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List of works by John Chiang

46 Reversed-phase high-performance liquid chromatography assay of cholesterol 7α-hydroxylase

scientific article published on 01 January 1991

A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene

scientific article

A form of rabbit liver cytochrome P-450 that catalyzes the 7 alpha-hydroxylation of cholesterol

scientific article published on 01 February 1983

A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene

scientific article

AMPK-dependent repression of hepatic gluconeogenesis via disruption of CREB.CRTC2 complex by orphan nuclear receptor small heterodimer partner.

scientific article

Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis ⬇️

scientific article published on June 5, 2011

All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade.

scientific article

An overlapping binding site in the CYP7A1 promoter allows activation of FXR to override the stimulation by LXRalpha

scientific article published on 09 August 2007

Basic transcription element binding protein (BTEB) transactivates the cholesterol 7 alpha-hydroxylase gene (CYP7A).

scientific article

Bile Acid Biology, Pathophysiology, and Therapeutics

scientific article published on 01 March 2020

Bile acid metabolism and signaling

scientific article

Bile acid metabolism in liver pathobiology

scientific article published on 11 January 2018

Bile acid receptors FXR and TGR5 signaling in fatty liver diseases and therapy

scientific article published on 27 January 2020

Bile acid regulation of gene expression: roles of nuclear hormone receptors.

scientific article

Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice.

scientific article

Bile acid signaling in metabolic disease and drug therapy

scientific article (publication date: October 2014)

Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells

scientific article

Bile acids as metabolic regulators

scientific article

Bile acids: regulation of synthesis

scientific article

Bile synthesis in rat models of inflammatory bowel diseases

scientific article published on 01 March 2007

Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes

scientific article

Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders

scientific article published on 04 May 2016

Cloning and 5'-flanking sequence of a rat cholesterol 7 alpha-hydroxylase gene

scientific article published on October 20, 1992

Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H)

scientific article published on 12 October 2011

Cytokine regulation of human sterol 12alpha-hydroxylase (CYP8B1) gene.

scientific article

Deficiency of Both Farnesoid X Receptor and Takeda G Protein-Coupled Receptor 5 Exacerbated Liver Fibrosis in Mice

scientific article published on 22 March 2019

Effect of thyroid hormone on hepatic cholesterol 7 alpha hydroxylase, LDL receptor, HMG-CoA reductase, farnesyl pyrophosphate synthetase and apolipoprotein A-I mRNA levels in hypophysectomized rats

scientific article published on 01 November 1990

Effects of bile acids and steroid/thyroid hormones on the expression of cholesterol 7 alpha-hydroxylase mRNA and the CYP7 gene in HepG2 cells

scientific article published on 01 January 1994

Eicosanoids in metabolic syndrome.

scientific article published on January 2013

Estrogen-mediated regulation of CYP7B1: a possible role for controlling DHEA levels in human tissues.

scientific article published on 23 May 2006

Estrogen-related receptor γ controls hepatic CB1 receptor-mediated CYP2E1 expression and oxidative liver injury by alcohol.

scientific article published on 29 September 2012

Expression of hepatic microsomal cholesterol 7 alpha-hydroxylase activity in lean and obese Zucker rats

scientific article published on 01 January 1988

Failure of intravenous infusion of taurocholate to down-regulate cholesterol 7 alpha-hydroxylase in rats with biliary fistulas.

scientific article published in February 1995

Farnesoid X receptor responds to bile acids and represses cholesterol 7alpha-hydroxylase gene (CYP7A1) transcription

scientific article published on 01 April 2000

Fenofibrate differentially regulates plasminogen activator inhibitor-1 gene expression via adenosine monophosphate-activated protein kinase-dependent induction of orphan nuclear receptor small heterodimer partner

scientific article published on September 2009

Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice

scientific article

Genomic cloning, sequencing, and analysis of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7).

scientific article published on November 1993

Glucagon and cAMP inhibit cholesterol 7alpha-hydroxylase (CYP7A1) gene expression in human hepatocytes: discordant regulation of bile acid synthesis and gluconeogenesis.

scientific article published in January 2006

Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity

scientific article published on 5 December 2011

Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes

scientific article

Guggulsterone antagonizes farnesoid X receptor induction of bile salt export pump but activates pregnane X receptor to inhibit cholesterol 7alpha-hydroxylase gene.

