List of works - M Scholz

"Radiobiology of Proton Therapy": Results of an international expert workshop

scientific article published on 01 June 2018

A Comparison of Kinetic Photon Cell Survival Models.

scientific article published on 20 October 2015

A model of photon cell killing based on the spatio-temporal clustering of DNA damage in higher order chromatin structures.

scientific article

A track structure model for simulation of strand breaks in plasmid DNA after heavy ion irradiation

scientific article published on 12 March 2003

Accuracy of the local effect model for the prediction of biologic effects of carbon ion beams in vitro and in vivo.

scientific article published on 20 April 2008

Acute response of pig skin to irradiation with 12C-ions or 200 kV X-rays

scientific article published on 01 January 1997

Assessment of potential advantages of relevant ions for particle therapy: a model based study.

scientific article published in February 2015

Biological intercomparison using gut crypt survivals for proton and carbon-ion beams

scientific article published on 01 January 2007

Biophysical calculation of cell survival probabilities using amorphous track structure models for heavy-ion irradiation.

scientific article published on 13 December 2007

Biophysical modeling of fragment length distributions of DNA plasmids after X and heavy-ion irradiation analyzed by atomic force microscopy

scientific article published on 01 June 2008

Carbon ion radiotherapy of human lung cancer attenuates HIF-1 signaling and acts with considerably enhanced therapeutic efficiency

scientific article published on 17 December 2013

Cell cycle delays induced by heavy ion irradiation of synchronous mammalian cells

scientific article published on 01 January 1989

Cell cycle delays induced by heavy ion irradiation of synchronous mammalian cells.

scientific article published on July 1994

Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: colocalization with proteins involved in DNA repair.

scientific article

Chromosome fragmentation after irradiation with C ions.

scientific article published in December 2004

Comments on "Formalization and theoretical analysis of the local effect model" by Beuve (radiat. Res. 172, 394-402, 2009)

scientific article published on 01 June 2010

Comments on 'Comments on "Modeling Cell Survival after Photon Irradiation Based on Double-Strand Break Clustering in Megabase Pair Chromatin Loops" by Thomas Friedrich, Marco Durante and Michael Scholz (Radiat Res 2012; 178:385-94)'

scientific article published on 01 May 2018

Comments on the paper “Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation” by A. Mairani et al., Int. J. Radiat. Biol. 89(10), 2013, 782–793

article

Comparative Risk Predictions of Second Cancers After Carbon-Ion Therapy Versus Proton Therapy

scientific article published on 16 February 2016

Comparison of biological effectiveness of carbon-ion beams in Japan and Germany.

scientific article published on April 2009

Comparison of chromosomal damage induced by X-rays and Ar ions with an LET of 1840 keV/micrometer in G1 V79 cells

scientific article published on 01 February 1996

Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells.

scientific article published on 27 May 2011

Computation of cell survival in heavy ion beams for therapy. The model and its approximation.

scientific article published in February 1997

DNA damage interactions on both nanometer and micrometer scale determine overall cellular damage

scientific article published in Scientific Reports

Design of and technical challenges involved in a framework for multicentric radiotherapy treatment planning studies.

scientific article

Direct evidence for the spatial correlation between individual particle traversals and localized CDKN1A (p21) response induced by high-LET radiation.

scientific article

Direct measurement of the 3-dimensional DNA lesion distribution induced by energetic charged particles in a mouse model tissue

scientific article

Efficient Rejoining of DNA Double-Strand Breaks despite Increased Cell-Killing Effectiveness following Spread-Out Bragg Peak Carbon-Ion Irradiation

scientific article published on 12 February 2016

Experimental investigations of the response of films to heavy-ion irradiation

scientific article published on 01 November 2001

Feasibility and toxicity of combined photon and carbon ion radiotherapy for locally advanced adenoid cystic carcinomas

scientific article published on 01 June 2003

Functional video-based analysis of 3D cardiac structures generated from human embryonic stem cells

scientific article published on 29 March 2018

Immediate localized CDKN1A (p21) radiation response after damage produced by heavy-ion tracks

scientific article published on 01 October 2000

Impact of enhancements in the local effect model (LEM) on the predicted RBE-weighted target dose distribution in carbon ion therapy.

