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List of works by David Nemazee

A VH11V kappa 9 B cell antigen receptor drives generation of CD5+ B cells both in vivo and in vitro

scientific article published on 01 May 2000

A functional B cell receptor transgene allows efficient IL-7-independent maturation of B cell precursors

scientific article published on 01 August 1997

A natural mutation between SARS-CoV-2 and SARS-CoV determines neutralization by a cross-reactive antibody

scientific article published on 21 September 2020

A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes.

scientific article published on April 2005

Aberrant wound healing and TGF-beta production in the autoimmune-prone MRL/+ mouse

scientific article published on 01 September 1999

An Engineered Antibody with Broad Protective Efficacy in Murine Models of SARS and COVID-19

scientific article published on 17 November 2020

An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system

scientific article

Analysis of central B cell tolerance in autoimmune-prone MRL/lpr mice bearing autoantibody transgenes

scientific article published on 01 July 1996

Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies.

scientific article published on January 1997

Antigen receptor 'capacity' and the sensitivity of self-tolerance.

scientific article published on January 1996

Antigen receptor selection by editing or downregulation of V(D)J recombination.

scientific article

Antigens varying in affinity for the B cell receptor induce differential B lymphocyte responses.

scientific article

Author Correction: Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

scientific article published on 07 December 2020

B cell receptor expression level determines the fate of developing B lymphocytes: receptor editing versus selection.

scientific article

B cell selection defects underlie the development of diabetogenic APCs in nonobese diabetic mice

scientific article published on April 2004

B cells are exquisitely sensitive to central tolerance and receptor editing induced by ultralow affinity, membrane-bound antigen.

scientific article

B cells expressing authentic naive human VRC01-class BCRs can be recruited to germinal centers and affinity mature in multiple independent mouse models

scientific article published on 01 September 2020

B cells from knock-in mice expressing broadly neutralizing HIV antibody b12 carry an innocuous B cell receptor responsive to HIV vaccine candidates

scientific article published on 12 August 2013

B lymphocytes from the autoimmune-prone mouse strain MLR/lpr manifest an intrinsic defect in tetraparental MRL/lpr in equilibrium DBA/2 chimeras

scientific article published on 01 October 1991

Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection.

scientific article published on May 2007

Broad neutralization of SARS-related viruses by human monoclonal antibodies

scientific article published on 15 June 2020

Cleavage of DNA and RNA by PLD3 and PLD4 limits autoinflammatory triggering by multiple sensors

scientific article published on 07 October 2021

Clonal deletion of B lymphocytes in a transgenic mouse bearing anti-MHC class I antibody genes

scientific article published in Nature

Contribution of Receptor Editing to the Antibody Repertoire

scientific article published in Science

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo

scientific article

Decoration of T-independent antigen with ligands for CD22 and Siglec-G can suppress immunity and induce B cell tolerance in vivo.

scientific article

Deletion of IgG-switched autoreactive B cells and defects in Fas(lpr) lupus mice.

scientific article published on 16 June 2010

DeltaBAFF, an alternate splice isoform that regulates receptor binding and biopresentation of the B cell survival cytokine, BAFF

scientific article

Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo.

scientific article published on 28 August 2017

Detection and activation of HIV broadly neutralizing antibody precursor B cells using anti-idiotypes

scientific article published on 25 July 2019

Developmental regulation of B lymphocyte immune tolerance compartmentalizes clonal selection from receptor selection.

scientific article published in January 1998

Distinct signal thresholds for the unique antigen receptor-linked gene expression programs in mature and immature B cells.

scientific article

Does immunological tolerance explain the waste in the B-lymphocyte immune system? Experiment and theory

scientific article published on 01 September 1995

Effect of cell:cell competition and BAFF expression on peripheral B cell tolerance and B-1 cell survival in transgenic mice expressing a low level of Igkappa-reactive macroself antigen

scientific article published on 01 April 2006

Efficient peripheral clonal elimination of B lymphocytes in MRL/lpr mice bearing autoantibody transgenes

scientific article

Engineered mice and B cell lines expressing broadly neutralizing antibodies and their unmutated precursors: tools for HIV vaccinology.

scientific article published on 13 September 2012

Enhancing antibody: a novel component of the immune response.

scientific article

FGD2, a CDC42-specific exchange factor expressed by antigen-presenting cells, localizes to early endosomes and active membrane ruffles

scientific article published on 5 December 2008

Functional immunoglobulin transgenes guide ordered B-cell differentiation in Rag-1-deficient mice

scientific article published on 01 May 1994

Generation of T-follicular helper cells in vitro: requirement for BCR cross-linking and cognate B- and T-cell interaction.

scientific article published on 7 September 2017

HIV-1 VACCINES. Priming a broadly neutralizing antibody response to HIV-1 using a germline-targeting immunogen.

scientific article

HIV-1 vaccine design through minimizing envelope metastability

article

High-Density Array of Well-Ordered HIV-1 Spikes on Synthetic Liposomal Nanoparticles Efficiently Activate B Cells.

scientific article published on 18 May 2016

Immune Tolerance Negatively Regulates B Cells in Knock-In Mice Expressing Broadly Neutralizing HIV Antibody 4E10 ⬇️

scientific article published on August 12, 2013

Immune complexes can trigger specific, T cell-dependent, autoanti-IgG antibody production in mice.

