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List of works by A B Firulli

A HANDful of questions: the molecular biology of the heart and neural crest derivatives (HAND)-subclass of basic helix-loop-helix transcription factors

scientific article

A Phox2- and Hand2-dependent Hand1 cis-regulatory element reveals a unique gene dosage requirement for Hand2 during sympathetic neurogenesis

scientific article published in February 2012

A bHLH code for cardiac morphogenesis

scientific article published on 24 December 2009

A glimpse of Cre-mediated controversies in epicardial signalling.

scientific article

A twist of insight - the role of Twist-family bHLH factors in development

scientific article published on January 2009

Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities

scientific article

An absence of Twist1 results in aberrant cardiac neural crest morphogenesis

scientific journal article

Analysis of a Hand1 hypomorphic allele reveals a critical threshold for embryonic viability ⬇️

scientific article published on October 1, 2010

Analysis of the Hand1 cell lineage reveals novel contributions to cardiovascular, neural crest, extra‐embryonic, and lateral mesoderm derivatives ⬇️

scientific article published on November 1, 2010

Another hat for myocardin

scientific article published on 01 October 2002

Cardiovascular development and the colonizing cardiac neural crest lineage

scientific article published on 3 July 2007

Combinatorial transcriptional interaction within the cardiac neural crest: a pair of HANDs in heart formation.

scientific article published in June 2004

Conditional deletion of Hand2 reveals critical functions in neurogenesis and cell type-specific gene expression for development of neural crest-derived noradrenergic sympathetic ganglion neurons

scientific article published on 8 April 2008

Cooperative interaction of Nkx2.5 and Mef2c transcription factors during heart development

scientific journal article

D-MEF2: a MADS box transcription factor expressed in differentiating mesoderm and muscle cell lineages during Drosophila embryogenesis

scientific article

DNA triplexes and regulation of the c-myc gene

scientific article published on 01 November 1994

Defective Hand1 phosphoregulation uncovers essential roles for Hand1 in limb morphogenesis.

scientific article published on 2 June 2017

Epigenetics and Heart Development

scientific article published on 06 May 2021

Exclusion of Dlx5/6 expression from the distal-most mandibular arches enables BMP-mediated specification of the distal cap.

scientific article published on 22 June 2016

Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity.

scientific article published on May 2013

Fluorescence resonance energy transfer (FRET) as a method to calculate the dimerization strength of basic Helix-Loop-Helix (bHLH) proteins

scientific article

Functional screening of intracardiac cell transplants using two-photon fluorescence microscopy.

scientific article published on 06 April 2012

Gene replacement strategies to test the functional redundancy of basic helix-loop-helix transcription factor

scientific article published on 14 February 2010

HAND1 and HAND2 are expressed in the adult-rodent heart and are modulated during cardiac hypertrophy.

scientific article

HAND1 loss-of-function within the embryonic myocardium reveals survivable congenital cardiac defects and adult heart failure

scientific article published on 01 March 2020

HAND2 synergistically enhances transcription of dopamine-beta-hydroxylase in the presence of Phox2a.

scientific article published on October 2003

Hand Factors in Cardiac Development

article

Hand factor ablation causes defective left ventricular chamber development and compromised adult cardiac function.

scientific article

Hand factors as regulators of cardiac morphogenesis and implications for congenital heart defects

scientific article published on April 2011

Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis

scientific article

Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration.

scientific article

Hand2 is an essential regulator for two Notch-dependent functions within the embryonic endocardium

scientific article published on 11 December 2014

Hand2 loss-of-function in Hand1-expressing cells reveals distinct roles in epicardial and coronary vessel development

scientific journal article

Heart and extra-embryonic mesodermal defects in mouse embryos lacking the bHLH transcription factor Hand1 ⬇️

scientific article published on March 1, 1998

Identification and characterization of a novel Schwann and outflow tract endocardial cushion lineage-restricted periostin enhancer.