scientific article published on 17 October 2012

Impact of fractionation and number of fields on dose homogeneity for intra-fractionally moving lung tumors using scanned carbon ion treatment.

scientific article published on 29 December 2015

Improvement of the local effect model (LEM)--implications of clustered DNA damage.

scientific article published on 12 December 2006

Induction and Processing of the Radiation-Induced Gamma-H2AX Signal and Its Link to the Underlying Pattern of DSB: A Combined Experimental and Modelling Study.

scientific article published on 11 June 2015

Integrated chromosome aberration yields determined for V79 cells after high LET radiation.

scientific article published in November 2002

Is the dose-averaged LET a reliable predictor for the relative biological effectiveness?

scientific article published on 10 January 2019

LET, track structure and models. A review.

scientific article published on January 1992

Modeling Radiation Effects of Ultrasoft X Rays on the Basis of Amorphous Track Structure

scientific article

Modeling cell survival after irradiation with Ultrasoft X rays using the giant loop binary lesion model.

scientific article published on 22 April 2014

Molecular ultrasound imaging of early vascular response in prostate tumors irradiated with carbon ions.

scientific article

New Insight into Quantitative Modeling of DNA Double-Strand Break Rejoining.

scientific article published on 25 August 2015

On the parameterization of the biological effect in a mixed radiation field.

scientific article published in October 1994

Particle species dependence of cell survival RBE: Evident and not negligible

article

Photon and carbon ion irradiation of a rat prostate carcinoma: does a higher fraction number increase the metastatic rate?

scientific article published on 20 May 2014

Physical and biological factors determining the effective proton range.

scientific article published on November 2013

Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning.

scientific article published on 21 August 2010

Radiation tolerance of the rat spinal cord after single and split doses of photons and carbon ions

scientific article published on 01 November 2003

Radiobiologic parameters and local effect model predictions for head-and-neck squamous cell carcinomas exposed to high linear energy transfer ions: in regard to Beuve et al. (Int J Radiat Oncol Biol Phys, In Press)

scientific article published on 01 September 2008

Radiobiological characterization of human tumor cell multilayers after conventional and particle irradiation.

scientific article published on June 2007

Rapid calculation of biological effects in ion radiotherapy

scientific article published on 30 March 2006

Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model

scientific article

Relative biological effectiveness of carbon ions in a rat prostate carcinoma in vivo: comparison of 1, 2, and 6 fractions

scientific article published on 06 March 2013

Response to the “Letter to the Editor” by K. H. Chadwick on our Article “A Comparison of Kinetic Photon Cell Survival Models”

Sensitivity of the Giant LOop Binary LEsion (GLOBLE) cell survival model on parameters characterising dose rate effects.

scientific article

Simulation of DSB yield for high LET radiation

scientific article published on 16 April 2015

Systematics of relative biological effectiveness measurements for proton radiation along the spread out Bragg peak: experimental validation of the local effect model

scientific article published on 10 January 2017

The impact of conventional and heavy ion irradiation on tumor cell migration in vitro.

scientific article published on November 2007

The increased biological effectiveness of heavy charged particles: from radiobiology to treatment planning.

scientific article published in October 2003

The link between cell-cycle dependent radiosensitivity and repair pathways: a model based on the local, sister-chromatid conformation dependent switch between NHEJ and HR.

scientific article

The physical and radiobiological basis of the local effect model: a response to the commentary by R. Katz

scientific article published on 01 May 2004

The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99 keV/μm

scientific article published on 09 November 2016

The relevance of very low energy ions for heavy-ion therapy

scientific article published on 13 March 2009

Track structure and the calculation of biological effects of heavy charged particles.

