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List of works by Richard A. Franklin

A new hope for treatment of glioblastomas.

scientific article published in July 2003

Activation of p42erk2 MAPK and p90rsk by IL-2 occurs independently of protein kinase C.

scientific article published on August 1996

Activation of the calcium/calmodulin-dependent protein kinases as a consequence of oxidative stress.

scientific article published on September 2006

Advances in targeting signal transduction pathways

scientific article

Alteration of Akt activity increases chemotherapeutic drug and hormonal resistance in breast cancer yet confers an achilles heel by sensitization to targeted therapy

scientific article published on 21 February 2008

Calcium-induced ERK activation in human T lymphocytes

scientific article published on 01 June 1999

Calcium-induced ERK activation in human T lymphocytes occurs via p56(Lck) and CaM-kinase.

scientific article

Calcium-induced p56(Lck) phosphorylation in human T lymphocytes via calmodulin dependent kinase

scientific article published on 01 June 1999

Calcium/calmodulin-dependent kinase I and calcium/calmodulin-dependent kinase kinase participate in the control of cell cycle progression in MCF-7 human breast cancer cells.

scientific article published on June 2005

Calcium/calmodulin-dependent protein kinases as potential targets in cancer therapy.

scientific article

Combining chemo-, hormonal and targeted therapies to treat breast cancer (Review).

scientific article published on March 2008

Ectopic NGAL expression can alter sensitivity of breast cancer cells to EGFR, Bcl-2, CaM-K inhibitors and the plant natural product berberine

scientific article published on 16 November 2012

Effects of deregulated RAF and MEK1 expression on the cytokine-dependency of hematopoietic cells.

scientific article

Effects of the RAF/MEK/ERK and PI3K/AKT signal transduction pathways on the abrogation of cytokine-dependence and prevention of apoptosis in hematopoietic cells.

scientific article published in April 2003

Enhanced ability of daniplestim and myelopoietin-1 to suppress apoptosis in human hematopoietic cells

scientific article published on 01 August 2001

Fibroblastic, hematopoietic, and hormone responsive epithelial cell lines and culture conditions for elucidation of signal transduction and drug resistance pathways by gene transfer.

scientific article

Human CD45RA+ and CD45R0+ T cells exhibit similar CD3/T cell receptor-mediated transmembrane signaling capacities but differ in response to co-stimulatory signals

scientific article published on 01 June 1994

Increased NGAL (Lnc2) expression after chemotherapeutic drug treatment.

scientific article

Induction of IL-2 and lymphokine activated killer cells in the cat

scientific article published on 01 September 1987

Inhibition of CREB transcriptional activity in human T lymphocytes by oxidative stress.

scientific article published in April 2005

Involvement of Akt and mTOR in chemotherapeutic- and hormonal-based drug resistance and response to radiation in breast cancer cells

scientific article published on September 2011

Involvement of Akt-1 and mTOR in sensitivity of breast cancer to targeted therapy

scientific article published on July 2011

Involvement of PI3K/Akt pathway in cell cycle progression, apoptosis, and neoplastic transformation: a target for cancer chemotherapy.

scientific article

Kinases: positive and negative regulators of apoptosis.

scientific article

Macrophages suppress lectin-induced proliferation of lymphocytes from aged rats

scientific article published on 01 February 1993

Microfilament assembly is required for anti-IgM dependent MAPK and p90rsk activation in human B lymphocytes.

scientific article published in April 1995

Novel approaches to target cancer initiating cells-eliminating the root of the cancer

scientific article published on January 2012

OSU-03012 in the treatment of glioblastoma.

scientific article published on 4 May 2006

Oxidative stress regulates the interaction of p16 with Cdk4

scientific article published on 01 September 2000

Phenotypic features of selective T cell deficiency characterized by absence of CD8+ T lymphocytes and undetectable mRNA for ZAP-70 kinase

scientific article published on 01 August 1997

Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes

scientific article published on 01 April 1995

Rapamycin inhibits the phosphorylation of p70 S6 kinase in IL-2 and mitogen-activated human T cells

scientific article published on August 14, 1992

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascade inhibitors: how mutations can result in therapy resistance and how to overcome resistance

scientific article

Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR inhibitors: rationale and importance to inhibiting these pathways in human health

scientific article published on March 2011

Reactive oxygen intermediates and signaling through kinase pathways

scientific article published on 01 September 2006

Redox regulation of the calcium/calmodulin-dependent protein kinases.

scientific article

Regulation of Pyk2 expression by p56(Lck) in Jurkat T lymphocytes.

scientific article published on January 2001

Regulation of cell cycle progression and apoptosis by the Ras/Raf/MEK/ERK pathway (Review).

scientific article

Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemia.

scientific article published in June 2003

Roles of the Raf/MEK/ERK pathway in cell growth, malignant transformation and drug resistance

scientific article

Roles of the Ras/Raf/MEK/ERK pathway in leukemia therapy.

scientific article published on 15 April 2011

Signal transduction mediated by the Ras/Raf/MEK/ERK pathway from cytokine receptors to transcription factors: potential targeting for therapeutic intervention.

scientific article

Signaling intermediates (MAPK and PI3K) as therapeutic targets in NSCLC.

scientific article published on January 2014

Suppression of PTEN function increases breast cancer chemotherapeutic drug resistance while conferring sensitivity to mTOR inhibitors.

scientific article published on 10 March 2008

Synergistic effects of pi3k/akt on abrogation of cytokine-dependency induced by oncogenic raf.

scientific article published in January 2001

Targeting the RAF/MEK/ERK, PI3K/AKT and p53 pathways in hematopoietic drug resistance.

scientific article published on 26 March 2007

Targeting the cancer initiating cell: The Achilles’ heel of cancer ⬇️

scientific article published on October 28, 2010

The epidermal growth factor receptor gene family as a target for therapeutic intervention in numerous cancers: what's genetics got to do with it?

scientific article

The proliferative response of rat T cells to calcium ionophores increases with age.

scientific article

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