List of works - Pedro Luis Herrera

A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice

scientific article published on 01 December 1994

A standardized method for in vivo mouse pancreas imaging and semiquantitative β cell mass measurement by dual isotope SPECT.

scientific article published on February 2015

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

scientific article published on 23 April 2006

Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas

scientific article

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

scientific article published on 01 June 2000

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.

scientific article

An amylase/Cre transgene marks the whole endoderm but the primordia of liver and ventral pancreas.

scientific article

An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice

scientific article

Argonaute2 mediates compensatory expansion of the pancreatic β cell

scientific article

Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.

scientific article published in December 2001

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.

scientific article published on 19 April 2016

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

scientific article published on 24 June 2016

Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice

scientific article

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

scientific article

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss

scientific article

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

scientific article published on 12 February 2017

Defining the cell lineages of the islets of Langerhans using transgenic mice.

scientific article

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

scientific article published on 17 November 2008

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

scientific article published on 08 December 2008

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.

scientific article

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

scientific article

Dnmt1 activity is dispensable in δ-cells but is essential for α-cell homeostasis

scientific article published on 21 January 2017

Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene

scientific article published on 01 December 1991

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

scientific article published on April 2007

Experimental models of beta-cell regeneration.

scientific article published on June 2008

Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.

scientific article published on 8 October 2010

Foxa2 is required for the differentiation of pancreatic alpha-cells

scientific journal article

GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells

scientific article published on 29 October 2019

Generation of Smad4/Dpc4 conditional knockout mice

scientific article published on 01 February 2002

Generation of human islet cell type-specific identity genesets

scientific article published on 19 April 2022

Genes controlling pancreas ontogeny.

scientific article published on January 2008

Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.

scientific article published on 8 May 2014

Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

scientific article published on 28 November 2006

Insulin and Glucagon: Partners for Life.

scientific article

Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice

scientific journal article

Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

scientific article published in April 2003

Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance

scientific article published in July 2000

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

scientific article published on 31 January 2015

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

scientific article published on 2 December 2015

Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin

scientific article published on September 2013

Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.

scientific article

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

scientific article published on 17 July 2013

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo.

scientific article published on 21 February 2017

Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter

scientific article published on 01 February 2000

Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands

scientific article published on 5 December 2011

Nestin expression in pancreatic exocrine cell lineages.

scientific article published in January 2004

Nogo-A downregulation improves insulin secretion in mice.

scientific article published on 28 December 2012

Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice

scientific article published on 09 October 2008

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.

scientific article published on 25 March 2017

Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice

scientific journal article

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells

scientific article published on 22 October 2018

Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis

scientific article published on March 2017

Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content.

scientific article published in March 2004

Peripheral tolerance limits CNS accumulation of CD8 T cells specific for an antigen shared by tumor cells and normal astrocytes.

scientific article

Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion

scientific article

Stabilization of beta-catenin impacts pancreas growth.

scientific article published on 12 April 2006

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.

scientific article published on 11 April 2016

Stress-induced adaptive islet cell identity changes

scientific article published on September 2016

TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro

scientific article published on 01 December 1994

TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes

scientific article published on 01 December 1995

Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.

scientific article

The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells.

scientific article published on 7 August 2007

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

scientific article

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

scientific article

The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice.

scientific article

Tissue repair brakes: A common paradigm in the biology of regeneration

scientific article published on 28 November 2019

Transgenic and other experimental models of pancreas and islet damage.

scientific article

Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

scientific article published on 29 September 2011

UCP2 regulates the glucagon response to fasting and starvation

scientific article published on 22 February 2013

Ultrafast pulse shaping modulates perceived visual brightness in living animals

scientific article published in 2021

β-cell regeneration: the pancreatic intrinsic faculty.

scientific article

List of works by Pedro Luis Herrera

A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice

A standardized method for in vivo mouse pancreas imaging and semiquantitative β cell mass measurement by dual isotope SPECT.

Ablation of PDK1 in pancreatic beta cells induces diabetes as a result of loss of beta cell mass

Activation of the Reg family genes by pancreatic-specific IGF-I gene deficiency and after streptozotocin-induced diabetes in mouse pancreas

Adult insulin- and glucagon-producing cells differentiate from two independent cell lineages

Alpha cell-specific Men1 ablation triggers the transdifferentiation of glucagon-expressing cells and insulinoma development.

An amylase/Cre transgene marks the whole endoderm but the primordia of liver and ventral pancreas.

An essential role for insulin and IGF1 receptors in regulating sertoli cell proliferation, testis size, and FSH action in mice

Argonaute2 mediates compensatory expansion of the pancreatic β cell

Beta-cell-targeted expression of a dominant-negative hepatocyte nuclear factor-1 alpha induces a maturity-onset diabetes of the young (MODY)3-like phenotype in transgenic mice.

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.

Cell type-specific deletion in mice reveals roles for PAS kinase in insulin and glucagon production

Connective tissue growth factor modulates adult β-cell maturity and proliferation to promote β-cell regeneration in mice

Context-specific α- to-β-cell reprogramming by forced Pdx1 expression.

Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss

Converting Adult Pancreatic Islet α Cells into β Cells by Targeting Both Dnmt1 and Arx.

