Search filters

List of works by Bishr Omary

"Heads and tails" of intermediate filament phosphorylation: multiple sites and functional insights.

scientific article published on 19 June 2006

"IF-pathies": a broad spectrum of intermediate filament-associated diseases.

scientific article published on July 2009

"Toxic memory" via chaperone modification is a potential mechanism for rapid Mallory-Denk body reinduction.

scientific article published in September 2008

A conserved rod domain phosphotyrosine that is targeted by the phosphatase PTP1B promotes keratin 8 protein insolubility and filament organization

scientific article published on 03 September 2013

A disease- and phosphorylation-related nonmechanical function for keratin 8.

scientific article

A multi-journal partnership to highlight joint first-authors of manuscripts

scientific article published on 01 February 2015

A multi-journal partnership to highlight joint first-authors of manuscripts

article by Bishr Omary et al published 1 February 2015 in Gut

A multi-journal partnership to highlight joint first-authors of manuscripts

scientific article published in February 2015

A multi-journal partnership to highlight joint first-authors of manuscripts

article by Bishr Omary et al published 1 February 2015 in Gastroenterology

A multi-journal partnership to highlight joint first-authors of manuscripts

article by Bishr Omary et al published 1 February 2015 in Gastrointestinal Endoscopy

A mutation of keratin 18 within the coil 1A consensus motif causes widespread keratin aggregation but cell type-restricted lethality in mice

scientific article published on 25 May 2007

A precursor-inducible zebrafish model of acute protoporphyria with hepatic protein aggregation and multiorganelle stress

scientific article published on 2 February 2016

A tyrosine sulfated human glycoprotein with an unusual cell distribution ⬇️

scientific article published on January 1, 1992

Absence of keratin 19 in mice causes skeletal myopathy with mitochondrial and sarcolemmal reorganization.

scientific article published on 30 October 2007

Absence of keratin 8 confers a paradoxical microflora-dependent resistance to apoptosis in the colon.

scientific article

Absence of keratin 8 or 18 promotes antimitochondrial autoantibody formation in aging male mice

scientific article

Absence of keratins 8 and 18 in rodent epithelial cell lines associates with keratin gene mutation and DNA methylation: Cell line selective effects on cell invasion

scientific article

Acknowledging joint first authors of published work: the time has come

scientific article published on 18 August 2012

Aggregation and loss of cytokeratin filament networks inhibit golgi organization in liver-derived epithelial cell lines.

scientific article published on January 2004

Ambient Light Promotes Selective Subcellular Proteotoxicity after Endogenous and Exogenous Porphyrinogenic Stress

scientific article

An OLTAM system for analysis of brown/beige fat thermogenic activity

scientific article

An in vitro model of epithelial cell growth stimulation in the rodent mammary gland

scientific article published on August 2003

Apoptosis Generates Stable Fragments of Human Type I Keratins ⬇️

scientific article published on December 26, 1997

Assays for Posttranslational Modifications of Intermediate Filament Proteins

scientific article published on 6 November 2015

Association of glucose-regulated protein (grp78) with human keratin 8.

scientific article published in November 1997

Autophagy activation by rapamycin eliminates mouse Mallory-Denk bodies and blocks their proteasome inhibitor-mediated formation.

scientific article

Autophagy modulates keratin-containing inclusion formation and apoptosis in cell culture in a context-dependent fashion.

scientific article

Biochemical and morphological differentiation of the human colonic epithelial cell line SW620 in the presence of dimethylsulfoxide

scientific article published on March 1, 1992

Carbamoyl phosphate synthetase-1 is a rapid turnover biomarker in mouse and human acute liver injury

scientific article published on 12 June 2014

Cell biology to disease and back

scientific article published on 02 December 2015

Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments.

scientific article

Characterization of in vivo keratin 19 phosphorylation on tyrosine-391

scientific article

Characterization of the major physiologic phosphorylation site of human keratin 19 and its role in filament organization.

scientific article

Chemistry and biology of dihydroisoxazole derivatives: selective inhibitors of human transglutaminase 2.

scientific article

Clusterin and Pycr1 alterations associate with strain and model differences in susceptibility to experimental pancreatitis.

scientific article published on 7 December 2016

Cytoskeletal keratin glycosylation protects epithelial tissue from injury.

scientific article published on 22 August 2010

Disturbances in hepatic cell-cycle regulation in mice with assembly-deficient keratins 8/18

scientific article published on 01 December 2001

E4BP4 is an insulin-induced stabilizer of nuclear SREBP-1c and promotes SREBP-1c-mediated lipogenesis.

