List of works by Brandon Keele

A limited number of simian immunodeficiency virus (SIV) env variants are transmitted to rhesus macaques vaginally inoculated with SIVmac251.

scientific article

A new approach for monitoring ebolavirus in wild great apes

scientific article

A rev1-vpu polymorphism unique to HIV-1 subtype A and C strains impairs envelope glycoprotein expression from rev-vpu-env cassettes and reduces virion infectivity in pseudotyping assays

scientific article published on 8 December 2009

A signature in HIV-1 envelope leader peptide associated with transition from acute to chronic infection impacts envelope processing and infectivity

scientific article

A single amino acid mutation in the envelope cytoplasmic tail restores the ability of an attenuated simian immunodeficiency virus mutant to deplete mucosal CD4+ T cells

scientific article published on 11 September 2013

A single gp120 residue can affect HIV-1 tropism in macaques.

scientific article published on 25 September 2017

A spatio-temporal assessment of simian/human immunodeficiency virus (SHIV) evolution reveals a highly dynamic process within the host.

scientific article

A vaccine against CCR5 protects a subset of macaques upon intravaginal challenge with simian immunodeficiency virus SIVmac251.

scientific article published on 04 December 2013

Adaptation of HIV-1 to its human host.

scientific article

Addendum: Immune clearance of highly pathogenic SIV infection

scientific article published in Nature

Adenovirus prime, Env protein boost vaccine protects against neutralization-resistant SIVsmE660 variants in rhesus monkeys

scientific article

Adjuvant Dependent Mucosal V2 Responses and RAS Activation in Vaccine Induced Protection from SIVmac251 Acquisition.

scientific article published in October 2014

Adjuvant-dependent innate and adaptive immune signatures of risk of SIVmac251 acquisition

scientific article published on 30 May 2016

Adoptive Transfer of Engineered Rhesus Simian Immunodeficiency Virus-Specific CD8+ T Cells Reduces the Number of Transmitted/Founder Viruses Established in Rhesus Macaques

scientific article published on 24 August 2016

Analysis of immunoglobulin transcripts and hypermutation following SHIV(AD8) infection and protein-plus-adjuvant immunization

scientific article

Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial

scientific article

Antibody to the gp120 V1/V2 loops and CD4+ and CD8+ T cell responses in protection from SIVmac251 vaginal acquisition and persistent viremia

scientific article

Autologous neutralizing antibodies to the transmitted/founder viruses emerge late after simian immunodeficiency virus SIVmac251 infection of rhesus monkeys

scientific article (publication date: June 2010)

Barriers to mucosal transmission of immunodeficiency viruses

scientific article

Blocking α4β7 integrin binding to SIV does not improve virologic control

scientific article published on 05 September 2019

Breakthrough Virus Neutralization Resistance as a Correlate of Protection in a Nonhuman Primate Heterologous Simian Immunodeficiency Virus Vaccine Challenge Study

scientific article

Broadly neutralizing antibodies targeting the HIV-1 envelope V2 apex confer protection against a clade C SHIV challenge

scientific article published on September 2017

Characterization of simian immunodeficiency virus (SIV) that induces SIV encephalitis in rhesus macaques with high frequency: role of TRIM5 and major histocompatibility complex genotypes and early entry to the brain

scientific article

Characterization of the follicular dendritic cell reservoir of human immunodeficiency virus type 1.

scientific article

Chimpanzee reservoirs of pandemic and nonpandemic HIV-1

scientific article

Clonally expanded CD4+ T cells can produce infectious HIV-1 in vivo

scientific article published on 8 February 2016

Combined HIV-1 sequence and integration site analysis informs viral dynamics and allows reconstruction of replicating viral ancestors

scientific article published on 27 November 2019

Comparative characterization of transfection- and infection-derived simian immunodeficiency virus challenge stocks for in vivo nonhuman primate studies

scientific article published on 13 February 2013

Control of Heterologous Simian Immunodeficiency Virus SIV Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques

scientific article published on 17 July 2018

Corrigendum to “Modeling sequence evolution in acute HIV-1 infection” [J. Theor. Biol. 261 (2009) 341–360]

article

Cross-sectional detection of acute HIV infection: timing of transmission, inflammation and antiretroviral therapy

scientific article (publication date: 10 May 2011)

