Search filters

List of works by Laura Sepp-Lorenzino

3-(Indol-2-yl)indazoles as Chek1 kinase inhibitors: Optimization of potency and selectivity via substitution at C6.

scientific article published on 15 September 2006

5'-(E)-Vinylphosphonate: A Stable Phosphate Mimic Can Improve the RNAi Activity of siRNA-GalNAc Conjugates.

scientific article

A Farnesyl-Protein Transferase Inhibitor Induces p21 Expression and G1 Block in p53 Wild Type Tumor Cells ⬇️

scientific article published on August 7, 1998

A novel orally bioavailable inhibitor of kinase insert domain-containing receptor induces antiangiogenic effects and prevents tumor growth in vivo

scientific article published on January 2004

A single dose of EGLN1 siRNA yields increased erythropoiesis in nonhuman primates

scientific article published on 01 December 2014

An allosteric Akt inhibitor effectively blocks Akt signaling and tumor growth with only transient effects on glucose and insulin levels in vivo

scientific article

An in vivo evaluation of amphiphilic, biodegradable peptide copolymers as siRNA delivery agents

scientific article published on 5 March 2014

An inhibitor of the kinesin spindle protein activates the intrinsic apoptotic pathway independently of p53 and de novo protein synthesis

scientific article published on 13 November 2006

Analysis of lipid nanoparticles by Cryo-EM for characterizing siRNA delivery vehicles

scientific article published on 23 October 2010

Analysis of the activating mutations within the activation loop of leukemia targets Flt-3 and c-Kit based on protein homology modeling

scientific article published in October 2004

Angiogenesis-research frontiers. A basic science conference of the New York Academy of Medicine

Antiangiogenic agents targeting vascular endothelial growth factor and its receptors in clinical development

scientific article

Biodistribution of small interfering RNA at the organ and cellular levels after lipid nanoparticle-mediated delivery

scientific article published on August 2011

Cell-cycle-dependent, differential prenylation of proteins

scientific article published on 01 September 1991

Cellular distribution of cholesterogenesis-linked, phosphoisoprenylated proteins in proliferating cells

scientific article published on 01 March 1989

Challenges and opportunities for local and systemic delivery of siRNA and antisense oligonucleotides

scientific article published on 17 September 2008

Design and synthesis of 3,7-diarylimidazopyridines as inhibitors of the VEGF-receptor KDR.

scientific article published in February 2004

Development and implementation of multiplexed cell-based imaging assays

scientific article published on January 2006

Development of 6-substituted indolylquinolinones as potent Chek1 kinase inhibitors

scientific article published on 20 September 2006

Development of a liver-targeted siRNA delivery platform with a broad therapeutic window utilizing biodegradable polypeptide-based polymer conjugates

scientific article

Development of thioquinazolinones, allosteric Chk1 kinase inhibitors

scientific article

Differential roles of PI3-kinase and Kit tyrosine 821 in Kit receptor-mediated proliferation, survival and cell adhesion in mast cells.

scientific article published on February 1995

Effective siRNA delivery and target mRNA degradation using an amphipathic peptide to facilitate pH-dependent endosomal escape

scientific article published on 01 April 2011

Endosomolytic bioreducible poly(amido amine disulfide) polymer conjugates for the in vivo systemic delivery of siRNA therapeutics

scientific article published on 25 March 2013

Evaluation of efficacy, biodistribution, and inflammation for a potent siRNA nanoparticle: effect of dexamethasone co-treatment

scientific article

Expression of asialoglycoprotein receptor 1 in human hepatocellular carcinoma

scientific article published on 26 August 2013

Expression of micro-RNA-145 is regulated by a highly conserved genomic sequence 3' to the pre-miR.

scientific article published on March 2011

Farnesyl transferase inhibitors cause enhanced mitotic sensitivity to taxol and epothilones

scientific article published in February 1998

Farnesyl:protein transferase inhibitors as potential agents for the management of human prostate cancer

scientific article published on January 2001

Farnesyltransferase inhibitors and anti-Ras therapy

scientific article published on January 1996

Growth inhibition by microRNAs that target the insulin receptor substrate-1.

