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List of works by R A Santos

A hypothesis regarding the function of angiotensin peptides in the brain.

scientific article published on January 1988

A potent vasoactive cytolysin isolated from Scorpaena plumieri scorpionfish venom.

scientific article published on 20 May 2010

ACE2 is augmented in dystrophic skeletal muscle and plays a role in decreasing associated fibrosis.

scientific article

ACE2–angiotensin-(1–7)–Mas axis in renal ischaemia/reperfusion injury in rats

scientific article published on 23 July 2010

AVE 0991, a non-peptide mimic of angiotensin-(1-7) effects, attenuates pulmonary remodelling in a model of chronic asthma.

scientific article published on October 2013

AVE 0991, a non‐peptide Mas‐receptor agonist, facilitates penile erection ⬇️

scientific article published on October 5, 2012

Activation of angiotensin-(1-7)/Mas axis in the brain lowers blood pressure and attenuates cardiac remodeling in hypertensive transgenic (mRen2)27 rats.

scientific article published on 14 May 2015

Alamandine acts via MrgD to induce AMPK/NO activation against Ang II hypertrophy in cardiomyocytes

scientific article published on 14 February 2018

Alamandine enhances cardiomyocyte contractility in hypertensive rats through a nitric oxide-dependent activation of CaMKII

scientific article published on 08 January 2020

Alamandine: a new member of the angiotensin family

scientific article published on March 2014

Alterations in gene expression in the testis of angiotensin-(1-7)-receptor Mas-deficient mice.

scientific article published on 28 December 2006

Altered renal response to acute volume expansion in transgenic rats harboring the human tissue kallikrein gene.

scientific article published in January 2005

An increased arginase activity is associated with corpus cavernosum impairment induced by hypercholesterolemia.

scientific article published on 25 February 2014

An oral formulation of angiotensin-(1-7) produces cardioprotective effects in infarcted and isoproterenol-treated rats

scientific article published on 31 January 2011

An oral formulation of angiotensin-(1-7) reverses corpus cavernosum damages induced by hypercholesterolemia.

scientific article

Ang-(1-7) activates the NO/cGMP and ATP-sensitive K+ channels pathway to induce peripheral antinociception in rats.

scientific article published on 17 December 2013

Angiotensin (1-7) and its receptor Mas are expressed in the human testis: implications for male infertility.

scientific article published in February 2010

Angiotensin (1-7) induces MAS receptor internalization.

scientific article published on 13 June 2011

Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice.

scientific article

Angiotensin II type 1 receptor blockade restores angiotensin-(1-7)-induced coronary vasodilation in hypertrophic rat hearts

scientific journal article

Angiotensin type 2 receptor (AT2R) and receptor Mas: a complex liaison

scientific article

Angiotensin(1-7) Blunts Hypertensive Cardiac Remodeling by a Direct Effect on the Heart

scientific article published on 09 October 2008

Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle

scientific article published on 08 December 2020

Angiotensin-(1-7) activates a tyrosine phosphatase and inhibits glucose-induced signalling in proximal tubular cells.

scientific article published on 14 January 2009

Angiotensin-(1-7) and Alamandine Promote Anti-inflammatory Response in Macrophages and

scientific article published on 21 February 2019

Angiotensin-(1-7) attenuates airway remodelling and hyperresponsiveness in a model of chronic allergic lung inflammation

scientific article

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas ⬇️

scientific article published on 5 February 2016

Angiotensin-(1-7) attenuates the anxiety and depression-like behaviors in transgenic rats with low brain angiotensinogen.

scientific article published on 7 September 2013

Angiotensin-(1-7) counterregulates angiotensin II signaling in human endothelial cells.

scientific article

Angiotensin-(1-7) in the basolateral amygdala attenuates the cardiovascular response evoked by acute emotional stress.