Deciphering human immunodeficiency virus type 1 transmission and early envelope diversification by single-genome amplification and sequencing

scientific article published on 6 February 2008

Defining early SIV replication and dissemination dynamics following vaginal transmission

article

Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection

scientific article published on 13 July 2016

Dolutegravir monotherapy of simian immunodeficiency virus-infected macaques selects for several patterns of resistance mutations with variable virological outcomes

scientific article published on 04 January 2019

Early low-titer neutralizing antibodies impede HIV-1 replication and select for virus escape

scientific article

Eastern chimpanzees, but not bonobos, represent a simian immunodeficiency virus reservoir

scientific article

Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques

scientific article

Efficient SIVcpz replication in human lymphoid tissue requires viral matrix protein adaptation

scientific article

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

scientific article published on 28 December 2015

Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif

scientific article

Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

scientific article published on 31 May 2016

Estimating Initial Viral Levels during Simian Immunodeficiency Virus/Human Immunodeficiency Virus Reactivation from Latency

scientific article published on 8 November 2017

Evaluating the Intactness of Persistent Viral Genomes in Simian Immunodeficiency Virus-Infected Rhesus Macaques after Initiating Antiretroviral Therapy within One Year of Infection

scientific article published on 12 December 2019

Evaluation of an antibody to α4β7 in the control of SIVmac239-nef-stop infection

scientific article published on 05 September 2019

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

scientific article

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques

scientific article (publication date: 2014)

Field immobilization for treatment of an unknown illness in a wild chimpanzee (Pan troglodytes schweinfurthii) at Gombe National Park, Tanzania: findings, challenges, and lessons learned

scientific article published on 20 July 2013

Flow virometric sorting and analysis of HIV quasispecies from plasma

scientific article published on 23 February 2017

Follicular dendritic cell contributions to HIV pathogenesis

scientific article

Follicular dendritic cell-mediated up-regulation of CXCR4 expression on CD4 T cells and HIV pathogenesis

scientific article published on 01 September 2002

Follicular dendritic cells and human immunodeficiency virus type 1 transcription in CD4+ T cells

scientific article published on 29 October 2008

Follicular dendritic cells and the persistence of HIV infectivity: the role of antibodies and Fcgamma receptors

scientific article published on March 2002

Functional cure of SIVagm infection in rhesus macaques results in complete recovery of CD4+ T cells and is reverted by CD8+ cell depletion

scientific article

Generation and characterization of a SIVmac239 clone corrected at four suboptimal nucleotides

scientific article published on 16 June 2015

Generation of infectious molecular clones of simian immunodeficiency virus from fecal consensus sequences of wild chimpanzees

scientific article published on 9 May 2007

Generation of transmitted/founder HIV-1 infectious molecular clones and characterization of their replication capacity in CD4 T lymphocytes and monocyte-derived macrophages

scientific article published on 21 December 2011

Genetic and antigenic features of the transmitted virus

scientific article published on September 2009

Genetic diversity and phylogeographic clustering of SIVcpzPtt in wild chimpanzees in Cameroon.

scientific article published on 24 July 2007

Genetic identity, biological phenotype, and evolutionary pathways of transmitted/founder viruses in acute and early HIV-1 infection

scientific article published on June 2009

Genetically barcoded SIV reveals the emergence of escape mutations in multiple viral lineages during immune escape

scientific article published on 16 December 2019

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy.

scientific article

HIV evolution in early infection: selection pressures, patterns of insertion and deletion, and the impact of APOBEC

scientific article

HIV vaccine candidate activation of hypoxia and the inflammasome in CD14 monocytes is associated with a decreased risk of SIV acquisition

article

HIV-1 Vpu Mediates HLA-C Downregulation

scientific article published on May 2016

HIV-1-induced AIDS in monkeys

scientific article

Heterogeneity in neutralization sensitivities of viruses comprising the simian immunodeficiency virus SIVsmE660 isolate and vaccine challenge stock

scientific article published on 6 March 2013

High Multiplicity Infection by HIV-1 in Men Who Have Sex with Men.

scientific article

High recombination potential of subtype A HIV-1.

scientific article published on 8 July 2015

Human immunodeficiency viruses: SIV infection in wild gorillas

scientific article

Hypercytotoxicity and rapid loss of NKp44+ innate lymphoid cells during acute SIV infection

scientific article (publication date: December 2014)

Identifying and characterizing recently transmitted viruses

scientific article

Immune clearance of highly pathogenic SIV infection

scientific article

Immunological and virological mechanisms of vaccine-mediated protection against SIV and HIV.

