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List of works by Manabu Kawada

A guanine derivative as a new MEK inhibitor produced by Streptomyces sp. MK63-43F2.

scientific article

A new indole glycoside from Kitasatospora sp. MG372-hF19 carrying a 6-deoxy-α-L-talopyranose moiety

scientific article published on 18 November 2019

A new proteasome inhibitor, TP-110, induces apoptosis in human prostate cancer PC-3 cells.

scientific article published on 7 April 2007

A new terrein glucoside, a novel inhibitor of angiogenin secretion in tumor angiogenesis. ⬇️

scientific article published on July 2008

A novel monoclonal antibody targeting coxsackie virus and adenovirus receptor inhibits tumor growth in vivo.

scientific article published on 11 January 2017

ATP Depletion Assay Led to the Isolation of New 36-Membered Polyol Macrolides Deplelides A and B from Streptomyces sp. MM581-NF15.

scientific article published on 08 August 2017

Acremopeptin, a new peptaibol from Acremonium sp. PF1450. ⬇️

scientific article published on 15 February 2017

Aminoglycoside antibiotics reduce glucose reabsorption in kidney through down-regulation of SGLT1.

scientific article published in September 2003

Androprostamines A and B, the new anti-prostate cancer agents produced by Streptomyces sp. MK932-CF8.

scientific article published on October 2014

Anti-CD133 Monoclonal Antibody CMab-43 Exerts Antitumor Activity in a Mouse Xenograft Model of Colon Cancer

scientific article published on 10 April 2019

Anti-Human Epidermal Growth Factor Receptor 2 Monoclonal Antibody H2Mab-41 Exerts Antitumor Activity in a Mouse Xenograft Model of Colon Cancer

scientific article published on 14 June 2019

Anti-podocalyxin antibody exerts antitumor effects via antibody-dependent cellular cytotoxicity in mouse xenograft models of oral squamous cell carcinoma.

scientific article published on 27 April 2018

Antipodocalyxin Antibody chPcMab-47 Exerts Antitumor Activity in Mouse Xenograft Models of Colorectal Adenocarcinomas.

scientific article

Antitumor effect of kigamicin D on mouse tumor models.

scientific article published on April 2006

Augmentation of cellular immunity by kigamicin D.

scientific article published in April 2006

Biological activities of unique isoflavones prepared from Apios americana Medik

scientific article published on 25 January 2016

Biological activity of intervenolin analogs with a phenyl substituent.

scientific article published on 11 October 2017

Catalytic Asymmetric Total Synthesis and Stereochemical Revision of Leucinostatin A: A Modulator of Tumor-Stroma Interaction

scientific article published on 13 July 2017

Circumvention of multidrug resistance in human carcinoma KB cells by polyether antibiotics

scientific article published on 01 April 1992

Cleavage mechanism and anti-tumor activity of 3,6-epidioxy-1,10-bisaboladiene isolated from edible wild plants.

scientific article published on 17 April 2012

Coccoquinones A and B, new anthraquinone derivatives produced by Staphylotrichum coccosporum PF1460. ⬇️

scientific article published on 14 October 2015

Cytostatin, an inhibitor of cell adhesion to extracellular matrix, selectively inhibits protein phosphatase 2A

scientific article published on 01 November 1999

Decalpenic acid induces early osteoblastic markers in pluripotent mesenchymal cells via activation of retinoic acid receptor γ.

scientific article published on 19 May 2012

Differential induction of apoptosis in B16 melanoma and EL-4 lymphoma cells by cytostatin and bactobolin.

scientific article published in February 1999

Enhancement of antiproliferative effects of interleukin-1beta and tumor necrosis factor-alpha on human prostate cancer LNCaP cells by coculture with normal fibroblasts through secreted interleukin-6.

scientific article

Establishment of a highly tumorigenic LNCaP cell line having inflammatory cytokine resistance.

scientific article published on 27 December 2005

Generation and evaluation of a chimeric antibody against coxsackievirus and adenovirus receptor for cancer therapy

scientific article published on 28 September 2019

Highly tumorigenic human androgen receptor-positive prostate cancer cells overexpress angiogenin.

scientific article published on March 2007

Human pancreatic cancer cells under nutrient deprivation are vulnerable to redox system inhibition

scientific article published on 25 September 2020

Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases.

scientific article published on October 2002

Impact of MET inhibition on small-cell lung cancer cells showing aberrant activation of the hepatocyte growth factor/MET pathway.

scientific article published on 5 May 2017

In vivo efficacy of β-lactam/tripropeptin C in a mouse septicemia model and the mechanism of reverse β-lactam resistance in methicillin-resistant Staphylococcus aureus mediated by tripropeptin C.

scientific article

Induction of p27Kip1 degradation and anchorage independence by Ras through the MAP kinase signaling pathway ⬇️

scientific article published on August 7, 1997

Inhibition of CTP: phosphocholine cytidylyltransferase activity by 15-deoxyspergualin.

scientific article published in August 2003

Inhibition of mitochondria ATP synthase suppresses prostate cancer growth through reduced insulin-like growth factor-1 secretion by prostate stromal cells

scientific article published on 06 March 2020

Inhibition of protein SUMOylation by davidiin, an ellagitannin from Davidia involucrata.

scientific article published on 15 January 2014

Inhibitory activity of dome formation in LLC-PK1 cells is a selective index of aminoglycoside nephrotoxicity

scientific article published on 01 June 2002

Inhibitory activity of the hypoxia-inducible factor-1 pathway by tartrolone C.

