute Promyelocytic Leukemia Patients With Arsenic Trioxide and Retinoic Acid in the United States

scientific article published on 05 August 2015

Current standard treatment of adult acute promyelocytic leukaemia

scientific article published on 21 December 2015

Cytogenetic and molecular diagnostic characterization combined to postconsolidation minimal residual disease assessment by flow cytometry improves risk stratification in adult acute myeloid leukemia

scientific article published on 14 June 2010

Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

scientific article

Development of a high-resolution melting curve analysis screening test for SRSF2 splicing factor gene mutations in myelodysplastic syndromes

scientific article published on 24 October 2014

Diagnosis and management of AML in adults: 2017 ELN recommendations from an international expert panel

scientific article

Diphtheria toxin fused to variant human interleukin-3 induces cytotoxicity of blasts from patients with acute myeloid leukemia according to the level of interleukin-3 receptor expression

scientific article published on 31 May 2005

Early detection of meningeal localization in acute promyelocytic leukaemia patients with high presenting leucocyte count

scientific article published in January 2003

Early hemorrhagic death before starting therapy in acute promyelocytic leukemia: association with high WBC count, late diagnosis and delayed treatment initiation

scientific article published on 16 December 2009

Early prediction of treatment outcome in acute myeloid leukemia by measurement of WT1 transcript levels in peripheral blood samples collected after chemotherapy

scientific article

Efficacy of prolonged therapy with combined arsenic trioxide and ATRA for relapse of acute promyelocytic leukemia ⬇️

scientific article published on June 9, 2011

Elevated expression of IL-3Ralpha in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis

scientific article published in October 2002

Evaluation of the prognostic relevance of L-selectin and ICAM1 expression in myelodysplastic syndromes

scientific article published on 17 November 2007

Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia

scientific article

FLT3 inhibition as a targeted therapy for acute myeloid leukemia

scientific article

FLT3-ITD confers poor prognosis in patients with acute promyelocytic leukemia treated with AIDA protocols: long-term follow-up analysis

scientific article published on December 2013

Front-line treatment of acute promyelocytic leukemia with AIDA induction followed by risk-adapted consolidation for adults younger than 61 years: results of the AIDA-2000 trial of the GIMEMA Group

scientific article

GIMEMA AML1310 trial of risk-adapted, MRD-directed therapy for young adults with newly diagnosed acute myeloid leukemia

scientific article published on 08 August 2019

Gemtuzumab ozogamicin (Mylotarg) as a single agent for molecularly relapsed acute promyelocytic leukemia

scientific article published on 8 June 2004

Gemtuzumab ozogamicin for the treatment of acute promyelocytic leukemia: mechanisms of action and resistance, safety and efficacy ⬇️

scientific article published on December 11, 2010

Gemtuzumab ozogamicin: time to resurrect?

scientific article

High ΔNp73/TAp73 ratio is associated with poor prognosis in acute promyelocytic leukemia

scientific article published on October 2015

History of acute promyelocytic leukemia: a tale of endless revolution ⬇️

scientific article published on December 21, 2011

Human chromosome 7: DNA sequence and biology

scientific article

Identification of a potential "hotspot" DNA region in the RUNX1 gene targeted by mitoxantrone in therapy-related acute myeloid leukemia with t(16;21) translocation

scientific article published in March 2009

Identification of a potential topoisomerase II "hotspot" DNA region in the DEK gene in two t(6;9)-positive therapy-related myeloid neoplasms

scientific article published on 13 October 2016

Identification of emerging FLT3 ITD-positive clones during clinical remission and kinetics of disease relapse in acute myeloid leukaemia with mutated nucleophosmin.

scientific article published on 11 March 2013

Identification of i(X)(p10) as the sole molecular abnormality in atypical chronic myeloid leukemia evolved into acute myeloid leukemia

scientific article published on 29 December 2017

Idiopathic hypereosinophilic syndrome: a case evolving in B-lymphoblastic lymphoma.

scientific article

Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

scientific article published on 23 May 2006

Improved Outcomes With Retinoic Acid and Arsenic Trioxide Compared With Retinoic Acid and Chemotherapy in Non-High-Risk Acute Promyelocytic Leukemia: Final Results of the Randomized Italian-German APL0406 Trial

scientific article published on 31 October 2016

Improving acute promyelocytic leukemia (APL) outcome in developing countries through networking, results of the International Consortium on APL.

