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List of works by J. Julian Blow

A Role for Dormant Origins in Tumor Suppression ⬇️

scientific article published on March 4, 2011

A Xenopus Dbf4 homolog is required for Cdc7 chromatin binding and DNA replication

scientific article

A model for DNA replication showing how dormant origins safeguard against replication fork failure.

scientific article published on 13 February 2009

A new role for Ran in ensuring precise duplication of chromosomal DNA.

scientific article published in April 2003

A role for the nuclear envelope in controlling DNA replication within the cell cycle ⬇️

scientific article published on April 7, 1988

Biochemical and cellular effects of roscovitine, a potent and selective inhibitor of the cyclin-dependent kinases cdc2, cdk2 and cdk5.

scientific article published in January 1997

Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication.

scientific article

Both Chromosome Decondensation and Condensation Are Dependent on DNA Replication in C. elegans Embryos.

scientific article published on 9 July 2015

Both cyclin A and cyclin E have S-phase promoting (SPF) activity in Xenopus egg extracts

scientific article published on 01 June 1996

Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks.

scientific article

Cdt1 downregulation by proteolysis and geminin inhibition prevents DNA re-replication in Xenopus

scientific article published on 16 December 2004

Cell Cycle Synchronization in Xenopus Egg Extracts.

scientific article

Cell cycle control of DNA replication by p34cdc2

scientific article published on August 1, 1991

Characterization of the Xenopus replication licensing system.

scientific article published in January 1997

Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. ⬇️

scientific article published on 20 December 2010

Chromatin proteins involved in the initiation of DNA replication.

scientific article published on April 1997

Chromosome replication: from ORC to fork

scientific article

Chronic p53-independent p21 expression causes genomic instability by deregulating replication licensing

scientific article published on 20 June 2016

Cip1 blocks the initiation of DNA replication in Xenopus extracts by inhibition of cyclin-dependent kinases

scientific article published on 01 October 1994

Clusters, factories and domains: The complex structure of S-phase comes into focus.

scientific article published on 11 August 2010

Combinatorial regulation of meiotic holliday junction resolution in C. elegans by HIM-6 (BLM) helicase, SLX-4, and the SLX-1, MUS-81 and XPF-1 nucleases

scientific article (publication date: 2013)

DNA replication initiates at multiple sites on plasmid DNA in Xenopus egg extracts.

scientific article

DNA replication licensing factor ⬇️

scientific article published on January 1, 1996

DNA replication: stable driving prevents fatal smashes

scientific article

Defects in the origin licensing checkpoint stresses cells exiting G0

scientific article published on 11 June 2019

Deregulated origin licensing leads to chromosomal breaks by rereplication of a gapped DNA template

scientific article

Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision.

scientific article published on November 2006

Development of BromoTag: A “Bump-and-Hole”–PROTAC System to Induce Potent, Rapid, and Selective Degradation of Tagged Target Proteins

scientific article published on 17 October 2021

Direct non transcriptional role of NF-Y in DNA replication.

scientific article published on 27 December 2015

Dormant Origins, the Licensing Checkpoint, and the Response to Replicative Stresses ⬇️

scientific article published on October 1, 2012

Dormant origins licensed by excess Mcm2-7 are required for human cells to survive replicative stress.

scientific article published on December 2007

Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans

scientific article

Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos.

scientific article

ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and replication licensing

scientific article published on 6 September 2007

Editorial overview

scientific article published in December 2000

Erratum: Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans.

scientific article published on 12 February 2015

Evidence for a mammalian late-G1 phase inhibitor of replication licensing distinct from geminin or Cdk activity ⬇️

scientific article published on September 1, 2011

Excess Mcm2-7 license dormant origins of replication that can be used under conditions of replicative stress.

scientific article published on June 2006

Functional domains of the Xenopus replication licensing factor Cdt1

scientific article

Geminin becomes activated as an inhibitor of Cdt1/RLF-B following nuclear import.

scientific article published on April 2002

Histone H4K20 methylation mediated chromatin compaction threshold ensures genome integrity by limiting DNA replication licensing

scientific article published in Nature Communications

Inevitability and containment of replication errors for eukaryotic genome lengths spanning megabase to gigabase.

scientific article published on 14 September 2016

Interaction between the origin recognition complex and the replication licensing system in Xenopus.

scientific article published in October 1996

Lgr5+ intestinal stem cells reside in an unlicensed G1 phase.

