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List of works by Peter D. Kwong

454 pyrosequencing and bioinformatics analysis of the lineage of the broad and potent gp41-directed antibody 10e8.

scientific article published on 13 September 2012

A Conserved HIV gp120 Glycoprotein Structure Involved in Chemokine Receptor Binding ⬇️

scientific article published on June 19, 1998

A Cysteine Zipper Stabilizes a Pre-Fusion F Glycoprotein Vaccine for Respiratory Syncytial Virus

scientific article (publication date: 2015)

A Neutralizing Antibody Recognizing Primarily N-Linked Glycan Targets the Silent Face of the HIV Envelope.

scientific article published on 7 March 2018

A Single Shot Pre-fusion-Stabilized Bovine RSV F Vaccine is Safe and Effective in Newborn Calves with Maternally Derived Antibodies

scientific article published on 18 May 2020

A Universal Approach to Optimize the Folding and Stability of Prefusion-Closed HIV-1 Envelope Trimers

scientific article

A V3 loop-dependent gp120 element disrupted by CD4 binding stabilizes the human immunodeficiency virus envelope glycoprotein trimer.

scientific article

A Versatile Platform to Incorporate Viral Trimeric Antigens into Self-Assembling Nanoparticle Immunogens

scientific article published on 12 June 2020

A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice

scientific article published on 26 January 2022

A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite.

scientific article published on 19 March 2018

A matrix of structure-based designs yields improved VRC01-class antibodies for HIV-1 therapy and prevention

publication published on 01 January 2021

A pH-dependent switch mediates conformational masking of SARS-CoV-2 spike

scientific article published on 04 July 2020

A platform incorporating trimeric antigens into self-assembling nanoparticles reveals SARS-CoV-2-spike nanoparticles to elicit substantially higher neutralizing responses than spike alone

scientific article published on 23 October 2020

A proof of concept for structure-based vaccine design targeting RSV in humans

scientific article published on 01 August 2019

A short segment in the HIV-1 gp120 V1/V2 region is a major determinant of neutralization resistance to PG9-like antibodies.

scientific article published on 13 September 2012

A short segment of the HIV-1 gp120 V1/V2 region is a major determinant of resistance to V1/V2 neutralizing antibodies

scientific article

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

scientific article

Access of antibody molecules to the conserved coreceptor binding site on glycoprotein gp120 is sterically restricted on primary human immunodeficiency virus type 1

scientific article

Accurate Prediction for Antibody Resistance of Clinical HIV-1 Isolates

scientific article published on 11 October 2019

Activation and lysis of human CD4 cells latently infected with HIV-1

scientific article

Adjuvants and the vaccine response to the DS-Cav1-stabilized fusion glycoprotein of respiratory syncytial virus

scientific article published on 26 October 2017

An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses

scientific article published on 25 May 2022

Analysis of a clonal lineage of HIV-1 envelope V2/V3 conformational epitope-specific broadly neutralizing antibodies and their inferred unmutated common ancestors

scientific article

Analysis of the Interaction of Antibodies with a Conserved, Enzymatically Deglycosylated Core of the HIV Type 1 Envelope Glycoprotein 120 ⬇️

scientific article published on February 10, 1998

Antibodies VRC01 and 10E8 neutralize HIV-1 with high breadth and potency even with Ig-framework regions substantially reverted to germline

scientific article

Antibody Lineages with Vaccine-Induced Antigen-Binding Hotspots Develop Broad HIV Neutralization

scientific article published on 01 July 2019

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

scientific article published on 8 March 2021

Antibody Resistance of SARS-CoV-2 Variants B.1.351 and B.1.1.7

Antibody mechanics on a membrane-bound HIV segment essential for GP41-targeted viral neutralization

scientific article published on 16 October 2011

Antibody neutralization and escape by HIV-1

scientific article (publication date: 20 March 2003)

Antibody-guided structure-based vaccines

scientific article published on 24 November 2020

Antibodyomics: bioinformatics technologies for understanding B-cell immunity to HIV-1.

scientific article published in January 2017

Antigenic conservation and immunogenicity of the HIV coreceptor binding site

scientific article

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

scientific article published on 10 April 2019

Attenuated Human Parainfluenza Virus Type 1 Expressing the Respiratory Syncytial Virus (RSV) Fusion (F) Glycoprotein from an Added Gene: Effects of Prefusion Stabilization and Packaging of RSV F

scientific article

Author Correction: A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite

scientific article published on 01 January 2019

Author Correction: Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

scientific article published on 01 June 2019

Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains

scientific article published on 01 November 2020

Beta-bungarotoxin. Preparation and characterization of crystals suitable for structural analysis

scientific article published on 01 November 1989

Binding mode characterization of NBD series CD4-mimetic HIV-1 entry inhibitors by X-ray structure and resistance study

scientific article

Biochemical and structural characterization of cathepsin L-processed Ebola virus glycoprotein: implications for viral entry and immunogenicity

scientific article

Bispecific Antibodies Targeting Different Epitopes on the HIV-1 Envelope Exhibit Broad and Potent Neutralization.

