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List of works by Edward K.L. Chan

'Rod and ring' formation from IMP dehydrogenase is regulated through the one-carbon metabolic pathway

scientific article published on 24 June 2016

17-beta-estradiol increases expression of 52-kDa and 60-kDa SS-A/Ro autoantigens in human keratinocytes and breast cancer cell line MCF-7.

scientific article published on October 1996

A Comprehensive Overview on Myositis-Specific Antibodies: New and Old Biomarkers in Idiopathic Inflammatory Myopathy.

scientific article published on 30 September 2015

A cell-cycle nuclear autoantigen containing WD-40 motifs expressed mainly in S and G2 phase cells

scientific article

A microscale method for depleting cross-reactive anti-antibodies used in indirect immunofluorescence microscopy

scientific article published on 01 December 1994

A new immunoprecipitation-real time quantitative PCR assay for anti-Th/To and anti-U3RNP antibody detection in systemic sclerosis.

scientific article

A re-evaluation of anti-NA-14 antibodies in patients with primary Sjögren's syndrome: Significant role of interferon-γ in the production of autoantibodies against NA-14.

scientific article published on 21 June 2016

A secretagogue-small interfering RNA conjugate confers resistance to cytotoxicity in a cell model of Sjögren's syndrome.

scientific article published on October 2011

An SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182

scientific article published on January 1, 2013

An immunoassay differentiating sera with antibodies to Sm alone, antibodies to Sm/RNP complex, and antibodies to RNP alone

scientific article published on 01 April 1987

Analysis of an exon 1 polymorphism of the B2 bradykinin receptor gene and its transcript in normal subjects and patients with C1 inhibitor deficiency.

scientific article published on January 1997

Aneurysm-Specific miR-221 and miR-146a Participates in Human Thoracic and Abdominal Aortic Aneurysms

scientific article

Anti-SSA/Ro and anti-SSB/La autoantibodies bind the surface of apoptotic fetal cardiocytes and promote secretion of TNF-alpha by macrophages

scientific article published on 01 November 2000

Anti-Th/To Are Common Antinucleolar Autoantibodies in Italian Patients with Scleroderma

article

Anti-rods/rings autoantibody generation in hepatitis C patients during interferon-α/ribavirin therapy

scientific article

Anti-rods/rings autoantibody seropositivity does not affect response to telaprevir treatment for chronic hepatitis C infection

scientific article

Anti-rods/rings: a human model of drug-induced autoantibody generation

scientific article

Antibody detection using tumor-associated antigen mini-array in immunodiagnosing human hepatocellular carcinoma.

scientific article published on 25 September 2006

Antibody reactivity to alpha-enolase in mothers of children with congenital heart block.

scientific article

Antinuclear antibodies (ANAs): diagnostically specific immune markers and clues toward the understanding of systemic autoimmunity.

scientific article published on May 1988

Antinuclear antibodies and mortality in the National Health and Nutrition Examination Survey (1999-2004).

scientific article published on 9 October 2017

Antinuclear antibody test: when to order?

scientific article published on 01 October 2013

Assembly of IMPDH2-based, CTPS-based, and mixed rod/ring structures is dependent on cell type and conditions of induction

scientific article published on 18 April 2015

Associations Between Selected Xenobiotics and Antinuclear Antibodies in the National Health and Nutrition Examination Survey, 1999-2004

scientific article

AutoAbSC.Org -- Autoantibody Standardization Committee in 2006

scientific article published on 25 May 2007

Autoantibodies against the replication protein A complex in systemic lupus erythematosus and other autoimmune diseases.

scientific article published in January 2006

Autoantibodies to RNA helicase A: a new serologic marker of early lupus.

scientific article published in February 2007

Autoantibody to hLSm4 and the heptameric LSm complex in anti-Sm sera.

scientific article

Autoimmune response to anti-apoptotic protein survivin and its association with antibodies to p53 and c-myc in cancer detection

scientific article published on 01 January 2005

Autoimmune responses to mRNA binding proteins p62 and Koc in diverse malignancies

scientific article (publication date: August 2001)

Biomarkers and Pathogenic Mechanisms in Autoimmunity

scientific article published on 01 February 2017

CD70 as a target for chimeric antigen receptor T cells in head and neck squamous cell carcinoma

scientific article published on 20 February 2018

CIP2A expression and localization in oral carcinoma and dysplasia.

