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List of works by Seppo Heinonen

A Non-Targeted LC-MS Profiling Reveals Elevated Levels of Carnitine Precursors and Trimethylated Compounds in the Cord Plasma of Pre-Eclamptic Infants

scientific article published in Scientific Reports

A highly reproducible xenograft model for human ovarian carcinoma and application of MRI and ultrasound in longitudinal follow-up

scientific article published on 4 May 2006

A population-based study of the effect of pregnancy history on risk of stillbirth

scientific article

A population‐based register study to determine indications for episiotomy in Finland ⬇️

scientific article published on July 20, 2011

A prior cesarean section and incidence of obstetric anal sphincter injury

scientific article published on 5 December 2012

A survey of the attitudes of infertile and parous women towards the availability of assisted reproductive technology

scientific article

ADMA concentration changes across the menstrual cycle and during oral contraceptive use: the Cardiovascular Risk in Young Finns Study

scientific article published on 24 November 2009

Adiponectin gene haplotype is associated with preeclampsia

scientific article published in January 2006

Adverse Outcomes of IVF/ICSI Pregnancies Vary Depending on Aetiology of Infertility ⬇️

scientific article published on April 9, 2012

Adverse perinatal outcomes associated with moderate or severe maternal anaemia based on parity in Finland during 2006-10.

scientific article published on 17 June 2014

Altered differentiation of neural stem cells in fragile X syndrome

scientific article

Ambulatory arterial stiffness index and nocturnal blood pressure dipping in pregnancies complicated by hypertension ⬇️

scientific article published on June 19, 2013

Ambulatory arterial stiffness index is unchanged in uncomplicated third-trimester singleton and twin pregnancies ⬇️

scientific article published on May 1, 2011

Amniocentesis--a routine procedure, but invasive

scientific article published in September 2003

An RGS2 3'UTR polymorphism is associated with preeclampsia in overweight women

scientific article

An obesity-related FTO variant and the risk of preeclampsia in a Finnish study population

scientific article published on 3 November 2011

Anaemia in the first but not in the second or third trimester is a risk factor for low birth weight

scientific article

Analysis of Complement C3 Gene Reveals Susceptibility to Severe Preeclampsia

scientific article

Androgen receptor gene CAG length polymorphism in women with polycystic ovary syndrome

scientific article published in June 2005

Androgen receptor gene CAG repeat length in women with metabolic syndrome

scientific article published in July 2008

Angiogenic profile and smoking in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.

scientific article published on 9 June 2017

Angiogenic profile in the Finnish Genetics of Pre-Eclampsia Consortium (FINNPEC) cohort.

scientific article

Antiangiogenic gene therapy with soluble VEGF-receptors -1, -2 and -3 together with paclitaxel prolongs survival of mice with human ovarian carcinoma

scientific article

Antiangiogenic gene therapy with soluble VEGFR-1, -2, and -3 reduces the growth of solid human ovarian carcinoma in mice

scientific article

Assessment of Bony Pelvis and Vaginally Assisted Deliveries ⬇️

scientific article published on April 4, 2013

Assessment of attitudes towards assisted reproduction: a survey among medical students and parous women

scientific article published on November 2006

Association of risk variants for type 2 diabetes and hyperglycemia with gestational diabetes ⬇️

scientific article published on July 29, 2013

Association of the rs1424954 polymorphism of the ACVR2A gene with the risk of pre-eclampsia is not replicated in a Finnish study population

scientific article

Associations between two single nucleotide polymorphisms in the adiponectin gene and polycystic ovary syndrome

scientific article published in September 2005

Breech presentation at term and associated obstetric risks factors-a nationwide population based cohort study

scientific article published on 7 February 2017

CTLA-4 polymorphism 49A-G is associated with placental abruption and preeclampsia in Finnish women

Carotid artery elasticity decreases during pregnancy - the Cardiovascular Risk in Young Finns study

scientific article

Changing associations of episiotomy and anal sphincter injury across risk strata: results of a population-based register study in Finland 2004-2011.

scientific article published on 17 August 2013

Children exposed to valproate in utero--population based evaluation of risks and confounding factors for long-term neurocognitive development

scientific article published in July 2005

Clinical significance of true umbilical knots: a population-based analysis

scientific article published in April 2002

Cohort profile: the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC).

