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List of works by Jan Albrecht

2-Amino-1,3,4-thiadiazole derivative (FABT) inhibits the extracellular signal-regulated kinase pathway and induces cell cycle arrest in human non-small lung carcinoma cells.

scientific article

A novel glycine site-specific N-methyl-D-aspartate receptor antagonist prevents activation of the NMDA/NO/CGMP pathway by ammonia

scientific article

Acrylamide stimulates glutamine uptake in Fischer 344 rat astrocytes by a mechanism involving upregulation of the amino acid transport system N.

scientific article published in August 2005

Activation of arginine metabolism to glutamate in rat brain synaptosomes in thioacetamide-induced hepatic encephalopathy: an adaptative response?

scientific article published on 01 January 1990

Acute ammonia treatment in vitro and in vivo inhibits the synthesis of a neuroprotectant kynurenic acid in rat cerebral cortical slices.

scientific article published in March 1998

Acute hepatic encephalopathy decreases potassium-evoked calcium uptake in astrocytes but not in synaptosomes of the rat

scientific article published on 01 April 1990

Aluminum chloride stimulates NACl-dependent release of taurine and ?-aminobutyric acid in rat cortical astrocytes

scientific article published on 01 January 1991

Aluminum chloride stimulates the release of endogenous glutamate, taurine and adenosine from cultured rat cortical astrocytes ⬇️

scientific article published on June 10, 1991

Ammonia Reduces Intracellular Asymmetric Dimethylarginine in Cultured Astrocytes Stimulating Its y⁺LAT2 Carrier-Mediated Loss.

scientific article published on 2 November 2017

Ammonia added in vitro, but not moderate hyperammonemia in vivo, stimulates glutamate uptake and H(+)-ATPase activity in synaptic vesicles of the rat brain

scientific article published on 01 September 1994

Ammonia affects the activity and expression of soluble and particulate GC in cultured rat astrocytes

scientific article published on 3 March 2006

Ammonia at pathophysiologically relevant concentrations activates kynurenic acid synthesis in cultured astrocytes and neurons.

scientific article published on 14 February 2006

Ammonia increases paracellular permeability of rat brain endothelial cells by a mechanism encompassing oxidative/nitrosative stress and activation of matrix metalloproteinases.

scientific article published on 15 February 2012

Ammonia inhibits the C-type natriuretic peptide-dependent cyclic GMP synthesis and calcium accumulation in a rat brain endothelial cell line

scientific article published on 15 December 2007

Ammonia reduces intracellular ADMA level in cultured astrocytes and endothelial cells: possible involvement of increased y+LAT2-mediated efflux.

scientific article

Ammonia-induced extracellular accumulation of taurine in the rat striatum in vivo: role of ionotropic glutamate receptors.

scientific article

Ammonia-induced taurine release from cultured rabbit Müller cells is an osmoresistant process mediated by intracellular accumulation of cyclic AMP

scientific article published on 01 October 1996

Astrocyte glutamate receptor activation promotes inositol phospholipid turnover and calcium flux

scientific article published on 01 December 1986

Astroglial NMDA receptors inhibit expression of Kir4.1 channels in glutamate-overexposed astrocytes in vitro and in the brain of rats with acute liver failure.

scientific article published on 23 October 2014

Both GLS silencing and GLS2 overexpression synergize with oxidative stress against proliferation of glioma cells.

scientific article

Brain carbonic anhydrase activity in rats in experimental hepatogenic encephalopathy

scientific article published on 01 March 1984

Brain extracellular levels of dimethylarginines (ADMA, SDMA) and cGMP and their modulation by exogenous S-adenosylmethionine in rats with acute liver failure.

scientific article published on 12 June 2015

Carnosine Reduces Oxidative Stress and Reverses Attenuation of Righting and Postural Reflexes in Rats with Thioacetamide-Induced Liver Failure

scientific article published on 22 January 2016

Cerebral RNA synthesis in experimental hepatogenic encephalopathy

scientific article published on 01 January 1981

Changes in the cytoplasmic (lactate dehydrogenase) and plasma membrane (acetylcholinesterase) marker enzymes in the synaptic and nonsynaptic mitochondria derived from rats with moderate hyperammonemia

scientific article published on 01 April 1993

Changes in the mitochondrial antioxidant systems in neurodegenerative diseases and acute brain disorders.

scientific article published on 06 January 2015

Changes in the striatal extracellular levels of dopamine and dihydroxyphenylacetic acid evoked by ammonia and N-methyl-D-aspartate: modulation by taurine.