Defining the cell lineages of the islets of Langerhans using transgenic mice.

Deletion of glutamate dehydrogenase in beta-cells abolishes part of the insulin secretory response not required for glucose homeostasis.

Deletion of the von Hippel-Lindau gene in pancreatic beta cells impairs glucose homeostasis in mice.

Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers.

Diabetes relief in mice by glucose-sensing insulin-secreting human α-cells.

Dnmt1 activity is dispensable in δ-cells but is essential for α-cell homeostasis

Embryogenesis of the murine endocrine pancreas; early expression of pancreatic polypeptide gene

Embryonic endocrine pancreas and mature beta cells acquire alpha and PP cell phenotypes upon Arx misexpression.

Experimental models of beta-cell regeneration.

Fgf9 signalling stimulates Spred and Sprouty expression in embryonic mouse pancreas mesenchyme.

Foxa2 is required for the differentiation of pancreatic alpha-cells

GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells

Generation of Smad4/Dpc4 conditional knockout mice

Generation of human islet cell type-specific identity genesets

Genes controlling pancreas ontogeny.

Glycoprotein 130 receptor signaling mediates α-cell dysfunction in a rodent model of type 2 diabetes.

Increasing uncoupling protein-2 in pancreatic beta cells does not alter glucose-induced insulin secretion but decreases production of reactive oxygen species.

Insulin and Glucagon: Partners for Life.

Insulin and IGF1 receptors are essential for XX and XY gonadal differentiation and adrenal development in mice

Islet beta-cell secretion determines glucagon release from neighbouring alpha-cells.

Junctional communication of pancreatic beta cells contributes to the control of insulin secretion and glucose tolerance

LKB1 and AMPKα1 are required in pancreatic alpha cells for the normal regulation of glucagon secretion and responses to hypoglycemia

Lack of Prox1 Downregulation Disrupts the Expansion and Maturation of Postnatal Murine β-Cells

Leptin engages a hypothalamic neurocircuitry to permit survival in the absence of insulin

Lixisenatide accelerates restoration of normoglycemia and improves human beta-cell function and survival in diabetic immunodeficient NOD-scid IL-2rg(null) RIP-DTR mice engrafted with human islets.

Loss of prohibitin induces mitochondrial damages altering β-cell function and survival and is responsible for gradual diabetes development.

Mafa Enables Pdx1 to Effectively Convert Pancreatic Islet Progenitors and Committed Islet α-Cells Into β-Cells In Vivo.

Mosaic Cre-mediated recombination in pancreas using the pdx-1 enhancer/promoter

Multimodal image coregistration and inducible selective cell ablation to evaluate imaging ligands

Nestin expression in pancreatic exocrine cell lineages.

Nogo-A downregulation improves insulin secretion in mice.

Pancreatic Inactivation of c-Myc Decreases Acinar Mass and Transdifferentiates Acinar Cells Into Adipocytes in Mice

Pancreatic alpha cell-selective deletion of Tcf7l2 impairs glucagon secretion and counter-regulatory responses to hypoglycaemia in mice.

Pancreatic beta-cell-specific ablation of the multiple endocrine neoplasia type 1 (MEN1) gene causes full penetrance of insulinoma development in mice

Pancreatic islet-autonomous insulin and smoothened-mediated signalling modulate identity changes of glucagon α-cells

Pancreatic α Cell-Derived Glucagon-Related Peptides Are Required for β Cell Adaptation and Glucose Homeostasis

Pax2 mutant mice display increased number and size of islets of Langerhans but no change in insulin and glucagon content.

Peripheral tolerance limits CNS accumulation of CD8 T cells specific for an antigen shared by tumor cells and normal astrocytes.

Regeneration of pancreatic insulin-producing cells by in situ adaptive cell conversion

Stabilization of beta-catenin impacts pancreas growth.

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.

Stress-induced adaptive islet cell identity changes

TGF-beta 1 influences the relative development of the exocrine and endocrine pancreas in vitro

TGF-beta 1 overexpression in murine pancreas induces chronic pancreatitis and, together with TNF-alpha, triggers insulin-dependent diabetes

Targeting GLP-1 receptors for repeated magnetic resonance imaging differentiates graded losses of pancreatic beta cells in mice.

The GluCre-ROSA26EYFP mouse: a new model for easy identification of living pancreatic alpha-cells.

The Zinc Transporter Slc30a8/ZnT8 Is Required in a Subpopulation of Pancreatic α-Cells for Hypoglycemia-induced Glucagon Secretion

The transcription factor Rfx3 regulates beta-cell differentiation, function, and glucokinase expression

The zinc finger protein ZBTB20 regulates transcription of fructose-1,6-bisphosphatase 1 and β cell function in mice.

Tissue repair brakes: A common paradigm in the biology of regeneration

Transgenic and other experimental models of pancreas and islet damage.

Transgenic overexpression of the transcription factor Nkx6.1 in β-cells of mice does not increase β-cell proliferation, β-cell mass, or improve glucose clearance.

UCP2 regulates the glucagon response to fasting and starvation

Ultrafast pulse shaping modulates perceived visual brightness in living animals

β-cell regeneration: the pancreatic intrinsic faculty.