scientific article published on January 1985

Immunoglobulin transgenes in B lymphocyte development, tolerance, and autoimmunity.

scientific article

Inability of IL-2 and IL-10 to counteract B cell clonal deletion

scientific article published on 01 June 1992

Induction of rheumatoid antibodies in the mouse. Regulated production of autoantibody in the secondary humoral response ⬇️

scientific article published on August 1, 1983

Isolation of potent SARS-CoV-2 neutralizing antibodies and protection from disease in a small animal model

scientific article published on 15 June 2020

Liver-expressed Igkappa superantigen induces tolerance of polyclonal B cells by clonal deletion not kappa to lambda receptor editing.

scientific article

Maternal B lymphocytes specific for paternal histocompatibility antigens are partially deleted during pregnancy ⬇️

scientific article published on September 15, 1998

Mechanisms and meaning of B-lymphocyte tolerance.

scientific article

Mechanisms of central tolerance for B cells.

scientific article

Negative selection by IgM superantigen defines a B cell central tolerance compartment and reveals mutations allowing escape

scientific article published on 31 October 2011

PLD3 and PLD4 are single-stranded acid exonucleases that regulate endosomal nucleic-acid sensing

scientific article published on 13 August 2018

Paucity of V-D-D-J rearrangements and VH replacement events in lupus prone and nonautoimmune TdT-/- and TdT+/+ mice.

scientific article

Peripheral B cell tolerance and function in transgenic mice expressing an IgD superantigen.

scientific article

Peripheral B lymphocyte tolerance.

scientific article published in September 2004

Precursor Frequency and Affinity Determine B Cell Competitive Fitness in Germinal Centers, Tested with Germline-Targeting HIV Vaccine Immunogens

scientific article published on 26 December 2017

Presenting native-like trimeric HIV-1 antigens with self-assembling nanoparticles

scientific article published on 28 June 2016

Promotion and prevention of autoimmunity by B lymphocytes.

scientific article published on December 1993

Rational immunogen design to target specific germline B cell receptors

scientific article published on 13 September 2012

Receptor editing and commitment in B lymphocytes ⬇️

scientific article published on April 1, 1998

Receptor editing and genetic variability in human autoreactive B cells.

scientific article

Receptor editing and marginal zone B cell development are regulated by the helix-loop-helix protein, E2A

scientific article

Receptor editing in lymphocyte development and central tolerance.

scientific article

Receptor editing in self-reactive bone marrow B cells. The Journal of Experimental Medicine. 1993. 177: 1009-1020.

scientific article published on February 2011

Receptor editing occurs frequently during normal B cell development.

scientific article

Receptor editing: genetic reprogramming of autoreactive lymphocytes.

scientific article

Regulation of B-cell development and tolerance by different members of the miR-17∼92 family microRNAs

scientific article published on 02 August 2016

Regulation of the B cell receptor repertoire and self-reactivity by BAFF

scientific article published on 3 September 2010

Role of RS/kappaDE in B cell receptor editing.

scientific article published on January 2007

Role of receptor editing and revision in shaping the B and T lymphocyte repertoire.

scientific article

Self-antigen does not accelerate immature B cell apoptosis, but stimulates receptor editing as a consequence of developmental arrest.

scientific article published on August 1997

Skewed primary Igκ repertoire and V-J joining in C57BL/6 mice: implications for recombination accessibility and receptor editing.

scientific article published on 27 January 2012

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

scientific article published on 06 August 2020

Structural analysis of full-length SARS-CoV-2 spike protein from an advanced vaccine candidate

scientific article published on 20 October 2020

Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens

scientific article published on 11 August 2020

Tailored Immunogens Direct Affinity Maturation toward HIV Neutralizing Antibodies

scientific article published on September 2016

Targeting cytotoxic T cells to antigen-specific B lymphocytes

scientific article published on 01 March 1987

The Bacterial Peptidoglycan-Sensing Molecules NOD1 and NOD2 Promote CD8+ Thymocyte Selection.

scientific article published on 15 February 2017

The design and implementation of the immune epitope database and analysis resource

scientific article published on 14 May 2005

The immune epitope database and analysis resource: from vision to blueprint

scientific article

The microRNA miR-148a functions as a critical regulator of B cell tolerance and autoimmunity.

scientific article

Theoretical limits to massive receptor editing in immature B cells.

scientific article published on January 1998

Tolerance-induced receptor selection: scope, sensitivity, locus specificity, and relationship to lymphocyte-positive selection.

scientific article published on February 2004

Unexpected autoantibody production in membrane Ig-mu-deficient/lpr mice

scientific article published on 01 October 2000

V(D)J Recombination in Mature B Cells: A Mechanism for Altering Antibody Responses

scientific article

V(D)J recombinase induction in splenic B lymphocytes is inhibited by antigen-receptor signalling ⬇️

scientific article published on July 16, 1998

Vaccine elicitation of HIV broadly neutralizing antibodies from engineered B cells

scientific article published on 17 November 2020

Variable region sequences of murine IgM anti-IgG monoclonal autoantibodies (rheumatoid factors). II. Comparison of hybridomas derived by lipopolysaccharide stimulation and secondary protein immunization.

scientific article

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