List of works - William Nigel Hunter

A Structural Rationale for N-Methylbicuculline Acting as a Promiscuous Competitive Antagonist of Inhibitory Pentameric Ligand-Gated Ion Channels

scientific article published on 20 December 2019

A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.

scientific article

A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei.

scientific article published on June 2005

A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure

scientific article

Acinetobacter baumanniiFolD ligand complexes - potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571

scientific article

Active site of trypanothione reductase. A target for rational drug design.

scientific article published on September 1992

Additional crystal forms of theE.coliclass II fructose-1,6-bisphosphate aldolase

scientific article published on 01 September 1995

An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex

scientific article

Assessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target

scientific article

Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases.

scientific article published on 27 August 2009

Biological chemistry: the making of Moco.

scientific article

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

scientific article

Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

scientific article

Crystal and molecular structure of d(CGTAGATCTACG) at 2.25 A resolution

scientific article

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

scientific article

Crystal structure of activated ModE reveals conformational changes involving both oxyanion and DNA-binding domains

scientific article (publication date: 21 February 2003)

Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major.

scientific article published on 14 May 2015

Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate ⬇️

scientific article published on May 9, 2011

Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment

scientific article

Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues

scientific article

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates

scientific article

Crystallization and X-ray diffraction measurements on recombinant molbindin, MopII, from Clostridium pasteurianum

scientific article published on 25 October 2001

Crystallization of Recombinant Crithidia fasciculata Tryparedoxin

article

Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1)

scientific article published on 01 September 1999

Crystallographic studies of DNA containing mismatches, modified and unpaired bases

scientific article published on January 1, 1992

Crystals on the cover 2014.

scientific article

Crystals on the cover 2015.

scientific article published in January 2015

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

scientific article

Do C-H...O hydrogen bonds contribute to the stability of nucleic acid base pairs?

scientific article published on 01 March 1995

Enantioselective synthesis of C3 fluoro-MEP

scientific article published on 10 November 2006

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

scientific article published on 04 September 2019

EssC: domain structures inform on the elusive translocation channel in the Type VII secretion system

scientific article

Evidence for two distinct azurins in Alcaligenes xylosoxidans (NCIMB 11015): potential electron donors to nitrite reductase.

scientific article published in August 1995

Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity

scientific article

Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains

scientific article

High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase

scientific article

High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei.

scientific article published on 5 May 2006

High-resolution structure of recombinant Trichomonas vaginalis thioredoxin.

scientific article published on 18 January 2006

High-resolution structure of the M14-type cytosolic carboxypeptidase fromBurkholderia cenocepaciarefined exploitingPDB_REDOstrategies

scientific article

High-resolution structures ofTrypanosoma bruceipteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target

scientific article

How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase

scientific article

Initiating a crystallographic study of a class II fructose-1,6-bisphosphate aldolase

scientific article published on 01 June 1992

Insight into the role of Escherichia coli MobB in molybdenum cofactor biosynthesis based on the high resolution crystal structure

scientific article (publication date: 27 June 2003)

Interactions between 2'-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues and acetylcholine-binding protein inform on potent antagonist activity against nicotinic receptors

scientific article published on 21 February 2022

Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites

scientific article (publication date: 2011)

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

scientific article

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

scientific article

Macromolecular crystallography and what it can contribute to antiparasite drug discovery

scientific article published on 25 April 2015

Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex

scientific article

Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus.

scientific article published on 20 January 2016

Mutations in POGLUT1 in Galli-Galli/Dowling-Degos disease.

scientific article published on August 2016

New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster of Serratia marcescens

scientific article

Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis

scientific article

Oxyanion binding alters conformation and quaternary structure of the c-terminal domain of the transcriptional regulator mode. Implications for molybdate-dependent regulation, signaling, storage, and transport

scientific article

Passive acquisition of ligand by the MopII molbindin from Clostridium pasteurianum: structures of apo and oxyanion-bound forms

scientific article

Pseudomonas aeruginosa 4-Amino-4-Deoxychorismate Lyase: Spatial Conservation of an Active Site Tyrosine and Classification of Two Types of Enzyme ⬇️

scientific article published on September 15, 2011

Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.

