List of works - Jonathan Wadsworth

A naturally occurring variant of the human prion protein completely prevents prion disease.

scientific article

A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.

scientific article published on 7 May 2015

A novel prion disease associated with diarrhea and autonomic neuropathy

scientific article

A novel small conductance Ca2+-activated K+ channel blocker from Oxyuranus scutellatus taipan venom. Re-evaluation of taicatoxin as a selective Ca2+ channel probe

scientific article (publication date: 8 August 1997)

A systematic investigation of production of synthetic prions from recombinant prion protein

scientific article

Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins

scientific article

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.

scientific article published on January 2013

Analysis of 2000 consecutive UK tonsillectomy specimens for disease-related prion protein.

scientific article published in October 2004

Atypical scrapie prions from sheep and lack of disease in transgenic mice overexpressing human prion protein.

scientific article

Botulinum type F neurotoxin. Large-scale purification and characterization of its binding to rat cerebrocortical synaptosomes.

scientific article published on May 1990

Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease.

scientific article published on November 2008

Characterization of two distinct prion strains derived from bovine spongiform encephalopathy transmissions to inbred mice

scientific article published on 01 August 2004

Clinical Trial Simulations Based on Genetic Stratification and the Natural History of a Functional Outcome Measure in Creutzfeldt-Jakob Disease

scientific article

Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report.

scientific article published in December 2006

Clues to the multi-phasic inhibitory action of botulinum neurotoxins on release of transmitters

scientific article published on 01 January 1990

Comparable 30-kDa apamin binding polypeptides may fulfill equivalent roles within putative subtypes of small conductance Ca(2+)-activated K+ channels.

scientific article published in July 1994

Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin.

scientific article published on December 2008

Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis.

scientific article published on 12 September 2005

Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations.

scientific article published on 16 January 2006

Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study

scientific article published on 10 December 2010

Evaluating the causality of novel sequence variants in the prion protein gene by example

article

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

scientific article

Ex vivo mammalian prions are formed of paired double helical prion protein fibrils.

scientific article

Experimental sheep BSE prions generate the vCJD phenotype when serially passaged in transgenic mice expressing human prion protein. ⬇️

scientific article

Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases

scientific article

First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation.

scientific article published in September 2008

Heterologous combinations of heavy and light chains from botulinum neurotoxin A and tetanus toxin inhibit neurotransmitter release in Aplysia

scientific article published on 01 May 1991

High levels of disease related prion protein in the ileum in variant Creutzfeldt-Jakob disease.

scientific article published in October 2005

Highly infectious prions are not directly neurotoxic

scientific article published on 08 September 2020

Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years.

scientific article

Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein.

scientific article

Inherited prion disease with 4-octapeptide repeat insertion: disease requires the interaction of multiple genetic risk factors

scientific article published on 01 June 2011

Inherited prion disease with six octapeptide repeat insertional mutation--molecular analysis of phenotypic heterogeneity.

scientific article published on September 2006

Inhibition of neurotransmitter release by botulinum neurotoxins and tetanus toxin at Aplysia synapses: role of the constituent chains

scientific article published on 01 January 1990

Inhibition of proteinase K activity by copper(II) ions.

scientific article published in January 2007

Inhibition of transmitter release by botulinum neurotoxin A. Contribution of various fragments to the intoxication process

scientific article published on 01 October 1989

Involvement of the constituent chains of botulinum neurotoxins A and B in the blockade of neurotransmitter release

scientific article published on 01 November 1988

Irregular presence of abnormal prion protein in appendix in variant Creutzfeldt-Jakob disease.

scientific article published in November 2002

Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid

scientific article (publication date: 20 December 2010)

Methods for Molecular Diagnosis of Human Prion Disease

scientific article published in January 2017

Molecular and clinical classification of human prion disease ⬇️

scientific article published on January 1, 2003

Molecular biology of prion propagation.

scientific article

Molecular classification of sporadic Creutzfeldt-Jakob disease.

scientific article published in June 2003

Molecular diagnosis of human prion disease.

