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List of works by Jeffrey Lifson

3D visualization of HIV transfer at the virological synapse between dendritic cells and T cells

scientific article

A MIV-150/zinc acetate gel inhibits SHIV-RT infection in macaque vaginal explants

scientific article

A combination microbicide gel protects macaques against vaginal simian human immunodeficiency virus-reverse transcriptase infection, but only partially reduces herpes simplex virus-2 infection after a single high-dose cochallenge

scientific article

A dendritic cell-based vaccine elicits T cell responses associated with control of HIV-1 replication

scientific article published in January 2013

A live-attenuated RhCMV/SIV vaccine shows long-term efficacy against heterologous SIV challenge

scientific article published on 01 July 2019

A macaque model to study vaginal HSV-2/immunodeficiency virus co-infection and the impact of HSV-2 on microbicide efficacy

scientific article

A modified zinc acetate gel, a potential nonantiretroviral microbicide, is safe and effective against simian-human immunodeficiency virus and herpes simplex virus 2 infection in vivo

scientific article published on 10 June 2013

A potent combination microbicide that targets SHIV-RT, HSV-2 and HPV

scientific article

A single dose of a MIV-150/Zinc acetate gel provides 24 h of protection against vaginal simian human immunodeficiency virus reverse transcriptase infection, with more limited protection rectally 8-24 h after gel use.

scientific article

A single gp120 residue can affect HIV-1 tropism in macaques.

scientific article published on 25 September 2017

A single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges

scientific article published on 27 April 2016

A tonsillar PolyICLC/AT-2 SIV therapeutic vaccine maintains low viremia following antiretroviral therapy cessation

scientific article

AAV-Delivered Antibody Mediates Significant Protective Effects against SIVmac239 Challenge in the Absence of Neutralizing Activity

scientific article (publication date: August 2015)

AAV-delivered eCD4-Ig protects rhesus macaques from high-dose SIVmac239 challenges

scientific article published on 01 July 2019

AAV-expressed eCD4-Ig provides durable protection from multiple SHIV challenges

scientific article

ADCC develops over time during persistent infection with live-attenuated SIV and is associated with complete protection against SIV(mac)251 challenge

scientific article

An Antiretroviral/Zinc Combination Gel Provides 24 Hours of Complete Protection against Vaginal SHIV Infection in Macaques ⬇️

scientific article published on January 5, 2011

An Intravaginal Ring That Releases the NNRTI MIV-150 Reduces SHIV Transmission in Macaques ⬇️

scientific article published on September 5, 2012

An intravaginal ring that releases three antiviral agents and a contraceptive blocks SHIV-RT infection, reduces HSV-2 shedding, and suppresses hormonal cycling in rhesus macaques

scientific article published on 9 June 2017

Antibodies with high avidity to the gp120 envelope protein in protection from simian immunodeficiency virus SIV(mac251) acquisition in an immunization regimen that mimics the RV-144 Thai trial

scientific article

Antibody-mediated immunotherapy of macaques chronically infected with SHIV suppresses viraemia

scientific article

Antifibrotic therapy in simian immunodeficiency virus infection preserves CD4+ T-cell populations and improves immune reconstitution with antiretroviral therapy

scientific article

Antiretroviral Therapy in Simian Immunodeficiency Virus-Infected Sooty Mangabeys: Implications for AIDS Pathogenesis

scientific article published on 08 June 2016

Author Correction: Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

scientific article published on 01 February 2020

B cell follicle sanctuary permits persistent productive simian immunodeficiency virus infection in elite controllers

scientific article

Blocking α4β7 integrin binding to SIV does not improve virologic control

scientific article published on 05 September 2019

CD4+ T-cell death induced by infectious and noninfectious HIV-1: role of type 1 interferon-dependent, TRAIL/DR5-mediated apoptosis

scientific article published on 26 July 2005

CD8 T cell response maturation defined by anentropic specificity and repertoire depth correlates with SIVΔnef-induced protection

scientific article (publication date: February 2015)