scientific article published on 4 January 2006

Reevaluation of the PPAR-β/δ Ligand Binding Domain Model Reveals Why It Exhibits the Activated Form

article

Refined structure of concanavalin A complexed with methyl alpha-D-mannopyranoside at 2.0 A resolution and comparison with the saccharide-free structure.

scientific article published in November 1994

Specificity and Mechanism ofAcinetobacter baumaniiNicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide

scientific article

Specificity and Reactivity in Menaquinone Biosynthesis: The Structure of Escherichia coli MenD (2-Succinyl-5-Enolpyruvyl-6-Hydroxy-3-Cyclohexadiene-1-Carboxylate Synthase)

scientific article

Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis

scientific article

Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism.

scientific article

Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus

scientific article

Structure of Staphylococcus aureus EsxA Suggests a Contribution to Virulence by Action as a Transport Chaperone and/or Adaptor Protein

scientific article

Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme

scientific article

Structure of ferric soybean leghemoglobin a nicotinate at 2.3 A resolution.

scientific article

Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur

scientific article

Structure ofPseudomonas aeruginosainosine 5′-monophosphate dehydrogenase ⬇️

scientific article published on February 22, 2013

Structure ofStaphylococcus aureus1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA

scientific article

Structure ofStaphylococcus aureusadenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery

scientific article

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase

scientific article

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

scientific article

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

scientific article

Structure-based ligand design and the promise held for antiprotozoan drug discovery.

scientific article published on 22 December 2008

Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.

scientific article published in September 2005

Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the

scientific article published on 28 July 2015

Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism

scientific article

Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile

scientific article

Syringyl lignin is unaltered by severe sinapyl alcohol dehydrogenase suppression in tobacco.

scientific article published on 9 December 2011

The architecture ofTrypanosoma bruceitubulin-binding cofactor B and implications for function

scientific article

The ethanolamine branch of the Kennedy pathway is essential in the bloodstream form of Trypanosoma brucei.

scientific article published on 23 June 2009

The high resolution crystal structure of recombinant Crithidia fasciculata tryparedoxin-I

scientific article

The identification of isoprenoids that bind in the intersubunit cavity of Escherichia coli 2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase by complementary biophysical methods.

scientific article published on 17 December 2004

The non-mevalonate pathway of isoprenoid precursor biosynthesis.

scientific article published on 18 April 2007

The power of three.

scientific article published on 27 November 2015

The role of Co2+in the crystallization of human SENP1 and comments on the limitations of automated refinement protocols

scientific article

The state-of-the art in macromolecular crystallization: the IYCr series concludes.

scientific article published on January 2016

The structure of Serratia marcescens Lip, a membrane-bound component of the type VI secretion system

scientific article

The structure of a Trypanosoma cruzi glucose-6-phosphate dehydrogenase reveals differences from the mammalian enzyme

scientific article

The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly

scientific article published on 21 April 2015

The thermodynamic profile and molecular interactions of a C(9)-cytisine derivative-binding acetylcholine-binding protein from Aplysia californica

scientific article published on 03 February 2020

Two crystal forms of ModE, the molybdate-dependent transcriptional regulator from Escherichia coli

scientific article published on 01 February 1999

Two high-resolution structures of the human E3 ubiquitin ligase Siah1

scientific article

List of works by William Nigel Hunter

A Structural Rationale for N-Methylbicuculline Acting as a Promiscuous Competitive Antagonist of Inhibitory Pentameric Ligand-Gated Ion Channels

A double mutation of Escherichia coli2C-methyl-D-erythritol-2,4-cyclodiphosphate synthase disrupts six hydrogen bonds with, yet fails to prevent binding of, an isoprenoid diphosphate.