scientific article published on 18 December 2013

Impact of simian immunodeficiency virus infection on chimpanzee population dynamics

scientific article

In Vivo Validation of the Viral Barcoding of Simian Immunodeficiency Virus SIVmac239 and the Development of New Barcoded SIV and Subtype B and C Simian-Human Immunodeficiency Viruses

scientific article published on 12 December 2019

In vivo gp41 antibodies targeting the 2F5 monoclonal antibody epitope mediate human immunodeficiency virus type 1 neutralization breadth

scientific article

Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz

scientific article

Inflammatory genital infections mitigate a severe genetic bottleneck in heterosexual transmission of subtype A and C HIV-1

scientific article

Initial B-cell responses to transmitted human immunodeficiency virus type 1: virion-binding immunoglobulin M (IgM) and IgG antibodies followed by plasma anti-gp41 antibodies with ineffective control of initial viremia

scientific article

Intestinal damage precedes mucosal immune dysfunction in SIV infection

scholarly article by Tiffany Hensley-McBain et al published September 2018 in Mucosal Immunology

Lack of therapeutic efficacy of an antibody to α4β7 in SIVmac251-infected rhesus macaques

scientific article published on 05 September 2019

Large number of rebounding/founder HIV variants emerge from multifocal infection in lymphatic tissues after treatment interruption

scientific article

Limited or no protection by weakly or nonneutralizing antibodies against vaginal SHIV challenge of macaques compared with a strongly neutralizing antibody

scientific article

Long-Acting Rilpivirine (RPV) Preexposure Prophylaxis Does Not Inhibit Vaginal Transmission of RPV-Resistant HIV-1 or Select for High-Frequency Drug Resistance in Humanized Mice

scientific article published on 31 March 2020

Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression

scientific article

Low-dose mucosal simian immunodeficiency virus infection restricts early replication kinetics and transmitted virus variants in rhesus monkeys

scientific article

Low-dose rectal inoculation of rhesus macaques by SIVsmE660 or SIVmac251 recapitulates human mucosal infection by HIV-1.

scientific article published on 04 May 2009

Low-level alternative tRNA priming of reverse transcription of HIV-1 and SIV in vivo

scholarly article by Christine M Fennessey et al published 4 April 2019 in Retrovirology

Male dominance rank and reproductive success in chimpanzees, Pan troglodytes schweinfurthii

scientific article

Mapping the complete glycoproteome of virion-derived HIV-1 gp120 provides insights into broadly neutralizing antibody binding

scientific article published on 08 September 2016

Marginal Effects of Systemic CCR5 Blockade with Maraviroc on Oral Simian Immunodeficiency Virus Transmission to Infant Macaques

article

Minimal Contribution of APOBEC3-Induced G-to-A Hypermutation to HIV-1 Recombination and Genetic Variation

scientific article

Mitigation of endemic GI-tract pathogen-mediated inflammation through development of multimodal treatment regimen and its impact on SIV acquisition in rhesus macaques

scientific article published on 10 May 2021

Modeling sequence evolution in acute HIV-1 infection

scientific article published on 04 August 2009

Molecular ecology and natural history of simian foamy virus infection in wild-living chimpanzees

scientific article

Molecular identification, cloning and characterization of transmitted/founder HIV-1 subtype A, D and A/D infectious molecular clones

scientific article published on November 2012

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events

scientific article

Nonhuman primate models for the evaluation of HIV-1 preventive vaccine strategies: model parameter considerations and consequences

scientific article

Novel circular DNA viruses in stool samples of wild-living chimpanzees

scientific article

OA06-04. The role of early T-cell responses in subjects with acute HIV-1 infection

scientific article published on 22 October 2009

Origin of AIDS: contaminated polio vaccine theory refuted.

scientific article

Origin of Rebound Plasma HIV Includes Cells with Identical Proviruses That Are Transcriptionally Active before Stopping of Antiretroviral Therapy

scientific article

Origin of the human malaria parasite Plasmodium falciparum in gorillas

scientific article

Origin of the human malaria parasite Plasmodium falciparum in gorillas.

scientific article

Partial efficacy of a broadly neutralizing antibody against cell-associated SHIV infection

scientific article published on August 2017

Pathogenic features associated with increased virulence upon Simian immunodeficiency virus cross-species transmission from natural hosts

scientific article

Pathogenicity and mucosal transmissibility of the R5-tropic simian/human immunodeficiency virus SHIV(AD8) in rhesus macaques: implications for use in vaccine studies

scientific article

Pathologic lesions in chimpanzees (Pan trogylodytes schweinfurthii) from Gombe National Park, Tanzania, 2004-2010

scientific article published on December 2011

Plasmodium falciparum-like parasites infecting wild apes in southern Cameroon do not represent a recurrent source of human malaria

scientific article

Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure

scientific article published on 16 January 2013

Proviruses with identical sequences comprise a large fraction of the replication-competent HIV reservoir