scientific article published on 14 January 2013

Influence of time to complete remission and duration of all-trans retinoic acid therapy on the relapse risk in patients with acute promyelocytic leukemia receiving AIDA protocols ⬇️

scientific article published on December 20, 2012

Introducing biological features at diagnosis improves the relapse risk stratification in patients with acute promyelocytic leukemia treated with ATRA and chemotherapy

scientific article

Involvement of central nervous system in adult patients with acute myeloid leukemia: Incidence and impact on outcome

scientific article published on 21 February 2018

Long-term results of all-trans retinoic acid and arsenic trioxide in non-high-risk acute promyelocytic leukemia: update of the APL0406 Italian-German randomized trial

scientific article published on 14 October 2019

Longitudinal detection of DNMT3AR882H transcripts in patients with acute myeloid leukemia.

scientific article published on 8 February 2018

M4 and M5 acute myeloid leukaemias display a high sensitivity to Bortezomib-mediated apoptosis

scientific article published in October 2007

MRD in AML: The Role of New Techniques

scientific article published on 23 July 2019

Management of acute promyelocytic leukemia in the elderly ⬇️

scientific article published on June 8, 2013

Management of acute promyelocytic leukemia: recommendations from an expert panel on behalf of the European LeukemiaNet

scientific article

Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet

scholarly article by Miguel A Sanz et al published 11 April 2019 in Blood

Mechanisms of anti-cancer effects of ascorbate: Cytotoxic activity and epigenetic modulation

scientific article published on 21 September 2017

MiR-424 and miR-155 deregulated expression in cytogenetically normal acute myeloid leukaemia: correlation with NPM1 and FLT3 mutation status

scientific article published on 8 June 2012

Midostaurin in patients with acute myeloid leukemia and FLT3-TKD mutations: a subanalysis from the RATIFY trial

scientific article published on 01 October 2020

Midostaurin plus Chemotherapy for Acute Myeloid Leukemia with a FLT3 Mutation

scientific article published on 23 June 2017

Minimal residual disease as a biomarker for outcome prediction and therapy optimization in acute myeloid leukemia

scientific article published on 07 March 2018

Minimal residual disease as biomarker for optimal biologic dosing of ARA-C in patients with acute myeloid leukemia

scientific article published on 24 November 2014

Mitoxantrone-related acute leukemia in MS: an open or closed book?

scientific article published on April 2013

Modern Approaches to Treating Acute Promyelocytic Leukemia ⬇️

scientific article published on January 10, 2011

Molecular characterization of paediatric idiopathic hypereosinophilia

scientific article published on 19 October 2010

Molecular remission in advanced acute promyelocytic leukaemia after treatment with the oral synthetic retinoid Tamibarotene

scientific article published on 5 July 2010

Monitoring of minimal residual disease in acute myeloid leukemia

scientific article published on 01 November 2009

Mutational landscape of patients with acute promyelocytic leukemia at diagnosis and relapse

scientific article published on 23 July 2019

Mutations affecting both the rearranged and the unrearranged PML alleles in refractory acute promyelocytic leukaemia

scientific article published on 5 January 2016

NPM1 gene deletions in myelodysplastic syndromes with 5q- and complex karyotype ⬇️

scientific article published on March 10, 2011

Negative prognostic value of glutathione S-transferase (GSTM1 and GSTT1) deletions in adult acute myeloid leukemia

scientific article published in October 2002

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

scientific article

Oncogenic Role of Fusion-circRNAs Derived from Cancer-Associated Chromosomal Translocations

scientific article published on 30 March 2016

Overexpression of BP1, a homeobox gene, is associated with resistance to all-trans retinoic acid in acute promyelocytic leukemia cells

scientific article published on 20 November 2007

PAX5 expression in acute leukemias: higher B-lineage specificity than CD79a and selective association with t(8;21)-acute myelogenous leukemia

scientific article

PML Controls PTEN Localization and Function in APL through a Novel Deubiquitination Pathway ⬇️

scholarly article

PML-RAR alpha induces the downmodulation of HHEX: a key event responsible for the induction of an angiogenetic response

scientific article published on 07 April 2016

PML-RAR induces promyelocytic leukemias with high efficiency following retroviral gene transfer into purified murine hematopoietic progenitors

scientific article published in October 2002

Panobinostat for the treatment of acute myelogenous leukemia

scientific article published on 2 August 2016

Patient-reported outcomes in hematology: is it time to focus more on them in clinical trials and hematology practice?

scientific article published on 10 July 2017

Podocalyxin is expressed in normal and leukemic monocytes

scientific article published on 23 October 2006

Polycombs and microRNA-223 regulate human granulopoiesis by transcriptional control of target gene expression.

