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List of works by Michael Wigler

A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions

scientific article

A mutation in the catalytic subunit of cAMP-dependent protein kinase that disrupts regulation

scientific article published on 01 April 1988

A unified genetic theory for sporadic and inherited autism

scientific article

A versatile statistical analysis algorithm to detect genome copy number variation

scholarly article

Accurate de novo and transmitted indel detection in exome-capture data using microassembly

scientific article

Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change.

scientific article

An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer

scientific article

Analysis of the transforming potential of the human H-ras gene by random mutagenesis ⬇️

scientific article published on July 1, 1984

Annotating large genomes with exact word matches

scientific article

Application of ROMA (representational oligonucleotide microarray analysis) to patients with cytogenetic rearrangements

article

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor ⬇️

scientific article published on July 1, 1978

Broad applications of single-cell nucleic acid analysis in biomedical research.

scientific article published on 30 October 2012

Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell.

scientific article

Characterization of two new human oncogenes

scientific article published on 01 January 1986

Chromosomal assignment of a family of human oncogenes

scientific article published on July 1983

Circular binary segmentation for the analysis of array-based DNA copy number data

scientific article (publication date: October 2004)

Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae

scientific article

Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae

scientific article

Comparative genomic analysis of tumors: detection of DNA losses and amplification

scientific article

Complex synthetic chemical libraries indexed with molecular tags

scientific article

DBC2, a candidate for a tumor suppressor gene involved in breast cancer

scientific article

DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma

scientific article

DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables

scientific article published on 2 December 2010

DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase

scientific article

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells

scientific article

Damaging de novo mutations diminish motor skills in children on the autism spectrum

scientific article published on 6 February 2018

De Novo Gene Disruptions in Children on the Autistic Spectrum

scientific article (publication date: April 2012)

Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor ⬇️

scientific article published on October 30, 2001

Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations

scientific article

Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins

scientific article

Direct isolation of polymorphic markers linked to a trait by genetically directed representational difference analysis

scientific article published on 01 January 1994

Distribution of short paired duplications in mammalian genomes

scholarly article

Dosage-dependent phenotypes in models of 16p11.2 lesions found in autism

scientific article

Early Detection of Cancer in Blood Using Single-Cell Analysis: A Proposal

scientific article published on 03 June 2017

Facilitated sequence counting and assembly by template mutagenesis

scientific article

Functional homology of mammalian and yeast RAS genes.

scientific article

Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model

scientific article

GAPs in understanding Ras

scientific article published in Nature

Genetic analysis using genomic representations

scientific article

Genetic and physical linkage of exogenous sequences in transformed cells

scientific article

Genetics. Wild by nature

scientific article published on 01 May 2002

Genome-wide copy number analysis of single cells.

scientific article

Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene

scientific article

Genomic architecture characterizes tumor progression paths and fate in breast cancer patients

scientific article published on June 2010

High definition profiling of mammalian DNA methylation by array capture and single molecule bisulfite sequencing

scientific article published on 06 July 2009

High-resolution ROMA CGH and FISH analysis of aneuploid and diploid breast tumors

scientific article published on 01 January 2005

Human-tumor-derived cell lines contain common and different transforming genes

scientific article

Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach

scientific article

Identification of alterations in DNA copy number in host stromal cells during tumor progression

scholarly article

Inferring tumor progression from genomic heterogeneity

scientific article (publication date: 2010)

Interactive analysis and assessment of single-cell copy-number variations

scientific article published on 7 September 2015

Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts ⬇️

scientific article published on November 1, 1979

Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains

scientific article

Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells

scientific article

Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line

scientific article

Isolation of the chicken thymidine kinase gene by plasmid rescue.