scientific article

Blocking α4β7 integrin binding to SIV does not improve virologic control

scientific article published on 05 September 2019

Broad and potent HIV-1 neutralization by a human antibody that binds the gp41-gp120 interface

scientific article

Broad and potent neutralization of HIV-1 by a gp41-specific human antibody

scientific article

Broad and potent neutralizing antibody responses elicited in natural HIV-2 infection

scientific article

Broadly Neutralizing Human Immunodeficiency Virus Type 1 Antibody Gene Transfer Protects Nonhuman Primates from Mucosal Simian-Human Immunodeficiency Virus Infection

scientific article published on 3 June 2015

Broadly neutralizing antibodies and the search for an HIV-1 vaccine: the end of the beginning ⬇️

scientific article published on September 1, 2013

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

scientific article published on September 2017

CD4 binding site antibodies inhibit human immunodeficiency virus gp120 envelope glycoprotein interaction with CCR5

scientific article

CD4 receptor diversity in chimpanzees protects against SIV infection

scientific article published on 04 February 2019

CD4-binding-Site Recognition by VH1-46 Germline-derived HIV-1 Neutralizers.

scientific article published in October 2014

CRISPro: An Automated Pipeline for Protein Conformation Stabilization by Proline

scientific article published on 19 October 2018

Characteristics of HIV-1 gp120 molecules that bind ancestor, intermediate and mature forms of VRC01-like antibodies

article

Characterization of broadly neutralizing antibody responses to HIV-1 in a cohort of long term non-progressors.

scientific article

Characterization of human immunodeficiency virus type 1 monomeric and trimeric gp120 glycoproteins stabilized in the CD4-bound state: antigenicity, biophysics, and immunogenicity ⬇️

scientific article published on 14 March 2007

Co-evolution of a broadly neutralizing HIV-1 antibody and founder virus

scientific article

Cocrystal Structures of Antibody N60-i3 and Antibody JR4 in Complex with gp120 Define More Cluster A Epitopes Involved in Effective Antibody-Dependent Effector Function against HIV-1

scientific article published on 17 June 2015

Combinatorial Optimization of a CD4-Mimetic Miniprotein and Cocrystal Structures with HIV-1 gp120 Envelope Glycoprotein

scientific article

Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV

article

Completeness of HIV-1 Envelope Glycan Shield at Transmission Determines Neutralization Breadth

article

Comprehensive sieve analysis of breakthrough HIV-1 sequences in the RV144 vaccine efficacy trial

scientific article

Computation-guided backbone grafting of a discontinuous motif onto a protein scaffold

scientific article

Computational prediction of N-linked glycosylation incorporating structural properties and patterns ⬇️

scientific article published on July 10, 2012

Conformational changes of gp120 in epitopes near the CCR5 binding site are induced by CD4 and a CD4 miniprotein mimetic

scientific article

Conformational characterization of aberrant disulfide-linked HIV-1 gp120 dimers secreted from overexpressing cells.

scientific article

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

scientific article

Considerations on the folding topology and evolutionary origin of cadherin domains

scientific article

Consistent elicitation of cross-clade HIV-neutralizing responses achieved in guinea pigs after fusion peptide priming by repetitive envelope trimer boosting

article

Cooperation of B cell lineages in induction of HIV-1-broadly neutralizing antibodies

scientific article

Correction for Acharya et al., Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

article

Correction for Ingale et al., Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

scientific article published on June 2015

Correction to Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

scientific article published on 18 May 2017

Correction: HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies

article

Correction: Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 02 December 2019

Correction: Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

scientific article published on 24 May 2016

Corrigendum: Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer

scientific article published on 01 June 2017

Cross-Reactive HIV-1-Neutralizing Human Monoclonal Antibodies Identified from a Patient with 2F5-Like Antibodies

Cross-reactive HIV-1-neutralizing human monoclonal antibodies identified from a patient with 2F5-like antibodies

scientific article

Cryo-EM Structures of SARS-CoV-2 Spike without and with ACE2 Reveal a pH-Dependent Switch to Mediate Endosomal Positioning of Receptor-Binding Domains

scientific article published on 17 November 2020

Crystal Structure and Immunogenicity of the DS-Cav1-Stabilized Fusion Glycoprotein From Respiratory Syncytial Virus Subtype B

scientific article published on 11 December 2019

Crystal Structure of Human Antibody 2909 Reveals Conserved Features of Quaternary Structure-Specific Antibodies That Potently Neutralize HIV-1

scientific article

Crystal Structure of PG16 and Chimeric Dissection with Somatically Related PG9: Structure-Function Analysis of Two Quaternary-Specific Antibodies That Effectively Neutralize HIV-1

scientific article

Crystal Structures of GII.10 and GII.12 Norovirus Protruding Domains in Complex with Histo-Blood Group Antigens Reveal Details for a Potential Site of Vulnerability

scientific article

Crystal Structures of HIV-1 gp120 Envelope Glycoprotein in Complex with NBD Analogues That Target the CD4-Binding Site

scientific article

Crystal structure of a fully glycosylated HIV-1 gp120 core reveals a stabilizing role for the glycan at Asn262.

scientific article published on 22 January 2015

Crystal structure of an HIV-binding recombinant fragment of human CD4.

scientific article

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

scientific article

Crystal structures of trimeric HIV envelope with entry inhibitors BMS-378806 and BMS-626529.

scientific article

De novo identification of VRC01 class HIV-1-neutralizing antibodies by next-generation sequencing of B-cell transcripts

scientific article published on 08 October 2013

Deep sequencing with longitudinal sampling of a VRC01-like-antibody response in a chronically infected individual

scientific article published on 13 September 2012

Delineating antibody recognition in polyclonal sera from patterns of HIV-1 isolate neutralization

scientific article

Design and Characterization of Epitope-Scaffold Immunogens That Present the Motavizumab Epitope from Respiratory Syncytial Virus

scientific article

Design clues from functional constraints and broadly neutralizing antibodies

Design of an HIV Env antigen that binds with high affinity to antibodies against linear, conformational and broadly neutralizing epitopes within V1/V2.