scientific article published on 10 February 2012

Practice points, consensus, and controversial issues in the management of patients with newly diagnosed acute promyelocytic leukemia

scientific article

Predictors of thrombohemorrhagic early death in children and adolescents with t(15;17)-positive acute promyelocytic leukemia treated with ATRA and chemotherapy

scientific article published on 08 June 2017

Presenting features and treatment outcome of acute promyelocytic leukemia arising after multiple sclerosis ⬇️

scientific article published on December 29, 2010

Prognostic and therapeutic implications of minimal residual disease detection in acute myeloid leukemia

scientific article published on 28 October 2011

Prognostic factors in acute promyelocytic leukemia: strategies to define high-risk patients

scientific article published on 26 February 2016

Prognostic impact of KMT2E transcript levels on outcome of patients with acute promyelocytic leukaemia treated with all-trans retinoic acid and anthracycline-based chemotherapy: an International Consortium on Acute Promyelocytic Leukaemia study

scientific article

Prognostic impact of genetic characterization in the GIMEMA LAM99P multicenter study for newly diagnosed acute myeloid leukemia

scientific article published on 27 May 2008

Progress and criticalities in the management of acute promyelocytic leukemia

scientific article published on 12 November 2017

Prolonged molecular remission in a newly diagnosed acute promyelocytic leukaemia with a severe cardiomyopathy using low-dose gemtuzumab ozogamicin and all-trans retinoic acid.

scientific article

Prospective minimal residual disease monitoring to predict relapse of acute promyelocytic leukemia and to direct pre-emptive arsenic trioxide therapy.

scientific article

Rapid detection of IDH2 (R140Q and R172K) mutations in acute myeloid leukemia ⬇️

scientific article published on August 15, 2013

Rapid detection of nucleophosmin (NPM1) mutations in acute myeloid leukemia by denaturing HPLC.

scientific article

Reply to M. Koehler et al.

scientific article published on 17 February 2015

Retinoic acid and arsenic trioxide for acute promyelocytic leukemia

scientific article

Revised recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia

scientific article published on December 2003

Role of gamma-glutamyl cysteine synthetase (gamma-GCS) gene expression as marker of drug sensitivity in acute myeloid leukemias

scientific article published on 18 October 2005

Sequential valproic acid/all-trans retinoic acid treatment reprograms differentiation in refractory and high-risk acute myeloid leukemia

scientific article published on 01 September 2006

Successful pregnancy after arsenic trioxide therapy for relapsed acute promyelocytic leukaemia

Tamibarotene in patients with acute promyelocytic leukaemia relapsing after treatment with all-trans retinoic acid and arsenic trioxide

scientific article published on 24 July 2015

Targeted Therapy Alone for Acute Promyelocytic Leukemia

scientific article

The biology of acute promyelocytic leukemia and its impact on diagnosis and treatment

scientific article published on January 2006

The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network

scientific article

The experience of the International Consortium on Acute Promyelocytic Leukemia in monitoring minimal residual disease in acute promyelocytic leukaemia

scientific article

The genotype nucleophosmin mutated and FLT3-ITD negative is characterized by high bax/bcl-2 ratio and favourable outcome in acute myeloid leukaemia.

scientific article published on 8 February 2010

The hidden genomic landscape of acute myeloid leukemia: subclonal structure revealed by undetected mutations

scientific article

The importance of molecular monitoring in acute promyelocytic leukaemia

scientific article

Toward optimization of postremission therapy for residual disease-positive patients with acute myeloid leukemia.

scientific article published on 7 July 2008

Transcriptional silencing of the ETS1 oncogene contributes to human granulocytic differentiation

scientific article

Treatment of Low-Blast Count AML using Hypomethylating Agents

scientific article

Tricks of the trade for the appropriate management of newly diagnosed acute promyelocytic leukemia

scientific article

Trisenox: a paradigm shift in APL therapy, an interview with Francesco Lo-Coco.

scientific article published in November 2016

Understanding the molecular pathogenesis of acute promyelocytic leukemia

scientific article

Use of arsenic trioxide in secondary acute promyelocytic leukemia developing after treatment of multiple sclerosis with mitoxantrone.

scientific article published in July 2009

Using patient-reported health status to improve prognostic assessment in patients with acute myeloid leukemia: current challenges and future applications

scientific article

Utilization of molecular phenotypes to detect relapse and optimize the management of acute promyelocytic leukemia

scientific article published on October 2010

What is the standard regimen for patients with acute promyelocytic leukemia?

scientific article published on June 2014

miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia.

scientific article published on 10 September 2012

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