scientific article published on April 2003

Hamster hepatic cytochrome b5: purifications, immunochemical properties, and in vitro synthesis

scientific article published in 1985

Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes

scientific journal article

Hepatocyte nuclear factor 4alpha regulation of bile acid and drug metabolism

scientific article published on 01 February 2009

Identification and partial purification of hamster microsomal cytochrome P-450 isoenzymes

scientific article published on 01 April 1983

Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c.

scientific article

Interaction of purified microsomal cytochrome P-450 with cytochrome b5 ⬇️

scientific article published on October 15, 1981

Intestinal CYP3A4 protects against lithocholic acid-induced hepatotoxicity in intestine-specific VDR-deficient mice.

scientific article published on 16 December 2013

Intestine farnesoid X receptor agonist and the gut microbiota activate G-protein bile acid receptor-1 signaling to improve metabolism.

scientific article published on 27 February 2018

Is CYP2C70 the key to new mouse models to understand bile acids in humans?

scientific article published on 21 January 2020

Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription.

scientific article

Mechanism of vitamin D receptor inhibition of cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes

scientific article published on 23 December 2008

Modulation of reconstituted cholesterol 7 alpha-hydroxylase by phosphatase and protein kinase

scientific article published on 01 January 1986

Negative feedback regulation of bile acid metabolism: impact on liver metabolism and diseases

scientific article

Nuclear receptors in bile acid metabolism ⬇️

scientific article published on February 1, 2013

Nuclear receptors in drug metabolism and beyond

scientific article published on February 2013

Orphan Nuclear Receptor Small Heterodimer Partner Negatively Regulates Growth Hormone-mediated Induction of Hepatic Gluconeogenesis through Inhibition of Signal Transducer and Activator of Transcription 5 (STAT5) Transactivation ⬇️

scientific article published on September 12, 2012

Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression

scientific article published on 29 June 2015

Orphan receptors chicken ovalbumin upstream promoter transcription factor II (COUP-TFII) and retinoid X receptor (RXR) activate and bind the rat cholesterol 7alpha-hydroxylase gene (CYP7A)

scientific article published on 01 April 1997

PPARs, RXRs, and Drug-Metabolizing Enzymes.

scientific article published on January 2009

Polymorphisms of human cholesterol 7 alpha-hydroxylase.

scientific article published in June 1992

Protein Kinase Cβ: Linking Intestine Fibroblast Growth Factor 15 to Hepatic Extracellular Signal Regulated Kinase 1/2 Signaling in Bile Acid and Cholesterol Homeostasis

scientific article published on 5 June 2015

Recent advances in understanding bile acid homeostasis.

scientific article published on 20 November 2017

Regulation of bile acid and cholesterol metabolism by PPARs

scientific article published on 14 July 2009

Regulation of bile acid synthesis: pathways, nuclear receptors, and mechanisms.

scientific article published on March 2004

Regulation of human sterol 27-hydroxylase gene (CYP27A1) by bile acids and hepatocyte nuclear factor 4alpha (HNF4alpha).

scientific article published on August 2003

Regulation of the hamster cholesterol 7 alpha-hydroxylase gene (CYP7A): prevalence of negative over positive transcriptional control.

scientific article published on September 1996

Retinoic acid-related orphan receptor α regulates diurnal rhythm and fasting induction of sterol 12α-hydroxylase in bile acid synthesis

scientific article

Role of nuclear receptors in lipid dysfunction and obesity-related diseases.

scientific article

Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice.

scientific article published on 31 July 2013

Short-term circadian disruption impairs bile acid and lipid homeostasis in mice

scientific article

The effect of beta-naphthoflavone on rabbit liver protein synthesis, and on the induction of cytochrome P-450 LM4 mRNA

scientific article published on 01 June 1981

The identification of cytochrome P-450-LM2 synthesized in vitro from a rabbit liver polysomal mRNA template

scientific article published on 01 January 1981

The partial purification of rabbit liver cytochrome P450-LM2-mRNA

scientific article published on 01 May 1981

The quantitation of liver cytochrome P450-LM2 mRNA in rabbits of different ages and after phenobarbital treatment

scientific article published on 01 June 1982

Transcriptional regulation of human oxysterol 7alpha-hydroxylase by sterol response element binding protein.

scientific article

Transcriptional suppression of cytochrome P450 genes by endogenous and exogenous chemicals.

scientific article published on April 2004

Understanding Bile Acid Signaling in Diabetes: From Pathophysiology to Therapeutic Targets.

scientific article

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