List of works - James Arthos

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

scientific article (publication date: June 2016)

Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.

scientific article

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

scientific article published on 10 April 2019

Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies

scientific article published on 22 January 2002

Blocking α4β7 integrin binding to SIV does not improve virologic control

scientific article published on 05 September 2019

Broad-spectrum anti-human immunodeficiency virus (HIV) potential of a peptide HIV type 1 entry inhibitor

scientific article published on 24 January 2007

CCR5 Signal Transduction in Macrophages by Human Immunodeficiency Virus and Simian Immunodeficiency Virus Envelopes

Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility

scientific article

Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions

scientific article published in Nature Communications

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

scientific article

Correction for Lu et al., "Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands"

scientific article published on 27 October 2020

Correction: A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.

scientific article published on 14 July 2016

Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

scientific article published on 14 September 2017

Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers

scientific article published on 10 January 2008

Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers

scientific article published on July 2008

Cryoelectron tomographic analysis of an HIV-neutralizing protein and its complex with native viral gp120

scientific article published on 28 June 2007

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

scientific article

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques

scientific article published on 13 May 2019

Design clues from functional constraints and broadly neutralizing antibodies

Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1.

scientific article

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

scientific article published on 14 July 2008

Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7.

scientific article published on 16 August 2017

Functional Dynamics of the Interaction between HIV gp120 and α4β7.

scientific article published in October 2014

HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation

scientific article

HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication

scientific article

HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis

scientific article published in March 2003

HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions

scientific article published on 30 January 2020

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.

scientific article published on 21 March 2018

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

scientific article

HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV

scientific article (publication date: 2010)

HIV-1 gp120 Impairs B Cell Proliferation by Inducing TGF-β1 Production and FcRL4 Expression

HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells

article

HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells

scholarly article

HIV-1 gp120: A Target for Therapeutics and Vaccine Design.

scientific article

HIV-1 targets L-selectin for adhesion and induces its shedding for viral release

scientific article published in Nature Communications

HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection

scientific article published on 03 September 2020

HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target

scientific article

Human immunodeficiency virus type 1 evades T-helper responses by exploiting antibodies that suppress antigen processing

scientific article

IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa

scientific article

Innate Immunity in HIV Infection

article

Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions

article

Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques

scientific article published in December 2017

Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes.

scientific article published in January 2018

MAdCAM costimulation through Integrin-α4β7 promotes HIV replication

scientific article published on 06 June 2018

Neutralizing and Targeting Properties of a New Set of α4β7-Specific Antibodies Are Influenced by Their Isotype

scientific article published on 7 February 2017

Post-entry events of efficient R5 vs. inefficient X4 HIV-1 replication in primary CD4+T lymphocytes, a transcriptome analysis

article

Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands

scientific article published on 31 July 2013

Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies

scientific article

R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells

scholarly article

Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs

scientific article published on 25 August 2020

Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

scientific article published on 31 July 2017

Role of T-cell trafficking in the pathogenesis of HIV disease

scientific article published on 01 March 2019

SARS-CoV-2 genomic and quasispecies analyses in cancer patients reveal relaxed intrahost virus evolution

scientific article published on 26 August 2020

Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines

scientific article published on 21 September 2017

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

article

Shedding-resistant HIV-1 envelope glycoproteins adopt downstream conformations that remain responsive to conformation-preferring ligands

scientific article published on 10 June 2020

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

scientific article

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.

scientific article published on 20 February 2018

Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes

scientific article published on 28 December 2020

Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates

scientific article

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

scientific article

Structural basis for the interaction between focal adhesion kinase and CD4

scientific article

Structural definition of a conserved neutralization epitope on HIV-1 gp120

scientific article

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

scientific article

Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy

scientific article

Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy.

scientific article published on February 2005

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

scientific article

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression

scientific article published on 27 October 2013

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1(+) lymph node macrophages

scientific article

The Role of Integrin α4β7 in HIV Pathogenesis and Treatment.

scientific article published on 24 February 2018

The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies

scientific article published on 06 November 2020

The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.

scientific article published on December 2013

The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission

scientific article

The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

scientific article

The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cells

scientific article published on 01 January 2002

Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates

scientific article

Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity

scientific article published on 03 February 2014

Virion attachment and entry: HIV gp120 Env biotinylation, gp120 Env, or integrin ligand-binding assay

scientific article published on January 2014

Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing

scientific article published on May 2017

Worldwide Genetic Features of HIV-1 Env α4β7 Binding Motif: The Local Dissemination Impact of the LDI Tripeptide

scientific article published on December 2015

List of works by James Arthos

A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3

Antibody responses elicited through homologous or heterologous prime-boost DNA and protein vaccinations differ in functional activity and avidity.

