List of works - Carmine Giuseppe Fanelli

A multistep approach for the stratification of the risk of severe hypoglycemia in patients with type 2 diabetes

scientific article published on 01 December 2018

A randomized controlled trial to evaluate the efficacy of ultrasound-guided laser photocoagulation for treatment of benign thyroid nodules.

scientific article

Adrenergic mechanisms contribute to the late phase of hypoglycemic glucose counterregulation in humans by stimulating lipolysis ⬇️

scientific article published on June 1, 1992

Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes.

scientific article published in September 1998

Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia.

scientific article published in August 2001

Brief twice-weekly episodes of hypoglycemia reduce detection of clinical hypoglycemia in type 1 diabetes mellitus

scientific article published on 01 September 1998

Comparison of Pharmacokinetics and Dynamics of the Long-Acting Insulin Analogs Glargine and Detemir at Steady State in Type 1 Diabetes: A double-blind, randomized, crossover study

article

Counterregulatory hormone and symptom responses to insulin-induced hypoglycemia in the postprandial state in humans.

scientific article published in November 2003

Different brain responses to hypoglycemia induced by equipotent doses of the long-acting insulin analog detemir and human regular insulin in humans.

scientific article

Different insulin concentrations in resuspended vs. unsuspended NPH insulin: Practical aspects of subcutaneous injection in patients with diabetes.

scientific article

Durable reversal of hypoglycemia unawareness in type 1 diabetes

scientific article published on 01 May 1999

Early improvement of glucose tolerance after ileal transposition in a non-obese type 2 diabetes rat model.

scientific article published in October 2005

Effect of cigarette smoking and of a transdermal nicotine delivery system on glucoregulation in type 2 diabetes mellitus

scientific article published on January 1, 1992

Effect of storage temperature of insulin on pharmacokinetics and pharmacodynamics of insulin mixtures injected subcutaneously in subjects with type 1 (insulin-dependent) diabetes mellitus

scientific article published on 01 November 1988

Effect of the amino acid alanine on glucagon secretion in non-diabetic and type 1 diabetic subjects during hyperinsulinaemic euglycaemia, hypoglycaemia and post-hypoglycaemic hyperglycaemia

scientific article published on 12 December 2006

Effects of an Intensive Lifestyle Intervention to Treat Overweight/Obese Children and Adolescents

scientific article

Equipotency of insulin glargine 300 U/mL AND 100 U/mL with intravenous dosing but differential bioavailability with subcutaneous dosing in dogs

scientific article published on 01 October 2020

Estimating plasma glucose from interstitial glucose: the issue of calibration algorithms in commercial continuous glucose monitoring devices.

scientific article published on 03 December 2010

GLP-1 RAs as compared to prandial insulin after failure of basal insulin in type 2 diabetes: lessons from the 4B and Get-Goal DUO 2 trials

scientific article

Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia.

scientific article published in October 2002

Glargine metabolism over 24 h following its subcutaneous injection in patients with type 2 diabetes mellitus: a dose-response study

scientific article published on 22 February 2014

Glucagon: the effects of its excess and deficiency on insulin action.

scientific article

How to Accurately Establish Pharmacokinetics/Pharmacodynamics of Long-Acting Insulins in Humans: Relevance to Biosimilar Insulins

scientific article published on 01 December 2015

Hypoglycemia per se stimulates sympathetic neural as well as adrenomedullary activity, but, unlike the adrenomedullary response, the forearm sympathetic neural response is not reduced after recent hypoglycemia

scientific article published on 01 July 1999

Impact of patient and treatment characteristics on glycemic control and hypoglycemia in patients with type 2 diabetes initiated to insulin glargine or NPH: A post hoc, pooled, patient-level analysis of 6 randomized controlled trials

scientific article published on February 2017

Impact of recent antecedent hypoglycemia on hypoglycemic cognitive dysfunction in nondiabetic humans.