scientific article published on 13 November 2014

Angiotensin-(1-7) is an endogenous ligand for the G protein-coupled receptor Mas

scientific article

Angiotensin-(1-7) is involved in the endothelium-dependent modulation of phenylephrine-induced contraction in the aorta of mRen-2 transgenic rats

scientific article

Angiotensin-(1-7) prevents T3-induced cardiomyocyte hypertrophy by upregulating FOXO3/SOD1/catalase and downregulating NF-ĸB

scientific article published on 23 September 2020

Angiotensin-(1-7) prevents cardiomyocyte pathological remodeling through a nitric oxide/guanosine 3',5'-cyclic monophosphate-dependent pathway.

scientific article

Angiotensin-(1-7) receptor Mas is an essential modulator of extracellular matrix protein expression in the heart.

scientific article published on 26 January 2012

Angiotensin-(1-7) regulates the levels of angiotensin II receptor subtype AT1 mRNA differentially in a strain-specific fashion

scientific article published on 01 November 2000

Angiotensin-(1-7) through Mas receptor activation induces peripheral antinociception by interaction with adrenoreceptors

scientific article published on 17 April 2015

Angiotensin-(1-7), its receptor Mas, and the angiotensin-converting enzyme type 2 are expressed in the human ovary.

scientific article

Angiotensin-(1-7)-Mediated Signaling in Cardiomyocytes ⬇️

scientific article published on March 4, 2012

Angiotensin-(1-7).

scientific article published on 24 March 2014

Angiotensin-(1-7)/Mas axis modulates fear memory and extinction in mice.

scientific article

Angiotensin-(1-7)/angiotensin-converting enzyme 2/mas receptor axis and related mechanisms.

scientific article published on 9 April 2012

Angiotensin-(1-7): a novel peptide in the ovary.

scientific article published in May 2003

Angiotensin-(1-7): an update.

scientific article

Angiotensin-(1-7): beyond the cardio-renal actions.

scientific article published on April 2013

Angiotensin-(1-7): blood, heart, and blood vessels.

scientific article

Angiotensin-(1–7) Induces Peripheral Antinociception through Mas Receptor Activation in an Opioid-Independent Pathway ⬇️

scientific article published on March 12, 2012

Angiotensin-converting enzyme 2 activation improves endothelial function

scientific article published on 22 April 2013

Angiotensin-converting enzyme 2 activation protects against hypertension-induced cardiac fibrosis involving extracellular signal-regulated kinases ⬇️

scientific article published on December 10, 2010

Angiotensin-converting enzyme 2, angiotensin-(1-7) and Mas: new players of the renin-angiotensin system.

scientific article published on 18 January 2013

Angiotensin-converting enzyme inhibition increases glucose-induced insulin secretion in response to acute restraint

scientific article published on 01 December 2012

Angiotensins as therapeutic targets beyond heart disease.

scientific article published on 03 April 2015

Antioxidant Effects of Oral Ang-(1-7) Restore Insulin Pathway and RAS Components Ameliorating Cardiometabolic Disturbances in Rats

scientific article published on 14 July 2019

Antioxidant Solution in Combination with Angiotensin-(1-7) Provides Myocardial Protection in Langendorff-Perfused Rat Hearts

scientific article published on 30 July 2020

Are Agonistic Autoantibodies against G-Protein Coupled Receptors Involved in the Development of Long-Term Side Effects of Tumor Chemotherapy? ⬇️

scientific article published on February 21, 2013

Attenuation of isoproterenol-induced cardiac fibrosis in transgenic rats harboring an angiotensin-(1-7)-producing fusion protein in the heart.

scientific article published on 5 January 2010

Autonomic control in rats with overactivity of tissue renin-angiotensin or kallikrein-kinin system.

scientific article published in July 2005

BPP-5a produces a potent and long-lasting NO-dependent antihypertensive effect

scientific article published on 27 October 2011

Baroreflex modulation by angiotensins at the rat rostral and caudal ventrolateral medulla.