Associating HIV-1 envelope glycoprotein structures with states on the virus observed by smFRET

Biochemical and biological characterization of a dodecameric CD4-Ig fusion protein: implications for therapeutic and vaccine strategies

Blocking α4β7 integrin binding to SIV does not improve virologic control

Broad-spectrum anti-human immunodeficiency virus (HIV) potential of a peptide HIV type 1 entry inhibitor

CCR5 Signal Transduction in Macrophages by Human Immunodeficiency Virus and Simian Immunodeficiency Virus Envelopes

Characterization of a human cervical CD4+ T cell subset coexpressing multiple markers of HIV susceptibility

Common helical V1V2 conformations of HIV-1 Envelope expose the α4β7 binding site on intact virions

Conformational dynamics of single HIV-1 envelope trimers on the surface of native virions

Correction for Lu et al., "Shedding-Resistant HIV-1 Envelope Glycoproteins Adopt Downstream Conformations That Remain Responsive to Conformation-Preferring Ligands"

Correction: A Small Molecule, Which Competes with MAdCAM-1, Activates Integrin α4β7 and Fails to Prevent Mucosal Transmission of SHIV-SF162P3.

Correction: Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers

Cross-subtype antibody and cellular immune responses induced by a polyvalent DNA prime-protein boost HIV-1 vaccine in healthy human volunteers

Cryoelectron tomographic analysis of an HIV-neutralizing protein and its complex with native viral gp120

Crystal structure, conformational fixation and entry-related interactions of mature ligand-free HIV-1 Env

Delayed vaginal SHIV infection in VRC01 and anti-α4β7 treated rhesus macaques

Design clues from functional constraints and broadly neutralizing antibodies

Enhanced immunogenicity of gp120 protein when combined with recombinant DNA priming to generate antibodies that neutralize the JR-FL primary isolate of human immunodeficiency virus type 1.

Evidence for HIV-associated B cell exhaustion in a dysfunctional memory B cell compartment in HIV-infected viremic individuals

Extracellular Matrix Proteins Mediate HIV-1 gp120 Interactions with α4β7.

Functional Dynamics of the Interaction between HIV gp120 and α4β7.

HIV Envelope gp120 Alters T Cell Receptor Mobilization in the Immunological Synapse of Uninfected CD4 T Cells and Augments T Cell Activation

HIV envelope induces a cascade of cell signals in non-proliferating target cells that favor virus replication

HIV envelope induces virus expression from resting CD4+ T cells isolated from HIV-infected individuals in the absence of markers of cellular activation or apoptosis

HIV vaccine delayed boosting increases Env variable region 2-specific antibody effector functions

HIV-1 Env trimer opens through an asymmetric intermediate in which individual protomers adopt distinct conformations.

HIV-1 envelope protein binds to and signals through integrin α4β7, the gut mucosal homing receptor for peripheral T cells

HIV-1 envelope, integrins and co-receptor use in mucosal transmission of HIV

HIV-1 gp120 Impairs B Cell Proliferation by Inducing TGF-β1 Production and FcRL4 Expression

HIV-1 gp120 induces NFAT nuclear translocation in resting CD4+ T-cells

HIV-1 gp120 inhibits TLR9-mediated activation and IFN-{alpha} secretion in plasmacytoid dendritic cells

HIV-1 gp120: A Target for Therapeutics and Vaccine Design.