scientific article published in August 1996

Insulin is required for prandial ghrelin suppression in humans

scientific article published on 01 December 2003

Intensive lifestyle intervention is particularly advantageous in poorly controlled type 2 diabetes

scientific article published on 21 June 2017

Late post-prandial hypoglycaemia as the sole presenting feature of secreting pancreatic beta-cell adenoma in a subtotally gastrectomized patient.

scientific article published in January 1997

Long-term intensive insulin therapy in IDDM: effects on HbA1c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia

scientific article published on 01 June 1996

Long-term intensive therapy of IDDM patients with clinically overt autonomic neuropathy: effects on hypoglycemia awareness and counterregulation.

scientific article

Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM

scientific article published on 01 December 1994

Low Levels of Unmodified Insulin Glargine in Plasma of People With Type 2 Diabetes Requiring High Doses of Basal Insulin

scientific article published on 01 July 2015

Mechanisms of arterial hypotension after therapeutic dose of subcutaneous insulin in diabetic autonomic neuropathy.

scientific article

Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis

scientific article

Metabolic and endocrine effects of physiological increments in plasma ghrelin concentrations.

scientific article published on 20 October 2005

Metabolism of insulin glargine after repeated daily subcutaneous injections in subjects with type 2 diabetes

scientific article

Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM

scientific article published on 01 November 1993

Nocturnal spikes of growth hormone secretion cause the dawn phenomenon in type 1 (insulin-dependent) diabetes mellitus by decreasing hepatic (and extrahepatic) sensitivity to insulin in the absence of insulin waning.

scientific article

Pharmacokinetics and Pharmacodynamics of NPH Insulin in Type 1 Diabetes: The Importance of Appropriate Resuspension Before Subcutaneous Injection.

scientific article

Pharmacokinetics and pharmacodynamics of insulin glargine given in the evening as compared with in the morning in type 2 diabetes

scientific article published on 18 December 2014

Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine after 1 week of use compared with its first administration in subjects with type 1 diabetes

scientific article published on 15 February 2007

Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: a randomized cross-over study.

scientific article published on 15 April 2011

Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28),Pro(B29)] in IDDM

scientific article published on 01 July 1994

Pivotal role of timely basal insulin replacement after metformin failure in sustaining long-term blood glucose control at a target in type 2 diabetes.

scientific article

Plasma Insulin Levels and Hypoglycemia Affect Subcutaneous Interstitial Glucose Concentration

scientific article published on 12 March 2018

Plasma leptin and insulin relationships in obese and nonobese humans.

scientific article

Portal vein glucose sensors do not play a major role in modulating physiological responses to insulin-induced hypoglycemia in humans.

scientific article published on 13 October 2008

Post-hypoglycaemic hyperketonaemia does not contribute to brain metabolism during insulin-induced hypoglycaemia in humans

scientific article published on 01 November 1993

Posttraumatic ileal stenosis mimicking Crohn's disease

scientific article published on 01 June 1995

Premeal insulin treatment during basal-bolus regimen in young children with type 1 diabetes

scientific article published on 01 October 2006

Prevention and Management of Severe Hypoglycemia and Hypoglycemia Unawareness: Incorporating Sensor Technology

scientific article published on 18 August 2018

Rate of fall of blood glucose and physiological responses of counterregulatory hormones, clinical symptoms and cognitive function to hypoglycaemia in Type I diabetes mellitus in the postprandial state.

scientific article published on 9 November 2002

Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans

scientific article published on 01 August 1994

Reversibility of unawareness of hypoglycemia in patients with insulinomas

scientific article published on 01 September 1993

Shift of glycaemic thresholds for cognitive function in hypoglycaemia unawareness in humans

scientific article published on 01 June 1998

Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humans.

scientific article published on 26 May 2009

Sulphonylureas and pregnancy

scientific article published on 01 June 1998

Superiority of insulin analogues versus human insulin in the treatment of diabetes mellitus

scientific article published on 01 February 2008

Thirty years of research on the dawn phenomenon: lessons to optimize blood glucose control in diabetes

scientific article published on December 2013

Unawareness of hypoglycemia

scientific article published on 01 December 1995

Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects.

scientific article published in February 2003

List of works by Carmine Giuseppe Fanelli

A multistep approach for the stratification of the risk of severe hypoglycemia in patients with type 2 diabetes

A randomized controlled trial to evaluate the efficacy of ultrasound-guided laser photocoagulation for treatment of benign thyroid nodules.