CD8(+) Lymphocytes Are Required for Maintaining Viral Suppression in SIV-Infected Macaques Treated with Short-Term Antiretroviral Therapy.

scientific article published on September 2016

CXCR5-Dependent Entry of CD8 T Cells into Rhesus Macaque B-Cell Follicles Achieved through T-Cell Engineering

scientific article published on 15 March 2017

Catching HIV 'in the act' with 3D electron microscopy

scientific article

Characterization of peripheral and mucosal immune responses in rhesus macaques on long-term tenofovir and emtricitabine combination antiretroviral therapy.

scientific article

Considerations in the development of nonhuman primate models of combination antiretroviral therapy for studies of AIDS virus suppression, residual virus, and curative strategies

scientific article

Control of Heterologous Simian Immunodeficiency Virus SIV Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques

scientific article published on 17 July 2018

Control of viremia and prevention of simian-human immunodeficiency virus-induced disease in rhesus macaques immunized with recombinant vaccinia viruses plus inactivated simian immunodeficiency virus and human immunodeficiency virus type 1 particles

scientific article

Correction: Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes

scholarly article published by Elena Chertova in 2018

Cumulative mechanisms of lymphoid tissue fibrosis and T cell depletion in HIV-1 and SIV infections

scientific article

DNA and protein co-immunization improves the magnitude and longevity of humoral immune responses in macaques

scientific article

Damaged intestinal epithelial integrity linked to microbial translocation in pathogenic simian immunodeficiency virus infections

scientific article

Defining HIV and SIV Reservoirs in Lymphoid Tissues.

scientific article published on January 2016

Defining early SIV replication and dissemination dynamics following vaginal transmission

article

Defining total-body AIDS-virus burden with implications for curative strategies

scientific article published on 2 October 2017

Derivation and Characterization of Pathogenic Transmitted/Founder Molecular Clones from Simian Immunodeficiency Virus SIVsmE660 and SIVmac251 following Mucosal Infection

scientific article published on 13 July 2016

Differential infection patterns of CD4+ T cells and lymphoid tissue viral burden distinguish progressive and nonprogressive lentiviral infections

scientific article

Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes

scientific article

Distinct phenotype, longitudinal changes of numbers and cell-associated virus in blood dendritic cells in SIV-infected CD8-lymphocyte depleted macaques

scientific article

Distribution, persistence, and efficacy of adoptively transferred central and effector memory-derived autologous simian immunodeficiency virus-specific CD8+ T cell clones in rhesus macaques during acute infection

scientific article

Double-stranded RNA analog poly(I:C) inhibits human immunodeficiency virus amplification in dendritic cells via type I interferon-mediated activation of APOBEC3G.

scientific article

Downregulation of robust acute type I interferon responses distinguishes nonpathogenic simian immunodeficiency virus (SIV) infection of natural hosts from pathogenic SIV infection of rhesus macaques

scientific article

Early antibody therapy can induce long-lasting immunity to SHIV

scientific article

Effect of CD8+ lymphocyte depletion on virus containment after simian immunodeficiency virus SIVmac251 challenge of live attenuated SIVmac239delta3-vaccinated rhesus macaques

scientific article

Effect of humoral immune responses on controlling viremia during primary infection of rhesus monkeys with simian immunodeficiency virus

scientific article

Effect of suberoylanilide hydroxamic acid (SAHA) administration on the residual virus pool in a model of combination antiretroviral therapy-mediated suppression in SIVmac239-infected indian rhesus macaques

scientific article

Effective treatment of SIVcpz-induced immunodeficiency in a captive western chimpanzee

scientific article

Effects of cytotoxic T lymphocytes (CTL) directed against a single simian immunodeficiency virus (SIV) Gag CTL epitope on the course of SIVmac239 infection

scientific article

Effects of treatment with suppressive combination antiretroviral drug therapy and the histone deacetylase inhibitor suberoylanilide hydroxamic acid; (SAHA) on SIV-infected Chinese rhesus macaques

scientific article (publication date: 2014)