scientific article published on 13 September 2012

Design of epitope-specific probes for sera analysis and antibody isolation

scientific article (publication date: 2012)

Design, Synthesis, and Antiviral Activity of Entry Inhibitors That Target the CD4-Binding Site of HIV-1 ⬇️

scientific article published on May 10, 2012

Design, synthesis and biological evaluation of small molecule inhibitors of CD4-gp120 binding based on virtual screening

scientific article

Development of a 3Mut-Apex-Stabilized Envelope Trimer that Expands HIV-1 Neutralization Breadth When Used To Boost Fusion Peptide-Directed Vaccine-Elicited Responses

scientific article published on 15 April 2020

Developmental Pathway of the MPER-Directed HIV-1-Neutralizing Antibody 10E8

scientific article

Developmental pathway for potent V1V2-directed HIV-neutralizing antibodies

scientific article

Dimeric association and segmental variability in the structure of human CD4

scientific article

Distinct disease features in chimpanzees infected with a precore HBV mutant associated with acute liver failure in humans

scientific article published on 31 August 2020

Disulfide stabilization of human norovirus GI.1 virus-like particles focuses immune response toward blockade epitopes

scientific article published on 14 December 2020

Does Noggin head a new class of Kunitz domain? ⬇️

scientific article published on June 1, 1993

Drift of the HIV-1 envelope glycoprotein gp120 toward increased neutralization resistance over the course of the epidemic: a comprehensive study using the most potent and broadly neutralizing monoclonal antibodies.

scientific article

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

scientific article

Effective isotope labeling of proteins in a mammalian expression system.

scientific article

Effects of Darwinian Selection and Mutability on Rate of Broadly Neutralizing Antibody Evolution during HIV-1 Infection

scientific article

Elicitation of HIV-1-neutralizing antibodies against the CD4-binding site.

scientific article

Elicitation of structure-specific antibodies by epitope scaffolds

scientific article

Eliminating antibody polyreactivity through addition of N-linked glycosylation

scientific article published on 12 May 2015

Energetics of the HIV gp120-CD4 binding reaction

scientific article

Enhanced Neutralizing Antibody Response Induced by Respiratory Syncytial Virus Prefusion F Protein Expressed by a Vaccine Candidate.

scientific article

Enhanced exposure of the CD4-binding site to neutralizing antibodies by structural design of a membrane-anchored human immunodeficiency virus type 1 gp120 domain

scientific article published on 04 March 2009

Enhanced potency of a broadly neutralizing HIV-1 antibody in vitro improves protection against lentiviral infection in vivo

scientific article

Enhancing protein crystallization through precipitant synergy

scientific article

Enhancing the Solubility of HIV-1-neutralizing Antibody 10E8.

scientific article published in October 2014

Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

scientific article published on 31 May 2016

Epitope mapping and characterization of a novel CD4-induced human monoclonal antibody capable of neutralizing primary HIV-1 strains ⬇️

scientific article published on October 10, 2003

Epitope mapping of broadly neutralizing HIV-2 human monoclonal antibodies

scientific article published on 29 August 2012

Epitope-based vaccine design yields fusion peptide-directed antibodies that neutralize diverse strains of HIV-1

scientific article published on 04 June 2018

Erratum: Antibody neutralization and escape by HIV-1

scientific article published in Nature

Evaluation of candidate vaccine approaches for MERS-CoV.

scientific article published on 28 July 2015

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

scientific article published on 28 July 2020

Expression-system-dependent modulation of HIV-1 envelope glycoprotein antigenicity and immunogenicity

scientific article

Extended antibody-framework-to-antigen distance observed exclusively with broad HIV-1-neutralizing antibodies recognizing glycan-dense surfaces

scientific article published on 09 November 2021

Fab-dimerized glycan-reactive antibodies are a structural category of natural antibodies

scientific article

Focused Evolution of HIV-1 Neutralizing Antibodies Revealed by Structures and Deep Sequencing

scientific article

Free Energy Perturbation Calculation of Relative Binding Free Energy between Broadly Neutralizing Antibodies and the gp120 Glycoprotein of HIV-1.

scientific article

Fusion peptide of HIV-1 as a site of vulnerability to neutralizing antibody

scientific article

Gene-Specific Substitution Profiles Describe the Types and Frequencies of Amino Acid Changes during Antibody Somatic Hypermutation

scientific article

Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core

article

Glycan Masking Focuses Immune Responses to the HIV-1 CD4-Binding Site and Enhances Elicitation of VRC01-Class Precursor Antibodies

scientific article published on 31 July 2018

Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies

scientific article published on 21 October 2020

HIV vaccine design and the neutralizing antibody problem

scientific article published in March 2004

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations

scientific article published on 21 March 2018

HIV-1 Envelope Glycan Modifications that Permit Neutralization by Germline-Reverted VRC01-Class Broadly Neutralizing Antibodies

article

HIV-1 Envelope and MPER Antibody Structures in Lipid Assemblies

scientific article published on 01 April 2020

HIV-1 Vaccines Based on Antibody Identification, B Cell Ontogeny, and Epitope Structure

scientific article

HIV-1 and influenza antibodies: seeing antigens in new ways

scientific article

HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites

scientific article (publication date: 12 December 2002)

