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List of works by Penelope Duerksen-Hughes

A new approach to identifying genotoxic carcinogens: p53 induction as an indicator of genotoxic damage.

scientific article published on June 1998

ATM and ATR: sensing DNA damage.

scientific article published on January 2004

ATM, ATR and DNA-PK: initiators of the cellular genotoxic stress responses.

scientific article

Affinity chromatography using protein immobilized via arginine residues: purification of ubiquitin carboxyl-terminal hydrolases

scientific article published in 1989

Approaches and Methods to Measure Oxidative Stress in Clinical Samples: Research Applications in the Cancer Field

scientific article published on 12 March 2019

Benzo[a]pyrene treatment leads to changes in nuclear protein expression and alternative splicing.

scientific article published on 25 January 2010

Bid is cleaved upstream of caspase-8 activation during TRAIL-mediated apoptosis in human osteosarcoma cells.

scientific article published on July 2007

Both tumor necrosis factor and nitric oxide participate in lysis of simian virus 40-transformed cells by activated macrophages ⬇️

scientific article published on September 15, 1992

C18 ceramide analysis in mammalian cells employing reversed-phase high-performance liquid chromatography tandem mass spectrometry.

scientific article

Cancer stem cell self-renewal as a therapeutic target in human oral cancer

scientific article published on 01 April 2019

Cellular levels of oxidative stress affect the response of cervical cancer cells to chemotherapeutic agents

scientific article

Ceramide and other sphingolipids in cellular responses.

scientific article published on January 2004

Chronic oxidative stress increases the integration frequency of foreign DNA and human papillomavirus 16 in human keratinocytes

scientific article published on 15 March 2016

Cisplatin treatment leads to changes in nuclear protein and microRNA expression.

scientific article

Cold parenting is associated with cellular aging in offspring: A retrospective study

scientific article published on 20 April 2019

Combined ultrasound-curcumin treatment of human cervical cancer cells.

scientific article published on August 2015

Complexes of human papillomavirus type 16 E6 proteins form pseudo-death-inducing signaling complex structures during tumor necrosis factor-mediated apoptosis.

scientific article published on 08 October 2008

DNA damage induces down-regulation of UDP-glucose ceramide glucosyltransferase, increases ceramide levels and triggers apoptosis in p53-deficient cancer cells.

scientific article published on 11 February 2012

Effects of Lifestyle Factors on Cognitive Resilience: Commentary on "What This Sunny, Religious Town in California Teaches Us About Living Longer"

scientific article published on 15 February 2020

Effects of benzo(a)pyrene on the contractile function of the thoracic aorta of Sprague-Dawley rats

scientific article published on 01 October 2012

Flavonol and imidazole derivatives block HPV16 E6 activities and reactivate apoptotic pathways in HPV⁺ cells

scientific article (publication date: 21 January 2016)

HPV 16 E6 blocks TNF-mediated apoptosis in mouse fibroblast LM cells.

scientific article

Human papillomavirus type 16 E6* induces oxidative stress and DNA damage

scientific article

Induction of susceptibility to tumor necrosis factor by E1A is dependent on binding to either p300 or p105-Rb and induction of DNA synthesis

scientific article published in January 1996

Inorganic and dimethylated arsenic species induce cellular p53.

scientific article published on March 2003

Interleukin 24: mechanisms and therapeutic potential of an anti-cancer gene.

scientific article published on 14 September 2012

Linifanib (ABT-869), enhances cytotoxicity with poly (ADP-ribose) polymerase inhibitor, veliparib (ABT-888), in head and neck carcinoma cells.

scientific article published on 13 April 2014

Long-term, progressive, aerobic training increases adiponectin in middle-aged, overweight, untrained males and females ⬇️

scientific article published on January 27, 2011

Mass spectrometric studies on epigenetic interaction networks in cell differentiation.

scientific article

Methyl methanesulfonate induces apoptosis in p53-deficient H1299 and Hep3B cells through a caspase 2- and mitochondria-associated pathway ⬇️

scientific article published on October 8, 2012

Modulation of apoptosis by human papillomavirus (HPV) oncoproteins.

scientific article published on 27 July 2006

Modulation of apoptotic pathways by human papillomaviruses (HPV): mechanisms and implications for therapy.

scientific article

Nuclear proteome analysis of cisplatin-treated HeLa cells.

scientific article published on 9 June 2010

Overexpression of HPV16 E6* Alters β-Integrin and Mitochondrial Dysfunction Pathways in Cervical Cancer Cells

scientific article published on January 2016

Paraspeckle protein 1 (PSPC1) is involved in the cisplatin induced DNA damage response--role in G1/S checkpoint

scientific article

Protein kinases and their involvement in the cellular responses to genotoxic stress.

scientific article

Proteomic analysis of cellular response induced by multi-walled carbon nanotubes exposure in A549 cells

scientific article

Quantum dot-related genotoxicity perturbation can be attenuated by PEG encapsulation ⬇️

scientific article published on February 13, 2013

Recent Progress in Therapeutic Treatments and Screening Strategies for the Prevention and Treatment of HPV-Associated Head and Neck Cancer

scientific article

Selenium Attenuates HPV-18 Associated Apoptosis in Embryo-Derived Trophoblastic Cells but Not Inner Cell Mass In Vitro.

scientific article published on 4 August 2015

Small molecule inhibitors of the HPV16-E6 interaction with caspase 8

scientific article

Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5. E1A is immunodominant in H-2b, but not in H-2d or H-2k mice

scientific article published on 01 June 1991

Splice variants of mda-7/IL-24 differentially affect survival and induce apoptosis in U2OS cells ⬇️

scientific article published on August 16, 2011

Structure and function of ubiquitin: evidence for differential interactions of arginine-74 with the activating enzyme and the proteases of ATP-dependent proteolysis

scientific article published on 01 November 1987

Subpopulations of cancer stem cells found in papillary thyroid carcinoma

scientific article published on 20 December 2017

The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor ⬇️

scientific article published on August 1, 1991

The Agency for Toxic Substances and Disease Registry's role in development and application of biomarkers in public health practice.

scientific article published on November 1993

The E1B 19,000-molecular-weight protein of group C adenoviruses prevents tumor necrosis factor cytolysis of human cells but not of mouse cells ⬇️

scientific article published on June 1, 1991

The Potential of Immune Checkpoint Blockade in Cervical Cancer: Can Combinatorial Regimens Maximize Response? A Review of the Literature

scientific article published on 06 October 2020

The amino-terminal portion of CD1 of the adenovirus E1A proteins is required to induce susceptibility to tumor necrosis factor cytolysis in adenovirus-infected mouse cells ⬇️

scientific article published on March 1, 1991

The human papillomavirus 16 E6 protein binds to Fas-associated death domain and protects cells from Fas-triggered apoptosis.

scientific article

The human papillomavirus 16 E6 protein binds to tumor necrosis factor (TNF) R1 and protects cells from TNF-induced apoptosis.

scientific article published on 4 April 2002

The interaction between human papillomavirus type 16 and FADD is mediated by a novel E6 binding domain.

scientific article published on 16 July 2008

The large and small isoforms of human papillomavirus type 16 E6 bind to and differentially affect procaspase 8 stability and activity

scientific article published on 31 January 2007

The small splice variant of HPV16 E6, E6, reduces tumor formation in cervical carcinoma xenografts

scientific article published on January 2014

Viral carcinogenesis: factors inducing DNA damage and virus integration

scientific article

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