Efficacy of Carraguard-based microbicides in vivo despite variable in vitro activity

scientific article

Electron tomography analysis of envelope glycoprotein trimers on HIV and simian immunodeficiency virus virions

scientific article

Electron tomography of the contact between T cells and SIV/HIV-1: implications for viral entry.

scientific article

Elevated Plasma Viral Loads in Romidepsin-Treated Simian Immunodeficiency Virus-Infected Rhesus Macaques on Suppressive Combination Antiretroviral Therapy

scientific article published on 28 December 2015

Elimination of retroviral infectivity by N-ethylmaleimide with preservation of functional envelope glycoproteins

scientific article

Elite Control, Gut CD4 T Cell Sparing, and Enhanced Mucosal T Cell Responses in Macaca nemestrina Infected by a Simian Immunodeficiency Virus Lacking a gp41 Trafficking Motif

scientific article

Envelope residue 375 substitutions in simian-human immunodeficiency viruses enhance CD4 binding and replication in rhesus macaques

scientific article published on 31 May 2016

Envelope-modified single-cycle simian immunodeficiency virus selectively enhances antibody responses and partially protects against repeated, low-dose vaginal challenge

scientific article

Evaluation of an antibody to α4β7 in the control of SIVmac239-nef-stop infection

scientific article published on 05 September 2019

Evidence of dysregulation of dendritic cells in primary HIV infection

scientific article published on 6 August 2010

Experimental colitis in SIV-uninfected rhesus macaques recapitulates important features of pathogenic SIV infection

scientific article

Exposure to MIV-150 from a high-dose intravaginal ring results in limited emergence of drug resistance mutations in SHIV-RT infected rhesus macaques

scientific article (publication date: 2014)

Gammaherpesvirus infection and malignant disease in rhesus macaques experimentally infected with SIV or SHIV

scientific article published on 12 July 2018

Genetic diversity of simian immunodeficiency virus encoding HIV-1 reverse transcriptase persists in macaques despite antiretroviral therapy

scientific article

Genetically-barcoded SIV facilitates enumeration of rebound variants and estimation of reactivation rates in nonhuman primates following interruption of suppressive antiretroviral therapy.

scientific article

Glycerol monolaurate prevents mucosal SIV transmission

scientific article

HIV vaccine design: insights from live attenuated SIV vaccines

scientific article

HIV-1 Vpu Mediates HLA-C Downregulation

scientific article published on May 2016

HIV-1-induced AIDS in monkeys

scientific article

HLA-B*35-Px-mediated acceleration of HIV-1 infection by increased inhibitory immunoregulatory impulses

scientific article

HSV-2 infection of dendritic cells amplifies a highly susceptible HIV-1 cell target

scientific article

HSV-2-driven increase in the expression of α4β7 correlates with increased susceptibility to vaginal SHIV(SF162P3) infection

scientific article (publication date: December 2014)

Human Immunodeficiency Virus Type 1 Monoclonal Antibodies Suppress Acute Simian-Human Immunodeficiency Virus Viremia and Limit Seeding of Cell-Associated Viral Reservoirs

scientific article

IL-15 induces CD4 effector memory T cell production and tissue emigration in nonhuman primates

scientific article

Immune clearance of highly pathogenic SIV infection

scientific article

Immunization of macaques with single-cycle simian immunodeficiency virus (SIV) stimulates diverse virus-specific immune responses and reduces viral loads after challenge with SIVmac239

scientific article

Immunization with single-cycle SIV significantly reduces viral loads after an intravenous challenge with SIV(mac)239.

scientific article

Impact of early cART in the gut during acute HIV infection

scientific article published on July 2016

In vitro priming recapitulates in vivo HIV-1 specific T cell responses, revealing rapid loss of virus reactive CD4 T cells in acute HIV-1 infection

scientific article published on 23 January 2009

In vivo binding and retention of CD4-specific DARPin 57.2 in macaques

scientific article (publication date: 2010)

