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List of works by Douglas Keller

A pharmaceutical industry perspective on microphysiological kidney systems for evaluation of safety for new therapies

scientific article published on 28 January 2020

Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines.

scientific article published in July 1998

An analysis of pharmaceutical experience with decades of rat carcinogenicity testing: support for a proposal to modify current regulatory guidelines.

scientific article

Current nonclinical testing paradigm enables safe entry to First-In-Human clinical trials: The IQ consortium nonclinical to clinical translational database.

scientific article

Developing in vitro assays to transform gastrointestinal safety assessment: potential for microphysiological systems

scientific article published on 04 March 2020

Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity

scientific article published on 25 August 2010

Effect of 4-vinylcyclohexene on micronucleus formation in the bone marrow of rats and mice.

scientific article published in August 2001

Effects of HCFC-123 exposure to maternal and infant rhesus monkeys on hepatic biochemistry, lactational parameters and postnatal growth.

scientific article published in November 2002

Evaluation of Therapeutics for Advanced-Stage Heart Failure and Other Severely-Debilitating or Life-Threatening Diseases.

scientific article published on 5 May 2017

Fluoroacetate-mediated toxicity of fluorinated ethanes

scientific article published on 01 April 1996

FutureTox II: in vitro data and in silico models for predictive toxicology

scientific article

FutureTox III: Bridges for Translation.

scientific article published on 25 October 2016

Histochemical localization of formaldehyde dehydrogenase in the rat.

scientific article

Identification and characterization of adverse effects in 21st century toxicology

scientific article published on 19 January 2012

In vitro metabolism of 4-vinylcyclohexene in rat and mouse liver, lung, and ovary

scientific article published on 01 May 1997

Liver microphysiological systems development guidelines for safety risk assessment in the pharmaceutical industry

scientific article published on 04 December 2019

Mechanistic studies on chloral toxicity: Relationship to trichloroethylene carcinogenesis ⬇️

scientific article published on August 1, 1988

Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.

scientific article published in January 2017

Neonatal Mouse Model: Review of Methods and Results ⬇️

scientific article published on January 1, 2001

On the use of juvenile animal studies to support oncology medicine development in children

scientific article published on 02 June 2016

Pharmacokinetics and metabolism of vinyl fluoride in vivo and in vitro.

scientific article

Regulatory Forum Opinion Piece*: Use and Utility of Animal Models of Disease for Nonclinical Safety Assessment: A Pharmaceutical Industry Survey

scientific article published on January 2017

Subchronic Nasal Toxicity of Hexamethylphosphoramide Administered to Rats Orally for 90 Days ⬇️

scientific article published on 01 November 1997

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