A preliminary crystallographic analysis of the putative mevalonate diphosphate decarboxylase from Trypanosoma brucei.

A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure

Acinetobacter baumanniiFolD ligand complexes - potent inhibitors of folate metabolism and a re-evaluation of the structure of LY374571

Active site of trypanothione reductase. A target for rational drug design.

Additional crystal forms of theE.coliclass II fructose-1,6-bisphosphate aldolase

An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex

Assessment of Pseudomonas aeruginosa N5,N10-Methylenetetrahydrofolate Dehydrogenase - Cyclohydrolase as a Potential Antibacterial Drug Target

Biochemical characterization of the initial steps of the Kennedy pathway in Trypanosoma brucei: the ethanolamine and choline kinases.

Biological chemistry: the making of Moco.

Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity

Characterization of Staphylococcus aureus EssB, an integral membrane component of the Type VII secretion system: atomic resolution crystal structure of the cytoplasmic segment

Crystal and molecular structure of d(CGTAGATCTACG) at 2.25 A resolution

Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors

Crystal structure of activated ModE reveals conformational changes involving both oxyanion and DNA-binding domains

Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major.

Crystal structures of Burkholderia cenocepacia dihydropteroate synthase in the apo-form and complexed with the product 7,8-dihydropteroate ⬇️

Crystal structures of IspF from Plasmodium falciparum and Burkholderia cenocepacia: comparisons inform antimicrobial drug target assessment

Crystal structures of Toxoplasma gondii pterin-4a-carbinolamine dehydratase and comparisons with mammalian and parasite orthologues

Crystal structures of a bacterial 6-phosphogluconate dehydrogenase reveal aspects of specificity, mechanism and mode of inhibition by analogues of high-energy reaction intermediates

Crystallization and X-ray diffraction measurements on recombinant molbindin, MopII, from Clostridium pasteurianum

Crystallization of Recombinant Crithidia fasciculata Tryparedoxin

Crystallization of recombinant Leishmania major pteridine reductase 1 (PTR1)

Crystallographic studies of DNA containing mismatches, modified and unpaired bases

Crystals on the cover 2014.

Crystals on the cover 2015.

Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development

Do C-H...O hydrogen bonds contribute to the stability of nucleic acid base pairs?

Enantioselective synthesis of C3 fluoro-MEP

Engineering a surrogate human heteromeric α/β glycine receptor orthosteric site exploiting the structural homology and stability of acetylcholine-binding protein

EssC: domain structures inform on the elusive translocation channel in the Type VII secretion system

Evidence for two distinct azurins in Alcaligenes xylosoxidans (NCIMB 11015): potential electron donors to nitrite reductase.

Exploiting the high-resolution crystal structure of Staphylococcus aureus MenH to gain insight into enzyme activity

Heterogeneity in ess transcriptional organization and variable contribution of the Ess/Type VII protein secretion system to virulence across closely related Staphylocccus aureus strains

High resolution structure of the phosphohistidine-activated form of Escherichia coli cofactor-dependent phosphoglycerate mutase

High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei.

High-resolution structure of recombinant Trichomonas vaginalis thioredoxin.

High-resolution structure of the M14-type cytosolic carboxypeptidase fromBurkholderia cenocepaciarefined exploitingPDB_REDOstrategies

High-resolution structures ofTrypanosoma bruceipteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target

How the structure of the large subunit controls function in an oxygen-tolerant [NiFe]-hydrogenase

Initiating a crystallographic study of a class II fructose-1,6-bisphosphate aldolase

Insight into the role of Escherichia coli MobB in molybdenum cofactor biosynthesis based on the high resolution crystal structure

Interactions between 2'-fluoro-(carbamoylpyridinyl)deschloroepibatidine analogues and acetylcholine-binding protein inform on potent antagonist activity against nicotinic receptors

Isoprenoid precursor biosynthesis offers potential targets for drug discovery against diseases caused by apicomplexan parasites

IspE inhibitors identified by a combination of in silico and in vitro high-throughput screening

Leishmania trypanothione synthetase-amidase structure reveals a basis for regulation of conflicting synthetic and hydrolytic activities

Macromolecular crystallography and what it can contribute to antiparasite drug discovery

Mechanistic implications for Escherichia coli cofactor-dependent phosphoglycerate mutase based on the high-resolution crystal structure of a vanadate complex

Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus.