Increased CD4+ T cell levels during IL-7 administration of antiretroviral therapy-treated simian immunodeficiency virus-positive macaques are not dependent on strong proliferative responses

scientific article

Influence of HLA-C expression level on HIV control

scientific article published on April 2013

Inhibitory TCR coreceptor PD-1 is a sensitive indicator of low-level replication of SIV and HIV-1 ⬇️

scientific article

Interleukin-21 combined with ART reduces inflammation and viral reservoir in SIV-infected macaques

scientific article

International AIDS Society global scientific strategy: towards an HIV cure 2016.

scientific article published on 11 July 2016

Live simian immunodeficiency virus vaccine correlate of protection: local antibody production and concentration on the path of virus entry

scientific article

Liver macrophage-associated inflammation correlates with SIV burden and is substantially reduced following cART.

scientific article published on 21 February 2018

Local and systemic effects of intranodally injected CpG-C immunostimulatory-oligodeoxyribonucleotides in macaques

scientific article published on December 2006

Location and dynamics of the immunodominant CD8 T cell response to SIVΔnef immunization and SIVmac251 vaginal challenge

scientific article (publication date: 2013)

Loss of a tyrosine-dependent trafficking motif in the simian immunodeficiency virus envelope cytoplasmic tail spares mucosal CD4 cells but does not prevent disease progression

scientific article

Macrophages relate presynaptic and postsynaptic damage in simian immunodeficiency virus encephalitis

scientific article

Magnetic resonance spectroscopy reveals that activated monocytes contribute to neuronal injury in SIV neuroAIDS.

scientific article

Magnitude and Quality of Cytokine and Chemokine Storm during Acute Infection Distinguish Nonprogressive and Progressive Simian Immunodeficiency Virus Infections of Nonhuman Primates

scientific article published on 14 September 2016

Maturation of the HIV-1 core by a non-diffusional phase transition.

scientific article

Mechanisms underlying γδ T-cell subset perturbations in SIV-infected Asian rhesus macaques

scientific article

Molecular architectures of trimeric SIV and HIV-1 envelope glycoproteins on intact viruses: strain-dependent variation in quaternary structure

scientific article (publication date: 2010)

Molecularly tagged simian immunodeficiency virus SIVmac239 synthetic swarm for tracking independent infection events

scientific article

Noninfectious X4 but not R5 human immunodeficiency virus type 1 virions inhibit humoral immune responses in human lymphoid tissue ex vivo

scientific article published in July 2004

Obituary: Remembering Michael Piatak, Jr.

scientific article

Optimization of the doxycycline-dependent simian immunodeficiency virus through in vitro evolution

scientific article published on 5 June 2008

Partial efficacy of a broadly neutralizing antibody against cell-associated SHIV infection

scientific article published on August 2017

Pembrolizumab induces HIV latency reversal in people living with HIV and cancer on antiretroviral therapy

scientific article published on 26 January 2022

Persistence of viral reservoirs in multiple tissues after antiretroviral therapy suppression in a macaque RT-SHIV model

scientific article (publication date: 2013)

PolyICLC Exerts Pro- and Anti-HIV Effects on the DC-T Cell Milieu In Vitro and In Vivo

scientific article (publication date: 2016)

Probiotic/prebiotic supplementation of antiretrovirals improves gastrointestinal immunity in SIV-infected macaques.

scientific article published on 16 January 2013

Protection afforded by an HIV vaccine candidate in macaques depends on the dose of SIVmac251 at challenge exposure

scientific article published on 16 January 2013

Proteomic and biochemical analysis of purified human immunodeficiency virus type 1 produced from infected monocyte-derived macrophages

scientific article

RT-SHIV subpopulation dynamics in infected macaques during anti-HIV therapy

scientific article

Rare Control of SIVmac239 Infection in a Vaccinated Rhesus Macaque

scientific article published on 13 May 2017

Rational design and in vivo selection of SHIVs encoding transmitted/founder subtype C HIV-1 envelopes

article

Recombinant modified vaccinia virus Ankara provides durable protection against disease caused by an immunodeficiency virus as well as long-term immunity to an orthopoxvirus in a non-human primate

