List of works - Johan W.M. Heemskerk

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies

scientific article

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

scientific article

Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses ⬇️

scientific article published on 01 October 1997

Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model

scientific article

Decreased responsiveness and development of activation markers of PLTs stored in plasma

scientific article

Do dietary fatty acids affect platelet aggregation and arterial thrombosis tendency in a rat model?

scientific article published on 01 October 1992

Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis ⬇️

scientific article

Effect of membrane-permeable sulfhydryl reagents and depletion of glutathione on calcium mobilisation in human platelets ⬇️

scientific article published on May 15, 1997

Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro

scientific article published on 07 January 2021

Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation

scientific article

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

scientific article

Identification of platelet function defects by multi-parameter assessment of thrombus formation

scientific article

Intravital imaging of thrombus formation in small and large mouse arteries: experimentally induced vascular damage and plaque rupture in vivo

scientific article

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

scientific article

Microparticles from apoptotic platelets promote resident macrophage differentiation.

scientific article

Modulation of rat platelet activation by vessel wall-derived prostaglandin and platelet-derived thromboxane: effects of dietary fish oil on thromboxane-prostaglandin balance

scientific article

Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent

scientific article

Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation

scientific article published on 03 December 2020

Novel methodology for assessment of prophylactic platelet transfusion therapy by measuring increased thrombus formation and thrombin generation

scientific article

OC-08 - Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy

scientific article

Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype

scientific article

PKCalpha regulates platelet granule secretion and thrombus formation in mice

scientific article

Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow

scientific article

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

scientific article

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

scientific article published on 26 December 2020

Platelet dysfunction in thrombosis patients treated with vitamin K antagonists and recurrent bleeding

scientific article

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

scientific article

Platelet-based coagulation: different populations, different functions

scientific article

Polyphosphates: a link between platelet activation, intrinsic coagulation and inflammation? ⬇️

scientific article published on 01 June 2010

Ragged spiking of free calcium in ADP-stimulated human platelets: regulation of puff-like calcium signals in vitro and ex vivo

scientific article

Receptors and signalling mechanisms in the procoagulant response of platelets

scientific article

Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count

scientific article

Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation

scientific article

Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation

scientific article

Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton.

scientific article

Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear

scientific article

Spiking in cytosolic calcium concentration in single fibrinogen-bound fura-2-loaded human platelets ⬇️

scientific article published on April 15, 1992

Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques

scientific article (publication date: 12 April 2010)

The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function

scientific article published in 2022

Transcriptional diversity during lineage commitment of human blood progenitors

scientific article

αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia

scientific article

List of works by Johan W.M. Heemskerk

A dominant gain-of-function mutation in universal tyrosine kinase SRC causes thrombocytopenia, myelofibrosis, bleeding, and bone pathologies

Atherosclerotic geometries exacerbate pathological thrombus formation poststenosis in a von Willebrand factor-dependent manner

Collagen but not fibrinogen surfaces induce bleb formation, exposure of phosphatidylserine, and procoagulant activity of adherent platelets: evidence for regulation by protein tyrosine kinase-dependent Ca2+ responses ⬇️

Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model

Decreased responsiveness and development of activation markers of PLTs stored in plasma

Do dietary fatty acids affect platelet aggregation and arterial thrombosis tendency in a rat model?

Dual-specificity phosphatase 3 deficiency or inhibition limits platelet activation and arterial thrombosis ⬇️

Effect of membrane-permeable sulfhydryl reagents and depletion of glutathione on calcium mobilisation in human platelets ⬇️

Galectin-1 and platelet factor 4 (CXCL4) induce complementary platelet responses in vitro

Genetic analysis of the role of protein kinase Ctheta in platelet function and thrombus formation

Glycoprotein VI but not alpha2beta1 integrin is essential for platelet interaction with collagen

Identification of platelet function defects by multi-parameter assessment of thrombus formation

Intravital imaging of thrombus formation in small and large mouse arteries: experimentally induced vascular damage and plaque rupture in vivo

Key role of glycoprotein Ib/V/IX and von Willebrand factor in platelet activation-dependent fibrin formation at low shear flow

Microparticles from apoptotic platelets promote resident macrophage differentiation.

Modulation of rat platelet activation by vessel wall-derived prostaglandin and platelet-derived thromboxane: effects of dietary fish oil on thromboxane-prostaglandin balance

Molecular MRI of early thrombus formation using a bimodal alpha2-antiplasmin-based contrast agent

Nonredundant Roles of Platelet Glycoprotein VI and Integrin αIIbβ3 in Fibrin-Mediated Microthrombus Formation

Novel methodology for assessment of prophylactic platelet transfusion therapy by measuring increased thrombus formation and thrombin generation

OC-08 - Multiple functional defects in platelets from thrombocytopenic cancer patients undergoing chemotherapy

Overexpression of the platelet P2X1 ion channel in transgenic mice generates a novel prothrombotic phenotype

PKCalpha regulates platelet granule secretion and thrombus formation in mice

Plasminogen associates with phosphatidylserine-exposing platelets and contributes to thrombus lysis under flow

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

Platelet dysfunction in thrombosis patients treated with vitamin K antagonists and recurrent bleeding

Platelet function is modified by common sequence variation in megakaryocyte super enhancers

Platelet-based coagulation: different populations, different functions

Polyphosphates: a link between platelet activation, intrinsic coagulation and inflammation? ⬇️

Ragged spiking of free calcium in ADP-stimulated human platelets: regulation of puff-like calcium signals in vitro and ex vivo

Receptors and signalling mechanisms in the procoagulant response of platelets

Recombinant factor VIIa enhances platelet adhesion and activation under flow conditions at normal and reduced platelet count

Roles of platelet STIM1 and Orai1 in glycoprotein VI- and thrombin-dependent procoagulant activity and thrombus formation

Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation

Shedding of procoagulant microparticles from unstimulated platelets by integrin-mediated destabilization of actin cytoskeleton.

Spatial distribution of factor Xa, thrombin, and fibrin(ogen) on thrombi at venous shear

Spiking in cytosolic calcium concentration in single fibrinogen-bound fura-2-loaded human platelets ⬇️

Stabilizing role of platelet P2Y(12) receptors in shear-dependent thrombus formation on ruptured plaques

The Amino Acid Homoarginine Inhibits Atherogenesis by Modulating T-Cell Function

Transcriptional diversity during lineage commitment of human blood progenitors

αIIbβ3 variants defined by next-generation sequencing: predicting variants likely to cause Glanzmann thrombasthenia