List of works - Ben Bax

1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3

scientific article

5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors

scientific article

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance

scientific article published on 10 March 2018

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I.

scientific article published in July 1999

Challenges for and current status of research into positive modulators of AMPA receptors.

scientific article

Common themes and surprising differences in small G-proteins.

scientific article published on August 1997

Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences

scientific article published on 13 February 2018

Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide

scientific article

Crystallization and preliminary X-ray diffraction studies on ADP-ribosylation factor 1

scientific article (publication date: 16 December 1994)

Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase

scientific article published on 15 September 2020

Crystallization of a new form of the eye lens protein beta B2-crystallin

scientific article published on 01 August 1989

Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy

scientific article

Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator

scientific article

Frog lens beta A1-crystallin: the nucleotide sequence of the cloned cDNA and computer graphics modelling of the three-dimensional structure.

scientific article published in November 1987

From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome

scientific article published on 7 September 2017

GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity ⬇️

scientific article published on November 2, 2001

Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry.

scientific article

High resolution structure of an oligomeric eye lens beta-crystallin. Loops, arches, linkers and interfaces in beta B2 dimer compared to a monomeric gamma-crystallin

scientific article published on 01 December 1991

Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors ⬇️

scientific article published on June 29, 2011

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

scientific article published on 26 January 2015

Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators ⬇️

scientific article published on December 3, 2010

Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons

scientific article published on 17 May 2018

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase

scientific article published on 28 February 2019

Nerve growth factor alpha subunit: effect of site-directed mutations on catalytic activity and 7S NGF complex formation.

scientific article

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

scientific article

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases

scientific article

Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design

scientific article

Purification, crystallization and preliminary X-ray crystallographic studies of theMycobacterium tuberculosisDNA gyrase ATPase domain ⬇️

scientific article published on May 25, 2013

Purification, crystallization and preliminary crystallographic analysis of bovine cytosolic brain-type creatine kinase ⬇️

scientific article published on September 1, 1998

Structural aspects of the functional modules in human protein kinase-C alpha deduced from comparative analyses

scientific article published on 01 October 1996

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.

scientific article published on 7 December 2015

Structure of oligomeric beta B2-crystallin: an application of the T2 translation function to an asymmetric unit containing two dimers

scientific article published on 01 December 1991

The Structure of Phosphorylated GSK-3β Complexed with a Peptide, FRATtide, that Inhibits β-Catenin Phosphorylation ⬇️

scientific article published on December 1, 2001

The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.

scientific article published on June 2004

Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

scientific article

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase

scientific article published on 11 April 2022

List of works by Ben Bax

1-Aryl-3,4-dihydroisoquinoline inhibitors of JNK3

5-Aryl-4-carboxamide-1,3-oxazoles: potent and selective GSK-3 inhibitors

A new class of antibacterials, the imidazopyrazinones, reveal structural transitions involved in DNA gyrase poisoning and mechanisms of resistance

ADP ribosylation factor 1 mutants identify a phospholipase D effector region and reveal that phospholipase D participates in lysosomal secretion but is not sufficient for recruitment of coatomer I.

Challenges for and current status of research into positive modulators of AMPA receptors.

Common themes and surprising differences in small G-proteins.

Coupling the core of the anticancer drug etoposide to an oligonucleotide induces topoisomerase II-mediated cleavage at specific DNA sequences

Crystallization and initial crystallographic analysis of covalent DNA-cleavage complexes of Staphyloccocus aureus DNA gyrase with QPT-1, moxifloxacin and etoposide

Crystallization and preliminary X-ray diffraction studies on ADP-ribosylation factor 1

Crystallization and structure of ebselen bound to Cys141 of human inositol monophosphatase

Crystallization of a new form of the eye lens protein beta B2-crystallin

Crystallizing Membrane Proteins in the Lipidic Mesophase. Experience with Human Prostaglandin E2 Synthase 1 and an Evolving Strategy

Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator

Frog lens beta A1-crystallin: the nucleotide sequence of the cloned cDNA and computer graphics modelling of the three-dimensional structure.

From PIM1 to PI3Kδ via GSK3β: Target Hopping through the Kinome

GSK‐3 inhibition by adenoviral FRAT1 overexpression is neuroprotective and induces Tau dephosphorylation and β‐catenin stabilisation without elevation of glycogen synthase activity ⬇️

Getting the chemistry right: protonation, tautomers and the importance of H atoms in biological chemistry.

High resolution structure of an oligomeric eye lens beta-crystallin. Loops, arches, linkers and interfaces in beta B2 dimer compared to a monomeric gamma-crystallin

Identification of 2-(4-pyridyl)thienopyridinones as GSK-3β inhibitors ⬇️

Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation.

Integration of Lead Optimization with Crystallography for a Membrane-Bound Ion Channel Target: Discovery of a New Class of AMPA Receptor Positive Allosteric Modulators ⬇️

Mechanism of Action of Mycobacterium tuberculosis Gyrase Inhibitors: A Novel Class of Gyrase Poisons

Mechanistic and Structural Basis for the Actions of the Antibacterial Gepotidacin against Staphylococcus aureus Gyrase

Nerve growth factor alpha subunit: effect of site-directed mutations on catalytic activity and 7S NGF complex formation.

Novel hydroxyl tricyclics (e.g., GSK966587) as potent inhibitors of bacterial type IIA topoisomerases

Novel tricyclics (e.g., GSK945237) as potent inhibitors of bacterial type IIA topoisomerases

Protein arginine deiminase 2 binds calcium in an ordered fashion: implications for inhibitor design

Purification, crystallization and preliminary X-ray crystallographic studies of theMycobacterium tuberculosisDNA gyrase ATPase domain ⬇️

Purification, crystallization and preliminary crystallographic analysis of bovine cytosolic brain-type creatine kinase ⬇️

Structural aspects of the functional modules in human protein kinase-C alpha deduced from comparative analyses

Structural basis of DNA gyrase inhibition by antibacterial QPT-1, anticancer drug etoposide and moxifloxacin.

Structure of oligomeric beta B2-crystallin: an application of the T2 translation function to an asymmetric unit containing two dimers

The Structure of Phosphorylated GSK-3β Complexed with a Peptide, FRATtide, that Inhibits β-Catenin Phosphorylation ⬇️

The structure of MSK1 reveals a novel autoinhibitory conformation for a dual kinase protein.

Thiophene antibacterials that allosterically stabilize DNA-cleavage complexes with DNA gyrase

Tyrosine 121 moves revealing a ligandable pocket that couples catalysis to ATP-binding in serine racemase