scientific article published on October 2010

CIP2A immunosensor comprised of vertically-aligned carbon nanotube interdigitated electrodes towards point-of-care oral cancer screening

article

CIP2A regulates cancer metabolism and CREB phosphorylation in non-small cell lung cancer.

scientific article published on 17 October 2014

Cardiac 5-HT(4) serotoninergic receptors, 52kD SSA/Ro and autoimmune-associated congenital heart block.

scientific article published in August 2002

Clarification Needed Regarding Anti-Topoisomerase I as a Biomarker for Non-Small Cell Lung Cancer.

scientific article published on 18 April 2018

Clinical and serological associations of autoantibodies to GW bodies and a novel cytoplasmic autoantigen GW182

scientific article (publication date: December 2003)

Clinical interpretation of antinuclear antibody tests in systemic rheumatic diseases.

scientific article published on 10 March 2009

Cloning and expression of mouse 60 kDa ribonucleoprotein SS-A/Ro.

scientific article published on January 1996

Coexistence of anti-RNA polymerase III and anti-U1RNP antibodies in patients with systemic lupus erythematosus: two cases without features of scleroderma.

scientific article published on 24 October 2011

Common pathways of autoimmune inflammatory myopathies and genetic neuromuscular disorders.

scientific article published on February 2012

Congenital heart block not associated with anti-Ro/La antibodies: comparison with anti-Ro/La-positive cases

scientific article

Contrast in aberrant microRNA expression in systemic lupus erythematosus and rheumatoid arthritis: is microRNA-146 all we need?

scientific article published on April 2009

Cytoplasmic rods and rings autoantibodies developed during pegylated interferon and ribavirin therapy in patients with chronic hepatitis C.

scientific article published on December 2011

Defining a new role of GW182 in maintaining miRNA stability

scientific article published on October 23, 2012

Differential anti-Golgi complex autoantibody production following murine lactate dehydrogenase-elevating virus infection

scientific article published on 01 January 2008

Differential capacity of therapeutic drugs to induce Rods/Rings structures in vitro and in vivo and generation of anti-Rods/Rings autoantibodies

scientific article published on 13 October 2016

Diversity of antinuclear antibody responses in hepatocellular carcinoma

scientific article published on 01 June 1997

Does the cellular localization of antigens in or on apoptotic blebs influence the pathogenicity or benefit of cognate antibodies? Comment on the article by Dieudé et al

scientific article published on 01 July 2003

Effect of cationic proteins on the glomerular deposition of anionic proteins and immune complexes

scientific article published on 01 January 1986

Elevated signal transducers and activators of transcription 1 correlates with increased C-C motif chemokine ligand 2 and C-X-C motif chemokine 10 levels in peripheral blood of patients with systemic lupus erythematosus.

scientific article published on 23 January 2014

Emerging microRNAs in cancer diagnosis, progression, and immune surveillance

scientific article published on 17 September 2018

Enoxacin and bis-enoxacin stimulate 4T1 murine breast cancer cells to release extracellular vesicles that inhibit osteoclastogenesis

scientific article published in Scientific Reports

Establishment of international autoantibody reference standards for the detection of autoantibodies directed against PML bodies, GW bodies, and NuMA protein

scientific article published on 10 August 2020

Frequent coexistence of anti-topoisomerase I and anti-U1RNP autoantibodies in African American patients associated with mild skin involvement: a retrospective clinical study.

scientific article published on 10 May 2011

From autoantibody research to standardized diagnostic assays in the management of human diseases - report of the 12th Dresden Symposium on Autoantibodies.

scientific article published on July 2016

Function of GW182 and GW Bodies in siRNA and miRNA Pathways

scientific article published on January 1, 2013

Fusobacteria modulate oral carcinogenesis and promote cancer progression

scientific article published on 30 November 2020

Gender and ethnicity differences in the prevalence of scleroderma-related autoantibodies.

scientific article published on 27 April 2011

Glutamine deprivation initiates reversible assembly of mammalian rods and rings.

scientific article published on 30 January 2014

High resolution of microRNA signatures in human whole saliva.

scientific article

Human 60-kDa SS-A/Ro ribonucleoprotein autoantigen gene (SSA2) localized to 1q31 by fluorescence in situ hybridization

scientific article

Identification and characterization of a novel Golgi protein, golgin-67.

scientific article

Immune Response-Dependent Assembly of IMP Dehydrogenase Filaments

scientific article published on 29 November 2018

Immunocytochemical characterization of human NOR-90 (upstream binding factor) and associated antigens reactive with autoimmune sera. Two MR forms of NOR-90/hUBF autoantigens

scientific article published on 01 March 1994

Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies.