scientific article published on 23 November 2005

Behavioral effects of Bj-PRO-7a, a proline-rich oligopeptide from Bothrops jararaca venom

scientific article published on 07 November 2019

Beneficial Effects of Long-Term Administration of an Oral Formulation of Angiotensin-(1–7) in Infarcted Rats ⬇️

scientific article published on February 9, 2012

Blockade of endogenous angiotensin-(1-7) in the hypothalamic paraventricular nucleus reduces renal sympathetic tone.

scientific article published on 18 July 2005

Brain angiotensin-(1-7)/Mas axis: A new target to reduce the cardiovascular risk to emotional stress.

scientific article published on 26 October 2015

Butyrate impairs atherogenesis by reducing plaque inflammation and vulnerability and decreasing NFκB activation.

scientific article published on 25 January 2014

Cardiac ACE2/angiotensin 1-7/Mas receptor axis is activated in thyroid hormone-induced cardiac hypertrophy.

scientific article published on 28 December 2015

Cardiac and renal effects induced by different exercise workloads in renovascular hypertensive rats

scientific article published in June 2011

Cardiac angiotensin II type I and type II receptors are increased in rats submitted to experimental hypothyroidism

scientific article published on 31 May 2007

Cardioprotective effects of diminazene aceturate in pressure-overloaded rat hearts.

scientific article published on 3 May 2016

Cardiovascular and behavioral effects produced by administration of liposome-entrapped GABA into the rat central nervous system.

scientific article published on 13 November 2014

Cardiovascular effects of angiotensin A: a novel peptide of the renin-angiotensin system.

scientific article

Cardiovascular effects produced by bradykinin microinjection into the nucleus tractus solitarii of anesthetized rats.

scientific article published in May 1996

Cardiovascular effects produced by microinjection of angiotensins and angiotensin antagonists into the ventrolateral medulla of freely moving rats.

scientific article

Characterization of a new angiotensin antagonist selective for angiotensin-(1–7): Evidence that the actions of angiotensin-(1–7) are mediated by specific angiotensin receptors

article

Characterization of a new selective antagonist for angiotensin-(1-7), D-pro7-angiotensin-(1-7).

scientific article published on 20 January 2003

Chronic allergic pulmonary inflammation is aggravated in angiotensin-(1-7) Mas receptor knockout mice.

scientific article published on 4 November 2016

Chronic infusion of angiotensin-(1-7) into the lateral ventricle of the brain attenuates hypertension in DOCA-salt rats ⬇️

scientific article published on August 1, 2012

Chronic infusion of angiotensin-(1-7) reduces heart angiotensin II levels in rats.

scientific article

Chronic oral administration of Ang-(1-7) improves skeletal muscle, autonomic and locomotor phenotypes in muscular dystrophy.

scientific article

Circulating Renin Angiotensin System in Childhood Chronic Renal Failure: Marked Increase of Angiotensin-(1–7) in End-Stage Renal Disease

scientific article published on 25 October 2006

Comparative study of the action of purified scorpion toxin (tityustoxin) on the submandibular and parotid glands of the rat

scientific article published on 01 January 1981

Contribution of infralimbic cortex in the cardiovascular response to acute stress.

scientific article

Cross talk between angiotensin-(1-7)/Mas axis and sirtuins in adipose tissue and metabolism of high-fat feed mice.

scientific article published on 15 March 2014

Differential control of vasomotion by angiotensins in the rostral ventrolateral medulla of hypertensive rats.

scientific article published on 9 September 2015

Differential mechanisms of activation of the Ang peptide receptors AT1, AT2, and MAS: using in silico techniques to differentiate the three receptors

scientific article

Diminazene enhances stability of atherosclerotic plaques in ApoE-deficient mice.

scientific article published on 21 August 2015

Diminazene protects corpus cavernosum against hypercholesterolemia-induced injury.

