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List of works by Brian West

A method for isolation of intact, translationally active ribonucleic acid.

scientific article

A structural role for hormone in the thyroid hormone receptor.

scientific article published in December 1995

Activities in Pit-1 Determine Whether Receptor Interacting Protein 140 Activates or Inhibits Pit-1/Nuclear Receptor Transcriptional Synergy ⬇️

scientific article published on August 1, 1997

Antipsychotic Drugs Inhibit Prolactin Release from Rat Anterior Pituitary Cells in Culture by a Mechanism Not Involving the Dopamine Receptor* ⬇️

scientific article published on April 1, 1979

CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy

scientific article

CSF1/CSF1R blockade reprograms tumor-infiltrating macrophages and improves response to T-cell checkpoint immunotherapy in pancreatic cancer models.

scientific article

Characterizing newly repopulated microglia in the adult mouse: impacts on animal behavior, cell morphology, and neuroinflammation.

scientific article

Colony stimulating factor 1 receptor inhibition delays recurrence of glioblastoma after radiation by altering myeloid cell recruitment and polarization

scientific article published on 3 November 2015

Colony-Stimulating Factor 1 Receptor Antagonists Sensitize Human Immunodeficiency Virus Type 1-Infected Macrophages to TRAIL-Mediated Killing

scientific article published on 27 April 2016

Colony-stimulating factor 1 receptor inhibition prevents microglial plaque association and improves cognition in 3xTg-AD mice

scientific article published in August 2015

Colony-stimulating factor 1 receptor signaling is necessary for microglia viability, unmasking a microglia progenitor cell in the adult brain.

scientific article

Creatine kinase protein sequence encoded by a cDNA made from Torpedo californica electric organ mRNA.

scientific article

Dynamic microglial modulation of spatial learning and social behavior

scientific article published on 5 September 2015

ERbeta Binds N-CoR in the Presence of Estrogens via an LXXLL-like Motif in the N-CoR C-terminus

scientific article

Effects of estradiol on prolactin production and dihydroergocryptine-induced inhibition of prolactin production in primary cultures of rat pituitary cells

scientific article published on 01 April 1980

Eliminating microglia in Alzheimer's mice prevents neuronal loss without modulating amyloid-β pathology.

scientific article

Elimination of Microglia Improves Functional Outcomes Following Extensive Neuronal Loss in the Hippocampus.

scientific article

Elimination of microglia improves cognitive function following cranial irradiation

scientific article published on 12 August 2016

Eukaryotic regulatory elements lurking in plasmid DNA: the activator protein-1 site in pUC.

scientific article published on April 1994

Expression of the rat alpha 1 thyroid hormone receptor ligand binding domain in Escherichia coli and the use of a ligand-induced conformation change as a method for its purification to homogeneity.

scientific article

Hormone-Dependent Coactivator Binding to a Hydrophobic Cleft on Nuclear Receptors ⬇️

scientific article published on June 12, 1998

Identification of a tumor necrosis factor-responsive element in the tumor necrosis factor alpha gene ⬇️

scientific article published on May 25, 1991

Identification of the putative MAP kinase docking site in the thyroid hormone receptor-beta1 DNA-binding domain: functional consequences of mutations at the docking site.

scientific article

Inhibition of CSF-1R supports T-cell mediated melanoma therapy

scientific article

Inhibition of colony stimulating factor-1 receptor abrogates microenvironment-mediated therapeutic resistance in gliomas.

scientific article published on 31 July 2017

Interaction of a tissue-specific factor with an essential rat growth hormone gene promoter element.

scientific article published on March 1987

Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy

scientific article (publication date: June 2011)

Macrophage Depletion Ameliorates Peripheral Neuropathy in Aging Mice.

scientific article

Mechanisms of thyroid hormone action: insights from X-ray crystallographic and functional studies.

scientific article published in January 1998

Microglia control the spread of neurotropic virus infection via P2Y12 signalling and recruit monocytes through P2Y12-independent mechanisms

Microglia protect against brain injury and their selective elimination dysregulates neuronal network activity after stroke.

scientific article

Microglial Stimulation of Glioblastoma Invasion Involves Epidermal Growth Factor Receptor (EGFR) and Colony Stimulating Factor 1 Receptor (CSF-1R) Signaling ⬇️

scientific article published on May 9, 2012

Microglial depletion and activation: A [11C]PBR28 PET study in nonhuman primates.

scientific article

Microglial repopulation resolves inflammation and promotes brain recovery after injury.

scientific article published on 2 March 2017

Molecular and structural biology of thyroid hormone receptors.

scientific article

Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.

scientific article published on August 1997

Orally administered colony stimulating factor 1 receptor inhibitor PLX3397 in recurrent glioblastoma: an Ivy Foundation Early Phase Clinical Trials Consortium phase II study

scientific article published on 8 October 2015

Proximal recolonization by self-renewing microglia re-establishes microglial homeostasis in the adult mouse brain

scientific article published on 08 February 2019

Removal of a proteolytic activity associated with aggregates formed from expression of creatine kinase in Escherichia coli leads to improved recovery of active enzyme

scientific article published on October 1, 1990

Resolution by diagonal gel mobility shift assays of multisubunit complexes binding to a functionally important element of the rat growth hormone gene promoter.

scientific article published in August 1990

Selective modulation of thyroid hormone receptor action.

scientific article published in January 2001

Structure-based design and synthesis of a thyroid hormone receptor (TR) antagonist.

scientific article published on February 2002

Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model

scientific article published on 21 August 2019

Synergistic activation of the rat growth hormone promoter by Pit-1 and the thyroid hormone receptor

scientific article published on April 1, 1992

Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain.

scientific article

Targeting the colony stimulating factor 1 receptor alleviates two forms of Charcot-Marie-Tooth disease in mice

scientific article published on 21 August 2015

Targeting tumor-infiltrating macrophages decreases tumor-initiating cells, relieves immunosuppression, and improves chemotherapeutic responses

scientific article published on 5 December 2012

The core promoter region of the tumor necrosis factor alpha gene confers phorbol ester responsiveness to upstream transcriptional activators.

scientific article published on March 1992

The nuclear receptor corepressor (N-CoR) contains three isoleucine motifs (I/LXXII) that serve as receptor interaction domains (IDs).

scientific article

Therapeutic Peptide Vaccine-Induced CD8 T Cells Strongly Modulate Intratumoral Macrophages Required for Tumor Regression.

scientific article published on 17 April 2015

Thyroid hormone alters in vitro DNA binding of monomers and dimers of thyroid hormone receptors

scientific article published on July 1, 1992

Two resistance to thyroid hormone mutants with impaired hormone binding

scientific article

X-ray crystallographic and functional studies of thyroid hormone receptor ⬇️

scientific article published on April 1, 1998

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