scientific article published on July 1991

Immunological characterization of heterochromatin protein p25beta autoantibodies and relationship with centromere autoantibodies and pulmonary fibrosis in systemic scleroderma

scientific article published on 01 January 1998

Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren's syndrome before disease onset

scientific article published on 21 October 2008

Interaction between 52 kDa SSA/Ro and deubiquitinating enzyme UnpEL: a clue to function

scientific article

Interaction with GM130 during HERG ion channel trafficking. Disruption by type 2 congenital long QT syndrome mutations. Human Ether-à-go-go-Related Gene.

scientific article

Interleukin 1β-Responsive MicroRNA-146a Is Critical for the Cytokine-Induced Tolerance and Cross-Tolerance to Toll-Like Receptor Ligands

scientific article published on 18 April 2015

International Consensus on Antinuclear Antibody Patterns: defining negative results and reporting unidentified patterns

scientific article published on 01 September 2018

International consensus on ANA patterns (ICAP): the bumpy road towards a consensus on reporting ANA results

scientific article published on 30 January 2016

International consensus on antinuclear antibody patterns: definition of the AC-29 pattern associated with antibodies to DNA topoisomerase I

scientific article published on 01 September 2018

Introduction: The GW Body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology

scientific article published on January 1, 2013

Is the coiled body involved in nucleolar functions?

scientific article published on 01 April 1994

Isolated congenital heart block. Long-term outcome of mothers and characterization of the immune response to SS-A/Ro and to SS-B/La

scientific article published on 01 November 1993

Keratinization-associated miR-7 and miR-21 regulate tumor suppressor reversion-inducing cysteine-rich protein with kazal motifs (RECK) in oral cancer.

scientific article

Leucine zipper domain of 52 kDa SS-A/Ro promotes protein dimer formation and inhibits in vitro transcription activity

scientific article published on December 5, 2001

Life stress, negative mood states, and antibodies to heat shock protein 70 in endometrial cancer.

scientific article

Longitudinal study of a human drug-induced model of autoantibody to cytoplasmic rods/rings following HCV therapy with ribavirin and interferon-α

scientific article

Loukoumasomes Are Distinct Subcellular Structures from Rods and Rings and Are Structurally Associated with MAP2 and the Nuclear Envelope in Retinal Cells

scientific article

Lupus T cells switched on by DNA hypomethylation via microRNA?

scientific article published on May 2011

Mapping of Ago2-GW182 functional interactions

scientific article published on 01 January 2011

Maternal antibody responses to the 52-kd SSA/RO p200 peptide and the development of fetal conduction defects

scientific article published on 01 October 2005

Mechanistic role of microRNA-146a in endotoxin-induced differential cross-regulation of TLR signaling

scientific article published on 22 December 2010

MicroRNA in TLR signaling and endotoxin tolerance.

scientific article published on 8 August 2011

MicroRNA in autoimmunity and autoimmune diseases.

scientific article published on 19 March 2009

MicroRNA-146a in autoimmunity and innate immune responses.

scientific article

MicroRNA-375 as a biomarker for malignant transformation in oral lesions

scientific article published on 6 August 2016

MicroRNAs and autoimmunity.

scientific article

MicroRNAs and their emerging roles in immunology.

scientific article

MicroRNAs in rheumatoid arthritis.

scientific article

MicroRNAs in systemic rheumatic diseases

scientific article published on 13 July 2011

Microinjection of specific anti-IMPDH2 antibodies induces disassembly of cytoplasmic rods/rings that are primarily stationary and stable structures

scientific article

Molecular cell biology and immunobiology of mammalian rod/ring structures.

scientific article published on January 2014

Molecular cloning of a novel 97‐kd Golgi complex autoantigen associated with Sjögren's syndrome

scientific article published on September 1, 1997

Molecular remedy of complex I defects: Rotenone-insensitive internal NADH-quinone oxidoreductase of Saccharomyces cerevisiae mitochondria restores the NADH oxidase activity of complex I-deficient mammalian cells

scientific article published on August 4, 1998

Monoclonal autoantibodies to nuclear antigens from murine graft-versus-host disease

scientific article published on 01 July 1987

Novel nuclear autoantigen with splicing factor motifs identified with antibody from hepatocellular carcinoma

scientific article

Our Journey from the Study of Human Autoantibodies to the microRNA World

scientific article published on 11 March 2015

Overexpression of dicer as a result of reduced let-7 MicroRNA levels contributes to increased cell proliferation of oral cancer cells

scientific article

Periodontal bacterial colonization in synovial tissues exacerbates collagen-induced arthritis in B10.RIII mice

scientific article published on 12 July 2016

Polyclonal hypergammaglobulinemia and autoantibody production induced by vaccination in farmed Atlantic salmon.