scientific article published on June 2016

Effect of mutation and phosphorylation of type I keratins on their caspase-mediated degradation.

scientific article published on 16 May 2001

Effect of sulindac on sporadic colonic polyps.

scientific article

Enhancing career development of postdoctoral trainees: act locally and beyond

scientific article published on 31 March 2019

Epidemiology of alcohol-related liver and pancreatic disease in the United States.

scientific article published in March 2008

Ethanol and Acetaminophen Synergistically Induce Hepatic Aggregation and TCH346-Insensitive Nuclear Translocation of GAPDH

scientific article

Expression of human immunodeficiency virus-1 in human colonic cells.

scientific article published in January 1991

Expression of multiple isoenzymes of protein kinase C in airway smooth muscle

scientific article published on 01 September 1995

Fibrinogen-γ proteolysis and solubility dynamics during apoptotic mouse liver injury: heparin prevents and treats liver damage.

scientific article

Functional analysis of the human papillomavirus type 16 E1=E4 protein provides a mechanism for in vivo and in vitro keratin filament reorganization.

scientific article published on January 2004

Gastroenterology 2011-2016: Looking Back and Forward

scientific article published on 01 June 2016

Glucose and SIRT2 reciprocally mediate the regulation of keratin 8 by lysine acetylation.

scientific article published on 28 January 2013

HIF1-alpha Regulates Acinar Cell Function and Response to Injury in Mouse Pancreas.

scientific article published on 31 January 2018

Heme oxygenase-1 is induced in peripheral blood mononuclear cells of patients with acute pancreatitis: a potential therapeutic target

scientific article

Hemin-activated macrophages home to the pancreas and protect from acute pancreatitis via heme oxygenase-1 induction

scientific article

Hepatic NF-kB-inducing kinase (NIK) suppresses mouse liver regeneration in acute and chronic liver diseases

scientific article published on 02 August 2018

Hepatocyte-Specific Deletion of Mouse Lamin A/C Leads to Male-Selective Steatohepatitis

scientific article published on 6 July 2017

High-Throughput Screening for Drugs that Modulate Intermediate Filament Proteins

scientific article published on 19 November 2015

Human Ran cysteine 112 oxidation by pervanadate regulates its binding to keratins.

scientific article published on 3 February 2005

Human cell surface glycoprotein related to cell proliferation is the receptor for transferrin ⬇️

scientific article published on May 1, 1981

Human cell-surface glycoprotein with unusual properties.

scientific article published on August 1980

Human homologue of murine T200 glycoprotein.

scientific article

Human keratin 8 variants promote mouse acetaminophen hepatotoxicity coupled with c-jun amino-terminal kinase activation and protein adduct formation.

scientific article

Hyposmotic stress induces cell growth arrest via proteasome activation and cyclin/cyclin-dependent kinase degradation.

scientific article published on 15 March 2002

Identification of a keratin-associated protein that localizes to a membrane compartment

scientific article published on March 1994

Identification of the major physiologic phosphorylation site of human keratin 18: potential kinases and a role in filament reorganization ⬇️

scientific article published on October 1, 1994

Increased co-first authorships in biomedical and clinical publications: a call for recognition.

scientific article

Interferon-alpha induces nmi-IFP35 heterodimeric complex formation that is affected by the phosphorylation of IFP35

scientific article

Intermediate filament proteins of digestive organs: physiology and pathophysiology

scientific article published on 30 March 2017

Keratin 18 overexpression but not phosphorylation or filament organization blocks mouse Mallory body formation

scientific article published on 01 January 2007

Keratin 20 helps maintain intermediate filament organization in intestinal epithelia

scientific article

Keratin 20 serine 13 phosphorylation is a stress and intestinal goblet cell marker

scientific article

Keratin 8 absence down-regulates colonocyte HMGCS2 and modulates colonic ketogenesis and energy metabolism.

scientific article published on 22 April 2015

Keratin 8 and 18 hyperphosphorylation is a marker of progression of human liver disease

scientific article published on 01 August 2004

Keratin 8 and 18 mutations are risk factors for developing liver disease of multiple etiologies.

scientific article

Keratin 8 modulates β-cell stress responses and normoglycaemia

scientific article

Keratin 8 phosphorylation by p38 kinase regulates cellular keratin filament reorganization: modulation by a keratin 1-like disease causing mutation

scientific article (publication date: 29 March 2002)

