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List of works by Joost Holthuis

A search for ceramide binding proteins using bifunctional lipid analogs yields CERT-related protein StarD7.

scientific article

A switchable ceramide transfer protein for dissecting the mechanism of ceramide-induced mitochondrial apoptosis

scientific article published on 14 October 2020

A vertebrate homolog of the actin-bundling protein fascin.

scientific article published on September 1994

Cell biology: A brake on lipid synthesis.

scientific article published in February 2010

Cellular microcompartments constitute general suborganellar functional units in cells.

scientific article published on February 2013

Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen

scientific article

Ceramide phosphoethanolamine synthase SMSr is a target of caspase-6 during apoptotic cell death.

scientific article published on 28 June 2017

Ceramides bind VDAC2 to trigger mitochondrial apoptosis

scientific article published on 23 April 2019

Coordination of protein-DNA interactions in the promoters of human H4, H3, and H1 histone genes during the cell cycle, tumorigenesis, and development

scientific article published on 01 July 1991

Diverting CERT-mediated ceramide transport to mitochondria triggers Bax-dependent apoptosis.

scientific article published on 25 November 2016

ER residency of the ceramide phosphoethanolamine synthase SMSr relies on homotypic oligomerization mediated by its SAM domain

scientific article (publication date: 25 January 2017)

Fat & fabulous: bifunctional lipids in the spotlight.

scientific article published on 15 January 2014

Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate.

scientific article published in January 2010

Functional characterization of enzymes catalyzing ceramide phosphoethanolamine biosynthesis in mice

scientific journal article

In vivo profiling and visualization of cellular protein-lipid interactions using bifunctional fatty acids.

scientific article published on 28 February 2013

Inhibition of the vacuolar H+-ATPase perturbs the transport, sorting, processing and release of regulated secretory proteins

scientific article published on 01 September 2000

Inner workings and biological impact of phospholipid flippases

scientific article

Intracellular trafficking of the vacuolar H+-ATPase accessory subunit Ac45.

scientific article published on October 1998

Lipid landscapes and pipelines in membrane homeostasis

scientific article

Lipid traffic: floppy drives and a superhighway.

scientific article

Mapping functional interactions in a heterodimeric phospholipid pump

scientific journal article

Mechanism and significance of P4 ATPase-catalyzed lipid transport: lessons from a Na+/K+-pump.

scientific article published on 21 February 2009

Membrane contact sites between apicoplast and ER in Toxoplasma gondii revealed by electron tomography.

scientific article

Membrane contact sites, ancient and central hubs of cellular lipid logistics.

scientific article

Molecular probing of the secretory pathway in peptide hormone-producing cells.

scientific article published on October 1995

Monitoring Changes in the Oligomeric State of a Candidate Endoplasmic Reticulum (ER) Ceramide Sensor by Single-molecule Photobleaching

scientific article published on 10 October 2016

New frontiers in sphingolipid biology. Preface

scientific article published on 01 May 2014

Optical manipulation of sphingolipid biosynthesis using photoswitchable ceramides

scientific article published on 05 February 2019

Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2

scientific article published on 04 April 2019

Phosphatidylserine stimulation of Drs2p·Cdc50p lipid translocase dephosphorylation is controlled by phosphatidylinositol-4-phosphate.

scientific article published on 20 February 2012

Phosphatidylserine stimulation of Drs2p·Cdc50p lipid translocase dephosphorylation is controlled by phosphatidylinositol-4-phosphate.

scientific article published in December 2012

Prevention of side effects by hemoglobin solutions; the selection of optimal test models, especially concerning thrombogenicity

scientific article published on 01 January 1994

Protein sorting in the late Golgi of Saccharomyces cerevisiae does not require mannosylated sphingolipids.

scientific article published on 28 October 2003

Pumping lipids with P4-ATPases.

scientific article published on January 2011

Secretogranin III is a sulfated protein undergoing proteolytic processing in the regulated secretory pathway.

scientific article

Sphingolipid transport in eukaryotic cells.

scientific article

Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER

scientific article

Sphingomyelin synthase-related protein SMSr is a suppressor of ceramide-induced mitochondrial apoptosis

scientific article published on 20 November 2013

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site engineering of sphingomyelin synthases.

scientific article published on 10 May 2016

Switching head group selectivity in mammalian sphingolipid biosynthesis by active-site-engineering of sphingomyelin synthases

scientific article published on 23 March 2017

Tales and Mysteries of the Enigmatic Sphingomyelin Synthase Family ⬇️

scientific article published on January 1, 2010

The CLN9 protein, a regulator of dihydroceramide synthase.

scientific article

The Sec1p homologue Vps45p binds to the syntaxin Tlg2p

scientific article published on 01 December 1998

The activation of human blood coagulation factor X on the surface of endothelial cells: a comparison with various vascular cells, platelets and monocytes

scientific article published on 01 June 1994

The multigenic sphingomyelin synthase family

scientific article

Tracking down lipid flippases and their biological functions.

scientific article published on February 2004

Two syntaxin homologues in the TGN/endosomal system of yeast

scientific article published in January 1998

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