scientific article published on January 2008

Molecular pathology of human prion disease ⬇️

scientific article published on August 8, 2010

Multiple domains of botulinum neurotoxin contribute to its inhibition of transmitter release in Aplysia neurons

scientific article published on 01 December 1989

Phenotypic heterogeneity in inherited prion disease (P102L) is associated with differential propagation of protease-resistant wild-type and mutant prion protein.

scientific article published on 5 April 2006

Photolabile derivatives of 125I-apamin: defining the structural criteria required for labeling high and low molecular mass polypeptides associated with small conductance Ca(2+)-activated K+ channels

scientific article published on 01 June 1996

Physical, chemical and kinetic factors affecting prion infectivity

scientific article

Prion infectivity in variant Creutzfeldt-Jakob disease rectum.

scientific article published on 8 June 2006

Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked.

scientific article

Recent Advances in Understanding Mammalian Prion Structure: A Mini Review

scientific article published on 09 July 2019

Review. The origin of the prion agent of kuru: molecular and biological strain typing.

scientific article published on November 2008

Review: contribution of transgenic models to understanding human prion disease.

scientific article

Seven-year discordance in age at onset in monozygotic twins with inherited prion disease (P102L).

scientific article published on 21 January 2009

Soluble Aβ aggregates can inhibit prion propagation.

scientific article published in November 2017

Spontaneous generation of mammalian prions

scientific article

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS

scientific article published on 09 June 2020

Strain-specific prion-protein conformation determined by metal ions

article

Structural Diversity among Subtypes of Small-Conductance Ca2+-Activated Potassium Channels ⬇️

scientific article published on October 1, 1997

Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro

scientific article published in Scientific Reports

Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay

scientific article published in The Lancet

Transmission Properties of Human PrP 102L Prions Challenge the Relevance of Mouse Models of GSS.

scientific article published on 2 July 2015

Update on human prion disease.

scientific article published on March 2007

Variant Creutzfeldt-Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129.

scientific article published in January 2017

Variant Creutzfeldt-Jakob disease with extremely low lymphoreticular deposition of prion protein

scientific article

List of works by Jonathan Wadsworth

A naturally occurring variant of the human prion protein completely prevents prion disease.

A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.

A novel prion disease associated with diarrhea and autonomic neuropathy

A novel small conductance Ca2+-activated K+ channel blocker from Oxyuranus scutellatus taipan venom. Re-evaluation of taicatoxin as a selective Ca2+ channel probe

A systematic investigation of production of synthetic prions from recombinant prion protein

Absence of spontaneous disease and comparative prion susceptibility of transgenic mice expressing mutant human prion proteins

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.

Analysis of 2000 consecutive UK tonsillectomy specimens for disease-related prion protein.

Atypical scrapie prions from sheep and lack of disease in transgenic mice overexpressing human prion protein.

Botulinum type F neurotoxin. Large-scale purification and characterization of its binding to rat cerebrocortical synaptosomes.

Central and peripheral pathology of kuru: pathological analysis of a recent case and comparison with other forms of human prion disease.

Characterization of two distinct prion strains derived from bovine spongiform encephalopathy transmissions to inbred mice

Clinical Trial Simulations Based on Genetic Stratification and the Natural History of a Functional Outcome Measure in Creutzfeldt-Jakob Disease

Clinical presentation and pre-mortem diagnosis of variant Creutzfeldt-Jakob disease associated with blood transfusion: a case report.

Clues to the multi-phasic inhibitory action of botulinum neurotoxins on release of transmitters

Comparable 30-kDa apamin binding polypeptides may fulfill equivalent roles within putative subtypes of small conductance Ca(2+)-activated K+ channels.

Detection and characterization of proteinase K-sensitive disease-related prion protein with thermolysin.

Disease-related prion protein forms aggresomes in neuronal cells leading to caspase activation and apoptosis.

Distinct glycoform ratios of protease resistant prion protein associated with PRNP point mutations.