scientific article published on 20 November 2014

Diuresis and natriuresis produced by long term administration of a selective Angiotensin-(1–7) antagonist in normotensive and hypertensive rats

scientific article published on 01 June 1998

Effect of acute volume expansion associated with salt load on the profile of plasma angiotensins in rats

scientific article published on 01 June 1996

Effect of chronic angiotensin converting enzyme inhibition on angiotensin I and bradykinin metabolism in rats

scientific article published on 01 October 1999

Effects of genetic deletion of angiotensin-(1–7) receptor Mas on cardiac function during ischemia/reperfusion in the isolated perfused mouse heart

scientific article published on 16 September 2006

Erratum for: Transforming growth factor type-β inhibits Mas receptor expression in fibroblasts but not in myoblasts or differentiated myotubes; Relevance to fibrosis associated to muscular dystrophies

scientific article published on 01 May 2015

Evidence for Heterodimerization and Functional Interaction of the Angiotensin Type 2 Receptor and the Receptor MAS.

scientific article published in May 2017

Evidence for Mas-Mediated Bradykinin Potentiation by the Angiotensin-(1-7) Nonpeptide Mimic AVE 0991 in Normotensive Rats

scientific article published in October 2007

Evidence for a new angiotensin-(1–7) receptor subtype in the aorta of Sprague–Dawley rats

article

Evidence that angiotensin-(1-7) is an intermediate of gonadotrophin-induced oocyte maturation in the rat preovulatory follicle.

scientific article published on 13 January 2012

Evidence that angiotensin-(1–7) plays a role in the central control of blood pressure at the ventro-lateral medulla acting through specific receptors

scientific article published in November 1994

Exercise training restores oxidative stress and nitric oxide synthases in the rostral ventrolateral medulla of renovascular hypertensive rats.

scientific article

GENETIC DELETION OF THE ALAMANDINE RECEPTOR MRGD LEADS TO DILATED CARDIOMYOPATHY IN MICE

scientific article published on 19 October 2018

Hemodynamic effect produced by microinjection of angiotensins at the caudal ventrolateral medulla of spontaneously hypertensive rats.

scientific article

Hemorphin and hemorphin-like peptides isolated from dog pancreas and sheep brain are able to potentiate bradykinin activity in vivo.

scientific article published on 9 August 2006

Identification of novel bradykinin-potentiating peptides (BPPs) in the venom gland of a rattlesnake allowed the evaluation of the structure-function relationship of BPPs.

scientific article

Immunocytochemical localization of angiotensin-(1-7) in the rat forebrain

scientific article published on 01 November 1988

Immunofluorescence localization of the receptor Mas in cardiovascular-related areas of the rat brain.

scientific article

Impairment of In Vitro and In Vivo Heart Function in Angiotensin-(1-7) Receptor Mas Knockout Mice

scientific article published on 27 March 2006

Increased vascular sympathetic modulation in mice with Mas receptor deficiency

scientific article published in January 2016

Increasing angiotensin-(1-7) levels in the brain attenuates metabolic syndrome-related risks in fructose-fed rats

scientific article published on 10 February 2014

Insights into cardiovascular effects of proline-rich oligopeptide (Bj-PRO-10c) revealed by structure-activity analyses: dissociation of antihypertensive and bradycardic effects.

scientific article published on 14 December 2013

Isoproterenol-induced impairment of heart function and remodeling are attenuated by the nonpeptide angiotensin-(1-7) analogue AVE 0991

scientific article published on 03 August 2007

Knockout of angiotensin 1-7 receptor Mas worsens the course of two-kidney, one-clip Goldblatt hypertension: roles of nitric oxide deficiency and enhanced vascular responsiveness to angiotensin II.

scientific article published on 10 November 2010

Lifetime overproduction of circulating Angiotensin-(1-7) attenuates deoxycorticosterone acetate-salt hypertension-induced cardiac dysfunction and remodeling.

scientific article published on 8 March 2010

Liposome-entrapped GABA modulates the expression of nNOS in NG108-15 cells

scientific article published on 11 August 2016

MAS and its related G protein-coupled receptors, Mrgprs.

scientific article published on October 2014

Mas receptor deficiency exacerbates lipopolysaccharide-induced cerebral and systemic inflammation in mice.

scientific article published on 29 July 2015

Mas receptors in modulating relaxation induced by perivascular adipose tissue.