scientific article

Comparison of the pregnancy outcomes of subfertile women after infertility treatment and in naturally conceived pregnancies ⬇️

scientific article published on February 14, 2012

Considering medical risk information and communicating values: A mixed-method study of women's choice in prenatal testing

scientific article

Contribution of risk factors to extremely, very and moderately preterm births - register-based analysis of 1,390,742 singleton births

scientific article

Contribution of socioeconomic status to the risk of small for gestational age infants--a population-based study of 1,390,165 singleton live births in Finland

scientific article published on May 2013

Decreased PAPP-A is associated with preeclampsia, premature delivery and small for gestational age infants but not with placental abruption ⬇️

scientific article published on April 8, 2011

Development of gliadin-specific immune responses in children with HLA-associated genetic risk for celiac disease

scientific article published on 10 July 2015

Does gestational diabetes affect women's health-related quality of life after delivery?

scientific article published in January 2010

Does unemployment in family affect pregnancy outcome in conditions of high quality maternity care?

scientific article

Downregulated CD44 and hyaluronan expression in vulvar intraepithelial neoplasia and squamous cell carcinomas

scientific article published in January 2010

Dynamic MRI confirms support of the mid-urethra by TVT and TVT-O surgery for stress incontinence ⬇️

scientific article published on April 15, 2011

Dynamic magnetic resonance imaging of the behavior of the mid-urethra in healthy and stress incontinent women

scientific article published in March 2010

Early signs of maternal iron deficiency do not influence the iron status of the newborn, but are associated with higher infant birthweight

scientific article published in January 2009

Endothelial Nitric Oxide Synthase Polymorphism in Preeclampsia ⬇️

scientific article published on April 1, 2003

Erratum to "An Obesity-Related FTO Variant and the Risk of Preeclampsia in a Finnish Study Population".

scientific article published on 24 July 2012

Etiology, syndrome diagnosis, and cognition in childhood-onset epilepsy: A population-based study.

scientific article

Exome sequencing in pooled DNA samples to identify maternal pre-eclampsia risk variants

scientific article published on 07 July 2016

Fear of childbirth predicts postpartum depression: a population-based analysis of 511 422 singleton births in Finland

scientific article

Fertility rates and the postponement of first births: a descriptive study with Finnish population data

article by Zahra Roustaei et al published 15 January 2019 in BMJ Open

Fetal Microsatellite in the Heme Oxygenase 1 Promoter Is Associated With Severe and Early-Onset Preeclampsia

scientific article published on 4 December 2017

Fetal membranes act as a barrier for adenoviruses: gene transfer into exocoelomic cavity of rat fetuses does not affect cells in the fetus

scientific article published in January 2004

First trimester serum placental growth factor and hyperglycosylated human chorionic gonadotropin are associated with pre-eclampsia: a case control study

scientific article

Flow-Mediated Vasodilation Is Not Attenuated in Hypertensive Pregnancies Despite Biochemical Signs of Inflammation ⬇️

scientific article published on January 17, 2012

Frequent gene dosage alterations in stromal cells of epithelial ovarian carcinomas

article

Future risk of metabolic syndrome in women with a previous LGA delivery stratified by gestational glucose tolerance: a prospective cohort study

Gene therapy and ovarian cancer: more questions than answers

scientific article published in January 2006

Gene transfer to human placenta ex vivo: a novel application of dual perfusion of human placental cotyledon

article

Genetic alterations in the peritumoral stromal cells of malignant and borderline epithelial ovarian tumors as indicated by allelic imbalance on chromosome 3p.

scientific article

Genetic dissection of the pre-eclampsia susceptibility locus on chromosome 2q22 reveals shared novel risk factors for cardiovascular disease

scientific article published on 18 February 2013

Genome-wide association scan identifies a risk locus for preeclampsia on 2q14, near the inhibin, beta B gene

scientific article

Glycosylated fibronectin as a first-trimester biomarker for prediction of gestational diabetes

scientific article published in September 2013

Good outcome of teenage pregnancies in high-quality maternity care

scientific article

Guidelines for the management of postterm pregnancy

scientific article published in March 2010

High episiotomy rate protects from obstetric anal sphincter ruptures: a birth register-study on delivery intervention policies in Finland