scientific article

Rectal Acquisition of SIVmac239 Infection Despite Vaccine-Induced Immune Responses Against the Entire SIV Proteome

scientific article published on 07 October 2020

Reduced inflammation and lymphoid tissue immunopathology in rhesus macaques receiving anti-tumor necrosis factor treatment during primary simian immunodeficiency virus infection

scientific article published on 19 October 2012

Restricted replication of xenotropic murine leukemia virus-related virus in pigtailed macaques

scientific article published on 11 January 2012

Rhesus Macaques Vaccinated with , , and Manifest Early Control of SIVmac239 Replication

scholarly article by Mauricio A Martins et al published 15 August 2018 in Journal of Virology

Robust and persistent reactivation of SIV and HIV by N-803 and depletion of CD8+ cells

scientific article published on 22 January 2020

Selection of unadapted, pathogenic SHIVs encoding newly transmitted HIV-1 envelope proteins

scientific article

Sex differences in the Toll-like receptor-mediated response of plasmacytoid dendritic cells to HIV-1.

scientific article

Short communication: a repeated simian human immunodeficiency virus reverse transcriptase/herpes simplex virus type 2 cochallenge macaque model for the evaluation of microbicides

scientific article

Suppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy

scientific article

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo

scientific article published on 22 January 2020

The Nonnucleoside Reverse Transcription Inhibitor MIV-160 Delivered from an Intravaginal Ring, But Not from a Carrageenan Gel, Protects Against Simian/Human Immunodeficiency Virus-RT Infection ⬇️

scientific article published on August 27, 2012

The frequency of α₄β₇(high) memory CD4⁺ T cells correlates with susceptibility to rectal simian immunodeficiency virus infection.

scientific article published on December 2013

The use of nonhuman primate models in HIV vaccine development

scientific article

Three-dimensional imaging of HIV-1 virological synapses reveals membrane architectures involved in virus transmission.

scientific article

Three-dimensional structures of soluble CD4-bound states of trimeric simian immunodeficiency virus envelope glycoproteins determined by using cryo-electron tomography

scientific article

Tonsillar application of AT-2 SIV affords partial protection against rectal challenge with SIVmac239.

scientific article published on December 2009

Tracking the luminal exposure and lymphatic drainage pathways of intravaginal and intrarectal inocula used in nonhuman primate models of HIV transmission

scientific article (publication date: 2014)

Trafficking, persistence, and activation state of adoptively transferred allogeneic and autologous Simian Immunodeficiency Virus-specific CD8(+) T cell clones during acute and chronic infection of rhesus macaques

scientific article

Treatment with native heterodimeric IL-15 increases cytotoxic lymphocytes and reduces SHIV RNA in lymph nodes.

scientific article

Type I interferon responses in rhesus macaques prevent SIV infection and slow disease progression

scientific article published on 9 July 2014

Vaccination with Gag, Vif, and Nef gene fragments affords partial control of viral replication after mucosal challenge with SIVmac239

scientific article

Vaccine-Elicited Mucosal and Systemic Antibody Responses Are Associated with Reduced Simian Immunodeficiency Viremia in Infant Rhesus Macaques

scientific article

Vaccine-Induced Simian Immunodeficiency Virus-Specific CD8+ T-Cell Responses Focused on a Single Nef Epitope Select for Escape Variants Shortly after Infection

scientific article

Vaccine-induced CD8+ T cells control AIDS virus replication

scientific article published on 30 September 2012

Vaccine-induced immune responses against both Gag and Env improve control of simian immunodeficiency virus replication in rectally challenged rhesus macaques.

scientific article

Vectored delivery of anti-SIV envelope targeting mAb via AAV8 protects rhesus macaques from repeated limiting dose intrarectal swarm SIVsmE660 challenge

scientific article published on 05 December 2018

Virologic effects of broadly neutralizing antibody VRC01 administration during chronic HIV-1 infection

scientific article published on December 2015

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