Adrenergic mechanisms contribute to the late phase of hypoglycemic glucose counterregulation in humans by stimulating lipolysis ⬇️

Blood-to-brain glucose transport and cerebral glucose metabolism are not reduced in poorly controlled type 1 diabetes.

Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia.

Brief twice-weekly episodes of hypoglycemia reduce detection of clinical hypoglycemia in type 1 diabetes mellitus

Comparison of Pharmacokinetics and Dynamics of the Long-Acting Insulin Analogs Glargine and Detemir at Steady State in Type 1 Diabetes: A double-blind, randomized, crossover study

Counterregulatory hormone and symptom responses to insulin-induced hypoglycemia in the postprandial state in humans.

Different brain responses to hypoglycemia induced by equipotent doses of the long-acting insulin analog detemir and human regular insulin in humans.

Different insulin concentrations in resuspended vs. unsuspended NPH insulin: Practical aspects of subcutaneous injection in patients with diabetes.

Durable reversal of hypoglycemia unawareness in type 1 diabetes

Early improvement of glucose tolerance after ileal transposition in a non-obese type 2 diabetes rat model.

Effect of cigarette smoking and of a transdermal nicotine delivery system on glucoregulation in type 2 diabetes mellitus

Effect of storage temperature of insulin on pharmacokinetics and pharmacodynamics of insulin mixtures injected subcutaneously in subjects with type 1 (insulin-dependent) diabetes mellitus

Effect of the amino acid alanine on glucagon secretion in non-diabetic and type 1 diabetic subjects during hyperinsulinaemic euglycaemia, hypoglycaemia and post-hypoglycaemic hyperglycaemia

Effects of an Intensive Lifestyle Intervention to Treat Overweight/Obese Children and Adolescents

Equipotency of insulin glargine 300 U/mL AND 100 U/mL with intravenous dosing but differential bioavailability with subcutaneous dosing in dogs

Estimating plasma glucose from interstitial glucose: the issue of calibration algorithms in commercial continuous glucose monitoring devices.

GLP-1 RAs as compared to prandial insulin after failure of basal insulin in type 2 diabetes: lessons from the 4B and Get-Goal DUO 2 trials

Ghrelin is not necessary for adequate hormonal counterregulation of insulin-induced hypoglycemia.

Glargine metabolism over 24 h following its subcutaneous injection in patients with type 2 diabetes mellitus: a dose-response study

Glucagon: the effects of its excess and deficiency on insulin action.

How to Accurately Establish Pharmacokinetics/Pharmacodynamics of Long-Acting Insulins in Humans: Relevance to Biosimilar Insulins

Hypoglycemia per se stimulates sympathetic neural as well as adrenomedullary activity, but, unlike the adrenomedullary response, the forearm sympathetic neural response is not reduced after recent hypoglycemia

Impact of patient and treatment characteristics on glycemic control and hypoglycemia in patients with type 2 diabetes initiated to insulin glargine or NPH: A post hoc, pooled, patient-level analysis of 6 randomized controlled trials

Impact of recent antecedent hypoglycemia on hypoglycemic cognitive dysfunction in nondiabetic humans.

Insulin is required for prandial ghrelin suppression in humans

Intensive lifestyle intervention is particularly advantageous in poorly controlled type 2 diabetes

Late post-prandial hypoglycaemia as the sole presenting feature of secreting pancreatic beta-cell adenoma in a subtotally gastrectomized patient.