scientific article

Hospital-based lateral episiotomy and obstetric anal sphincter injury rates: a retrospective population-based register study

scientific article published on 28 February 2012

How Can We Increase Postpartum Glucose Screening in Women at High Risk for Gestational Diabetes Mellitus? ⬇️

scientific article published on March 25, 2012

How to improve the quality of research reporting? ⬇️

scientific article published on June 1, 2013

Hyaluronan synthases (HAS1-3) and hyaluronidases (HYAL1-2) in the accumulation of hyaluronan in endometrioid endometrial carcinoma

scientific article

Impact of obesity on angiogenic and inflammatory markers in the Finnish Genetics of Pre-eclampsia Consortium (FINNPEC) cohort

article

Increased time-to-pregnancy and first trimester Down's syndrome screening

scientific article

Induced abortion: not an independent risk factor for pregnancy outcome, but a challenge for health counseling

scientific article

Induction of labor in breech presentations at term: a retrospective observational study

scientific article

Infertility treatment and umbilical cord length-novel markers of childhood epilepsy?

scientific article published on 13 February 2013

Influence of delivery characteristics and socioeconomic status on giving birth by caesarean section - a cross sectional study during 2000-2010 in Finland

scientific article

Intrauterine bacterial growth at birth and risk of asthma and allergic sensitization among offspring at the age of 15 to 17 years

scientific article

Intravenous oxycodone for pain relief in the first stage of labour--maternal pharmacokinetics and neonatal exposure

scientific article

Kuopio birth cohort - design of a Finnish joint research effort for identification of environmental and lifestyle risk factors for the wellbeing of the mother and the newborn child

Long-term changes in glucose metabolism after gestational diabetes: a double cohort study

scientific article

Low maternal pregnancy-associated plasma protein A during the first trimester of pregnancy and pregnancy outcomes

scientific article published on 3 November 2016

Low-dose aspirin therapy and hypertensive pregnancy complications in unselected IVF and ICSI patients: a randomized, placebo-controlled, double-blind study ⬇️

scientific article published on October 13, 2010

Magnetic resonance imaging sheds light on the nature of smoking-induced effects on fetal brain

scientific article published in February 2010

Marriage still protects pregnancy

scientific article

Maternal Use of Selective Serotonin Reuptake Inhibitors and Lengthening of the Umbilical Cord: Indirect Evidence of Increased Foetal Activity-A Retrospective Cohort Study

scientific article

Maternal anemia during pregnancy and slightly higher risk of asthma in male offspring

scientific article published on 4 January 2018

Maternal drug or alcohol abuse is associated with decreased head size from mid-pregnancy to childhood

scientific article published in April 2016

Maternal fecundity and asthma among offspring—is the risk programmed preconceptionally? Retrospective observational study ⬇️

scientific article published on November 10, 2012

Maternal pro-hepcidin at term correlates with cord blood pro-hepcidin at birth

scientific article

Maternal serum ADMA is not associated with proinflammatory cytokines or C-reactive protein during normal pregnancy

scientific article published on 5 March 2009

Maternal serum hepcidin is low at term and independent of cord blood iron status

scientific article published on 22 July 2010

Maternal socioeconomic status and the risk of asthma among offspring

scientific article

Microsatellite marker association at chromosome region 2p13 in Finnish patients with preeclampsia and obstetric cholestasis suggests a common risk locus

scientific article published in March 2003

Need for and consequences of episiotomy in vaginal birth: a critical approach

scientific article published on 18 September 2008

Need for critical care in gynaecology: a population-based analysis

scientific article

Need for insulin to control gestational diabetes is reflected in the ambulatory arterial stiffness index ⬇️

scientific article published on January 16, 2013

Neurodevelopmental outcome at the age of 4 years according to the planned mode of delivery in term breech presentation: a nationwide, population-based record linkage study

scientific article published on 9 September 2017

Normalization of vasoactive changes in preeclampsia precedes clinical recovery

scientific article published in January 2002

Novel red cell indices indicating reduced availability of iron are associated with high erythropoietin concentration and low ph level in the venous cord blood of newborns

scientific article published in August 2008

Obstetric outcome in post-term pregnancies: time for reappraisal in clinical management