scientific article published on November 2006

Inostamycin, an inhibitor of P-glycoprotein function, interacts specifically with phosphatidylethanolamine.

scientific article

Insulin-like growth factor I secreted from prostate stromal cells mediates tumor-stromal cell interactions of prostate cancer.

scientific article published on April 2006

Intervenolin suppresses gastric cancer cell growth through the induction of TSP-1 secretion from fibroblast-like stromal cells

scientific article published on 21 September 2018

Intervenolin, a new antitumor compound with anti-Helicobacter pylori activity, from Nocardia sp. ML96-86F2. ⬇️

scientific article published on May 2013

Isolation of new derivatives of the 20-membered macrodiolide bispolide from Kitasatospora sp. MG372-hF19

Leucinostatin A inhibits prostate cancer growth through reduction of insulin-like growth factor-I expression in prostate stromal cells.

scientific article published on February 2010

Leucinostatin Y: A Peptaibiotic Produced by the Entomoparasitic Fungus Purpureocillium lilacinum 40-H-28

scientific article published on 24 April 2019

Mitochondrial complex I inhibitors suppress tumor growth through concomitant acidification of the intra- and extracellular environment

scientific article published in 2021

Mitochondrial inhibitors show preferential cytotoxicity to human pancreatic cancer PANC-1 cells under glucose-deprived conditions.

scientific article

Mitochondrial uncoupler exerts a synthetic lethal effect against β-catenin mutant tumor cells

scientific article

Monotherapy with a novel intervenolin derivative, AS-1934, is an effective treatment for Helicobacter pylori infection.

scientific article published on 28 February 2018

NA22598, a novel antitumor compound, reduces cyclin D1 levels, arrests cell cycle at G1 phase, and inhibits anchorage-independent growth of human tumor cells

scientific article published on 01 June 1999

NBRI16716A, a new antitumor compound against human prostate cancer cells, produced by Perisporiopsis melioloides Mer-f16716. ⬇️

scientific article

NBRI17671, a new antitumor compound, produced by Acremonium sp. CR17671. ⬇️

scientific article published on 9 April 2010

New Naphthoquinones, f13102A and B, from a Fungus Strain F-13102

scientific article published on 19 January 2009

New anti-cancer chemicals Ertredin and its derivatives, regulate oxidative phosphorylation and glycolysis and suppress sphere formation in vitro and tumor growth in EGFRvIII-transformed cells

scientific article

New atpenins, NBRI23477 A and B, inhibit the growth of human prostate cancer cells. ⬇️

scientific article published on 13 March 2009

New metastatic model of human small-cell lung cancer by orthotopic transplantation in mice

scientific article published on 26 February 2015

Novel approaches for identification of anti-tumor drugs and new bioactive compounds

scientific article published on 30 August 2017

PP2A Inhibitors, Harzianic Acid and Related Compounds Produced by Fungus Strain F-1531

scientific article published on 01 March 2012

Phenazine carboxylic acid and its derivative induce osteoblast differentiation in preosteoblastic MC3T3-E1 cells but adipocyte differentiation in pluripotent mesenchymal C3H10T1/2 cells

scientific article published on 25 October 2017

Phthoxazolin A inhibits prostate cancer growth by modulating tumor-stromal cell interactions.

scientific article

Podocalyxin is crucial for the growth of oral squamous cell carcinoma cell line HSC-2

scientific article published on 07 August 2018

Potential Anticancer Activity of Auranofin

scientific article published on 01 January 2019

Prevention of neomycin-induced nephrotoxic event in pig proximal tubular epithelial cell line by apolipoprotein E3.

scientific article

Remembering Dr. Masaaki Ishizuka (February 4, 1938-July 16, 2020)

scientific article published on 01 October 2020

Rubratoxin A specifically and potently inhibits protein phosphatase 2A and suppresses cancer metastasis.

scientific article

Small molecules modulating tumor-stromal cell interactions: new candidates for anti-tumor drugs.

scientific article published on 23 March 2016

Specific inhibitors of protein phosphatase 2A inhibit tumor metastasis through augmentation of natural killer cells

scientific article published on 01 February 2003

Stromal cells positively and negatively modulate the growth of cancer cells: stimulation via the PGE2-TNFα-IL-6 pathway and inhibition via secreted GAPDH-E-cadherin interaction

scientific article

Structures and biological activities of novel 4'-acetylated analogs of chrysomycins A and B.

scientific article published on 6 September 2017

Suppression of in vitro invasion of human fibrosarcoma cells by a leupeptin analogue inhibiting the urokinase-plasmin system

scientific article published on 01 April 1995

Synthesis and Structure-Activity Relationship Study of NBRI16716B, an Antitumor Natural Product.

scientific article published on January 2015

Synthesis of intervenolin, an antitumor natural quinolone with unusual substituents.

scientific article published on 17 April 2013

The long-lasting antiproliferative effect of 15-deoxyspergualin through its spermidine moiety

scientific article published on 01 July 2000

The mouse-canine chimeric anti-dog podoplanin antibody P38B exerts antitumor activity in mouse xenograft models

scientific article published on 24 November 2018

The therapeutic potential of microbial proteasome inhibitors.

scientific article

Up‐regulation of p27Kip1 Correlates Inversely with Anchorage‐independent Growth of Human Cancer Cell Lines ⬇️

scientific article published on February 1, 1998

Vibrio japonicus sp. nov., a novel member of the Nereis clade in the genus Vibrio isolated from the coast of Japan

scientific article

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