scientific article published in July 2003

Changes of the thioredoxin system, glutathione peroxidase activity and total antioxidant capacity in rat brain cortex during acute liver failure: modulation by L-histidine.

scientific article published on 27 August 2014

Characteristics of large neutral amino acid-induced release of preloaded L-glutamine from rat cerebral capillaries in vitro: effects of ammonia, hepatic encephalopathy, and gamma-glutamyl transpeptidase inhibitors

scientific article published on June 1, 1992

Citrulline uptake in rat cerebral cortex slices: modulation by Thioacetamide -Induced hepatic failure.

scientific article

Cognitive flexibility but not cognitive coordination is affected in rats with toxic liver failure.

scientific article published on 19 April 2006

Contrasting effects of thioacetamide-induced liver damage on the brain uptake indices of ornithine, arginine and lysine: modulation by treatment with ornithine aspartate.

scientific article published in September 1996

Cortical Synaptic Transmission and Plasticity in Acute Liver Failure Are Decreased by Presynaptic Events.

scientific article published on 23 January 2017

Cortical synapses in acute hepatic encephalopathy: morphology and expression of proteins involved in synaptic transmission.

scientific article

Cyclic GMP in blood and minimal hepatic encephalopathy: fine-tuning of the diagnosis

scientific article published on 02 February 2007

Decrease of glutathione content in the prefrontal cortical mitochondria of rats with acute hepatic encephalopathy: prevention by histidine.

scientific article

Decreased potassium-stimulated release of [3H]d-aspartate from hippocampal slices distinguishes encephalopathy related to acute liver failure from that induced by simple hyperammonemia ⬇️

scientific article published on December 13, 1991

Deficit of astroglia-derived thrombospondin-1 and loss of synaptic proteins in hepatic encephalopathy: do ammonia-overexposed astrocytes derange the synaptic hardware?

scientific article published on 08 August 2014

Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in cultured cerebral cortical neurons.

scientific article published in June 2005

Demonstration of kynurenine aminotransferases I and II and characterization of kynurenic acid synthesis in oligodendrocyte cell line (OLN-93).

scientific article published on August 2005

Direct exposure to ammonia and hyperammonemia increase the extracellular accumulation and degradation of astroglia-derived glutathione in the rat prefrontal cortex

scientific article

Down-regulation of Kir4.1 in the cerebral cortex of rats with liver failure and in cultured astrocytes treated with glutamine: Implications for astrocytic dysfunction in hepatic encephalopathy

scientific article published on 02 May 2011

Downregulation of GLS2 in glioblastoma cells is related to DNA hypermethylation but not to the p53 status.

scientific article

Durable inhibition of rat cerebral capillary Na+/K+-ATPase after in vivo administration of mercuric chloride ⬇️

scientific article published on December 1, 1991

Effect of ammonia on taurine transport in C6 glioma cells

scientific article published in January 2003

Effect of carbon monoxide intoxication on individual steps of protein synthesis in rat brain.

scientific article published in December 1973

Effect of glutamine synthesis inhibition with methionine sulfoximine on the nitric oxide-cyclic GMP pathway in the rat striatum treated acutely with ammonia: a microdialysis study

scientific article published on 29 August 2007

Effect of hypoxia, ischemia and carbon monoxide intoxication on in vivo protein synthesis in neuron and glia cell enriched fractions from rat brain

scientific article published on January 1, 1975

Effects of ammonia in vitro on endogenous taurine efflux and cell volume in rat cerebrocortical minislices: influence of inhibitors of volume-sensitive amino acid transport.

scientific article

Effects of methionine sulfoximine on the glutamine and glutamate content and cell volume in rat cerebral cortical slices: involvement of mechanisms not related to inhibition of glutamine synthesis.

scientific article published in March 2004

Endogenous neuro-protectants in ammonia toxicity in the central nervous system: facts and hypotheses.

scientific article

Enhanced GABA release in cerebral cortical slices derived from rats with thioacetamide-induced hepatic encephalopathy

scientific article published on December 1, 1992

Enhanced RNA and protein synthesis in vitro in astrocytes derived from rats in the early stage of experimental hepatogenic encephalopathy

scientific article published on 01 October 1984

Enhanced potassium-stimulated gamma-aminobutyric acid release by astrocytes derived from rats with early hepatogenic encephalopathy

scientific article published on 01 July 1987

Erratum: Majewska, E. et al. Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway. Cancers 2019, 11, 115

scientific article published on 27 July 2020

Evidence for an interaction between GABAB and glutamate receptors in astrocytes as revealed by changes in Ca2+ flux

scientific article published on 01 June 1986

Exchange-mode glutamine transport across CNS cell membranes

scientific article published on 08 March 2019

Excitotoxic mechanism of cell swelling in rat cerebral cortical slices treated acutely with ammonia

scientific article published in September 2003

Experimental models of hepatic encephalopathy: ISHEN guidelines.