scientific article published in January 2006

Obstetric prognosis after placental abruption

scientific article

Obstetric prognosis in sisters of preeclamptic women - implications for genetic linkage studies

scientific article

Ophthalmologic and neurologic findings in two children exposed to vigabatrin in utero

scientific article published in June 2005

Outcome of assisted reproductive technology (ART) and subsequent self-reported life satisfaction

scientific article

Parental smoking and cessation during pregnancy and the risk of childhood asthma

scientific article

Placenta percreta: methotrexate treatment and MRI findings

scientific article published on 4 January 2008

Placenta previa and risk of major congenital malformations among singleton births in Finland

scientific article published on 24 March 2015

Placenta previa and the risk of delivering a small-for-gestational-age newborn

scientific article

Plasma cell membrane glycoprotein-1 K121Q polymorphism in preeclampsia

scientific article published on 2 November 2005

Plasminogen activator inhibitor-1 polymorphism in women with pre-eclampsia

scientific article published in January 2003

Polymorphism in the tumor necrosis factor-alpha gene in women with preeclampsia

scientific article

Post-challenge glycemia during pregnancy as a marker of future risk of type 2 diabetes: a prospective cohort study

scientific article

Preclinical safety, toxicology, and biodistribution study of adenoviral gene therapy with sVEGFR-2 and sVEGFR-3 combined with chemotherapy for ovarian cancer

scientific article published in March 2013

Preeclampsia and androgen receptor gene CAG repeat length: results from both children and women

scientific article

Preeclampsia complicated by advanced maternal age: a registry-based study on primiparous women in Finland 1997-2008.

scientific article

Pregnancy outcomes in women aged 35 years or older with gestational diabetes - a registry-based study in Finland

scientific article published on 8 December 2014

Pregnancy outcomes of overweight and obese women aged 35 years or older - A registry-based study in Finland

scientific article published on 5 June 2015

Preoperative angiopoietin-2 serum levels: a marker of malignant potential in ovarian neoplasms and poor prognosis in epithelial ovarian cancer

scientific article published in December 2010

Prolonged time to pregnancy is associated with a greater risk of adverse outcomes

scientific article published on 11 December 2009

Protective Low-Frequency Variants for Preeclampsia in the Fms Related Tyrosine Kinase 1 Gene in the Finnish Population

scientific article published on 26 June 2017

Risk factors and adverse pregnancy outcomes among births affected by velamentous umbilical cord insertion: a retrospective population-based register study ⬇️

scientific article published on September 1, 2012

Risk factors and outcomes in "well-selected" vaginal breech deliveries: a retrospective observational study

scientific article published on 6 April 2016

Risk factors associated with adverse perinatal outcome in planned vaginal breech labors at term: a retrospective population-based case-control study

scientific article published on 20 March 2017

Risk factors for and perinatal outcomes of major depression during pregnancy: a population-based analysis during 2002-2010 in Finland

scientific article

Serum L-homoarginine concentration is elevated during normal pregnancy and is related to flow-mediated vasodilatation

scientific article

Serum angiopoietin-2 and soluble VEGFR-2 levels predict malignancy of ovarian neoplasm and poor prognosis in epithelial ovarian cancer

scientific article

Serum hyperglycosylated human chorionic gonadotrophin at 14-17 weeks of gestation does not predict preeclampsia

Smoking among older childbearing women - a marker of risky health behaviour a registry-based study in Finland

scientific article

Smoking cessation in the first trimester reduces most obstetric risks, but not the risks of major congenital anomalies and admission to neonatal care: a population-based cohort study of 1,164,953 singleton pregnancies in Finland.

scientific article published on 24 October 2013

Smoking during pregnancy is associated with a decreased incidence of obstetric anal sphincter injuries in nulliparous women

scientific article

Smoking during pregnancy was up to 70% more common in the most deprived municipalities - a multilevel analysis of all singleton births during 2005-2010 in Finland

scientific article published on 28 June 2014

Smooth muscle tumor of the placenta - an entrapped maternal leiomyoma: a case report

scientific article published on 17 June 2009

Social disparity affects the incidence of placental abruption among multiparous but not nulliparous women: a register-based analysis of 1,162,126 singleton births

scientific article

Socioeconomic status affects the prevalence, but not the perinatal outcomes, of in vitro fertilization pregnancies.