Keratin 8 phosphorylation by protein kinase C delta regulates shear stress-mediated disassembly of keratin intermediate filaments in alveolar epithelial cells

scientific journal article

Keratin 8 phosphorylation regulates its transamidation and hepatocyte Mallory‐Denk body formation ⬇️

scientific article published on February 23, 2012

Keratin 8 phosphorylation regulates keratin reorganization and migration of epithelial tumor cells ⬇️

scientific article published on February 17, 2012

Keratin 8/18 breakdown and reorganization during apoptosis.

scientific article published on July 2004

Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression

scientific article

Keratin hypersumoylation alters filament dynamics and is a marker for human liver disease and keratin mutation.

scientific article

Keratin impact on PKCδ- and ASMase-mediated regulation of hepatocyte lipid raft size - implication for FasR-associated apoptosis.

scientific article

Keratin mutation in transgenic mice predisposes to Fas but not TNF-induced apoptosis and massive liver injury.

scientific article published in May 2003

Keratin mutation predisposes to mouse liver fibrosis and unmasks differential effects of the carbon tetrachloride and thioacetamide models.

scientific article published on 18 January 2008

Keratin mutation primes mouse liver to oxidative injury.

scientific article

Keratin overexpression levels correlate with the extent of spontaneous pancreatic injury.

scientific article published on 18 March 2008

Keratin variants associate with progression of fibrosis during chronic hepatitis C infection

scientific article published on 01 June 2006

Keratin variants predispose to acute liver failure and adverse outcome: race and ethnic associations.

scientific article published on 9 June 2010

Keratin-8 null mice have different gallbladder and liver susceptibility to lithogenic diet-induced injury

scientific journal article

Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment

scientific article published on 19 April 2005

Keratin-containing inclusions affect cell morphology and distribution of cytosolic cellular components.

scientific article published on 21 January 2005

Keratins let liver live: Mutations predispose to liver disease and crosslinking generates Mallory-Denk bodies.

scientific article published on November 2007

Keratins turn over by ubiquitination in a phosphorylation-modulated fashion

scientific article

Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver.

scientific article published on 8 February 2016

Lamin A/C Maintains Exocrine Pancreas Homeostasis by Regulating Stability of RB and Activity of E2F.

scientific article published on 20 January 2018

Lamin aggregation is an early sensor of porphyria-induced liver injury

scientific article published on 02 May 2013

Lamins and Lamin-Associated Proteins in Gastrointestinal Health and Disease.

scientific article

Lipogenic transcription factor ChREBP mediates fructose-induced metabolic adaptations to prevent hepatotoxicity.

scientific article published on 19 June 2017

Loss of hepatocyte β-Catenin protects mice from experimental porphyria-associated liver injury

scientific article published on 01 October 2018

Mallory-Denk bodies are associated with outcomes and histologic features in patients with chronic hepatitis C.

scientific article

Mentoring: A Necessary But Not Sufficient Ingredient for Enhancing Success

scientific article published on 3 March 2016

Method of cell handling affects leakiness of cell surface labeling and detection of intracellular keratins ⬇️

scientific article published on January 1, 1993

Modulation of cytoskeletal dynamics by mammalian nucleoside diphosphate kinase (NDPK) proteins

scientific article

Molecular complexity of leukocyte surface glycoproteins related to the macrophage differentiation antigen Mac-1.

scientific article

Monitoring of epithelial cell caspase activation via detection of durable keratin fragment formation.

scientific article published in June 2008

Mouse hepatocyte overexpression of NF-κB-inducing kinase (NIK) triggers fatal macrophage-dependent liver injury and fibrosis.

scientific article

Mutation of a major keratin phosphorylation site predisposes to hepatotoxic injury in transgenic mice

scientific article

Mutation of caspase-digestion sites in keratin 18 interferes with filament reorganization, and predisposes to hepatocyte necrosis and loss of membrane integrity.

scientific article published on 24 January 2014

Mutation of human keratin 18 in association with cryptogenic cirrhosis

scientific article

New consensus nomenclature for mammalian keratins

scientific article

Non-invasive transgenic mouse genotyping using stool analysis

scientific article published on 01 November 1999

Not All Mice Are the Same: Standardization of Animal Research Data Presentation

scientific article published on 08 April 2016

Not All Mice Are the Same: Standardization of Animal Research Data Presentation

scientific article published on 06 May 2016

Not All Mice Are the Same: Standardization of Animal Research Data Presentation.

scientific article

Not all mice are the same: Standardization of animal research data presentation

Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.

scientific article published on 13 September 2017

Organ-specific stress induces mouse pancreatic keratin overexpression in association with NF-kappaB activation.