scientific article published on July 2009

Expression of RNAs Coding for Metal Transporters in Blood of Patients with Huntington's Disease

scientific article published on 15 October 2015

Gain of function of Kir4.1 channel increases cell resistance to changes of potassium fluxes and cell volume evoked by ammonia and hypoosmotic stress

scientific article published on 01 November 2010

Glutamate uptake is inhibited by L-arginine in mitochondria isolated from rat cerebrum ⬇️

scientific article published on July 7, 1997

Glutamate-glutamine homeostasis in the CNS: physiological and pathophysiological aspects

scientific article published on 01 August 2000

Glutaminases in slowly proliferating gastroenteropancreatic neuroendocrine neoplasms/tumors (GEP-NETs): Selective overexpression of mRNA coding for the KGA isoform

scientific article published on 12 November 2015

Glutamine as a mediator of ammonia neurotoxicity: A critical appraisal.

scientific article published on 21 July 2010

Glutamine as a pathogenic factor in hepatic encephalopathy.

scientific article

Glutamine in the central nervous system: function and dysfunction.

scientific article

Glutamine inhibits ammonia-induced accumulation of cGMP in rat striatum limiting arginine supply for NO synthesis

scientific article published on 18 April 2009

Glutamine transport in C6 glioma cells shows ASCT2 system characteristics.

scientific article published on September 2003

Glutamine transport in C6 glioma cells.

scientific article published in August 2000

Glutamine transport in C6 glioma cells: Substrate specificity and modulation in a glutamine deprived culture medium ⬇️

scientific article published on December 1, 2001

Glutamine uptake and expression of mRNA's of glutamine transporting proteins in mouse cerebellar and cerebral cortical astrocytes and neurons.

scientific article published in January 2004

Hepatic Encephalopathy in Our Genes? ⬇️

scientific article published on 01 September 2010

Hepatic encephalopathy: molecular mechanisms underlying the clinical syndrome.

scientific article

Hyperammonemia increases the expression and activity of the glutamine/arginine transporter y+LAT2 in rat cerebral cortex: Implications for the nitric oxide/cGMP pathway

scientific article published on 27 November 2010

Hyperammonemia inhibits the natriuretic peptide receptor 2 (NPR-2)-mediated cyclic GMP synthesis in the astrocytic compartment of rat cerebral cortex slices.

scientific article

Increased expression of a glutamine transporter SNAT3 is a marker of malignant gliomas

scientific article

Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+)LAT2 transporter

scientific article published on 8 October 2015

Inhibition of Glutamate Release, but Not of Glutamine Recycling to Glutamate, Is Involved in Delaying the Onset of Initial Lithium-Pilocarpine-Induced Seizures in Young Rats by a Non-Convulsive MSO Dose

scientific article published on 15 October 2021

Interstitial ion homeostasis and acid-base balance are maintained in oedematous brain of mice with acute toxic liver failure

scientific article published on 14 May 2018

Introduction to special issue in honor of Michael D. Norenberg: a pathologist who incorporated glutamine to the astrocytic-neuronal crosstalk.

scientific article published in February 2015

Is neurotransmitter histamine predominantly inactivated in astrocytes?

scientific article published on 01 September 1987

Kynurenic acid synthesis in cerebral cortical slices of rats with progressing symptoms of thioacetamide-induced hepatic encephalopathy.

scientific article published on February 2004

L-arginine uptake in rat cerebral mitochondria.

scientific article published in September 1998

L-glutamate stimulates the efflux of newly taken up glutamine from astroglia but not from synaptosomes of the rat.

scientific article

Lack of expression of the liver-type glutaminase (LGA) mRNA in human malignant gliomas.

scientific article published in February 2005

Lectin histochemistry of the rat brain following thioacetamide-induced hepatic failure.

scientific article published in September 1997

Long-term treatment with ammonia affects the content and release of taurine in cultured cerebellar astrocytes and granule neurons.

scientific article

Loss of GABAB binding sites in the cerebral cortex of rats with acute hepatic encephalopathy

scientific article published on 01 December 1993

Manganese induces oxidative impairment in cultured rat astrocytes.

scientific article published on 27 April 2007

Mechanisms of Excessive Extracellular Glutamate Accumulation in Temporal Lobe Epilepsy

scientific article published on 21 November 2016

Mechanisms of ammonia-induced cell death in rat cortical neurons: roles of NMDA receptors and glutathione.

