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List of works by Matt Kaeberlein

A Drosophila model of mitochondrial disease caused by a complex I mutation that uncouples proton pumping from electron transfer

scientific article

A genomic analysis of chronological longevity factors in budding yeast

scientific article

A genomic approach to yeast chronological aging

scientific article published on January 2009

A method for high-throughput quantitative analysis of yeast chronological life span

scientific article published in February 2008

A molecular mechanism of chronological aging in yeast.

scientific article published on 23 April 2009

A natural polymorphism in rDNA replication origins links origin activation with calorie restriction and lifespan

scientific article

A new chronological survival assay in mammalian cell culture

scientific article published on 15 January 2012

A physicochemical perspective of aging from single-cell analysis of pH, macromolecular and organellar crowding in yeast

scientific article published on 29 September 2020

A randomized controlled trial to establish effects of short-term rapamycin treatment in 24 middle-aged companion dogs.

scientific article published on 3 April 2017

A role for SIRT1 in the hypoxic response

scientific article published on 01 June 2010

A system to identify inhibitors of mTOR signaling using high-resolution growth analysis in Saccharomyces cerevisiae.

scientific article

AGEID: a database of aging genes and interventions

scientific article published on 01 April 2002

Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila

scientific article

Activation of the mitochondrial unfolded protein response does not predict longevity in Caenorhabditis elegans

scientific article published on 24 March 2014

Age- and calorie-independent life span extension from dietary restriction by bacterial deprivation in Caenorhabditis elegans

scientific article

Age-associated vulval integrity is an important marker of nematode healthspan

scientific article

Age-dependent deterioration of nuclear pore assembly in mitotic cells decreases transport dynamics.

scientific article

Ageing: A healthy diet for stem cells.

scientific article

Ageing: A midlife longevity drug?

scientific article published on 8 July 2009

Aneuploidy shortens replicative lifespan in Saccharomyces cerevisiae

scientific article published on 13 January 2016

Asymptomatic heart valve dysfunction in healthy middle-aged companion dogs and its implications for cardiac aging.

scientific article

Author's Reply

Biochemical Genetic Pathways that Modulate Aging in Multiple Species

scientific article

Buffering the pH of the culture medium does not extend yeast replicative lifespan

scientific article published on 15 October 2013

Caffeine extends life span, improves healthspan, and delays age-associated pathology in Caenorhabditis elegans

scientific article published on December 2012

Cell biology: A molecular age barrier

scientific article published on 01 August 2008

Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span

scientific article

Composition and acidification of the culture medium influences chronological aging similarly in vineyard and laboratory yeast

scientific article

Composition of Caenorhabditis elegans extracellular vesicles suggests roles in metabolism, immunity, and aging

scientific article published on 24 June 2020

Corrigendum: Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency

scientific article published on 22 December 2017

DNA damage checkpoint activation impairs chromatin homeostasis and promotes mitotic catastrophe during aging

scientific article published on 12 November 2019

Deciphering the role of natural variation in age-related protein homeostasis.

scientific article

Defining Molecular Basis for Longevity Traits in Natural Yeast Isolates

scientific article published on 28 September 2015

Defining the impact of mutation accumulation on replicative lifespan in yeast using cancer-associated mutator phenotypes

scientific article published on 04 February 2019

Development. Chemical warfare in the battle of the sexes

scientific article published in January 2014

Dietary restriction and mitochondrial function link replicative and chronological aging in Saccharomyces cerevisiae

scientific article published on 9 December 2012

Dietary restriction by bacterial deprivation increases life span in wild-derived nematodes

scientific article published on 17 November 2007

Dietary restriction suppresses proteotoxicity and enhances longevity by an hsf-1-dependent mechanism in Caenorhabditis elegans

scientific article

Does resveratrol activate yeast Sir2 in vivo?

scientific article published on 01 August 2007

Electrophysiological measures of aging pharynx function in C. elegans reveal enhanced organ functionality in older, long-lived mutants.

scientific article published on 18 November 2017

Elevated MTORC1 signaling and impaired autophagy

scientific article published on 12 October 2012

Elevated proteasome capacity extends replicative lifespan in Saccharomyces cerevisiae

scientific article

Elimination of replication block protein Fob1 extends the life span of yeast mother cells.

scientific article

End-of-life cell cycle arrest contributes to stochasticity of yeast replicative aging

scientific article

Environmental Canalization of Life Span and Gene Expression in Caenorhabditis elegans

scientific article published on 22 February 2017

Extension of chronological life span in yeast by decreased TOR pathway signaling

scientific article

Fertile waters for aging research

scientific article published in February 2015

Flavin-containing monooxygenases in aging and disease: Emerging roles for ancient enzymes

scientific article published on 17 May 2017

Genes determining yeast replicative life span in a long-lived genetic background

scientific article

Genetic interaction with temperature is an important determinant of nematode longevity.