HIV-1 targets L-selectin for adhesion and induces its shedding for viral release

HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection

HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target

Human immunodeficiency virus type 1 evades T-helper responses by exploiting antibodies that suppress antigen processing

IL-7 induces expression and activation of integrin α4β7 promoting naive T-cell homing to the intestinal mucosa

Innate Immunity in HIV Infection

Innate immune dysfunction in HIV infection: effect of HIV envelope-NK cell interactions

Integrin α4β7 Blockade Preferentially Impacts CCR6+ Lymphocyte Subsets in Blood and Mucosal Tissues of Naive Rhesus Macaques

Integrin α4β7 expression on peripheral blood CD4+ T cells predicts HIV acquisition and disease progression outcomes.

MAdCAM costimulation through Integrin-α4β7 promotes HIV replication

Neutralizing and Targeting Properties of a New Set of α4β7-Specific Antibodies Are Influenced by Their Isotype

Post-entry events of efficient R5 vs. inefficient X4 HIV-1 replication in primary CD4+T lymphocytes, a transcriptome analysis

Preferential HIV infection of CCR6+ Th17 cells is associated with higher levels of virus receptor expression and lack of CCR5 ligands

Profiles of human serum antibody responses elicited by three leading HIV vaccines focusing on the induction of Env-specific antibodies

R5 and X4 HIV envelopes induce distinct gene expression profiles in primary peripheral blood mononuclear cells

Racial differences in α4β7 expression on CD4+ T cells of HIV-negative men and women who inject drugs

Rare HIV-1 transmitted/founder lineages identified by deep viral sequencing contribute to rapid shifts in dominant quasispecies during acute and early infection

Role of T-cell trafficking in the pathogenesis of HIV disease

SARS-CoV-2 genomic and quasispecies analyses in cancer patients reveal relaxed intrahost virus evolution

Screening of primary gp120 immunogens to formulate the next generation polyvalent DNA prime-protein boost HIV-1 vaccines

Select gp120 V2 domain specific antibodies derived from HIV and SIV infection and vaccination inhibit gp120 binding to α4β7

Shedding-resistant HIV-1 envelope glycoproteins adopt downstream conformations that remain responsive to conformation-preferring ligands

Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.

Signal peptide of HIV envelope protein impacts glycosylation and antigenicity of gp120.

Signal peptide of HIV-1 envelope modulates glycosylation impacting exposure of V1V2 and other epitopes

Species-specific differences in the expression and regulation of α4β7 integrin in various nonhuman primates

Structural Basis of Immune Evasion at the Site of CD4 Attachment on HIV-1 gp120

Structural basis for the interaction between focal adhesion kinase and CD4

Structural definition of a conserved neutralization epitope on HIV-1 gp120

Structure of HIV-1 gp120 V1/V2 domain with broadly neutralizing antibody PG9

Sustained virologic control in SIV+ macaques after antiretroviral and α4β7 antibody therapy

Targeted lysis of HIV-infected cells by natural killer cells armed and triggered by a recombinant immunoglobulin fusion protein: implications for immunotherapy.

Targeting α4β7 integrin reduces mucosal transmission of simian immunodeficiency virus and protects gut-associated lymphoid tissue from infection

The HIV-1 envelope protein gp120 impairs B cell proliferation by inducing TGF-β1 production and FcRL4 expression

The HIV-1 envelope protein gp120 is captured and displayed for B cell recognition by SIGN-R1(+) lymph node macrophages

The Role of Integrin α4β7 in HIV Pathogenesis and Treatment.

The association of α4β7 expression with HIV acquisition and disease progression in people who inject drugs and men who have sex with men: Case control studies

The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.

The genotype of early-transmitting HIV gp120s promotes α (4) β(7)-reactivity, revealing α (4) β(7) +/CD4+ T cells as key targets in mucosal transmission

The integrin alpha4beta7 forms a complex with cell-surface CD4 and defines a T-cell subset that is highly susceptible to infection by HIV-1.

The role of the CD4 receptor versus HIV coreceptors in envelope-mediated apoptosis in peripheral blood mononuclear cells

Two closely related Env antigens from the same patient elicited different spectra of neutralizing antibodies against heterologous HIV-1 isolates

Tyrosine sulfation in the second variable loop (V2) of HIV-1 gp120 stabilizes V2-V3 interaction and modulates neutralization sensitivity

Virion attachment and entry: HIV gp120 Env biotinylation, gp120 Env, or integrin ligand-binding assay

Virion incorporation of integrin α4β7 facilitates HIV-1 infection and intestinal homing