scientific article published on 28 July 2011

Mechanisms of the anti-inflammatory actions of the angiotensin type 1 receptor antagonist losartan in experimental models of arthritis.

scientific article published on 31 May 2013

Metabolism of angiotensin I in isolated rat hearts. Effect of angiotensin converting enzyme inhibitors

scientific article published on 01 October 1995

Modifications in basal and stress-induced hypothalamic AMP-activated protein kinase (AMPK) activity in rats chronically treated with an angiotensin II receptor blocker.

scientific article

Molecular Mechanisms Involved in the Angiotensin-(1-7)/Mas Signaling Pathway in Cardiomyocytes

scientific article published on 11 August 2008

Molecular characterization and regulation of the angiotensin-converting enzyme type 2/angiotensin-(1-7)/MAS receptor axis during the ovulation process in cattle

scientific article published on 08 August 2011

Neprilysin is a Mediator of Alternative Renin-Angiotensin-System Activation in the Murine and Human Kidney

scientific article published on 21 September 2016

New components of the renin-angiotensin system: alamandine and the MAS-related G protein-coupled receptor D.

scientific article published on June 2014

New formulation of an old drug in hypertension treatment: the sustained release of captopril from cyclodextrin nanoparticles ⬇️

scientific article published on May 15, 2011

Nicotinamide phosphoribosyltransferase inhibition reduces intraplaque CXCL1 production and associated neutrophil infiltration in atherosclerotic mice

scientific article published on 7 November 2013

Nitric oxide at the CVLM is involved in the attenuation of the reflex bradycardia in renovascular hypertensive rats.

scientific article published on 14 January 2012

Nonpeptide AVE 0991 is an angiotensin-(1-7) receptor Mas agonist in the mouse kidney.

scientific article

Novel pharmaceutical composition of bradykinin potentiating penta peptide with beta-cyclodextrin: physical-chemical characterization and anti-hypertensive evaluation

scientific article published on 26 November 2006

Opposing actions of angiotensins on angiogenesis

scientific article published on 01 January 2000

Oral formulation of angiotensin-(1-7) improves lipid metabolism and prevents high-fat diet-induced hepatic steatosis and inflammation in mice.

scientific article published on 10 June 2013

Participation of AT1 and Mas receptors in the modulation of inflammatory pain

scientific article published on 26 August 2014

Pharmaceutical composition of valsartan: beta-cyclodextrin: physico-chemical characterization and anti-hypertensive evaluation.

scientific article

Pharmacological Activities and Hydrolysis by Peptidases of [Phospho-Ser(6)]-Bradykinin (pS(6)-BK).

scientific article published on 30 July 2015

Pharmacological effects of AVE 0991, a nonpeptide angiotensin-(1-7) receptor agonist

scientific article

Plasma angiotensin(1-7) immunoreactivity is increased by salt load, water deprivation, and hemorrhage

scientific article published on 01 January 1994

Potentiation of the hypotensive effect of bradykinin by angiotensin-(1–7)-related peptides

scientific article published in May 1999

Pressor action of angiotensin I at the ventrolateral medulla: effect of selective angiotensin blockade

scientific article published in June 1996

Recent advances in the angiotensin-converting enzyme 2-angiotensin(1-7)-Mas axis.

scientific article published on 29 February 2008

Receptor MAS protects mice against hypothermia and mortality induced by endotoxemia.

scientific article published in April 2014

Renal Effects and Underlying Molecular Mechanisms of Long-Term Salt Content Diets in Spontaneously Hypertensive Rats

scientific article published on 23 October 2015

Renoprotective Effects of AVE0991, a Nonpeptide Mas Receptor Agonist, in Experimental Acute Renal Injury.

scientific article published on 29 January 2012

Restoration of muscle strength in dystrophic muscle by angiotensin-1-7 through inhibition of TGF-β signalling

scientific article published on 24 October 2013

Role of PGI2 and effects of ACE inhibition on the bradykinin potentiation by angiotensin-(1-7) in resistance vessels of SHR.

