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List of works by M T Donato

A Comprehensive Untargeted Metabonomic Analysis of Human Steatotic Liver Tissue by RP and HILIC Chromatography Coupled to Mass Spectrometry Reveals Important Metabolic Alterations ⬇️

scientific article published on September 6, 2011

A Microassay for Measuring Cytochrome P450IA1 and Cytochrome P450IIB1 Activities in Intact Human and Rat Hepatocytes Cultured on 96-Well Plates

scientific article published on 01 August 1993

A Multi-Parametric Fluorescent Assay for the Screening and Mechanistic Study of Drug-Induced Steatosis in Liver Cells in Culture.

scientific article

A human hepatocellular in vitro model to investigate steatosis.

scientific article published on 23 November 2006

A lipidomic cell-based assay for studying drug-induced phospholipidosis and steatosis

scientific article

A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury.

scientific article

A newin vitroapproach for the simultaneous determination of phase I and phase II enzymatic activities of human hepatocyte preparations

scientific article published on 01 January 2008

A simple transcriptomic signature able to predict drug-induced hepatic steatosis.

scientific article published on 28 January 2014

A specific microassay for evaluating hepatic LDH activity in co-cultures of hepatocytes with other cells

article

Adenovirus-mediated gene transfer into human hepatocytes: analysis of the biochemical functionality of transduced cells.

scientific article

Advantageous use of HepaRG cells for the screening and mechanistic study of drug-induced steatosis.

scientific article published on 15 April 2016

An update on metabolism studies using human hepatocytes in primary culture

article

Assessment of cytochrome P450 induction in human hepatocytes using the cocktail strategy plus liquid chromatography tandem mass spectrometry.

scientific article

Assessment of the cytotoxic potential of an aqueous-ethanolic extract from Thalassia testudinum angiosperm marine grown in the Caribbean Sea

scientific article published on 30 August 2018

Both cholestatic and steatotic drugs trigger extensive alterations in the mRNA level of biliary transporters in rat hepatocytes: Application to develop new predictive biomarkers for early drug development.

scientific article published on 17 October 2016

Characterization of drug metabolizing activities in pig hepatocytes for use in bioartificial liver devices: comparison with other hepatic cellular models

article

Competency of different cell models to predict human hepatotoxic drugs

scientific article

Cryopreservation of rat, dog and human hepatocytes: influence of preculture and cryoprotectants on recovery, cytochrome P450 activities and induction upon thawing

scientific article published on 01 June 2006

Culture and Functional Characterization of Human Hepatoma HepG2 Cells.

scientific article

Customised in vitro model to detect human metabolism-dependent idiosyncratic drug-induced liver injury.

scientific article published on 31 July 2017

Cytochrome P-450 mRNA Expression in Human Liver and Its Relationship with Enzyme Activity

article

Cytochrome P450 expression and related metabolism in human buccal mucosa.

scientific article

Cytometric analysis for drug-induced steatosis in HepG2 cells.

scientific article

Determination of major human cytochrome P450s activities in 96-well plates using liquid chromatography tandem mass spectrometry

scientific article published on 19 April 2007

Diclofenac induces apoptosis in hepatocytes by alteration of mitochondrial function and generation of ROS.

scientific article published in December 2003

Drug metabolism by cultured human hepatocytes: how far are we from the in vivo reality?

scientific article

Drug metabolizing enzymes in rat hepatocytes co-cultured with cell lines.

scientific article published on November 1990

Drug-induced Liver Steatosis and Phospholipidosis: Cell-Based Assays for Early Screening of Drug Candidates ⬇️

scientific article published on October 1, 2012

Effect of model inducers on cytochrome P450 activities of human hepatocytes in primary culture

scientific article published on 01 May 1995

Effect of xenobiotics on monooxygenase activities in cultured human hepatocytes

scientific article published on 01 April 1990

Effects of Mangifera indica L. aqueous extract (Vimang) on primary culture of rat hepatocytes

scientific article published on 22 June 2007

Effects of steatosis on drug-metabolizing capability of primary human hepatocytes

scientific article published on 28 July 2006

Establishment and characterization of immortal hepatocytes derived from various transgenic mouse lines.

scientific article

Evaluation of Cytochrome P450 Activities in Human Hepatocytes In Vitro

scientific article published on 01 January 2012

Extending metabolome coverage for untargeted metabolite profiling of adherent cultured hepatic cells

scientific article published on 14 January 2016

Fluorescence-Based Screening of Cytochrome P450 Activities in Intact Cells ⬇️

scientific article published on January 1, 2013

Functional characterization of hepatocytes for cell transplantation: customized cell preparation for each receptor.

scientific article published in January 2010

Functionality of cultured human hepatocytes from elective samples, cadaveric grafts and hepatectomies.

scientific article published in October 2003

General Cytotoxicity Assessment by Means of the MTT Assay

scientific article published on January 2015

HepG2 cells simultaneously expressing five P450 enzymes for the screening of hepatotoxicity: identification of bioactivable drugs and the potential mechanism of toxicity involved.

scientific article published on 9 February 2013

Hepatic cell lines for drug hepatotoxicity testing: limitations and strategies to upgrade their metabolic competence by gene engineering.

scientific article

Hepatocytes--the choice to investigate drug metabolism and toxicity in man: in vitro variability as a reflection of in vivo.