Effect of fixation on brain and lymphoreticular vCJD prions and bioassay of key positive specimens from a retrospective vCJD prevalence study

Evaluating the causality of novel sequence variants in the prion protein gene by example

Evidence for human transmission of amyloid-β pathology and cerebral amyloid angiopathy

Ex vivo mammalian prions are formed of paired double helical prion protein fibrils.

Experimental sheep BSE prions generate the vCJD phenotype when serially passaged in transgenic mice expressing human prion protein. ⬇️

Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases

First report of Creutzfeldt-Jakob disease occurring in 2 siblings unexplained by PRNP mutation.

Heterologous combinations of heavy and light chains from botulinum neurotoxin A and tetanus toxin inhibit neurotransmitter release in Aplysia

High levels of disease related prion protein in the ileum in variant Creutzfeldt-Jakob disease.

Highly infectious prions are not directly neurotoxic

Iatrogenic CJD due to pituitary-derived growth hormone with genetically determined incubation times of up to 40 years.

Inherited prion disease A117V is not simply a proteinopathy but produces prions transmissible to transgenic mice expressing homologous prion protein.

Inherited prion disease with 4-octapeptide repeat insertion: disease requires the interaction of multiple genetic risk factors

Inherited prion disease with six octapeptide repeat insertional mutation--molecular analysis of phenotypic heterogeneity.

Inhibition of neurotransmitter release by botulinum neurotoxins and tetanus toxin at Aplysia synapses: role of the constituent chains

Inhibition of proteinase K activity by copper(II) ions.

Inhibition of transmitter release by botulinum neurotoxin A. Contribution of various fragments to the intoxication process

Involvement of the constituent chains of botulinum neurotoxins A and B in the blockade of neurotransmitter release

Irregular presence of abnormal prion protein in appendix in variant Creutzfeldt-Jakob disease.

Isolation of proteinase K-sensitive prions using pronase E and phosphotungstic acid

Methods for Molecular Diagnosis of Human Prion Disease

Molecular and clinical classification of human prion disease ⬇️

Molecular biology of prion propagation.

Molecular classification of sporadic Creutzfeldt-Jakob disease.

Molecular diagnosis of human prion disease.

Molecular pathology of human prion disease ⬇️

Multiple domains of botulinum neurotoxin contribute to its inhibition of transmitter release in Aplysia neurons

Phenotypic heterogeneity in inherited prion disease (P102L) is associated with differential propagation of protease-resistant wild-type and mutant prion protein.

Photolabile derivatives of 125I-apamin: defining the structural criteria required for labeling high and low molecular mass polypeptides associated with small conductance Ca(2+)-activated K+ channels

Physical, chemical and kinetic factors affecting prion infectivity

Prion infectivity in variant Creutzfeldt-Jakob disease rectum.

Prion neuropathology follows the accumulation of alternate prion protein isoforms after infective titre has peaked.

Recent Advances in Understanding Mammalian Prion Structure: A Mini Review

Review. The origin of the prion agent of kuru: molecular and biological strain typing.

Review: contribution of transgenic models to understanding human prion disease.

Seven-year discordance in age at onset in monozygotic twins with inherited prion disease (P102L).

Soluble Aβ aggregates can inhibit prion propagation.

Spontaneous generation of mammalian prions

Spontaneous generation of prions and transmissible PrP amyloid in a humanised transgenic mouse model of A117V GSS

Strain-specific prion-protein conformation determined by metal ions

Structural Diversity among Subtypes of Small-Conductance Ca2+-Activated Potassium Channels ⬇️

Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro

Tissue distribution of protease resistant prion protein in variant Creutzfeldt-Jakob disease using a highly sensitive immunoblotting assay

Transmission Properties of Human PrP 102L Prions Challenge the Relevance of Mouse Models of GSS.

Update on human prion disease.

Variant Creutzfeldt-Jakob Disease in a Patient with Heterozygosity at PRNP Codon 129.

Variant Creutzfeldt-Jakob disease with extremely low lymphoreticular deposition of prion protein