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List of works by Thomas Burris

8th Annual International Conference on Obesity and Non-Insulin Dependent Diabetes Mellitus: novel drug developments.

scientific article

A 15-ketosterol is a liver X receptor ligand that suppresses sterol-responsive element binding protein-2 activity.

scientific article published on 13 January 2006

A Selective ERRα/γ Inverse Agonist, SLU-PP-1072, Inhibits the Warburg Effect and Induces Apoptosis in Prostate Cancer Cells

scientific article published on 08 September 2020

A chemical switch regulates fibrate specificity for peroxisome proliferator-activated receptor alpha (PPARalpha ) versus liver X receptor.

scientific article published on 18 November 2002

A natural product ligand of the oxysterol receptor, liver X receptor.

scientific article

A novel method for analysis of nuclear receptor function at natural promoters: peroxisome proliferator-activated receptor gamma agonist actions on aP2 gene expression detected using branched DNA messenger RNA quantitation

scientific article published on 01 March 1999

A nuclear hormone receptor-associated protein that inhibits transactivation by the thyroid hormone and retinoic acid receptors

scientific article

A role for rev-erbα ligands in regulation of adipogenesis.

scientific article published on January 2011

A selective estrogen receptor modulator for the treatment of hot flushes.

scientific article published on February 2006

A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ.

scientific article published on 4 June 2019

Action of RORs and their ligands in (patho)physiology.

scientific article

Adropin: An endocrine link between the biological clock and cholesterol homeostasis

scientific article published on 30 December 2017

Ahch, the mouse homologue of DAX1: cloning, characterization and synteny with GyK, the glycerol kinase locus.

scientific article published in October 1996

Alternative splicing within the ligand binding domain of the human constitutive androstane receptor.

scientific article published in September 2003

An alternate binding site for PPARγ ligands

scientific article published on 07 April 2014

Anti-proliferative actions of a synthetic REV-ERBα/β agonist in breast cancer cells.

scientific article published on 12 June 2015

Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.

scientific article published on 31 October 2002

Artemisia extracts activate PPARγ, promote adipogenesis, and enhance insulin sensitivity in adipose tissue of obese mice.

scientific article published on 12 March 2014

Artemisia scoparia enhances adipocyte development and endocrine function in vitro and enhances insulin action in vivo

scientific article

Benzoxazinones as PPARgamma agonists. part 1: SAR of three aromatic regions

scientific article published on 01 July 2003

Broad Anti-tumor Activity of a Small Molecule that Selectively Targets the Warburg Effect and Lipogenesis

scientific journal article

Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR)

Characterization of the Core Mammalian Clock Component, NPAS2, as a REV-ERBα/RORα Target Gene ⬇️

scientific article published on September 3, 2010

Circadian clock protein Rev-erbα regulates neuroinflammation

scientific article published on 21 February 2019

Circadian rhythm-dependent and circadian rhythm-independent impacts of the molecular clock on type 3 innate lymphoid cells

scientific article published on 01 October 2019

Clock genes, pancreatic function, and diabetes

scientific article

Clock regulation of protein secretion

scientific article published on 01 January 2020

Comparison of the forms of the dopamine D2 receptor expressed in GH4C1 cells.

scientific article published on March 1994

Correction: Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression

scientific article published on 19 May 2016

Correlation of farnesoid X receptor coactivator recruitment and cholesterol 7alpha-hydroxylase gene repression by bile acids

scientific article (publication date: December 2000)

Corrigendum to "Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain" [GENE 655 (2018) 1-12]

scientific article published on 12 June 2018

Design and synthesis of a novel series of [1-(4-hydroxy-benzyl)-1H-indol-5-yloxy]-acetic acid compounds as potent, selective, thyroid hormone receptor β agonists

scientific article published on 03 March 2015

Development of novel liver X receptor modulators based on a 1,2,4-triazole scaffold

scientific article published on 15 December 2018

Disrupting the key circadian regulator CLOCK leads to age-dependent cardiovascular disease

scientific article published on 18 February 2017

Distinct roles for REV-ERBα and REV-ERBβ in oxidative capacity and mitochondrial biogenesis in skeletal muscle.

scientific article published on 3 May 2018

Divergent transcriptional programming of class-specific B cell memory by T-bet and RORα

scientific article

Doubled lifespan and patient-like pathologies in progeria mice fed high-fat diet

scientific article published on 12 December 2018

Effects of selective estrogen receptor modulators (SERMs) on coactivator nuclear receptor (NR) box binding to estrogen receptors.

scientific article

Endothelin-3 inhibits prolactin and stimulates LH, FSH and TSH secretion from pituitary cell culture

scientific article published on 01 January 1991

Estrogen: a mitochondrial energizer that keeps on going.

