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List of works by Klemens Kaupmann

A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein.

scientific article published on 28 November 2011

Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits.

scientific article published in February 2005

Altered hippocampal expression of calbindin-D-28k and calretinin in GABA(B(1))-deficient mice.

scientific article published in October 2004

Altered response to benzodiazepine anxiolytics in mice lacking GABA B(1) receptors

scientific article

Antagonizing Retinoic Acid-Related-Orphan Receptor Gamma Activity Blocks the T Helper 17/Interleukin-17 Pathway Leading to Attenuated Pro-inflammatory Human Keratinocyte and Skin Responses

article

Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines

scientific article

Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety.

scientific article published on 15 December 2006

Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior

scientific article

Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms.

scientific article published on 9 January 2017

Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats

scientific article

C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors.

scientific article

Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit

scientific article

Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor

scientific article

Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate.

scientific article published on 8 April 2015

Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1.

scientific article

Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, migfbp-2 ⬇️

scientific article published on February 28, 1993

Determination of the minimal functional ligand-binding domain of the GABAB1b receptor.

scientific article

Developmental changes of agonist affinity at GABABR1 receptor variants in rat brain.

scientific article published on September 1998

Differential compartmentalization and distinct functions of GABAB receptor variants

scientific article

Differential roles of GABAB1 subunit isoforms on locomotor responses to acute and repeated administration of cocaine

scientific article

Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure

scientific article published on 28 August 2020

Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain

scientific article

Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression.

scientific article

Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)).

scientific article published on July 2001

Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor.

scientific article published on 28 December 2010

Exploring the mammalian neuromuscular system by analysis of mutations: spinal muscular atrophy and myotonia.

scientific article published on February 1994

GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories.

scientific article published in August 2006

GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine

scientific article

GABA(B)-receptor subtypes assemble into functional heteromeric complexes.

scientific article

GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulation

scientific article published on 10 January 2007

GABAB receptors - the first 7TM heterodimers.

scientific article

GABAB receptors: drugs meet clones.

scientific article

GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice.

scientific article published on 21 September 2006

Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors.

scientific article published in November 1999

Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition.

scientific article published on 2 July 2006

Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior.

scientific article

Heteromerization of GABAB Receptors: A New Principle for G Protein-Coupled Receptors. Satellite Symposium to the 28th Annual Meeting of the Society for Neuroscience Los Angeles, CA, November 5-7, 1998.

scientific article

Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels

scientific article

Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice.

scientific article published on 5 April 2006

Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brain

scientific article published in September 2004

LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice

scientific article

Ligands for expression cloning and isolation of GABA(B) receptors

scientific article published on 01 March 2003

Localization of somatostatin (SRIF) SSTR-1, SSTR-2 and SSTR-3 receptor mRNA in rat brain by in situ hybridization.

scientific article published on February 1994

Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence.

scientific article published in August 2007

Molecular pharmacology of somatostatin-receptor subtypes.

scientific article published on September 1994

Molecular structure and physiological functions of GABA(B) receptors

scientific article published in July 2004

N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function.

scientific article

Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions.

scientific article published on July 2003

Optimizing a Weakly Binding Fragment into a Potent RORγt Inverse Agonist with Efficacy in an in Vivo Inflammation Model

scientific article published on 24 July 2018

PET imaging of T cells: Target identification and feasibility assessment.

scientific article

Pharmacological inhibition of RORγt suppresses the Th17 pathway and alleviates arthritis in vivo.

scientific article published on 20 November 2017

Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit.

scientific article published on 11 September 2006

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501

scientific article (publication date: November 2001)

Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats

scientific article

Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses

scientific article published on October 2003

Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice.

scientific article published in July 2004

Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats.

scientific article published in July 2009

Retinoic-acid-orphan-receptor-C inhibition suppresses Th17 cells and induces thymic aberrations.

scientific article published on 09 March 2017

Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release.

scientific article published on 30 July 2008

Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors.

scientific article published on January 2004

Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice

scientific article

Specific roles of GABA(B(1)) receptor isoforms in cognition.

scientific article

Structural States of RORγt: X-ray Elucidation of Molecular Mechanisms and Binding Interactions for Natural and Synthetic Compounds.

scientific article published on 7 June 2017

Structural basis of species-selective antagonist binding to the succinate receptor

scientific article published on 23 October 2019

Structure-Based and Property-Driven Optimization of N-Aryl Imidazoles toward Potent and Selective Oral RORγt Inhibitors

scientific article published on 03 December 2019

Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors.

scientific article

Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors

scientific article

Synthesis and Biological Evaluation of New Triazolo- and Imidazolopyridine RORγt Inverse Agonists

scientific article published on 30 November 2016

The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and its Expression is Not Affected in the Hereditary Motoneuron Disease 'Wobbler' of the Mouse.

scientific article published in October 1991

The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding.

scientific article published on August 1999

The RXR-type endoplasmic reticulum-retention/retrieval signal of GABAB1 requires distant spacing from the membrane to function

scientific article

The mouse homolog to the ras-related yeast gene YPT1 maps on chromosome 11 close to the wobbler (wr) locus

scientific article published on 01 January 1992

The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function

scientific journal article

Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11

scientific article published on May 1, 1992

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