scientific article published on 18 February 2011

Polymicrobial Infection with Periodontal Pathogens Specifically Enhances MicroRNA miR-146a in ApoE −/− Mice during Experimental Periodontal Disease

scientific article published on January 24, 2011

Positive correlation of STAT1 and miR-146a with anemia in patients with systemic lupus erythematosus.

scientific article published on December 2013

Preferential humoral immune response in prostate cancer to cellular proteins p90 and p62 in a panel of tumor-associated antigens.

scientific article

Preparation of covalently linked immune complexes of specific composition

scientific article published on 01 January 1980

Prescription medication use and antinuclear antibodies in the United States, 1999-2004

scientific article published on 18 May 2018

Reduced levels of CCL2 and CXCL10 in systemic lupus erythematosus patients under treatment with prednisone, mycophenolate mofetil, or hydroxychloroquine, except in a high STAT1 subset.

scientific article published on 24 January 2014

Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research

scientific article published on January 1, 2013

Regulation of TLR2-Mediated Tolerance and Cross-Tolerance through IRAK4 Modulation by miR-132 and miR-212

scientific article published on December 21, 2012

Report of the First International Consensus on Standardized Nomenclature of Antinuclear Antibody HEp-2 Cell Patterns 2014-2015

scientific article

Report on the second International Consensus on ANA Pattern (ICAP) workshop in Dresden 2015.

scientific article published on July 2016

Reproductive and hormonal risk factors for antinuclear antibodies (ANA) in a representative sample of U.S. women

scientific article

Residual Cajal bodies in coilin knockout mice fail to recruit Sm snRNPs and SMN, the spinal muscular atrophy gene product

scientific journal article

Ribavirin induces widespread accumulation of IMP dehydrogenase into rods/rings structures in multiple major mouse organs

scientific article published on 31 December 2018

Ribonucleoprotein SS-B/La belongs to a protein family with consensus sequences for RNA-binding

scientific article

Single-cell antibody nanowells: a novel technology in detecting anti-SSA/Ro60- and anti-SSB/La autoantibody-producing cells in peripheral blood of rheumatic disease patients

scientific article

Structure and characterization of the murine p80 coilin gene, Coil.

scientific article

Structure, expression and chromosomal localization of human p80-coilin gene

scientific article

Temporal evolution of human autoantibody response to cytoplasmic rods and rings structure during anti-HCV therapy with ribavirin and interferon-α.

scientific article published on October 2014

The 52-kd protein as a target of intermolecular spreading of the immune response to components of the SS-A/Ro-SS-B/La complex

scientific article published on 01 May 1997

The Discovery of GW Bodies

scientific article published on January 1, 2013

The GM130 and GRASP65 Golgi proteins cycle through and define a subdomain of the intermediate compartment

scientific article (publication date: December 2001)

The small nuclear ribonucleoprotein SS-B/La binds RNA with a conserved protease-resistant domain of 28 kilodaltons.

scientific article published on July 1987

The uses and misuses of multiplex autoantibody assays in systemic autoimmune rheumatic diseases

scientific article

Transcription activating property of autoantigen SG2NA and modulating effect of WD-40 repeats

scientific article

Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions.

scientific article published on 3 April 2013

Two major autoantigen-antibody systems of the mitotic spindle apparatus.

scientific article published on October 1996

Unusually high frequency of autoantibodies to PL-7 associated with milder muscle disease in Japanese patients with polymyositis/dermatomyositis

scientific article published on 01 June 2006

Vaccination-induced systemic autoimmunity in farmed Atlantic salmon.

scientific article published on October 2008

mRNA and protein expression of SSA/Ro and SSB/La in human fetal cardiac myocytes cultured using a novel application of the Langendorff procedure

scientific article (publication date: February 1999)

miR-146a is critical for endotoxin-induced tolerance: IMPLICATION IN INNATE IMMUNITY.

scientific article published on 19 October 2009

miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ

scientific article

miR-494 represses HOXA10 expression and inhibits cell proliferation in oral cancer

scientific article published on 12 December 2014