scientific article published on April 2004

Our new President--Emmet B. Keeffe, M.D.

scientific article published in May 2004

Oxidative stress, Nrf2 and keratin up-regulation associate with Mallory-Denk body formation in mouse erythropoietic protoporphyria ⬇️

scientific article published on April 25, 2012

PKC epsilon-related kinase associates with and phosphorylates cytokeratin 8 and 18 ⬇️

scientific article published on May 1, 1992

PKC412 normalizes mutation-related keratin filament disruption and hepatic injury in mice by promoting keratin-myosin binding

scientific article published on 30 June 2015

Pancreatic HIF2α Stabilization Leads to Chronic Pancreatitis and Predisposes to Mucinous Cystic Neoplasm

scientific article

Panhematin provides a therapeutic benefit in experimental pancreatitis.

scientific article published on 15 December 2010

Pharmacologic transglutaminase inhibition attenuates drug-primed liver hypertrophy but not Mallory body formation

scientific article published on 01 April 2006

Phosphorylation of human keratin 18 serine 33 regulates binding to 14-3-3 proteins

scientific article

Phosphorylation of human keratin 8 in vivo at conserved head domain serine 23 and at epidermal growth factor-stimulated tail domain serine 431

scientific article

Post-translational modifications of intermediate filament proteins: mechanisms and functions

scientific article

Preface

Prevalence of genetic variants of keratins 8 and 18 in patients with drug-induced liver injury

scientific article published on 19 August 2015

Proteasome inhibition induces inclusion bodies associated with intermediate filaments and fragmentation of the Golgi apparatus.

scientific article published in August 2003

Protein phosphatase inhibition in normal and keratin 8/18 assembly-incompetent mouse strains supports a functional role of keratin intermediate filaments in preserving hepatocyte integrity ⬇️

scientific article published on July 1, 1998

Protein phosphatase-2A associates with and dephosphorylates keratin 8 after hyposmotic stress in a site- and cell-specific manner.

scientific article published in April 2006

Reciprocal keratin 18 Ser48 O-GlcNAcylation and Ser52 phosphorylation using peptide analysis.

scientific article published on 27 October 2006

Reply: To PMID 23729294

scientific article published on 18 June 2014

Rescue of atypical protein kinase C in epithelia by the cytoskeleton and Hsp70 family chaperones.

scientific article published on 23 June 2009

Skin care by keratins

scientific article published in Nature

Spectrum of disease associated with partial lipodystrophy: lessons from a trial cohort

scientific article published on 15 February 2017

Sphingosylphosphorylcholine regulates keratin network architecture and visco-elastic properties of human cancer cells.

scientific article published on 24 August 2003

Stress, Apoptosis, and Mitosis Induce Phosphorylation of Human Keratin 8 at Ser-73 in Tissues and Cultured Cells ⬇️

scientific article (publication date: 11 July 1997)

T200 cell surface glycoprotein of the mouse. Polymorphism defined by the Ly-5 system of alloantigens.

scientific article

The NIH, research institutions and industry: working together on a shared goal

scientific article published on 01 May 2007

The genetic background modulates susceptibility to mouse liver Mallory-Denk body formation and liver injury.

scientific article published in September 2008

The hepatic BMAL1/AKT/Lipogenesis axis protects against alcoholic liver disease via promoting PPARα pathway.

scientific article published on 13 March 2018

The hypoxia-inducible factor-C/EBPα axis controls ethanol-mediated hepcidin repression.

scientific article

The intermediate filament protein keratin 8 is a novel cytoplasmic substrate for c-Jun N-terminal kinase.

scientific article published on 7 January 2002

The sweet side of vimentin.

scientific article published on 7 March 2018

Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity

scientific article (publication date: 2013)

Transglutaminase 2 regulates mallory body inclusion formation and injury-associated liver enlargement

scientific article published on 07 February 2007

Transglutaminase cross-links Sp1-mediated transcription to ethanol-induced liver injury.

scientific article published on 21 March 2009

Tumor-selective proteotoxicity of verteporfin inhibits colon cancer progression independently of YAP1

scientific article published on 6 October 2015

Two strikes: limited NIH R55 and R56 retooling funds and abolishment of the A2 grant mechanism ⬇️

scientific article published on October 5, 2011

Type II keratins are phosphorylated on a unique motif during stress and mitosis in tissues and cultured cells.

scientific article

Types I and II Keratin Intermediate Filaments.

scientific article

Unique amino acid signatures that are evolutionarily conserved distinguish simple-type, epidermal and hair keratins

scientific article

Paulina is supported by:

About Paulina

Help