HIV-1 gp120 as a therapeutic target: navigating a moving labyrinth

scientific article

Heavy Chain-Only IgG2b Llama Antibody Effects Near-Pan HIV-1 Neutralization by Recognizing a CD4-Induced Epitope That Includes Elements of Coreceptor- and CD4-Binding Sites

scientific article

Hemagglutinin-stem nanoparticles generate heterosubtypic influenza protection

scientific article

Heterologous epitope-scaffold prime:boosting immuno-focuses B cell responses to the HIV-1 gp41 2F5 neutralization determinant

scientific article

High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19

scientific article published on 08 April 2021

Highly stable trimers formed by human immunodeficiency virus type 1 envelope glycoproteins fused with the trimeric motif of T4 bacteriophage fibritin

scientific article

How HIV-1 entry mechanism and broadly neutralizing antibodies guide structure-based vaccine design

scientific article

Human antibodies that neutralize HIV-1: identification, structures, and B cell ontogenies

scientific article

Human immunodeficiency virus type 1 env trimer immunization of macaques and impact of priming with viral vector or stabilized core protein.

scientific article

Human immunodeficiency virus type 2 (HIV-2)/HIV-1 envelope chimeras detect high titers of broadly reactive HIV-1 V3-specific antibodies in human plasma

scientific article

Human immunodeficiency virus: refolding the envelope

scientific article published in February 2005

Human parainfluenza virus type 3 expressing the respiratory syncytial virus pre-fusion F protein modified for virion packaging yields protective intranasal vaccine candidates

scientific article published on 11 February 2020

Hyperglycosylated resurfaced stabilized GP120 core as an immunogen elicits antibodies targeted at the CD4-binding site

Hyperglycosylated stable core immunogens designed to present the CD4 binding site are preferentially recognized by broadly neutralizing antibodies

scientific article

Identification and Structure of a Multidonor Class of Head-Directed Influenza-Neutralizing Antibodies Reveal the Mechanism for Its Recurrent Elicitation

scientific article published on 01 September 2020

Identification of a CD4-Binding-Site Antibody to HIV that Evolved Near-Pan Neutralization Breadth.

scientific article published on November 2016

Identification of human monoclonal antibodies specific for CCR5 from an antibody library derived from HIV-infected long-term non-progressors

Immune Monitoring Reveals Fusion Peptide Priming to Imprint Cross-Clade HIV-Neutralizing Responses with a Characteristic Early B Cell Signature

scientific article published on 01 August 2020

Immunogenicity of a Prefusion HIV-1 Envelope Trimer in Complex with a Quaternary-Structure-Specific Antibody

scientific article published on 30 December 2015

Immunoglobulin gene insertions and deletions in the affinity maturation of HIV-1 broadly reactive neutralizing antibodies

scientific article

Immunotypes of a quaternary site of HIV-1 vulnerability and their recognition by antibodies

scientific article

Importance of neutralizing monoclonal antibodies targeting multiple antigenic sites on MERS-CoV Spike to avoid neutralization escape

scientific article published on 7 March 2018

Improved Prefusion Stability, Optimized Codon Usage, and Augmented Virion Packaging Enhance the Immunogenicity of Respiratory Syncytial Virus Fusion Protein in a Vectored-Vaccine Candidate.

scientific article published on 24 May 2017

Improvement of antibody functionality by structure-guided paratope engraftment

scientific article published in Nature Communications

Increased HIV-1 vaccine efficacy against viruses with genetic signatures in Env V2

scientific article

Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization

scientific article

Induction of Antibodies in Rhesus Macaques That Recognize a Fusion-Intermediate Conformation of HIV-1 gp41 ⬇️

scientific article published on November 30, 2011

Induction of HIV Neutralizing Antibody Lineages in Mice with Diverse Precursor Repertoires

scientific article published on September 2016

Inference of the HIV-1 VRC01 Antibody Lineage Unmutated Common Ancestor Reveals Alternative Pathways to Overcome a Key Glycan Barrier

article

Insights from NMR Spectroscopy into the Conformational Properties of Man-9 and Its Recognition by Two HIV Binding Proteins.

scientific article published on 6 February 2017

Interdomain Stabilization Impairs CD4 Binding and Improves Immunogenicity of the HIV-1 Envelope Trimer

article

Interfacial Cavity Filling To Optimize CD4–Mimetic Miniprotein Interactions with HIV-1 Surface Glycoprotein ⬇️

scientific article published on June 11, 2013

Interfacial metal and antibody recognition

scientific article

Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields

scientific article published on 02 October 2019

Iterative screen optimization maximizes the efficiency of macromolecular crystallization

scientific article published on 24 January 2019

Iterative structure-based improvement of a fusion-glycoprotein vaccine against RSV.

scientific article published on August 2016

Kernel-based logistic regression model for protein sequence without vectorialization

scientific article published on 22 December 2014

Lattice engineering enables definition of molecular features allowing for potent small-molecule inhibition of HIV-1 entry

scientific article published in Nature Communications

Lineage-specific differences between human and simian immunodeficiency virus regulation of gp120 trimer association and CD4 binding

scientific article

Local conformational stability of HIV-1 gp120 in unliganded and CD4-bound states as defined by amide hydrogen/deuterium exchange

scientific article

Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual

scientific article published on 12 March 2019

Low-dose in vivo protection and neutralization across SARS-CoV-2 variants by monoclonal antibody combinations

scientific article published on 29 October 2021

Mammalian expression of isotopically labeled proteins for NMR spectroscopy

scientific article published on January 2012

Mammalian production of an isotopically enriched outer domain of the HIV-1 gp120 glycoprotein for NMR spectroscopy.