scientific article

Role of renin-angiotensin system in inflammation, immunity and aging.

scientific article published on January 2012

Short-term cardiovascular physical programme ameliorates arterial stiffness and decreases oxidative stress in women with metabolic syndrome.

scientific article published in June 2013

Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters.

scientific article published on 10 March 2015

Structural libraries of protein models for multiple species to understand evolution of the renin-angiotensin system

scientific article

Structure-based identification of small-molecule angiotensin-converting enzyme 2 activators as novel antihypertensive agents.

scientific article

Structure-function studies of Tityus serrulatus Hypotensin-I (TsHpt-I): A new agonist of B(2) kinin receptor

scientific article published on 22 April 2010

Study of angiotensin-(1-7) vasoactive peptide and its beta-cyclodextrin inclusion complexes: complete sequence-specific NMR assignments and structural studies

scientific article

Supramolecular interactions between losartan and hydroxypropyl-β-CD: ESI mass-spectrometry, NMR techniques, phase solubility, isothermal titration calorimetry and anti-hypertensive studies ⬇️

scientific article published on November 17, 2010

Synergistic effect of angiotensin-(1-7) on bradykinin arteriolar dilation in vivo

scientific article published on 01 January 1999

The activation of the cannabinoid receptor type 2 reduces neutrophilic protease-mediated vulnerability in atherosclerotic plaques.

scientific article

The angiotensin type 2 receptor and the kidney

scientific article published on 27 October 2016

The angiotensin-(1-7)/Mas receptor axis is expressed in sinoatrial node cells of rats.

scientific article published on 23 May 2011

The cardiac expression of Mas receptor is responsive to different physiological and pathological stimuli.

scientific article published on 6 April 2012

The effect of angiotensin-converting enzyme inhibition throughout a superovulation protocol in ewes

scientific article published on 26 October 2015

The endothelium-dependent vasodilator effect of the nonpeptide Ang(1-7) mimic AVE 0991 is abolished in the aorta of mas-knockout mice.

scientific article published in September 2005

The nonpeptide angiotensin-(1-7) receptor Mas agonist AVE-0991 attenuates heart failure induced by myocardial infarction

scientific article published on 20 October 2006

The novel Mas agonist, CGEN-856S, attenuates isoproterenol-induced cardiac remodeling and myocardial infarction injury in rats.

scientific article

The pressor effect of angiotensin-(1-7) in the rat rostral ventrolateral medulla involves multiple peripheral mechanisms.

scientific article published on January 2013

The renin angiotensin system in childhood hypertension: selective increase of angiotensin-(1-7) in essential hypertension.

scientific article published in July 2004

The renin-angiotensin system: going beyond the classical paradigms

scientific article published on 01 February 2019

Therapeutic uses for Angiotensin-(1-7).

scientific article published on 28 April 2016

Time-course effects of aerobic exercise training on cardiovascular and renal parameters in 2K1C renovascular hypertensive rats.

scientific article published on 11 August 2015

Time-resolved quantitative phosphoproteomics: new insights into Angiotensin-(1-7) signaling networks in human endothelial cells.

scientific article

Tissue specific localization of angiotensin-(1-7) and its receptor Mas in the uterus of ovariectomized rats

scientific article published on 09 June 2012

Tityus serrulatus Hypotensins: a new family of peptides from scorpion venom.

scientific article

Transgenic angiotensin-converting enzyme 2 overexpression in vessels of SHRSP rats reduces blood pressure and improves endothelial function.

scientific article published on 22 September 2008

Treatment with Angiotensin-(1–7) reduces inflammation in carotid atherosclerotic plaques

scientific article published on 06 February 2014

Vascular Relaxation, Antihypertensive Effect, and Cardioprotection of a Novel Peptide Agonist of the Mas Receptor

scientific article published on 17 May 2010

Vasodilator effect of angiotensin-(1-7) in mature and sponge-induced neovasculature.

scientific article

Vasopressinergic hypothalamic neurons are recruited during the audiogenic seizure of WARs.

scientific article published on March 2005

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