scientific article

Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose

scientific article published on 01 November 2000

Treatment planning for scanned ion beams.

scientific article published on December 2004

Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or (12)C heavy ions.

scientific article published on 10 June 2010

Tumor therapy and track structure.

scientific article

What is the clinically relevant relative biologic effectiveness? A warning for fractionated treatments with high linear energy transfer radiation: in regard to Daşu and Toma-DAşu. (Int J Radiat Oncol Biol Phys 2008;70:867-874)

scientific article published on 01 April 2008

List of works by M Scholz

"Radiobiology of Proton Therapy": Results of an international expert workshop

A Comparison of Kinetic Photon Cell Survival Models.

A model of photon cell killing based on the spatio-temporal clustering of DNA damage in higher order chromatin structures.

A track structure model for simulation of strand breaks in plasmid DNA after heavy ion irradiation

Accuracy of the local effect model for the prediction of biologic effects of carbon ion beams in vitro and in vivo.

Acute response of pig skin to irradiation with 12C-ions or 200 kV X-rays

Assessment of potential advantages of relevant ions for particle therapy: a model based study.

Biological intercomparison using gut crypt survivals for proton and carbon-ion beams

Biophysical calculation of cell survival probabilities using amorphous track structure models for heavy-ion irradiation.

Biophysical modeling of fragment length distributions of DNA plasmids after X and heavy-ion irradiation analyzed by atomic force microscopy

Carbon ion radiotherapy of human lung cancer attenuates HIF-1 signaling and acts with considerably enhanced therapeutic efficiency

Cell cycle delays induced by heavy ion irradiation of synchronous mammalian cells

Cell cycle delays induced by heavy ion irradiation of synchronous mammalian cells.

Characterization of CDKN1A (p21) binding to sites of heavy-ion-induced damage: colocalization with proteins involved in DNA repair.

Chromosome fragmentation after irradiation with C ions.

Comments on "Formalization and theoretical analysis of the local effect model" by Beuve (radiat. Res. 172, 394-402, 2009)

Comments on 'Comments on "Modeling Cell Survival after Photon Irradiation Based on Double-Strand Break Clustering in Megabase Pair Chromatin Loops" by Thomas Friedrich, Marco Durante and Michael Scholz (Radiat Res 2012; 178:385-94)'

Comments on the paper “Modelling of cell killing due to sparsely ionizing radiation in normoxic and hypoxic conditions and an extension to high LET radiation” by A. Mairani et al., Int. J. Radiat. Biol. 89(10), 2013, 782–793

Comparative Risk Predictions of Second Cancers After Carbon-Ion Therapy Versus Proton Therapy

Comparison of biological effectiveness of carbon-ion beams in Japan and Germany.

Comparison of chromosomal damage induced by X-rays and Ar ions with an LET of 1840 keV/micrometer in G1 V79 cells

Comparison of the effects of carbon ion and photon irradiation on the angiogenic response in human lung adenocarcinoma cells.

Computation of cell survival in heavy ion beams for therapy. The model and its approximation.

DNA damage interactions on both nanometer and micrometer scale determine overall cellular damage

Design of and technical challenges involved in a framework for multicentric radiotherapy treatment planning studies.

Direct evidence for the spatial correlation between individual particle traversals and localized CDKN1A (p21) response induced by high-LET radiation.

Direct measurement of the 3-dimensional DNA lesion distribution induced by energetic charged particles in a mouse model tissue

Efficient Rejoining of DNA Double-Strand Breaks despite Increased Cell-Killing Effectiveness following Spread-Out Bragg Peak Carbon-Ion Irradiation

Experimental investigations of the response of films to heavy-ion irradiation

Feasibility and toxicity of combined photon and carbon ion radiotherapy for locally advanced adenoid cystic carcinomas

Functional video-based analysis of 3D cardiac structures generated from human embryonic stem cells

Immediate localized CDKN1A (p21) radiation response after damage produced by heavy-ion tracks

Impact of enhancements in the local effect model (LEM) on the predicted RBE-weighted target dose distribution in carbon ion therapy.