scientific article

Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death

scientific article published on 22 February 2014

Mis-Expression of a Cranial Neural Crest Cell-Specific Gene Program in Cardiac Neural Crest Cells Modulates HAND Factor Expression, Causing Cardiac Outflow Tract Phenotypes

scientific article published on 20 April 2020

Modular regulation of muscle gene transcription: a mechanism for muscle cell diversity ⬇️

scientific article published on September 1, 1997

Mutations within helix I of Twist1 result in distinct limb defects and variation of DNA binding affinities

scientific article published on 25 July 2007

Neonatal Deletion of Hand1 and Hand2 within Murine Cardiac Conduction System Reveals a Novel Role for HAND2 in Rhythm Homeostasis

scientific article published in 2022

Nkx2.5 regulates endothelin converting enzyme-1 during pharyngeal arch patterning.

scientific article published on 20 January 2017

Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification.

scientific article published on 8 February 2018

Ontogeny of cardiac sympathetic innervation and its implications for cardiac disease.

scientific article published on 03 March 2012

Overexpression of Foxn1 attenuates age-associated thymic involution and prevents the expansion of peripheral CD4 memory T cells

scientific article published on 9 September 2011

PKA, PKC, and the Protein Phosphatase 2A Influence HAND Factor Function

article by Beth A Firulli et al published November 2003 in Molecular Cell

PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation

scientific article (publication date: November 2003)

Partially Penetrant Cardiac Neural Crest Defects in Hand1 Phosphomutant Mice: Dimer Choice That Is Not So Critical

scientific article published on 23 July 2019

Periostin is required for maturation and extracellular matrix stabilization of noncardiomyocyte lineages of the heart

scientific article published on 22 February 2008

Phosphopeptide mapping of proteins ectopically expressed in tissue culture cell lines

scientific article

Phosphoregulation of Twist1 provides a mechanism of cell fate control

scientific article published on January 2008

Recombinant neuregulin 1 does not activate cardiomyocyte DNA synthesis in normal or infarcted adult mice.

scientific article

Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells

scientific article

Ribonucleoprotein and protein factors bind to an H-DNA-forming c-myc DNA element: possible regulators of the c-myc gene.

scientific article

SHROOM3 is downstream of the planar cell polarity pathway and loss-of-function results in congenital heart defects

scientific article published on 05 June 2020

Single-Cell Lineage Tracing Reveals that Oriented Cell Division Contributes to Trabecular Morphogenesis and Regional Specification

scientific article published on 22 March 2016

Structure-function studies of the bHLH phosphorylation domain of TWIST1 in prostate cancer cells

scientific article

Targeted deletion of Hand2 in cardiac neural crest-derived cells influences cardiac gene expression and outflow tract development

scientific journal article

The HAND1 frameshift A126FS mutation does not cause hypoplastic left heart syndrome in mice

scientific article

The basic-helix-loop-helix transcription factor HAND2 directly regulates transcription of the atrial naturetic peptide gene

scientific journal article

The heart of the neural crest: cardiac neural crest cells in development and regeneration

scientific article published on 15 October 2020

The identification of a tandem H-DNA structure in the c-myc nuclease sensitive promoter element

scientific article published on 01 May 1992

The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.

scientific article published on 09 August 2013

Transcription factors in cardiogenesis: the combinations that unlock the mysteries of the heart

scientific article

Trigenic neural crest-restricted Smad7 over-expression results in congenital craniofacial and cardiovascular defects.

scientific article

Triplex forming ability of a c-myc promoter element predicts promoter strength.

scientific article

Twist factor regulation of non-cardiomyocyte cell lineages in the developing heart.

scientific article published on 17 April 2012

Twist1 Inactivation in Dmp1-Expressing Cells Increases Bone Mass but Does Not Affect the Anabolic Response to Sclerostin Neutralization

scientific article published on 09 September 2019

Twist1 controls a cell-specification switch governing cell fate decisions within the cardiac neural crest

scientific article

Twist1 regulates Ifng expression in Th1 cells by interfering with Runx3 function.

scientific article published on 8 June 2012

Variation in a Left Ventricle-Specific Hand1 Enhancer Impairs GATA Transcription Factor Binding and Disrupts Conduction System Development and Function

scientific article published on 01 August 2019

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