scientific article

Mapping Polyclonal HIV-1 Antibody Responses via Next-Generation Neutralization Fingerprinting

scientific article

Maturation Pathway from Germline to Broad HIV-1 Neutralizer of a CD4-Mimic Antibody

scientific article

Maturation Pathways for the Broad and Potent Antibody 10E8 Using a Combination of Next Generation Sequencing, Bioinformatics and Functional Analysis

scientific article published in October 2014

Maturation and Diversity of the VRC01-Antibody Lineage over 15 Years of Chronic HIV-1 Infection

scientific article

Mechanism of human immunodeficiency virus type 1 resistance to monoclonal antibody B12 that effectively targets the site of CD4 attachment

scientific article published on 19 August 2009

Microsecond Dynamics and Network Analysis of the HIV-1 SOSIP Env Trimer Reveal Collective Behavior and Conserved Microdomains of the Glycan Shield.

scientific article published on 24 August 2017

Mimicry of an HIV broadly neutralizing antibody epitope with a synthetic glycopeptide.

scientific article published on March 2017

Mining the B cell repertoire for broadly neutralizing monoclonal antibodies to HIV-1.

scientific article

Mining the antibodyome for HIV-1-neutralizing antibodies with next-generation sequencing and phylogenetic pairing of heavy/light chains

scientific article published on 27 March 2013

Modifications that stabilize human immunodeficiency virus envelope glycoprotein trimers in solution

scientific article

Modular synthesis of N-glycans and arrays for the hetero-ligand binding analysis of HIV antibodies

scientific article published on 7 March 2016

Molecular characteristics of recombinant human CD4 as deduced from polymorphic crystals

scientific article

Molecular-level analysis of the serum antibody repertoire in young adults before and after seasonal influenza vaccination

scientific article

Mosaic nanoparticle display of diverse influenza virus hemagglutinins elicits broad B cell responses

scientific article published on 11 February 2019

Multidonor Analysis Reveals Structural Elements, Genetic Determinants, and Maturation Pathway for HIV-1 Neutralization by VRC01-Class Antibodies

scientific article

Mutagenic stabilization and/or disruption of a CD4-bound state reveals distinct conformations of the human immunodeficiency virus type 1 gp120 envelope glycoprotein

scientific article

N332-Directed broadly neutralizing antibodies use diverse modes of HIV-1 recognition: inferences from heavy-light chain complementation of function

scientific article

NEP: web server for epitope prediction based on antibody neutralization of viral strains with diverse sequences

scientific article

NMR spectroscopy of HIV-1 gp120 outer domain.

scientific article published on 13 September 2012

Neutralization properties of simian immunodeficiency viruses infecting chimpanzees and gorillas

scientific article published on 21 April 2015

Neutralization-guided design of HIV-1 envelope trimers with high affinity for the unmutated common ancestor of CH235 lineage CD4bs broadly neutralizing antibodies

scientific article published on 17 September 2019

Neutralizing antibodies to HIV-1 envelope protect more effectively in vivo than those to the CD4 receptor

scientific article

New Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional Potency

scientific article

Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses

scientific article

Next-generation sequencing of the intrahepatic antibody repertoire delineates a unique B-cell response in HBV-associated acute liver failure

scientific article published on 20 March 2020

Novel anti-CD4 monoclonal antibodies separate human immunodeficiency virus infection and fusion of CD4+ cells from virus binding ⬇️

scientific article published on October 1, 1990

Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus

scientific article

Optimization of a Clade A Env Outer Domain for Enhanced Binding to Germlines of Diverse VRC01 Class Antibodies

Optimization of the Solubility of HIV-1-Neutralizing Antibody 10E8 through Somatic Variation and Structure-Based Design

scientific article

Outer Domain of HIV-1 gp120: Antigenic Optimization, Structural Malleability, and Crystal Structure with Antibody VRC-PG04

scientific article

P04-38. Crystal structure of gp120 in complex with the CD4-binding-site antibody b13 suggests precise targeting is needed for neutralization.

scientific article published on 22 October 2009

P04-43. Neutralizing antibody responses against conformational envelope epitopes in early HIV-1 infection.

scientific article

P09-05. Mechanism of HIV-1 resistance to a monoclonal antibody that effectively targets the site of CD4 attachment

article

P09-13. Structure of HIV-1 gp41 interactive region: layered architecture and basis of conformational mobility

article

P12-12. Analysis of antibody and B cell responses following inoculation with computationally designed HIV-1 2F5 epitope scaffold proteins

scientific article

P13-01. Crystal structure and function of a monoclonal antibody against primate CD4 that blocks HIV/SIV infection

scientific article published on 22 October 2009

PGV04, an HIV-1 gp120 CD4 binding site antibody, is broad and potent in neutralization but does not induce conformational changes characteristic of CD4.

scientific article published on 15 February 2012

PaRSnIP: Sequence-Based Protein Solubility Prediction using Gradient Boosting Machine

scientific article published on 23 October 2017

Packaging and Prefusion Stabilization Separately and Additively Increase the Quantity and Quality of Respiratory Syncytial Virus (RSV)-Neutralizing Antibodies Induced by an RSV Fusion Protein Expressed by a Parainfluenza Virus Vector.

scientific article published on 31 August 2016

Partial germline reversions can increase VRC07 potency and breadth.

scientific article published on 13 September 2012

Peptides from second extracellular loop of C-C chemokine receptor type 5 (CCR5) inhibit diverse strains of HIV-1.

scientific article published on 8 March 2012

Platelet-derived growth factor-α receptor is the cellular receptor for human cytomegalovirus gHgLgO trimer

scientific article published on 06 June 2016

Potent Neutralizing Monoclonal Antibodies Directed to Multiple Epitopes on the SARS-CoV-2 Spike

scientific article published on 18 June 2020

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite

scientific article

Potent neutralizing antibodies directed to multiple epitopes on SARS-CoV-2 spike

scientific article published on 22 July 2020

Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen

scientific article published on 20 February 2020

Preferential induction of cross-group influenza A hemagglutinin stem-specific memory B cells after H7N9 immunization in humans

scientific article published on July 2017

Prefusion F-specific antibodies determine the magnitude of RSV neutralizing activity in human sera

scientific article

Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1).