scientific article published on 21 September 2017

Genetic screen identifies adaptive aneuploidy as a key mediator of ER stress resistance in yeast.

scientific article published on 5 September 2018

Genome-Wide RNAi Longevity Screens in Caenorhabditis elegans

scientific article

Genome-wide analysis of yeast aging

scientific article published on January 2012

Genome-wide identification of conserved longevity genes in yeast and worms

scientific article published on 28 November 2006

Genomics and genetics of aging.

scientific article published on November 2012

Grapes versus gluttony

scientific article published in Nature

HIF-1 modulates longevity and healthspan in a temperature-dependent manner

scientific article published on 23 February 2011

Healthy aging: The ultimate preventative medicine

scientific article

Hepatic S6K1 Partially Regulates Lifespan of Mice with Mitochondrial Complex I Deficiency

scientific article

Histone H4 lysine 16 acetylation regulates cellular lifespan

scientific article

Hot topics in aging research: protein translation and TOR signaling, 2010

scientific article

Hot topics in aging research: protein translation, 2009.

scientific article published on 11 September 2009

How healthy is the healthspan concept?

scientific article published on 06 August 2018

Hypertrophy and senescence factors in yeast aging. A reply to Bilinski et al ⬇️

scientific article published on March 27, 2012

Inactivating histone deacetylase HDA promotes longevity by mobilizing trehalose metabolism

scientific article published on 31 March 2021

Inactivation of yeast Isw2 chromatin remodeling enzyme mimics longevity effect of calorie restriction via induction of genotoxic stress response

scientific article

Increased life span due to calorie restriction in respiratory-deficient yeast

scientific article

Large-scale identification in yeast of conserved ageing genes

scientific article

Lessons on longevity from budding yeast

scientific article

Life span extension by glucose restriction is abrogated by methionine supplementation: Cross-talk between glucose and methionine and implication of methionine as a key regulator of life span

scientific article published on 05 August 2020

Life-span extension from hypoxia in Caenorhabditis elegans requires both HIF-1 and DAF-16 and is antagonized by SKN-1

scientific article published on 18 February 2013

Lifespan extension in Caenorhabditis elegans by complete removal of food

scientific article published in November 2006

Longevity and aging.

scientific article published on 4 March 2013

Longevity genomics across species.

scientific article published on April 2007

Measuring Caenorhabditis elegans life span on solid media

scientific article published on 12 May 2009

Measuring replicative life span in the budding yeast

scientific article published on 25 June 2009

Microfluidic technologies for yeast replicative lifespan studies

scientific article published on 22 March 2016

Modulating mTOR in aging and health

scientific article

Molecular basis of ageing

scientific article published on 7 September 2007

New functional and biophysical insights into the mitochondrial Rieske iron-sulfur protein from genetic suppressor analysis in C. elegans

scientific article

New insights into cell non-autonomous mechanisms of the C. elegans hypoxic response

scientific article published on 12 April 2016

Oral health in geroscience: animal models and the aging oral cavity.

scientific article published on 27 December 2017

PKC downregulation upon rapamycin treatment attenuates mitochondrial disease

scientific article published on 14 December 2020

Phenotypic and Genotypic Consequences of CRISPR/Cas9 Editing of the Replication Origins in the rDNA of Saccharomyces cerevisiae

scientific article published on 10 July 2019

Preserving youth: does rapamycin deliver?

scientific article

Proteasomal regulation of the hypoxic response modulates aging in C. elegans

scientific article

Protein translation, 2007.

scientific article published on 17 October 2007

Protein translation, 2008.

scientific article published on 08 September 2008

Pterocarpus marsupium extract extends replicative lifespan in budding yeast

scientific article published in 2021

Quantifying yeast chronological life span by outgrowth of aged cells

scientific article published on 6 May 2009

Quantitative evidence for conserved longevity pathways between divergent eukaryotic species

scientific article published on 13 March 2008

Quantitative evidence for early life fitness defects from 32 longevity-associated alleles in yeast ⬇️

scientific article published on January 1, 2011

Rapamycin and Alzheimer’s disease: Time for a clinical trial?

scientific article published on 01 January 2019

Rapamycin and ageing: when, for how long, and how much?

scientific article

Rapamycin enhances survival in a Drosophila model of mitochondrial disease

scientific article published on 11 October 2016

Rapamycin rejuvenates oral health in aging mice

scientific article published on 28 April 2020

Rapamycin treatment attenuates age-associated periodontitis in mice.