scientific article

Expression of DAX-1, the gene responsible for X-linked adrenal hypoplasia congenita and hypogonadotropic hypogonadism, in the hypothalamic-pituitary-adrenal/gonadal axis

scientific article

Genetic dissection of the functions of the melanocortin-3 receptor, a seven-transmembrane G-protein-coupled receptor, suggests roles for central and peripheral receptors in energy homeostasis.

scientific article published on 7 October 2011

HIV protease inhibitors block human preadipocyte differentiation, but not via the PPARgamma/RXR heterodimer

scientific article published on 01 February 2000

Helix-stabilized cyclic peptides as selective inhibitors of steroid receptor-coactivator interactions

scientific article

Identification and characterization of noncalcemic, tissue-selective, nonsecosteroidal vitamin D receptor modulators.

scientific article

Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ.

scientific article

Identification of SR2211: a potent synthetic RORγ-selective modulator.

scientific article published on 13 February 2012

Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist

scientific article

Identification of SR8278, a synthetic antagonist of the nuclear heme receptor REV-ERB.

scientific article

Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors

scientific article

Identification of a novel selective inverse agonist probe and analogs for the Retinoic acid receptor-related Orphan Receptor Alpha (RORα)

Identification of a putative steroidogenic factor-1 response element in the DAX-1 promoter

scientific article (publication date: 14 September 1995)

Identification of adropin as a secreted factor linking dietary macronutrient intake with energy homeostasis and lipid metabolism.

scientific article published on December 2008

Infusion of dopamine at low concentrations stimulates the release of prolactin from alpha-methyl-p-tyrosine-treated rats

scientific article published on 01 May 1993

Inhibition of Hepatotoxicity by a LXR Inverse Agonist in a Model of Alcoholic Liver Disease

scientific article published on 25 July 2018

Inhibition of RORα/γ suppresses atherosclerosis via inhibition of both cholesterol absorption and inflammation

scientific article published on 25 July 2016

International Union of Basic and Clinical Pharmacology. XC. multisite pharmacology: recommendations for the nomenclature of receptor allosterism and allosteric ligands.

scientific article

Ligand and coactivator identity determines the requirement of the charge clamp for coactivation of the peroxisome proliferator-activated receptor gamma.

scientific article published on 26 December 2002

Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism.

scientific article published on January 2012

Ligand-dependent coactivation of the human bile acid receptor FXR by the peroxisome proliferator-activated receptor gamma coactivator-1alpha.

scientific article

Ligands specify coactivator nuclear receptor (NR) box affinity for estrogen receptor subtypes.

scientific article published in June 2001

Liver X receptor and retinoic X receptor mediated ABCA1 regulation and cholesterol efflux in macrophage cells-messenger RNA measured by branched DNA technology.

scientific article published on September 2002

Liver X receptor is a therapeutic target in collagen-induced arthritis

scientific article published on 01 April 2007

Liver X receptor-retinoid X receptor (LXR-RXR) heterodimer cistrome reveals coordination of LXR and AP1 signaling in keratinocytes.

scientific article published on 24 February 2011

Metabolic Characterization of a Novel RORα Knockout Mouse Model without Ataxia

scientific article

Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands

scientific article

Nuclear Receptor Subfamily 1 Group D Member 1 Regulates Circadian Activity Of NLRP3 Inflammasome to Reduce the Severity of Fulminant Hepatitis in Mice.

scientific article published on 22 December 2017

Nuclear hormone receptors for heme: REV-ERBalpha and REV-ERBbeta are ligand-regulated components of the mammalian clock.

scientific article

Nuclear receptors and their selective pharmacologic modulators

scientific article

Nuclear receptors: PPARα ligands make memories

scientific article published on 01 November 2016

Oral IL-10 suppresses colon carcinogenesis via elimination of pathogenicCD4+ T-cells and induction of antitumor CD8+ T-cell activity.

scientific article published on 20 April 2017

Panning for SNuRMs: using cofactor profiling for the rational discovery of selective nuclear receptor modulators.

scientific article

Pharmacologic Evidence that a D2 Receptor Subtype Mediates Dopaminergic Stimulation of Prolactin Secretion from the Anterior Pituitary Gland ⬇️

scientific article published on August 1, 1991

Pharmacological Targeting the REV-ERBs in Sleep/Wake Regulation

scientific article

Pharmacological activation of the nuclear receptor REV-ERB reverses cognitive deficits and reduces amyloid-β burden in a mouse model of Alzheimer's disease

scientific article published on 11 April 2019

Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression

scientific article

Pharmacological inhibition of REV-ERB stimulates differentiation, inhibits turnover and reduces fibrosis in dystrophic muscle.