scientific article published on 28 November 2006

High-Content Imaging Technology for the Evaluation of Drug-Induced Steatosis Using a Multiparametric Cell-Based Assay ⬇️

scientific article published on November 23, 2011

High-content screening of drug-induced mitochondrial impairment in hepatic cells: effects of statins

scientific article published on 27 August 2014

High-content screening technology for studying drug-induced hepatotoxicity in cell models.

scientific article published on 19 March 2015

Human Upcyte Hepatocytes: Characterization of the Hepatic Phenotype and Evaluation for Acute and Long-Term Hepatotoxicity Routine Testing.

scientific article published on 4 May 2016

Human hepatic cell cultures: in vitro and in vivo drug metabolism

scientific article published on 01 May 2003

Human hepatocyte growth factor down-regulates the expression of cytochrome P450 isozymes in human hepatocytes in primary culture

scientific article published on 01 February 1998

Human hepatocytes as a tool for studying toxicity and drug metabolism.

scientific article

Human neonatal hepatocyte transplantation induces long-term rescue of unconjugated hyperbilirubinemia in the Gunn rat.

scientific article published in June 2015

In vitro ADME medium/high-throughput screening in drug preclinical development.

scientific article published on September 2006

In vitro evaluation of potential hepatotoxicity induced by drugs.

scientific article published on June 2010

In vitro modulation of the cytochrome P450 and ABCB1/P-glycoprotein activities of the aqueous extract of Allophylus cominia (L) Sw. leaves.

scientific article published on 25 November 2017

In vitro/in vivo screening of oxidative homeostasis and damage to DNA, protein, and lipids using UPLC/MS-MS.

scientific article published on 27 June 2014

Influence of preservation solution on the isolation and culture of human hepatocytes from liver grafts.

scientific article published in January 2005

Inhibition of human P450 enzymes by natural extracts used in traditional medicine.

scientific article

Inhibition of monooxygenase activities in human hepatocytes by interferons

scientific article published on 01 July 1993

LC-MS untargeted metabolomic analysis of drug-induced hepatotoxicity in HepG2 cells.

scientific article published in June 2015

Long-term and mechanistic evaluation of drug-induced liver injury in Upcyte human hepatocytes

scientific article published on 13 November 2018

Long-term expression of differentiated functions in hepatocytes cultured in three-dimensional collagen matrix

scientific article published on 01 December 1998

Mammalian cell metabolomics: experimental design and sample preparation.

scientific article published on 13 May 2013

Mechanism-based selection of compounds for the development of innovative in vitro approaches to hepatotoxicity studies in the LIINTOP project.

scientific article published on 23 July 2010

Metabolic activation and drug-induced liver injury: in vitro approaches for the safety risk assessment of new drugs.

scientific article published on 22 December 2015

Metabolism and bioactivation of toxicants in the lung. The in vitro cellular approach.

scientific article

Metabolomics discloses donor liver biomarkers associated with early allograft dysfunction.

scientific article published on 2 May 2014

Modulation of P450 enzymes by Cuban natural products rich in polyphenolic compounds in rat hepatocytes.

scientific article published on 24 October 2007

New non-woven polyurethane-based biomaterials for the cultivation of hepatocytes: expression of differentiated functions

scientific article published on 01 January 2000

Nitric oxide-mediated inhibition of cytochrome P450 by interferon-gamma in human hepatocytes

scientific article published on 01 April 1997

Oncostatin M down-regulates basal and induced cytochromes P450 in human hepatocytes

scientific article published on 01 April 1998

Potential Impact of Steatosis on Cytochrome P450 Enzymes of Human Hepatocytes Isolated from Fatty Liver Grafts

scientific article published on 08 June 2006

Rat hepatocytes cultured on a monkey kidney cell line: Expression of biotransformation and hepatic metabolic activities.

scientific article published on January 1991

Repression of the nuclear receptor small heterodimer partner by steatotic drugs and in advanced nonalcoholic fatty liver disease

scientific article published on 9 January 2015

Stem-cell derived hepatocyte-like cells for the assessment of drug-induced liver injury

scientific article published on 19 February 2019

Strategies and molecular probes to investigate the role of cytochrome P450 in drug metabolism: focus on in vitro studies.

scientific article

Synthesis of new, UV-photoactive dansyl derivatives for flow cytometric studies on bile acid uptake.

scientific article published on 24 September 2009

The Use of Hepatocytes to Investigate Drug Toxicity

article

The coumarin 7-hydroxylation microassay in living hepatic cells in culture

scientific article published on 01 March 1998

Toxicity of the antitumoral drug datelliptium in hepatic cells: Use of models in vitro for the prediction of toxicity in vivo.

scientific article published in July 1992

Transcriptional regulation and expression of CYP3A4 in hepatocytes.

scientific article published on February 2007

Ultra-performance liquid chromatography-mass spectrometry targeted profiling of bile acids: application to serum, liver tissue, and cultured cells of different species

scientific article published in January 2014

Upgrading HepG2 cells with adenoviral vectors that encode drug-metabolizing enzymes: application for drug hepatotoxicity testing

scientific article published on 27 September 2016

Upgrading cytochrome P450 activity in HepG2 cells co-transfected with adenoviral vectors for drug hepatotoxicity assessment ⬇️

scientific article published on November 25, 2011

Using high-content screening technology for studying drug-induced hepatotoxicity in preclinical studies.

scientific article published on 11 December 2016

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