scientific article published in July 2005

Metabolism of [U-13C]glutamine and [U-13C]glutamate in isolated rat brain mitochondria suggests functional phosphate-activated glutaminase activity in matrix

scientific article published on 01 September 2007

Methylmercury induces oxidative injury, alterations in permeability and glutamine transport in cultured astrocytes.

scientific article published on 19 December 2006

Modulation by kynurenine of extracellular kynurenate and glutamate in cerebral cortex of rats with acute liver failure

scientific article published on 13 April 2014

Modulation of glutamine uptake and phosphate-activated glutaminase activity in rat brain mitochondria by amino acids and their synthetic analogues

scientific article published on 01 April 2000

N-methyl-D-aspartate-evoked changes in the striatal extracellular levels of dopamine and its metabolites in vivo in rats with acute hepatic encephalopathy.

scientific article

NMDA Receptors in Astrocytes: In Search for Roles in Neurotransmission and Astrocytic Homeostasis ⬇️

scientific article published on 14 January 2019

Neuron-derived factors negatively modulate ryanodine receptor-mediated calcium release in cultured mouse astrocytes

scientific article published on 07 October 2020

Opposing roles of glutaminase isoforms in determining glioblastoma cell phenotype.

scientific article published on 18 December 2014

Our continuous interest to promote exchange of views on the most recent developments in the realm of glutamate is manifested by the title of this symposium.

scientific article published on 14 March 2009

Oxidative and nitrosative stress in ammonia neurotoxicity.

scientific article

Persistent Overexposure to N-Methyl-D-Aspartate (NMDA) Calcium-Dependently Downregulates Glutamine Synthetase, Aquaporin 4, and Kir4.1 Channel in Mouse Cortical Astrocytes.

scientific article

Pretreatment with a glutamine synthetase inhibitor MSO delays the onset of initial seizures induced by pilocarpine in juvenile rats

scientific article published in February 2021

Protein composition of chromatin subfractions prepared from chick embryos

scientific article published on March 2, 1977

Protein kinase C-mediated impairment of glutamine outward transport and SN1 transporter distribution by ammonia in mouse cortical astrocytes

scientific article published on 03 July 2018

Protein kinase G is involved in ammonia-induced swelling of astrocytes.

scientific article

Rabbit retinal organ culture as an in-vitro model of hepatic retinopathy.

scientific article published on 18 February 2004

Rapid decrease of high affinity ouabain binding sites in hippocampal CA1 region following short-term global cerebral ischemia in rat

scientific article published on 01 June 1989

Reduction of neurotoxicity of mercuric chloride and glutamate by a membrane-permeating thiol reagent in vitro

scientific article published on 01 December 1995

Regulation of pH in the mammalian central nervous system under normal and pathological conditions: facts and hypotheses.

scientific article published on 26 October 2007

Relation of taurine transport and brain edema in rats with simple hyperammonemia or liver failure

scientific article published on 01 July 1996

Relative expression of mRNAS coding for glutaminase isoforms in CNS tissues and CNS tumors

scientific article published on 17 October 2007

Release of [3H]dopamine from striatal and cerebral cortical slices from rats with thioacetamide-induced hepatic encephalopathy: different responses to stimulation by potassium ions and agonists of ionotropic glutamate receptors

scientific article published on 01 February 1997

Repeated exposure of adult rats to Aroclor 1254 induces neuronal injury and impairs the neurochemical manifestations of the NMDA receptor-mediated intracellular signaling in the hippocampus.

scientific article

Retinal gliopathy accompanying thioacetamide-induced liver insufficiency: light and electron microscopic observations ⬇️

scientific article published on July 1, 1998

Reversible decrease of dopamine D2 receptor density in the striatum of rats with acute hepatic failure.

scientific article published in May 2001

Role of N-methyl-D-aspartate receptors in the neuroprotective activation of extracellular signal-regulated kinase 1/2 by cisplatin.

scientific article published on 20 August 2003

Role of Ryanodine and NMDA Receptors in Tetrabromobisphenol A-Induced Calcium Imbalance and Cytotoxicity in Primary Cultures of Rat Cerebellar Granule Cells.

scientific article

Roles of changes in active glutamine transport in brain edema development during hepatic encephalopathy: an emerging concept

scientific article published on 26 September 2013

Roles of glutamate and glutamine transport in ammonia neurotoxicity: state of the art and question marks.

scientific article published on 19 December 2017

Roles of glutamine in neurotransmission.