scientific article

Quality and quantity of TFH cells are critical for broad antibody development in SHIVAD8 infection

scientific article published on July 2015

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

article

Recapitulating Cross-Species Transmission of Simian Immunodeficiency Virus SIVcpz to Humans by Using Humanized BLT Mice

scientific article

Recombination is required for efficient HIV-1 replication and the maintenance of viral genome integrity

article

Recurrent signature patterns in HIV-1 B clade envelope glycoproteins associated with either early or chronic infections

scientific article

Relationship between Vaccine-Induced Antibody Capture of Infectious Virus and Infection Outcomes following Repeated Low-Dose Rectal Challenges with Simian Immunodeficiency Virus SIVmac251

scientific article published on 20 July 2016

Replicating adenovirus-simian immunodeficiency virus (SIV) recombinant priming and envelope protein boosting elicits localized, mucosal IgA immunity in rhesus macaques correlated with delayed acquisition following a repeated low-dose rectal SIV(mac2

scientific article published on 15 February 2012

Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques

scientific article published on 11 January 2012

SIVmac251 is inefficiently transmitted to rhesus macaques by penile inoculation with a single SIVenv variant found in ramp-up phase plasma

scientific article published on 6 July 2011

Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins

scientific article

Selection pressure on HIV-1 envelope by broadly neutralizing antibodies to the conserved CD4-binding site

scientific article

Seminal Simian Immunodeficiency Virus in Chronically Infected Cynomolgus Macaques Is Dominated by Virus Originating from Multiple Genital Organs.

scientific article published on 29 June 2018

Short Communication: Comparative Evaluation of Coformulated Injectable Combination Antiretroviral Therapy Regimens in Simian Immunodeficiency Virus-Infected Rhesus Macaques

scientific article published on 6 July 2015

Simian immunodeficiency virus infection in free-ranging sooty mangabeys (Cercocebus atys atys) from the Taï Forest, Côte d'Ivoire: implications for the origin of epidemic human immunodeficiency virus type 2.

scientific article

Strong, but Age-Dependent, Protection Elicited by a Deoxyribonucleic Acid/Modified Vaccinia Ankara Simian Immunodeficiency Virus Vaccine

scientific article published on January 2016

TRIM5α does not affect simian immunodeficiency virus SIV(mac251) replication in vaccinated or unvaccinated Indian rhesus macaques following intrarectal challenge exposure

scientific article published on 14 September 2011

Tetherin-driven adaptation of Vpu and Nef function and the evolution of pandemic and nonpandemic HIV-1 strains.

scientific article

The first T cell response to transmitted/founder virus contributes to the control of acute viremia in HIV-1 infection

scientific article published on June 2009

Tracking HIV-1 recombination to resolve its contribution to HIV-1 evolution in natural infection.

scientific article

Tracking the luminal exposure and lymphatic drainage pathways of intravaginal and intrarectal inocula used in nonhuman primate models of HIV transmission

scientific article (publication date: 2014)

Transcription Start Site Heterogeneity and Preferential Packaging of Specific Full-Length RNA Species Are Conserved Features of Primate Lentiviruses

scientific article published in 2022

Transmission of single HIV-1 genomes and dynamics of early immune escape revealed by ultra-deep sequencing

scientific article

Transmitted/founder simian immunodeficiency virus envelope sequences in vesicular stomatitis and Semliki forest virus vector immunized rhesus macaques

scientific article

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

scientific article published on 9 July 2014

Ultrasensitive Immunoassay for Simian Immunodeficiency Virus p27

scholarly article by Adrienne E Swanstrom et al published November 2018 in AIDS Research and Human Retroviruses

Using nonhuman primates to model HIV transmission

scientific article

Vaccine-induced cellular responses control simian immunodeficiency virus replication after heterologous challenge

scientific article published on 29 April 2009

Vaccine-induced myeloid cell population dampens protective immunity to SIV

scientific article

Vector order determines protection against pathogenic simian immunodeficiency virus infection in a triple component vaccine by balancing CD4+ and CD8+ T-cell responses

scientific article published on 13 September 2017

Virological Control by the CD4-Binding Site Antibody N6 in Simian-Human Immunodeficiency Virus-Infected Rhesus Monkeys

scientific article published on 24 May 2017

Virus-driven Inflammation Is Associated With the Development of bNAbs in Spontaneous Controllers of HIV.

scientific article published on 3 February 2017

Wide variation in the multiplicity of HIV-1 infection among injection drug users

scientific article

Workshop summary: Novel biomarkers for HIV incidence assay development

scientific article

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