scientific article published in February 1999

Progress in the rational design of an AIDS vaccine ⬇️

scientific article published on October 12, 2011

Prolonged evolution of the memory B cell response induced by a replicating adenovirus-influenza H5 vaccine

scientific article published on 01 April 2019

Protection of calves by a prefusion-stabilized bovine RSV F vaccine

scientific article published on March 2017

Protective antibodies elicited by SARS-CoV-2 spike protein vaccination are boosted in the lung after challenge in nonhuman primates

Publisher Correction: The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions.

scientific article published on 8 January 2018

Quantification of the Impact of the HIV-1-Glycan Shield on Antibody Elicitation

scientific article published on April 2017

Quaternary contact in the initial interaction of CD4 with the HIV-1 envelope trimer

scientific article published on 20 February 2017

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

article

Rational design of envelope identifies broadly neutralizing human monoclonal antibodies to HIV-1

scientific article (publication date: 13 August 2010)

Rational design of vaccines to elicit broadly neutralizing antibodies to HIV-1.

scientific article published on September 2011

Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles

scientific article

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles

scientific article published on 13 September 2020

Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth

scientific article published on 19 November 2020

Recombinant Env proteins that bind the quaternary-specific, V1/V2-directed PGT antibodies.

scientific article

Relationship between antibody 2F5 neutralization of HIV-1 and hydrophobicity of its heavy chain third complementarity-determining region

scientific article

Removal of variable domain N-linked glycosylation as a means to improve the homogeneity of HIV-1 broadly neutralizing antibodies

scientific article published on 01 January 2020

Replication-competent variants of human immunodeficiency virus type 2 lacking the V3 loop exhibit resistance to chemokine receptor antagonists

scientific article

Residue-level prediction of HIV-1 antibody epitopes based on neutralization of diverse viral strains

scientific article published on 10 July 2013

Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure

article published in the Proceedings of the National Academy of Sciences of the United States of America

Routine single particle CryoEM sample and grid characterization by tomography.

scientific article

SONAR: A High-Throughput Pipeline for Inferring Antibody Ontogenies from Longitudinal Sequencing of B Cell Transcripts

scientific article published on 21 September 2016

Safety and pharmacokinetics of broadly neutralising human monoclonal antibody VRC07-523LS in healthy adults: a phase 1 dose-escalation clinical trial

scientific article published on 28 August 2019

Scorpion-toxin mimics of CD4 in complex with human immunodeficiency virus gp120 crystal structures, molecular mimicry, and neutralization breadth

scientific article

Selective effects of electrostatic changes in the CD4 CDR-3-like loop on infection by different human immunodeficiency virus type 1 isolates

scientific article published on July 1996

Selective interactions of polyanions with basic surfaces on human immunodeficiency virus type 1 gp120

scientific article

Sequence intrinsic somatic mutation mechanisms contribute to affinity maturation of VRC01-class HIV-1 broadly neutralizing antibodies

scientific article

Sequence-Signature Optimization Enables Improved Identification of Human HV6-1-Derived Class Antibodies That Neutralize Diverse Influenza A Viruses

scientific article

Sequencing HIV-neutralizing antibody exons and introns reveals detailed aspects of lineage maturation

scientific article published in Nature Communications

Sera Antibody Repertoire Analyses Reveal Mechanisms of Broad and Pandemic Strain Neutralizing Responses after Human Norovirus Vaccination

scientific article published on 01 June 2019

Single-Chain Soluble BG505.SOSIP gp140 Trimers as Structural and Antigenic Mimics of Mature Closed HIV-1 Env.

scientific article published on 4 March 2015

Single-Molecule FRET Delineates Asymmetric Trimer Conformations during HIV-1 Entry

article by Xiaochu Ma et al published February 2017 in Biophysical Journal

Small-molecule CD4 mimics interact with a highly conserved pocket on HIV-1 gp120.

scientific article

Soluble Prefusion Closed DS-SOSIP.664-Env Trimers of Diverse HIV-1 Strains

scientific article published in December 2017

Soluble mimetics of human immunodeficiency virus type 1 viral spikes produced by replacement of the native trimerization domain with a heterologous trimerization motif: characterization and ligand binding analysis

scientific article published on August 2005

Somatic Hypermutation-Induced Changes in the Structure and Dynamics of HIV-1 Broadly Neutralizing Antibodies

scientific article

Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization

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Somatic Populations of PGT135-137 HIV-1-Neutralizing Antibodies Identified by 454 Pyrosequencing and Bioinformatics

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Somatic hypermutation to counter a globally rare viral immunotype drove off-track antibodies in the CAP256-VRC26 HIV-1 V2-directed bNAb lineage

scientific article published on 03 September 2019

Stapled HIV-1 peptides recapitulate antigenic structures and engage broadly neutralizing antibodies

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Structural Basis for Accommodation of Emerging B.1.351 and B.1.1.7 Variants by Two Potent SARS-CoV-2 Neutralizing Antibodies

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Structural Basis for Broad Detection of Genogroup II Noroviruses by a Monoclonal Antibody That Binds to a Site Occluded in the Viral Particle

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Structural Basis for Broad and Potent Neutralization of HIV-1 by Antibody VRC01

scientific article

Structural Basis for HIV-1 Neutralization by 2F5-Like Antibodies m66 and m66.6

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Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 Å Cocrystal Structure of gp120 and M48U1

