List of works by Wenyi Wei

A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination

scientific article

AKT methylation by SETDB1 promotes AKT kinase activity and oncogenic functions

scientific article published on 28 January 2019

APC(Cdc20) suppresses apoptosis through targeting Bim for ubiquitination and destruction

scientific article

Acetylation-dependent regulation of MDM2 E3 ligase activity dictates its oncogenic function.

scientific article

Acetylation-dependent regulation of PD-L1 nuclear translocation dictates the efficacy of anti-PD-1 immunotherapy

scientific article published on 24 August 2020

Acetylation-dependent regulation of Skp2 function

scientific article

An evolving role for DEPTOR in tumor development and progression

scientific article

Author Correction: Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 01 May 2019

Author Correction: Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

scientific article published on 28 August 2020

Cancer-associated PTEN mutants act in a dominant-negative manner to suppress PTEN protein function

scientific article

Cdc20: a potential novel therapeutic target for cancer treatment

scientific article

Cdh1 inhibits WWP2-mediated ubiquitination of PTEN to suppress tumorigenesis in an APC-independent manner

scientific article published on 2 February 2016

Cdh1 regulates cell cycle through modulating the claspin/Chk1 and the Rb/E2F1 pathways

scientific article published on 28 May 2009

Cdh1 regulates craniofacial development via APC-dependent ubiquitination and activation of Goosecoid

scientific article published on 29 April 2016

Cdh1 regulates osteoblast function through an APC/C-independent modulation of Smurf1.

scientific article published on December 2011

Cell-cycle-regulated activation of Akt kinase by phosphorylation at its carboxyl terminus

scientific article

Cyclin C is a haploinsufficient tumour suppressor

scientific article

DNA damage-induced activation of ATM promotes β-TRCP-mediated Mdm2 ubiquitination and destruction

scientific article published on September 2012

DUB-independent regulation of pVHL by OTUD6B suppresses hepatocellular carcinoma

scientific article published on 22 April 2020

Degrading proteins in animals: "PROTAC"tion goes in vivo

scientific article published on 01 March 2019

Emerging roles of the FBW7 tumour suppressor in stem cell differentiation

scientific article published on 23 December 2011

Functional characterization of Anaphase Promoting Complex/Cyclosome (APC/C) E3 ubiquitin ligases in tumorigenesis

scientific article

K63-linked polyubiquitin chains bind to DNA to facilitate DNA damage repair.

scientific article

LATS suppresses mTORC1 activity to directly coordinate Hippo and mTORC1 pathways in growth control

scientific article published on 03 February 2020

Light-induced control of protein destruction by opto-PROTAC

scientific article published on 21 February 2020

MC1R is a potent regulator of PTEN after UV exposure in melanocytes

scientific article published on August 2013

Mcl-1 ubiquitination and destruction

scientific article published on March 2011

Mutually exclusive acetylation and ubiquitylation of the splicing factor SRSF5 control tumor growth.

scientific article

Negative regulation of the stability and tumor suppressor function of Fbw7 by the Pin1 prolyl isomerase

scientific article

Novel insights into the molecular mechanisms governing Mdm2 ubiquitination and destruction

scientific article published on November 2010

Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction

scientific article

Phosphorylation by casein kinase I promotes the turnover of the Mdm2 oncoprotein via the SCF(beta-TRCP) ubiquitin ligase

scientific article

Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway

scientific article published on 01 May 2019

Rictor Forms a Complex with Cullin-1 to Promote SGK1 Ubiquitination and Destruction ⬇️

scientific article published on September 10, 2010

Roles of F-box proteins in cancer

scientific article

SCF β-TRCP targets MTSS1 for ubiquitination-mediated destruction to regulate cancer cell proliferation and migration

scientific article published on December 2013

SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction

scientific article

SCF(Fbw7) modulates the NFkB signaling pathway by targeting NFkB2 for ubiquitination and destruction.

scientific article

SCF(β-TRCP) promotes cell growth by targeting PR-Set7/Set8 for degradation

scientific article

SCF(β-TRCP) suppresses angiogenesis and thyroid cancer cell migration by promoting ubiquitination and destruction of VEGF receptor 2.

scientific article

SCF(β-TRCP)-mediated degradation of NEDD4 inhibits tumorigenesis through modulating the PTEN/Akt signaling pathway

scientific article

SCF-mediated Cdh1 degradation defines a negative feedback system that coordinates cell-cycle progression.

scientific article published on 22 August 2013

SCF-mediated degradation of Brg1 suppresses gastric cancer metastasis

scientific article published in Nature Communications

SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination

scientific article

SGK3 mediates INPP4B-dependent PI3K signaling in breast cancer

scientific article

Sin1 phosphorylation impairs mTORC2 complex integrity and inhibits downstream Akt signalling to suppress tumorigenesis

scientific article published on 27 October 2013

Skp2 dictates cell cycle-dependent metabolic oscillation between glycolysis and TCA cycle

scientific article published on 15 July 2020

Skp2 is a promising therapeutic target in breast cancer

scientific article published on January 2012

Skp2-dependent reactivation of AKT drives resistance to PI3K inhibitors.

scientific article published on 13 March 2018

Skp2: a novel potential therapeutic target for prostate cancer

scientific article

TF-PROTACs Enable Targeted Degradation of Transcription Factors

scientific article published on 08 June 2021

Targeting Cdc20 as a novel cancer therapeutic strategy

scientific article published on 4 April 2015

Targeting the ubiquitin pathway for cancer treatment

scientific article

The CRL3BTBD9 E3 ubiquitin ligase complex targets TNFAIP1 for degradation to suppress cancer cell migration

scientific article published on 24 April 2020

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis.

scientific article published on 03 January 2017

The diverse roles of SPOP in prostate cancer and kidney cancer

scientific article published on 30 April 2020

The mTOR-S6K pathway links growth signalling to DNA damage response by targeting RNF168. ⬇️

scientific article

The p85 isoform of the kinase S6K1 functions as a secreted oncoprotein to facilitate cell migration and tumor growth.

scientific article

The role of ubiquitination in tumorigenesis and targeted drug discovery

scientific article published on 29 February 2020

The two faces of FBW7 in cancer drug resistance.

scientific article

Tumor suppressor functions of FBW7 in cancer development and progression

scientific article

USP8 inhibition reshapes an inflamed tumor microenvironment that potentiates the immunotherapy

scientific article published on 31 March 2022

Ubiquitin signaling in cell cycle control and tumorigenesis

scientific article published on 31 October 2020

WWP1 germline variants are associated with normocephalic autism spectrum disorder

scientific article published on 23 July 2020

mTOR drives its own activation via SCF(βTrCP)-dependent degradation of the mTOR inhibitor DEPTOR

scientific article

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