scientific article

Reactivation of RNA metabolism underlies somatic restoration after adult reproductive diapause in

scientific article published on 02 August 2018

Recent developments in yeast aging

scientific article

Regulation of mRNA translation as a conserved mechanism of longevity control

scientific article published on January 2010

Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients

scientific article

Rejuvenation: it's in our blood

scientific article published on July 2014

Replicative and chronological aging in Saccharomyces cerevisiae.

scientific article

Replicative life span analysis in budding yeast

scientific article published in January 2014

Restoration of senescent human diploid fibroblasts by modulation of the extracellular matrix

scientific article published on 01 February 2011

Resveratrol and rapamycin: are they anti-aging drugs?

scientific article

Resveratrol rescues SIRT1-dependent adult stem cell decline and alleviates progeroid features in laminopathy-based progeria

scientific article

Ribosome Deficiency Protects Against ER Stress in Saccharomyces cerevisiae ⬇️

scientific article published on February 29, 2012

Searching for the elusive mitochondrial longevity signal in C. elegans.

scientific article

Shortest-path network analysis is a useful approach toward identifying genetic determinants of longevity

scientific article

Single-gene deletions that restore mating competence to diploid yeast.

scientific article

Sir2 and calorie restriction in yeast: a skeptical perspective.

scientific article

Sir2 deletion prevents lifespan extension in 32 long-lived mutants

scientific article published on 3 October 2011

Sir2-independent life span extension by calorie restriction in yeast

scientific article

Sirtuin-independent effects of nicotinamide on lifespan extension from calorie restriction in yeast

scientific article published in December 2006

Sorbitol treatment extends lifespan and induces the osmotic stress response in Caenorhabditis elegans

scientific article

Spermidine surprise for a long life

scientific article published in November 2009

Stress profiling of longevity mutants identifies Afg3 as a mitochondrial determinant of cytoplasmic mRNA translation and aging

scientific article

Substrate-specific activation of sirtuins by resveratrol

scientific article

Systematic analysis of asymmetric partitioning of yeast proteome between mother and daughter cells reveals "aging factors" and mechanism of lifespan asymmetry

scientific article

Taurine deficiency as a driver of aging

scientific article published on 08 June 2023

Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein

scientific article

The MDT-15 subunit of mediator interacts with dietary restriction to modulate longevity and fluoranthene toxicity in Caenorhabditis elegans

scientific article (publication date: 2011)

The TOR pathway comes of age

scientific article

The enigmatic role of Sir2 in aging

scientific article

The hypoxia-inducible factor HIF-1 functions as both a positive and negative modulator of aging

scientific article published on October 2010

The hypoxic response and aging

scientific article published on 01 August 2009

The mitochondrial unfolded protein response and increased longevity: cause, consequence, or correlation?

scientific article

The ribosomal protein Rpl22 controls ribosome composition by directly repressing expression of its own paralog, Rpl22l1

scientific article

The sensitivity of yeast mutants to oleic acid implicates the peroxisome and other processes in membrane function

scientific article

Trajectories of Aging: How Systems Biology in Yeast Can Illuminate Mechanisms of Personalized Aging

scientific article published on 04 November 2019

Transient rapamycin treatment can increase lifespan and healthspan in middle-aged mice.

scientific article published on 23 August 2016

Translational Geroscience: From invertebrate models to companion animal and human interventions

scientific article published on 01 January 2018

Translational control of one-carbon metabolism underpins ribosomal protein phenotypes in cell division and longevity

scientific article published on 20 May 2020

Trinations aging symposium.

scientific article published on June 2011

UV-photoconversion of ethosuximide from a longevity-promoting compound to a potent toxin

scientific article (publication date: 2013)

WormBot, an open-source robotics platform for survival and behavior analysis in C. elegans

scientific article published on 14 November 2019

WormFarm: a quantitative control and measurement device toward automated Caenorhabditis elegans aging analysis

scientific article

YODA: software to facilitate high-throughput analysis of chronological life span, growth rate, and survival in budding yeast

scientific article

Yeast as a model to understand the interaction between genotype and the response to calorie restriction

scientific article

Yeast life span extension by depletion of 60s ribosomal subunits is mediated by Gcn4.

scientific article published on April 2008

Yeast replicative aging: a paradigm for defining conserved longevity interventions

scientific article

mTOR Inhibition: From Aging to Autism and Beyond.

scientific article

mTOR inhibition alleviates mitochondrial disease in a mouse model of Leigh syndrome

scientific article

mTOR is a key modulator of ageing and age-related disease

scientific article

pH neutralization protects against reduction in replicative lifespan following chronological aging in yeast

scientific article published on 8 August 2012

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