scientific article

Large-scale copy number polymorphism in the human genome

scientific article

Linkage and expression of foreign DNA in cultured animal cells

scientific article

Linkage, association, and gene-expression analyses identify CNTNAP2 as an autism-susceptibility gene

scientific article

Low load for disruptive mutations in autism genes and their biased transmission

scientific article

Measuring shared variants in cohorts of discordant siblings with applications to autism

scientific article

Molecular forceps from combinatorial libraries prevent the farnesylation of Ras by binding to its carboxyl terminus

scientific article published on 01 March 1999

Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens

scholarly article

Mutations in the SHR5 gene of Saccharomyces cerevisiae suppress Ras function and block membrane attachment and palmitoylation of Ras proteins

scientific article

New Human Transforming Genes Detected by a Tumorigenicity Assay ⬇️

scientific article published on September 1, 1984

Novel genomic alterations and clonal evolution in chronic lymphocytic leukemia revealed by representational oligonucleotide microarray analysis (ROMA)

scientific article published on 15 October 2008

Novel patterns of genome rearrangement and their association with survival in breast cancer

scientific article

Optimizing sparse sequencing of single cells for highly multiplex copy number profiling

scientific article published on 9 April 2015

P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase

scientific article

PROBER: oligonucleotide FISH probe design software

scientific article published in June 2006

Partial bisulfite conversion for unique template sequencing

scientific article published on 17 November 2017

Purification and characterization of human H-ras proteins expressed in Escherichia coli

scientific article published on May 1985

Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors

scientific article

RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

scientific article published on 01 November 1986

Rapid isolation of cDNA by hybridization

scientific article

Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells

scientific article

Rare De Novo and Transmitted Copy-Number Variation in Autistic Spectrum Disorders

scientific article (publication date: June 2011)

Rare de novo germline copy-number variation in testicular cancer

scientific article published on 2 August 2012

Rare de novo variants associated with autism implicate a large functional network of genes involved in formation and function of synapses

scientific article

Recurrent DNA copy number variation in the laboratory mouse

scientific article published on 28 October 2007

Reducing system noise in copy number data using principal components of self-self hybridizations

scientific article

Representational difference analysis in detection of genetic lesions in cancer

scientific article published on 01 January 1995

Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation

scientific article (publication date: October 2003)

Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae

scientific article published on 01 November 1987

Role of SWI/SNF in acute leukemia maintenance and enhancer-mediated Myc regulation

scientific article

SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits

scientific article

SMASH, a fragmentation and sequencing method for genomic copy number analysis ⬇️

scientific article

SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes.

scientific article

Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells

scientific article published on January 1, 1983

Signaling pathways in Ras-mediated tumorigenicity and metastasis.

scientific article

Strong association of de novo copy number mutations with autism

scientific article

Structure and activation of the human N-ras gene

scientific article

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1.

scientific article

Studies of RAS function in the yeast Saccharomyces cerevisiae

scientific article published on 01 January 1988

Target inference from collections of genomic intervals

scientific article published on 06 June 2013

The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast

scientific article

The adenylyl cyclase-encoding gene from Saccharomyces kluyveri

scientific article published on 01 June 1991

The cancer stem cell: cell type or cell state?

scientific article published on 18 October 2012

The contribution of de novo and rare inherited copy number changes to congenital heart disease in an unselected sample of children with conotruncal defects or hypoplastic left heart disease

scientific article published on 25 August 2013

The contribution of de novo coding mutations to autism spectrum disorder

scientific article

The lipid phosphatase activity of PTEN is critical for its tumor supressor function

scientific article

The role of de novo mutations in the genetics of autism spectrum disorders

scientific article published on 16 January 2014

The somatic replication of DNA methylation

scientific article

The transfer and stable integration of the HSV thymidine kinase gene into mouse cells ⬇️

scientific article published on May 1, 1978

Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase

scientific article

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells ⬇️

scientific article

Transformation of mammalian cells with an amplifiable dominant-acting gene

scientific article

Transformation of mammalian cells with genes from procaryotes and eucaryotes ⬇️

scientific article published on April 1, 1979

Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979.

scientific article published in January 1992

Tumour evolution inferred by single-cell sequencing

scientific article

Utility of single cell genomics in diagnostic evaluation of prostate cancer

scientific article published on 27 November 2017

Validation of S. pombe sequence assembly by microarray hybridization

scientific article published in January 2006

ras proteins can induce meiosis in Xenopus oocytes

scientific article published on 01 December 1985

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