scientific article

Roles of neuroactive amino acids in ammonia neurotoxicity ⬇️

scientific article published on January 15, 1998

Selective decrease of SN1(SNAT3) mRNA expression in human and rat glioma cells adapted to grow in acidic medium.

scientific article

Silencing of GLS and overexpression of GLS2 genes cooperate in decreasing the proliferation and viability of glioblastoma cells

scientific article

Some properties of a "crude" fraction of astrocytes prepared with trypsin.

scientific article published in April 1982

Stimulation of D-aspartate efflux by mercuric chloride from rat primary astrocyte cultures

scientific article published on 01 October 1993

Stimulation of natriuretic peptide receptor C attenuates accumulation of reactive oxygen species and nitric oxide synthesis in ammonia-treated astrocytes

scientific article

Synaptosomal uptake of alpha-ketoglutarate and glutamine in thioacetamide-induced hepatic encephalopathy in rats ⬇️

scientific article published on December 1, 1997

System N transporters are critical for glutamine release and modulate metabolic fluxes of glucose and acetate in cultured cortical astrocytes: changes induced by ammonia.

scientific article published on 7 October 2015

TNFα increases STAT3-mediated expression of glutaminase isoform KGA in cultured rat astrocytes

scientific article published on 22 July 2019

Taurine interaction with neurotransmitter receptors in the CNS: an update.

scientific article

Taurine prevents ammonia-induced accumulation of cyclic GMP in rat striatum by interaction with GABAA and glycine receptors

scientific article published in May 2005

Taurine reduces ammonia- and N-methyl-D-aspartate-induced accumulation of cyclic GMP and hydroxyl radicals in microdialysates of the rat striatum.

scientific article published in May 2003

The Status of Bile Acids and Farnesoid X Receptor in Brain and Liver of Rats with Thioacetamide-Induced Acute Liver Failure

scientific article published on 20 October 2020

The dimethylarginine (ADMA)/nitric oxide pathway in the brain and periphery of rats with thioacetamide-induced acute liver failure: Modulation by histidine.

scientific article published on 15 December 2014

The effect of acute and repeated hyperammonemia on gamma-glutamyl transpeptidase in homogenates and capillaries of various rat brain regions.

scientific article

The effect of ammonia and pH on brain gamma-glutamyl transpeptidase in young rats

scientific article published on April 6, 1992

The glutamatergic synapse in Aghia pelagia: the spirit of Wierzba moves south

scientific article published on 26 June 2012

The role of inhibitory amino acidergic neurotransmission in hepatic encephalopathy: a critical overview.

scientific article

The role of protein kinase C and cyclic AMP in the ammonia-induced shift of the taurine uptake/efflux balance towards efflux in C6 cells.

scientific article published on March 2005

The role of sulfhydryl groups and calcium in the mercuric chloride-induced inhibition of glutamate uptake in rat primary astrocyte cultures.

scientific article

The two catalytic components of the 2-oxoglutarate dehydrogenase complex in rat cerebral synaptic and nonsynaptic mitochondria: comparison of the response to in vitro treatment with ammonia, hyperammonemia, and hepatic encephalopathy.

scientific article published in February 1993

Transfection of a human glioblastoma cell line with liver-type glutaminase (LGA) down-regulates the expression of DNA-repair gene MGMT and sensitizes the cells to alkylating agents

scientific article

Transfection with GLS2 Glutaminase (GAB) Sensitizes Human Glioblastoma Cell Lines to Oxidative Stress by a Common Mechanism Involving Suppression of the PI3K/AKT Pathway

scientific article published on 19 January 2019

Transfection with liver-type glutaminase cDNA alters gene expression and reduces survival, migration and proliferation of T98G glioma cells.

scientific article

Two modes of stimulation by ammonia of taurine release from cultured rabbit Müller cells ⬇️

scientific article published on August 1, 1997

Two-stage transjugular intrahepatic porta-systemic shunt for patients with cirrhosis and a high risk of portal-systemic encephalopathy patients as a bridge to orthotopic liver transplantation: a preliminary report

scientific article published on 01 January 2006

Ultrastructural evidence that mercuric chloride lowers the threshold for glutamate neurotoxicity in an organotypic culture of rat cerebellum

scientific article published on 01 August 1993

Upregulation of cerebral cortical glutathione synthesis by ammonia in vivo and in cultured glial cells: the role of cystine uptake

scientific article published on 18 January 2007

Upregulation of the heteromeric y⁺LAT2 transporter contributes to ammonia-induced increase of arginine uptake in rat cerebral cortical astrocytes.

scientific article published on 27 February 2012

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