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Structural Basis for Norovirus Inhibition and Fucose Mimicry by Citrate

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Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

scientific article

Structural Definition of an Antibody-Dependent Cellular Cytotoxicity Response Implicated in Reduced Risk for HIV-1 Infection

scientific article (publication date: November 2014)

Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors

scientific article

Structural Survey of Broadly Neutralizing Antibodies Targeting the HIV-1 Env Trimer Delineates Epitope Categories and Characteristics of Recognition

article

Structural aspects of CD4 and CD8 involvement in the cellular immune response

scientific article published on January 1, 1992

Structural basis for diverse N-glycan recognition by HIV-1–neutralizing V1–V2–directed antibody PG16

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Structural basis of LAIR1 targeting by polymorphic Plasmodium RIFINs

scientific article published on 09 July 2021

Structural basis of cell-cell adhesion by cadherins

scientific article

Structural basis of malaria RIFIN binding by LILRB1-containing antibodies.

article by Yiwei Chen et al published April 2021 in Nature

Structural basis of respiratory syncytial virus neutralization by motavizumab

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Structural basis of tyrosine sulfation and VH-gene usage in antibodies that recognize the HIV type 1 coreceptor-binding site on gp120

scientific article

Structural comparison of somatically related PG9 and PG16 in complex with their epitope reveals differences in glycan recognition.

scientific article published on 13 September 2012

Structural definition for a new modality of broad and potent antibody neutralization at the CD4-binding site on HIV-1 gp120.

scientific article published on 13 September 2012

Structural definition of a conserved neutralization epitope on HIV-1 gp120

scientific article

Structural definition of a novel CD4-induced epitope that is targeted by a single-headed immunoglobulin to effect broad and potent HIV neutralization

scientific article published on 13 September 2012

Structure and Recognition of a Novel HIV-1 gp120-gp41 Interface Antibody that Caused MPER Exposure through Viral Escape.

scientific article

Structure and immune recognition of trimeric pre-fusion HIV-1 Env.

scientific article

Structure and mechanistic analysis of the anti-human immunodeficiency virus type 1 antibody 2F5 in complex with its gp41 epitope

scientific article

Structure of BMS-806, a Small-molecule HIV-1 Entry Inhibitor, Bound to BG505 SOSIP.664 HIV-1 Env Trimer.

scientific article published in October 2014

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Structure of HIV-1 gp120 with gp41-interactive region reveals layered envelope architecture and basis of conformational mobility

scientific article

Structure of MERS-Coronavirus Spike Receptor-binding Domain (England1 Strain) in Complex with Vaccine-Elicited Murine Neutralizing Antibody D12 (Crystal Form 2)

article

Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

scientific article

Structure of Respiratory Syncytial Virus Fusion Glycoprotein in the Postfusion Conformation Reveals Preservation of Neutralizing Epitopes

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Structure of Super-Potent Antibody CAP256-VRC26.25 in Complex with HIV-1 Envelope Reveals a Combined Mode of Trimer-Apex Recognition

scientific article published on 01 April 2020

Structure of a Major Antigenic Site on the Respiratory Syncytial Virus Fusion Glycoprotein in Complex with Neutralizing Antibody 101F

scientific article published in December 2010

Structure of a V3-containing HIV-1 gp120 core

scientific article

Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody ⬇️

scientific article published on June 18, 1998

Structure of an N276-Dependent HIV-1 Neutralizing Antibody Targeting a Rare V5 Glycan Hole Adjacent to the CD4 Binding Site

scientific article published on 31 August 2016

Structure of beta 2-bungarotoxin: potassium channel binding by Kunitz modules and targeted phospholipase action

scientific article

Structure of unbound MERS-CoV spike receptor-binding domain (England1 strain)

article

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

scientific article

Structure-Based Design of a Small Molecule CD4-Antagonist with Broad Spectrum Anti-HIV-1 Activity

scientific article

Structure-Based Design of a Soluble Prefusion-Closed HIV-1 Env Trimer with Reduced CD4 Affinity and Improved Immunogenicity

scientific article published on 8 March 2017

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes

scientific article published on 23 June 2020

Structure-Based Design with Tag-Based Purification and In-Process Biotinylation Enable Streamlined Development of SARS-CoV-2 Spike Molecular Probes ⬇️

scientific article published on 12 October 2020

Structure-Based Design, Synthesis, and Characterization of Dual Hotspot Small-Molecule HIV-1 Entry Inhibitors

scientific article

Structure-activity relationships in the binding of chemically derivatized CD4 to gp120 from human immunodeficiency virus

scientific article published on 6 September 2007

Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4

article published in the Proceedings of the National Academy of Sciences of the United States of America

Structure-based design of head-only fusion glycoprotein immunogens for respiratory syncytial virus

scientific article

Structure-based design, synthesis and validation of CD4-mimetic small molecule inhibitors of HIV-1 entry: conversion of a viral entry agonist to an antagonist.

scientific article

Structure-based identification and neutralization mechanism of tyrosine sulfate mimetics that inhibit HIV-1 entry

scientific article

Structure-based stabilization of HIV-1 gp120 enhances humoral immune responses to the induced co-receptor binding site

scientific article (publication date: May 2009)

Structure-based, targeted deglycosylation of HIV-1 gp120 and effects on neutralization sensitivity and antibody recognition.

scientific article published in September 2003

Structure-guided modification and optimization of antibody VRC07.