scientific article

Spontaneous and stimulated interleukin-6 and tumor necrosis factor-alpha production at delivery and three months after birth

scientific article

Stanniocalcin-1 Hormone in Nonpreeclamptic and Preeclamptic Pregnancy: Clinical, Life-Style, and Genetic Modulators

scientific article published on 07 September 2016

Subtle changes in ADMA and l-arginine concentrations in normal pregnancies are unlikely to account for pregnancy-related increased flow-mediated dilatation

scientific article

Success of trial of labor in women with a history of previous cesarean section for failed labor induction or labor dystocia: a retrospective cohort study

scientific article published on 21 May 2019

Susceptibility to pre-eclampsia in Finnish women is associated with R485K polymorphism in the factor V gene, not with Leiden mutation

scientific article published in March 2004

The administration of an adenoviral thymidine kinase suicide gene to the uterine artery of rabbits does not affect fertility: a safety study of pregnant and nonpregnant rabbits and their offspring

scientific article

The androgenic sex hormone profile is an essential feature of metabolic syndrome in premenopausal women: a controlled community-based study

scientific article

The association between gestational diabetes mellitus and postpartum depressive symptomatology: A prospective cohort study

scientific article published in December 2018

The association of episiotomy with obstetric anal sphincter injury--a population based matched cohort study

scientific article

The burden of OASIS increases along with socioeconomic position--register-based analysis of 980,733 births in Finland

scientific article

The burden of childhood asthma and late preterm and early term births

scientific article published on 6 November 2013

The diagnosis of pre-eclampsia using two revised classifications in the Finnish Pre-eclampsia Consortium (FINNPEC) cohort

scientific article

The effects of valproate exposure in utero on behavior and the need for educational support in school-aged children

scientific article published on 16 October 2006

The human placental proteome is affected by maternal smoking

scientific article

The increased incidence of obstetric anal sphincter rupture--an emerging trend in Finland

scientific article

The influence of smoking on the pregnancy-associated plasma protein A, free beta human chorionic gonadotrophin and nuchal translucency

scientific article published in July 2003

The relationship between red blood cell and reticulocyte indices and serum markers of iron status in the cord blood of newborns

scientific article published in January 2007

The risk of adverse pregnancy outcome among pregnancies with extremely low maternal PAPP-A.

scientific article published on 17 October 2016

The risk of metabolic syndrome in women with previous GDM in a long-term follow-up

scientific article published on 5 August 2016

The role of nocturnal delivery and delivery during the holiday period in Finland on obstetric anal sphincter rupture rates- a population based observational study

scientific article

The use of epidural analgesia for intrapartum pain relief in publicly funded healthcare

scientific article published on 17 January 2014

Transduction patterns and efficiencies in rabbit uterine tissues after intraluminal uterine adenovirus administration vary with the reproductive cycle

scientific article published in January 2007

Transition from overweight to obesity worsens pregnancy outcome in a BMI-dependent manner

scientific article

Transplacental transfer of acrylamide and glycidamide are comparable to that of antipyrine in perfused human placenta

scientific article

True umbilical cord knot and obstetric outcome ⬇️

scientific article published on March 21, 2013

Tumor suppressor and growth regulatory genes are overexpressed in severe early-onset preeclampsia--an array study on case-specific human preeclamptic placental tissue

scientific article published in July 2005

Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are associated with polycystic ovary syndrome

scientific article

Two exonic single nucleotide polymorphisms in the microsomal epoxide hydrolase gene are jointly associated with preeclampsia

scientific article

Under-attending free antenatal care is associated with adverse pregnancy outcomes

scientific article

Unemployment at municipality level is associated with an increased risk of small for gestational age births--a multilevel analysis of all singleton births during 2005-2010 in Finland

scientific article

Up to seven-fold inter-hospital differences in obstetric anal sphincter injury rates- A birth register-based study in Finland

scientific article

Use of advanced red blood cell and reticulocyte indices improves the accuracy in diagnosing iron deficiency in pregnant women at term

scientific article published in November 2007

Women with hypertensive pregnancies have difficulties in regaining pre-pregnancy weight and show metabolic disturbances

scientific article published on 20 August 2009

Women's choices for invasive or non-invasive testing: influence of gestational age and service delivery

scientific article published on 8 November 2016

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