Long-term intensive insulin therapy in IDDM: effects on HbA1c, risk for severe and mild hypoglycaemia, status of counterregulation and awareness of hypoglycaemia

Long-term intensive therapy of IDDM patients with clinically overt autonomic neuropathy: effects on hypoglycemia awareness and counterregulation.

Long-term recovery from unawareness, deficient counterregulation and lack of cognitive dysfunction during hypoglycaemia, following institution of rational, intensive insulin therapy in IDDM

Low Levels of Unmodified Insulin Glargine in Plasma of People With Type 2 Diabetes Requiring High Doses of Basal Insulin

Mechanisms of arterial hypotension after therapeutic dose of subcutaneous insulin in diabetic autonomic neuropathy.

Mechanisms of insulin resistance after insulin-induced hypoglycemia in humans: the role of lipolysis

Metabolic and endocrine effects of physiological increments in plasma ghrelin concentrations.

Metabolism of insulin glargine after repeated daily subcutaneous injections in subjects with type 2 diabetes

Meticulous prevention of hypoglycemia normalizes the glycemic thresholds and magnitude of most of neuroendocrine responses to, symptoms of, and cognitive function during hypoglycemia in intensively treated patients with short-term IDDM

Nocturnal spikes of growth hormone secretion cause the dawn phenomenon in type 1 (insulin-dependent) diabetes mellitus by decreasing hepatic (and extrahepatic) sensitivity to insulin in the absence of insulin waning.

Pharmacokinetics and Pharmacodynamics of NPH Insulin in Type 1 Diabetes: The Importance of Appropriate Resuspension Before Subcutaneous Injection.

Pharmacokinetics and pharmacodynamics of insulin glargine given in the evening as compared with in the morning in type 2 diabetes

Pharmacokinetics and pharmacodynamics of the long-acting insulin analog glargine after 1 week of use compared with its first administration in subjects with type 1 diabetes

Pharmacokinetics and pharmacodynamics of therapeutic doses of basal insulins NPH, glargine, and detemir after 1 week of daily administration at bedtime in type 2 diabetic subjects: a randomized cross-over study.

Pharmacokinetics, pharmacodynamics and glucose counterregulation following subcutaneous injection of the monomeric insulin analogue [Lys(B28),Pro(B29)] in IDDM

Pivotal role of timely basal insulin replacement after metformin failure in sustaining long-term blood glucose control at a target in type 2 diabetes.

Plasma Insulin Levels and Hypoglycemia Affect Subcutaneous Interstitial Glucose Concentration

Plasma leptin and insulin relationships in obese and nonobese humans.

Portal vein glucose sensors do not play a major role in modulating physiological responses to insulin-induced hypoglycemia in humans.

Post-hypoglycaemic hyperketonaemia does not contribute to brain metabolism during insulin-induced hypoglycaemia in humans

Posttraumatic ileal stenosis mimicking Crohn's disease

Premeal insulin treatment during basal-bolus regimen in young children with type 1 diabetes

Prevention and Management of Severe Hypoglycemia and Hypoglycemia Unawareness: Incorporating Sensor Technology

Rate of fall of blood glucose and physiological responses of counterregulatory hormones, clinical symptoms and cognitive function to hypoglycaemia in Type I diabetes mellitus in the postprandial state.

Relative roles of insulin and hypoglycaemia on induction of neuroendocrine responses to, symptoms of, and deterioration of cognitive function in hypoglycaemia in male and female humans

Reversibility of unawareness of hypoglycemia in patients with insulinomas

Shift of glycaemic thresholds for cognitive function in hypoglycaemia unawareness in humans

Short-term effects of the long-acting insulin analog detemir and human insulin on plasma levels of insulin-like growth factor-I and its binding proteins in humans.

Sulphonylureas and pregnancy

Superiority of insulin analogues versus human insulin in the treatment of diabetes mellitus

Thirty years of research on the dawn phenomenon: lessons to optimize blood glucose control in diabetes

Unawareness of hypoglycemia

Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects.