List of works - Vinay K. Pathak

5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate ⬇️

scientific article published on May 1, 1992

A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.

scientific article

A probability model predicting initiation efficiency of retroviral vectors with two primer-binding sites.

scientific article published on 24 April 2006

APOBEC3 proteins can copackage and comutate HIV-1 genomes.

scientific article published on 20 July 2016

APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model

scientific article

APOBEC3F and APOBEC3G inhibit HIV-1 DNA integration by different mechanisms.

scientific article

APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA

scientific article published on 13 February 2009

Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication

scientific article published in 2022

Capsid proteins from human immunodeficiency virus type 1 and simian immunodeficiency virus SIVmac can coassemble into mature cores of infectious viruses.

scientific article published on 25 June 2008

Characterization, mapping, and distribution of the two XMRV parental proviruses

scientific article

Coassembly and complementation of Gag proteins from HIV-1 and HIV-2, two distinct human pathogens.

scientific article published in July 2006

Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance

scientific article published on 13 October 2012

Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.

scientific article published on 25 June 2018

Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein

scientific article

Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate

scientific article

Design of retroviral vectors and helper cells for gene therapy.

scientific article

Determination of the ex vivo rates of human immunodeficiency virus type 1 reverse transcription by using novel strand-specific amplification analysis.

scientific article published on 21 February 2007

Distinct domains within APOBEC3G and APOBEC3F interact with separate regions of human immunodeficiency virus type 1 Vif.

scientific article

Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes

scientific article

Dynamics of HIV-1 RNA Near the Plasma Membrane during Virus Assembly

scientific article

Effect of distance between homologous sequences and 3' homology on the frequency of retroviral reverse transcriptase template switching.

scientific article

Frequent dual initiation in human immunodeficiency virus-based vectors containing two primer-binding sites: a quantitative in vivo assay for function of initiation complexes.

scientific article published on May 2004

Frequent dual initiation of reverse transcription in murine leukemia virus-based vectors containing two primer-binding sites.

scientific article published in August 2003

Functional complementation of nucleocapsid and late domain PTAP mutants of human immunodeficiency virus type 1 during replication.

scientific article published on 19 March 2008

Gag-dependent enrichment of HIV-1 RNA near the uropod membrane of polarized T cells

scientific article published on 21 August 2013

Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases ⬇️

scientific article published on February 1, 1988

Guidelines for naming nonprimate APOBEC3 genes and proteins

scientific article

HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein.

scientific article

HIV-1 Sequence Necessary and Sufficient to Package Non-viral RNAs into HIV-1 Particles.

scientific article published on 30 June 2017

HIV-1 and HIV-2 Vif interact with human APOBEC3 proteins using completely different determinants

scientific article

Homologous recombination occurs in a distinct retroviral subpopulation and exhibits high negative interference ⬇️

scientific article published on August 1, 1997

Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.

scientific article

Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function

scientific article published on 17 March 2017

Identification of specific determinants of human APOBEC3F, APOBEC3C, and APOBEC3DE and African green monkey APOBEC3F that interact with HIV-1 Vif.

scientific article

Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F.

scientific article

Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.

scientific article

Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.

scientific article published on 29 March 2018

Interactions between HIV-1 Gag and Viral RNA Genome Enhance Virion Assembly.

scientific article

Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA.

scientific article published on 04 June 2009

Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients ⬇️

scientific article published on September 8, 2011

Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance

scientific article

Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor.

scientific article

Mechanisms and factors that influence high frequency retroviral recombination

scientific article

Mechanisms of human immunodeficiency virus type 2 RNA packaging: efficient trans packaging and selection of RNA copackaging partners.

scientific article

Mov10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity.

scientific article published on 07 August 2013

Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all

scientific article

Multiple barriers to recombination between divergent HIV-1 variants revealed by a dual-marker recombination assay

scientific article

Multiple ways of targeting APOBEC3-virion infectivity factor interactions for anti-HIV-1 drug development.

scientific article

New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: synthesis, resolution, and inhibitory activity.

scientific article published on 9 March 2006

Nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes.

scientific article

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.

scientific article published on 17 November 2011

Patterns of Human Immunodeficiency Virus type 1 recombination ex vivo provide evidence for coadaptation of distant sites, resulting in purifying selection for intersubtype recombinants during replication.

scientific article

Phenotypic characterization of drug resistance-associated mutations in HIV-1 RT connection and RNase H domains and their correlation with thymidine analogue mutations.

scientific article

Psi- vectors: murine leukemia virus-based self-inactivating and self-activating retroviral vectors.

scientific article published in August 1997

Real-time PCR analysis of HIV-1 replication post-entry events.

scientific article

Recombinant origin of the retrovirus XMRV.

scientific article published on 31 May 2011

Recombinant origin, contamination, and de-discovery of XMRV

scientific article

Relative Rates of Retroviral Reverse Transcriptase Template Switching during RNA- and DNA-Dependent DNA Synthesis ⬇️

scientific article published on June 1, 1998

Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.

scientific article

Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.

scientific article

Selection of peptide mimics of HIV-1 epitope recognized by neutralizing antibody VRC01.

scientific article

Sensitive radiochemical assay for inosine 5'-monophosphate dehydrogenase and determination of activity in murine tumor and tissue extracts

scientific article published on 01 April 1983

Severe restriction of xenotropic murine leukemia virus-related virus replication and spread in cultured human peripheral blood mononuclear cells.

scientific article

Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet

scientific article published on 12 December 2008

Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions

scientific article

Structural basis of antagonism of human APOBEC3F by HIV-1 Vif

scientific article published on 02 December 2019

Structural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switching

scientific article published in August 2000

Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

scientific article published on July 2002

Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine.

scientific article published on 24 June 2009

Survey of int region DNA rearrangements in C3H and BALB/cfC3H mouse mammary tumor system

scientific article published on 01 February 1987

Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

scientific article published on 22 March 2021

The "Connection" Between HIV Drug Resistance and RNase H

scientific article

The role of amino-terminal sequences in cellular localization and antiviral activity of APOBEC3B.

scientific article

The roles of five conserved lentiviral RNA structures in HIV-1 replication.

scientific article published on 9 November 2017

Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels.

scientific article

Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.

scientific article

Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo.

scientific article

List of works by Vinay K. Pathak

5-Azacytidine and RNA secondary structure increase the retrovirus mutation rate ⬇️

A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors.

A probability model predicting initiation efficiency of retroviral vectors with two primer-binding sites.

APOBEC3 proteins can copackage and comutate HIV-1 genomes.

APOBEC3D and APOBEC3F potently promote HIV-1 diversification and evolution in humanized mouse model

APOBEC3F and APOBEC3G inhibit HIV-1 DNA integration by different mechanisms.

APOBEC3G induces a hypermutation gradient: purifying selection at multiple steps during HIV-1 replication results in levels of G-to-A mutations that are high in DNA, intermediate in cellular viral RNA, and low in virion RNA

Adaptation of HIV-1/HIV-2 Chimeras with Defects in Genome Packaging and Viral Replication

Capsid proteins from human immunodeficiency virus type 1 and simian immunodeficiency virus SIVmac can coassemble into mature cores of infectious viruses.

Characterization, mapping, and distribution of the two XMRV parental proviruses

Coassembly and complementation of Gag proteins from HIV-1 and HIV-2, two distinct human pathogens.

Connection subdomain mutations in HIV-1 subtype-C treatment-experienced patients enhance NRTI and NNRTI drug resistance

Crystal structure of the catalytic domain of HIV-1 restriction factor APOBEC3G in complex with ssDNA.

Cytoplasmic HIV-1 RNA is mainly transported by diffusion in the presence or absence of Gag protein

Deoxyribonucleoside triphosphate pool imbalances in vivo are associated with an increased retroviral mutation rate

Design of retroviral vectors and helper cells for gene therapy.

Determination of the ex vivo rates of human immunodeficiency virus type 1 reverse transcription by using novel strand-specific amplification analysis.

Distinct domains within APOBEC3G and APOBEC3F interact with separate regions of human immunodeficiency virus type 1 Vif.

Dynamics and regulation of nuclear import and nuclear movements of HIV-1 complexes

Dynamics of HIV-1 RNA Near the Plasma Membrane during Virus Assembly

Effect of distance between homologous sequences and 3' homology on the frequency of retroviral reverse transcriptase template switching.

Frequent dual initiation in human immunodeficiency virus-based vectors containing two primer-binding sites: a quantitative in vivo assay for function of initiation complexes.

Frequent dual initiation of reverse transcription in murine leukemia virus-based vectors containing two primer-binding sites.

Functional complementation of nucleocapsid and late domain PTAP mutants of human immunodeficiency virus type 1 during replication.

Gag-dependent enrichment of HIV-1 RNA near the uropod membrane of polarized T cells

Generation of a mutant form of protein synthesis initiation factor eIF-2 lacking the site of phosphorylation by eIF-2 kinases ⬇️

Guidelines for naming nonprimate APOBEC3 genes and proteins

HIV-1 RNA genome dimerizes on the plasma membrane in the presence of Gag protein.

HIV-1 Sequence Necessary and Sufficient to Package Non-viral RNAs into HIV-1 Particles.

HIV-1 and HIV-2 Vif interact with human APOBEC3 proteins using completely different determinants

Homologous recombination occurs in a distinct retroviral subpopulation and exhibits high negative interference ⬇️

Human apolipoprotein B mRNA-editing enzyme-catalytic polypeptide-like 3G (APOBEC3G) is incorporated into HIV-1 virions through interactions with viral and nonviral RNAs.

Identification of a tripartite interaction between the N-terminus of HIV-1 Vif and CBFβ that is critical for Vif function

Identification of specific determinants of human APOBEC3F, APOBEC3C, and APOBEC3DE and African green monkey APOBEC3F that interact with HIV-1 Vif.

Identification of two distinct human immunodeficiency virus type 1 Vif determinants critical for interactions with human APOBEC3G and APOBEC3F.

Inhibition of xenotropic murine leukemia virus-related virus by APOBEC3 proteins and antiviral drugs.

Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies.

Interactions between HIV-1 Gag and Viral RNA Genome Enhance Virion Assembly.

Intracellular interactions between APOBEC3G, RNA, and HIV-1 Gag: APOBEC3G multimerization is dependent on its association with RNA.

Lack of Detection of Xenotropic Murine Leukemia Virus-Related Virus in HIV-1 Lymphoma Patients ⬇️

Likely role of APOBEC3G-mediated G-to-A mutations in HIV-1 evolution and drug resistance

Mass spectrometric analysis of the HIV-1 integrase-pyridoxal 5'-phosphate complex reveals a new binding site for a nucleotide inhibitor.

Mechanisms and factors that influence high frequency retroviral recombination

Mechanisms of human immunodeficiency virus type 2 RNA packaging: efficient trans packaging and selection of RNA copackaging partners.

Mov10 and APOBEC3G localization to processing bodies is not required for virion incorporation and antiviral activity.

Multiple APOBEC3 restriction factors for HIV-1 and one Vif to rule them all

Multiple barriers to recombination between divergent HIV-1 variants revealed by a dual-marker recombination assay

Multiple ways of targeting APOBEC3-virion infectivity factor interactions for anti-HIV-1 drug development.

New HIV-1 reverse transcriptase inhibitors based on a tricyclic benzothiophene scaffold: synthesis, resolution, and inhibitory activity.

Nuclear import of APOBEC3F-labeled HIV-1 preintegration complexes.

Nucleic Acid, Antibody, and Virus Culture Methods to Detect Xenotropic MLV-Related Virus in Human Blood Samples.

Patterns of Human Immunodeficiency Virus type 1 recombination ex vivo provide evidence for coadaptation of distant sites, resulting in purifying selection for intersubtype recombinants during replication.

Phenotypic characterization of drug resistance-associated mutations in HIV-1 RT connection and RNase H domains and their correlation with thymidine analogue mutations.

Psi- vectors: murine leukemia virus-based self-inactivating and self-activating retroviral vectors.

Real-time PCR analysis of HIV-1 replication post-entry events.

Recombinant origin of the retrovirus XMRV.

Recombinant origin, contamination, and de-discovery of XMRV

Relative Rates of Retroviral Reverse Transcriptase Template Switching during RNA- and DNA-Dependent DNA Synthesis ⬇️

Role of murine leukemia virus reverse transcriptase deoxyribonucleoside triphosphate-binding site in retroviral replication and in vivo fidelity.

Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine.

Selection of peptide mimics of HIV-1 epitope recognized by neutralizing antibody VRC01.

Sensitive radiochemical assay for inosine 5'-monophosphate dehydrogenase and determination of activity in murine tumor and tissue extracts

Severe restriction of xenotropic murine leukemia virus-related virus replication and spread in cultured human peripheral blood mononuclear cells.

Species-specific inhibition of APOBEC3C by the prototype foamy virus protein bet

Stoichiometry of the antiviral protein APOBEC3G in HIV-1 virions

Structural basis of antagonism of human APOBEC3F by HIV-1 Vif

Structural determinants of murine leukemia virus reverse transcriptase that affect the frequency of template switching

Structure activity of 3-aryl-1,3-diketo-containing compounds as HIV-1 integrase inhibitors.

Subtype-specific differences in the human immunodeficiency virus type 1 reverse transcriptase connection subdomain of CRF01_AE are associated with higher levels of resistance to 3'-azido-3'-deoxythymidine.

Survey of int region DNA rearrangements in C3H and BALB/cfC3H mouse mammary tumor system

Targeting natural splicing plasticity of APOBEC3B restricts its expression and mutagenic activity

The "Connection" Between HIV Drug Resistance and RNase H

The role of amino-terminal sequences in cellular localization and antiviral activity of APOBEC3B.

The roles of five conserved lentiviral RNA structures in HIV-1 replication.

Xenotropic MLV envelope proteins induce tumor cells to secrete factors that promote the formation of immature blood vessels.

Y586F mutation in murine leukemia virus reverse transcriptase decreases fidelity of DNA synthesis in regions associated with adenine-thymine tracts.

Zinc finger domain of murine leukemia virus nucleocapsid protein enhances the rate of viral DNA synthesis in vivo.