scientific article published on 7 December 2017

Pharmacological targeting of the mammalian clock regulates sleep architecture and emotional behaviour

scientific article

Pharmacological targeting of the mammalian clock reveals a novel analgesic for osteoarthritis-induced pain.

scientific article published on 20 February 2018

Pharmacology of nuclear receptor-coregulator recognition.

scientific article published on January 2004

Potent inhibitors of LXXLL-based protein-protein interactions.

scientific article

Promiscuous activity of the LXR antagonist GSK2033 in a mouse model of fatty liver disease

scientific article published on 25 September 2016

REV-ERB and ROR nuclear receptors as drug targets.

scientific article

REV-ERBα ameliorates heart failure through transcription repression.

scientific article published on 7 September 2017

REV-ERBβ is Required to Maintain Normal Wakefulness and the Wake-Inducing Effect of dual REV-ERB Agonist SR9009.

scientific article published on 17 January 2018

ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes

scientific article

RORγ regulates the NLRP3 inflammasome

scientific article published on 19 November 2018

Recent Advances in the Medicinal Chemistry of Liver X Receptors

scientific article published on 30 July 2018

Reconstitution of functional nuclear receptor proteins using high pressure refolding.

scientific article

Regulation of FGF21 expression and secretion by retinoic acid receptor-related orphan receptor alpha.

scientific article

Regulation of adipogenesis by natural and synthetic REV-ERB ligands.

scientific article

Regulation of carbohydrate metabolism by the farnesoid X receptor

scientific journal article

Regulation of cholesterologenesis by the oxysterol receptor, LXRalpha.

scientific article

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

scientific article

Regulation of pyruvate dehydrogenase kinase expression by the farnesoid X receptor

scientific article (publication date: April 2005)

Relationship between circadian oscillations of Rev-erbalpha expression and intracellular levels of its ligand, heme.

scientific article published on 15 February 2008

Requirement of helix 1 and the AF-2 domain of the thyroid hormone receptor for coactivation by PGC-1

scientific article (publication date: 15 March 2002)

Restoration of the molecular clock is tumor suppressive in neuroblastoma

scientific article published on 28 June 2021

Retinoid X receptor is a nonsilent major contributor to vitamin D receptor-mediated transcriptional activation.

scientific article published on 31 July 2003

Rev-Erb co-regulates muscle regeneration via tethered interaction with the NF-Y cistrome

scientific article

Rev-erb regulation of cholesterologenesis.

scientific article published on 14 February 2017

Risk factors for self-reported visual symptoms with Intacs inserts for myopia

scientific article published on 01 January 2002

SIRT1 in the Ventromedial Hypothalamus: A Nutrient Sensor Input Into the Internal Timekeeper

scientific article published on June 2015

Segregation of Clock and Non-Clock Regulatory Functions of REV-ERB.

scientific article published on August 2015

Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erbα.

scientific article published on 08 May 2012

Structural and biophysical insights into the ligand-free Pitx2 homeodomain and a ring dermoid of the cornea inducing homeodomain mutant.

scientific article published on 6 January 2012

Structure of REV-ERB  Ligand-binding Domain Bound to a Porphyrin Antagonist

scientific article

Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA

scientific article

Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand

scientific article

Suppression of atherosclerosis by synthetic REV-ERB agonist.

scientific article published on 20 March 2015

Synthesis and SAR of tetrahydroisoquinolines as Rev-erbα agonists.

scientific article published on 13 April 2012

Targeting Th17-IL-17 Pathway in Prevention of Micro-Invasive Prostate Cancer in a Mouse Model

scientific article published on 27 February 2017

Th17 cells in Type 1 diabetes: a future perspective.

scientific article published on July 2015

The LXR inverse agonist SR9238 suppresses fibrosis in a model of non-alcoholic steatohepatitis

scientific article

The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist.

scientific article

The coactivator LXXLL nuclear receptor recognition motif.

scientific article published on March 2004

The gene responsible for adrenal hypoplasia congenita, DAX-1, encodes a nuclear hormone receptor that defines a new class within the superfamily.

scientific article published on January 1996

The nuclear receptor REV-ERBα modulates Th17 cell-mediated autoimmune disease

scientific article published on 27 August 2019

The optimal corepressor function of nuclear receptor corepressor (NCoR) for peroxisome proliferator-activated receptor γ requires G protein pathway suppressor 2.

scientific article

The pharmacology of LXR.

scientific article

The stimulatory and inhibitory effects of dopamine on prolactin secretion involve different G-proteins ⬇️

scientific article published on February 1, 1992

Therapeutic Effect of a Synthetic RORα/γ Agonist in an Animal Model of Autism

scientific article

Thioether side chain cyclization for helical peptide formation: inhibitors of estrogen receptor-coactivator interactions.

scientific article published in March 2004

Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange.

scientific article published on October 2009

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