Impact of fractionation and number of fields on dose homogeneity for intra-fractionally moving lung tumors using scanned carbon ion treatment.

Improvement of the local effect model (LEM)--implications of clustered DNA damage.

Induction and Processing of the Radiation-Induced Gamma-H2AX Signal and Its Link to the Underlying Pattern of DSB: A Combined Experimental and Modelling Study.

Integrated chromosome aberration yields determined for V79 cells after high LET radiation.

Is the dose-averaged LET a reliable predictor for the relative biological effectiveness?

LET, track structure and models. A review.

Modeling Radiation Effects of Ultrasoft X Rays on the Basis of Amorphous Track Structure

Modeling cell survival after irradiation with Ultrasoft X rays using the giant loop binary lesion model.

Molecular ultrasound imaging of early vascular response in prostate tumors irradiated with carbon ions.

New Insight into Quantitative Modeling of DNA Double-Strand Break Rejoining.

On the parameterization of the biological effect in a mixed radiation field.

Particle species dependence of cell survival RBE: Evident and not negligible

Photon and carbon ion irradiation of a rat prostate carcinoma: does a higher fraction number increase the metastatic rate?

Physical and biological factors determining the effective proton range.

Quantification of the relative biological effectiveness for ion beam radiotherapy: direct experimental comparison of proton and carbon ion beams and a novel approach for treatment planning.

Radiation tolerance of the rat spinal cord after single and split doses of photons and carbon ions

Radiobiologic parameters and local effect model predictions for head-and-neck squamous cell carcinomas exposed to high linear energy transfer ions: in regard to Beuve et al. (Int J Radiat Oncol Biol Phys, In Press)

Radiobiological characterization of human tumor cell multilayers after conventional and particle irradiation.

Rapid calculation of biological effects in ion radiotherapy

Relative biological effectiveness of carbon ions for tumor control, acute skin damage and late radiation-induced fibrosis in a mouse model

Relative biological effectiveness of carbon ions in a rat prostate carcinoma in vivo: comparison of 1, 2, and 6 fractions

Response to the “Letter to the Editor” by K. H. Chadwick on our Article “A Comparison of Kinetic Photon Cell Survival Models”

Sensitivity of the Giant LOop Binary LEsion (GLOBLE) cell survival model on parameters characterising dose rate effects.

Simulation of DSB yield for high LET radiation

Systematics of relative biological effectiveness measurements for proton radiation along the spread out Bragg peak: experimental validation of the local effect model

The impact of conventional and heavy ion irradiation on tumor cell migration in vitro.

The increased biological effectiveness of heavy charged particles: from radiobiology to treatment planning.

The link between cell-cycle dependent radiosensitivity and repair pathways: a model based on the local, sister-chromatid conformation dependent switch between NHEJ and HR.

The physical and radiobiological basis of the local effect model: a response to the commentary by R. Katz

The relative biological effectiveness of carbon ion irradiations of the rat spinal cord increases linearly with LET up to 99 keV/μm

The relevance of very low energy ions for heavy-ion therapy

Track structure and the calculation of biological effects of heavy charged particles.

Treatment planning for heavy-ion radiotherapy: calculation and optimization of biologically effective dose

Treatment planning for scanned ion beams.

Tumor cell migration is not influenced by p21 in colon carcinoma cell lines after irradiation with X-ray or (12)C heavy ions.

Tumor therapy and track structure.

What is the clinically relevant relative biologic effectiveness? A warning for fractionated treatments with high linear energy transfer radiation: in regard to Daşu and Toma-DAşu. (Int J Radiat Oncol Biol Phys 2008;70:867-874)