scientific article

Identification of biomarkers for tumor endothelial cell proliferation through gene expression profiling

scientific article

Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers

scientific article published on 01 March 2019

Improving the in vivo therapeutic index of siRNA polymer conjugates through increasing pH responsiveness

scientific article published on 10 January 2014

Induction of apoptosis by an inhibitor of the mitotic kinesin KSP requires both activation of the spindle assembly checkpoint and mitotic slippage

scientific article

Intratracheal Administration of siRNA Triggers mRNA Silencing in the Lung to Modulate T Cell Immune Response and Lung Inflammation

Isoprenylated proteins in myelin.

scientific article

Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice

scientific article published on 28 January 2020

LY294002-geldanamycin heterodimers as selective inhibitors of the PI3K and PI3K-related family

scientific article published in April 2001

Mechanistically probing lipid-siRNA nanoparticle-associated toxicities identifies Jak inhibitors effective in mitigating multifaceted toxic responses

scientific article

Micro RNA 145 targets the insulin receptor substrate-1 and inhibits the growth of colon cancer cells

scientific article published on 07 September 2007

Noninvasive imaging of lipid nanoparticle-mediated systemic delivery of small-interfering RNA to the liver

scientific article

Novel endosomolytic poly(amido amine) polymer conjugates for systemic delivery of siRNA to hepatocytes in rodents and nonhuman primates

scientific article published on 05 May 2014

Optimization of a pyrazoloquinolinone class of Chk1 kinase inhibitors

scientific article

Pharmacokinetic/pharmacodynamic-based decision making in the development of MK-0888, a VEGFR-2/FLT-3 kinase inhibitor

scientific article published on 19 December 2014

Potent 2-[(pyrimidin-4-yl)amine}-1,3-thiazole-5-carbonitrile-based inhibitors of VEGFR-2 (KDR) kinase

scientific article published on 20 December 2005

Potent N-(1,3-thiazol-2-yl)pyridin-2-amine vascular endothelial growth factor receptor tyrosine kinase inhibitors with excellent pharmacokinetics and low affinity for the hERG ion channel

scientific article

Proof-of-concept Studies for siRNA-mediated Gene Silencing for Coagulation Factors in Rat and Rabbit

scientific article published on 27 January 2015

Pyridyl aminothiazoles as potent Chk1 inhibitors: optimization of cellular activity

scientific article

Pyridyl aminothiazoles as potent inhibitors of Chk1 with slow dissociation rates

scientific article

Quantification of Cy-5 siRNA signal in the intra-vital multi-photon microscopy images

scientific article published in January 2012

Quantitative evaluation of siRNA delivery in vivo.

scientific article

Regulation of microRNA-145 by growth arrest and differentiation

scientific article published on 25 November 2010

Safety evaluation of 2'-deoxy-2'-fluoro nucleotides in GalNAc-siRNA conjugates

scientific article published on 01 April 2019

Silencing Myostatin Using Cholesterol-conjugated siRNAs Induces Muscle Growth

scientific article

Structure and function of the insulin-like growth factor I receptor ⬇️

scientific article published on February 1, 1998

Synthesis and evaluation of geldanamycin-estradiol hybrids

scientific article published on 01 May 1999

Synthesis and evaluation of geldanamycin-testosterone hybrids

scientific article published on 01 June 2000

Synthesis and evaluation of substituted benzoisoquinolinones as potent inhibitors of Chk1 kinase

scientific article

Systematic chemical modifications of single stranded siRNAs significantly improved CTNNB1 mRNA silencing

scientific article published on 28 July 2016

The microtubule-stabilizing agents epothilones A and B and their desoxy-derivatives induce mitotic arrest and apoptosis in human prostate cancer cells.

scientific article published on January 1999

Titrating haemophilia B phenotypes using siRNA strategy: evidence that antithrombotic activity is separated from bleeding liability

scientific article published on 19 March 2015

ras Mutation: does it have clinical import?

scientific article published on September 1, 1997

Paulina is supported by:

About Paulina

Help