scientific article published on 13 September 2012

Structures of HIV-1 Env V1V2 with broadly neutralizing antibodies reveal commonalities that enable vaccine design

scientific article

Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates

scientific article

Structures of the CCR5 N Terminus and of a Tyrosine-Sulfated Antibody with HIV-1 gp120 and CD4

scientific article

Structures of the Multidrug Transporter P-glycoprotein Reveal Asymmetric ATP Binding and the Mechanism of Polyspecificity

scientific article

Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles

scientific article published on 29 June 2020

Surface-Matrix Screening Identifies Semi-specific Interactions that Improve Potency of a Near Pan-reactive HIV-1-Neutralizing Antibody

scientific article published in February 2018

Sustained Delivery of a Broadly Neutralizing Antibody in Nonhuman Primates Confers Long-Term Protection against Simian/Human Immunodeficiency Virus Infection

scientific article published on 18 March 2015

Synthesis, Antiviral Potency, in Vitro ADMET, and X-ray Structure of Potent CD4 Mimics as Entry Inhibitors That Target the Phe43 Cavity of HIV-1 gp120.

scientific article published on 7 March 2017

Synthetic glycopeptides reveal the glycan specificity of HIV-neutralizing antibodies.

scientific article published on 30 June 2013

Targeted Isolation of Antibodies Directed against Major Sites of SIV Env Vulnerability

scientific article

The 447-52D antibody: hitting HIV-1 where its armor is thickest

scientific article published in February 2004

The Covalent SNAP Tag for Protein Display Quantification and Low-pH Protein Engineering

scientific article published on 16 June 2020

The Expression of Functional Vpx during Pathogenic SIVmac Infections of Rhesus Macaques Suppresses SAMHD1 in CD4+ Memory T Cells

scientific article

The antigenic structure of the HIV gp120 envelope glycoprotein ⬇️

scientific article published on June 18, 1998

The changing face of HIV vaccine research

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The mannose-dependent epitope for neutralizing antibody 2G12 on human immunodeficiency virus type 1 glycoprotein gp120.

scientific article

The rational design of an AIDS vaccine

scientific article published on February 2006

The β20-β21 of gp120 is a regulatory switch for HIV-1 Env conformational transitions

scientific article published on 19 October 2017

Thermoresponsive Polymer Nanoparticles Co-deliver RSV F Trimers with a TLR-7/8 Adjuvant.

scientific article

Topological layers in the HIV-1 gp120 inner domain regulate gp41 interaction and CD4-triggered conformational transitions

scientific article

Transforming epitope-specific gp120 monomer-based probes into immunogens with N-linked glycan masking

scientific article published on 13 September 2012

Transient Protein Expression Facilitates X-ray Structural Studies of HIV-1.

scientific article

Transitions to and from the CD4-bound conformation are modulated by a single-residue change in the human immunodeficiency virus type 1 gp120 inner domain

scientific article published on 17 June 2009

Transplanting supersites of HIV-1 vulnerability

scientific article

Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G

scientific article

Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques

scientific article

Two distinct broadly neutralizing antibody specificities of different clonal lineages in a single HIV-1-infected donor: implications for vaccine design

scientific article published in February 2012

Two-Component Ferritin Nanoparticles for Multimerization of Diverse Trimeric Antigens.

scientific article published on 16 February 2018

Tyrosine sulfation of human antibodies contributes to recognition of the CCR5 binding region of HIV-1 gp120.

scientific article published in July 2003

Tyrosine-sulfate isosteres of CCR5 N-terminus as tools for studying HIV-1 entry

scientific article

Uncleaved Soluble gp140 Constructs with Retained Native-like Trimer Conformation and Antigenicity.

scientific article published in October 2014

Unliganded HIV-1 gp120 core structures assume the CD4-bound conformation with regulation by quaternary interactions and variable loops

scientific article

Unprecedented Role of Hybrid N-Glycans as Ligands for HIV-1 Broadly Neutralizing Antibodies

scientific article published on 26 March 2018

V1/V2 Neutralizing Epitope is Conserved in Divergent Non-M Groups of HIV-1

scientific article published on 21 September 2015

V1/V2-directed antibodies elicited in RV144 vaccinees bind to a structurally polymorphic site

scientific article published on 13 September 2012

VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage

scientific article published on 03 March 2020

Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses

scientific article

Vaccine Design Reaches the Atomic Level ⬇️

scientific article published on July 13, 2011

Vaccine Induction of Antibodies against a Structurally Heterogeneous Site of Immune Pressure within HIV-1 Envelope Protein Variable Regions 1 and 2

scientific article

Vaccine Induction of Heterologous Tier 2 HIV-1 Neutralizing Antibodies in Animal Models

scientific article published in December 2017

Vaccine-Elicited Tier 2 HIV-1 Neutralizing Antibodies Bind to Quaternary Epitopes Involving Glycan-Deficient Patches Proximal to the CD4 Binding Site

scientific article

Vaccine-Induced Antibodies that Neutralize Group 1 and Group 2 Influenza A Viruses

scientific article

Viral variants that initiate and drive maturation of V1V2-directed HIV-1 broadly neutralizing antibodies

scientific article

Virus-Like Particle Based Vaccines Elicit Neutralizing Antibodies against the HIV-1 Fusion Peptide

scientific article published on 15 December 2020

Virus-like Particles Identify an HIV V1V2 Apex-Binding Neutralizing Antibody that Lacks a Protruding Loop

scientific article published on May 2017

What Are the Most Powerful Immunogen Design Vaccine Strategies?

scientific article (publication date: 3 February 2017)

cAb-Rep: A Database of Curated Antibody Repertoires for Exploring Antibody Diversity and Predicting Antibody Prevalence

scientific article published on 09 October 2019

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