Mutations in POGLUT1 in Galli-Galli/Dowling-Degos disease.

New secreted toxins and immunity proteins encoded within the Type VI secretion system gene cluster of Serratia marcescens

Nucleotide substrate recognition by UDP-N-acetylglucosamine acyltransferase (LpxA) in the first step of lipid A biosynthesis

Oxyanion binding alters conformation and quaternary structure of the c-terminal domain of the transcriptional regulator mode. Implications for molybdate-dependent regulation, signaling, storage, and transport

Passive acquisition of ligand by the MopII molbindin from Clostridium pasteurianum: structures of apo and oxyanion-bound forms

Pseudomonas aeruginosa 4-Amino-4-Deoxychorismate Lyase: Spatial Conservation of an Active Site Tyrosine and Classification of Two Types of Enzyme ⬇️

Recombinant human PPAR-beta/delta ligand-binding domain is locked in an activated conformation by endogenous fatty acids.

Reevaluation of the PPAR-β/δ Ligand Binding Domain Model Reveals Why It Exhibits the Activated Form

Refined structure of concanavalin A complexed with methyl alpha-D-mannopyranoside at 2.0 A resolution and comparison with the saccharide-free structure.

Specificity and Mechanism ofAcinetobacter baumaniiNicotinamidase: Implications for Activation of the Front-Line Tuberculosis Drug Pyrazinamide

Specificity and Reactivity in Menaquinone Biosynthesis: The Structure of Escherichia coli MenD (2-Succinyl-5-Enolpyruvyl-6-Hydroxy-3-Cyclohexadiene-1-Carboxylate Synthase)

Structure and reactivity of LpxD, the N-acyltransferase of lipid A biosynthesis

Structure and reactivity of hydroxypropylphosphonic acid epoxidase in fosfomycin biosynthesis by a cation- and flavin-dependent mechanism.

Structure of Hjc, a Holliday junction resolvase, from Sulfolobus solfataricus

Structure of Staphylococcus aureus EsxA Suggests a Contribution to Virulence by Action as a Transport Chaperone and/or Adaptor Protein

Structure of Trypanosoma brucei glutathione synthetase: Domain and loop alterations in the catalytic cycle of a highly conserved enzyme

Structure of ferric soybean leghemoglobin a nicotinate at 2.3 A resolution.

Structure of the macrocycle thiostrepton solved using the anomalous dispersion contribution of sulfur

Structure ofPseudomonas aeruginosainosine 5′-monophosphate dehydrogenase ⬇️

Structure ofStaphylococcus aureus1,4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA

Structure ofStaphylococcus aureusadenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery

Structure, substrate recognition and reactivity of Leishmania major mevalonate kinase

Structure-Based Design and Synthesis of Antiparasitic Pyrrolopyrimidines Targeting Pteridine Reductase 1

Structure-Based Design of Pteridine Reductase Inhibitors Targeting African Sleeping Sickness and the Leishmaniases

Structure-based ligand design and the promise held for antiprotozoan drug discovery.

Structures of Leishmania major pteridine reductase complexes reveal the active site features important for ligand binding and to guide inhibitor design.

Structures of Pseudomonas aeruginosa β-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the

Structures of Staphylococcus aureus D-tagatose-6-phosphate kinase implicate domain motions in specificity and mechanism

Structures of bacterial kynurenine formamidase reveal a crowded binuclear zinc catalytic site primed to generate a potent nucleophile