scientific article published on 29 March 2018

Many strands converge

scientific article published in Nature

Negative regulation of geminin by CDK-dependent ubiquitination controls replication licensing.

scientific article published on April 2004

Non-proteolytic inactivation of geminin requires CDK-dependent ubiquitination.

scientific article published on 08 February 2004

Nuclear structure and the control of DNA replication in the Xenopus embryo

scientific article published on 01 January 1989

Nuclei act as independent and integrated units of replication in a Xenopus cell-free DNA replication system.

scientific article

Optimisation of the two-dimensional gel electrophoresis protocol using the Taguchi approach

scientific article

PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192

scientific article

PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage

scientific journal article

Preventing re-replication of DNA in a single cell cycle: evidence for a replication licensing factor.

scientific article

Preventing re-replication of chromosomal DNA.

scientific article

Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing

scientific article

Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts.

scientific article published on 29 May 2008

Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation.

scientific article

Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels.

scientific article published on 18 January 2010

Replication forks, chromatin loops and dormant replication origins

scientific article published on 30 December 2008

Replication occurs at discrete foci spaced throughout nuclei replicating in vitro.

scientific article published in November 1989

Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts

scientific article published on 19 August 2013

Repression of origin assembly in metaphase depends on inhibition of RLF-B/Cdt1 by geminin

scientific article

Reversal of DDK-Mediated MCM Phosphorylation by Rif1-PP1 Regulates Replication Initiation and Replisome Stability Independently of ATR/Chk1. ⬇️

scientific article published on March 2017

Site-specific initiation of DNA replication in metazoan chromosomes and the role of nuclear organization

scientific article published on 01 January 1993

Stochastic association of neighboring replicons creates replication factories in budding yeast.

scientific article published on 23 September 2013

The Anthelmintic Drug Niclosamide and its Analogues Activate the Parkinson's Disease Associated Protein Kinase PINK1.

scientific article published on 10 December 2017

The DNA replication licensing system

scientific article published on January 1, 1997

The Geminin and Idas Coiled Coils Preferentially Form a Heterodimer That Inhibits Geminin Function in DNA Replication Licensing

scientific article

The High-Affinity Interaction between ORC and DNA that Is Required for Replication Licensing Is Inhibited by 2-Arylquinolin-4-Amines

scientific article published on 17 July 2017

The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability

scientific article published on 13 April 2016

The RLF-B component of the replication licensing system is distinct from Cdc6 and functions after Cdc6 binds to chromatin

scientific article published on February 1999

The RLF-M component of the replication licensing system forms complexes containing all six MCM/P1 polypeptides ⬇️

scientific article published on June 2, 1997

The SMC-5/6 Complex and the HIM-6 (BLM) Helicase Synergistically Promote Meiotic Recombination Intermediate Processing and Chromosome Maturation during Caenorhabditis elegans Meiosis

scientific article

The Xenopus origin recognition complex is essential for DNA replication and MCM binding to chromatin

scientific article published on 01 November 1996

The contribution of dormant origins to genome stability: from cell biology to human genetics.

scientific article published on 24 April 2014

The dynamics of replication licensing in live Caenorhabditis elegans embryos.

scientific article published on 16 January 2012

The licensing checkpoint opens up.

scientific article published on August 2009

The origin of CDK regulation

scientific article

The regulation of chromosome replication

scientific article published on June 1, 1992

The replication capacity of intact mammalian nuclei in Xenopus egg extracts declines with quiescence, but the residual DNA synthesis is independent of Xenopus MCM proteins.

scientific article published on February 2000

The replication licensing system.

scientific article published in August 1998

The role of DDK and Treslin–MTBP in coordinating replication licensing and pre-initiation complex formation

scientific article published on 27 October 2021

The role of cyclin synthesis, modification and destruction in the control of cell division.

scientific article

The role of the replication licensing system in cell proliferation and cancer ⬇️

scientific article published on January 1, 2003

Translation of cyclin mRNA is necessary for extracts of activated xenopus eggs to enter mitosis.

scientific article

Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability

scientific article

Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells

scientific article published on 11 August 2016

Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated protein phosphatase 1.

scientific article published on 8 January 2014

Xenopus Mcm10 is a CDK-substrate required for replication fork stability.

scientific article published on 21 June 2016

Xenopus cell-free extracts and their contribution to the study of DNA replication and other complex biological processes

scientific article published in January 2016

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