Search filters

List of works by Mark S. Gold

"Liking" and "wanting" linked to Reward Deficiency Syndrome (RDS): hypothesizing differential responsivity in brain reward circuitry

scientific article published on January 2012

A Novel Precision Approach to Overcome the “Addiction Pandemic” by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration

scientific article published on 16 March 2021

A Shared Molecular and Genetic Basis for Food and Drug Addiction: Overcoming Hypodopaminergic Trait/State by Incorporating Dopamine Agonistic Therapy in Psychiatry

scientific article published on September 2015

A Systematic, Intensive Statistical Investigation of Data from the Comprehensive Analysis of Reported Drugs (CARD) for Compliance and Illicit Opioid Abstinence in Substance Addiction Treatment with Buprenorphine/naloxone

scientific article published on 19 December 2017

A marked increase in cocaine-related deaths in the State of Florida: precursor to an epidemic?

scientific article published in January 2007

Alcohol consumption associated with collegiate American football pre-game festivities

scientific article

Altered functional brain networks in Prader-Willi syndrome

scientific article published on 21 January 2013

Altered small-world brain functional networks and duration of heroin use in male abstinent heroin-dependent individuals

scientific article

Analysis of Evidence for the Combination of Pro-dopamine Regulator (KB220PAM) and Naltrexone to Prevent Opioid Use Disorder Relapse

scientific article published on 30 July 2018

Animal models lead the way to further understanding food addiction as well as providing evidence that drugs used successfully in addictions can be successful in treating overeating

scientific article published on 28 May 2013

Antagonism of CRF receptors prevents the deficit in brain reward function associated with precipitated nicotine withdrawal in rats

scientific article published on 30 August 2006

Attention-Deficit/Hyperactivity Disorder: Is it time to Reappraise the Role of Sugar Consumption? ⬇️

scientific article published on September 1, 2011

Behavioral Characterization of the Effects of Cannabis Smoke and Anandamide in Rats

scientific article

Biomarker identification in psychiatric disorders: from neuroscience to clinical practice

scientific article

Biomarkers in psychiatry: how close are we?

scientific article published on January 2012

Brief educational intervention to improve medical student competence in managing patients exposed to secondhand smoke

scientific article published on January 2014

Brief intervention for medical inpatients with unhealthy alcohol use.

scientific article

Buprenorphine Response as a Function of Neurogenetic Polymorphic Antecedents: Can Dopamine Genes Affect Clinical Outcomes in Reward Deficiency Syndrome (RDS)?

scientific article

CREB phosphorylation regulates striatal transcriptional responses in the self-administration model of methamphetamine addiction in the rat.

scientific article published on 30 May 2013

Calpain and caspase proteolytic markers co-localize with rat cortical neurons after exposure to methamphetamine and MDMA.

scientific article

Calpain- and caspase-mediated alphaII-spectrin and tau proteolysis in rat cerebrocortical neuronal cultures after ecstasy or methamphetamine exposure

scientific article published on 2 August 2006

Calvin klein (CK) designer cocktail, new "Speedball" is the "grimm reaper": Brain dopaminergic surge a potential death sentence

scientific article published on 01 April 2020

Can Chronic Consumption of Caffeine by Increasing D2/D3 Receptors Offer Benefit to Carriers of the DRD2 A1 Allele in Cocaine Abuse?

scientific article published on 01 April 2019

Can drug design inhibit abuse?

scientific article

Changes in leptin, ghrelin, growth hormone and neuropeptide-Y after an acute model of MDMA and methamphetamine exposure in rats.

scientific article published on 2 October 2007

Chronic Methamphetamine Effects on Brain Structure and Function in Rats

scientific article

Chronic neuroleptic treatment combined with a high fat diet elevated [3H] flunitrazepam binding in the cerebellum

scientific article published in 2022

Clinically Combating Reward Deficiency Syndrome (RDS) with Dopamine Agonist Therapy as a Paradigm Shift: Dopamine for Dinner?

scientific article

Common Neurogenetic Diagnosis and Meso-Limbic Manipulation of Hypodopaminergic Function in Reward Deficiency Syndrome (RDS): Changing the Recovery Landscape

scientific article published on 12 May 2016

Comorbidity and "self-medication".

scientific article published in January 2007

Conceptualizing Addiction From an Osteopathic Perspective: Dopamine Homeostasis

scientific article published in February 2018

Concurrent calpain and caspase-3 mediated proteolysis of alpha II-spectrin and tau in rat brain after methamphetamine exposure: a similar profile to traumatic brain injury

scientific article published on 25 August 2005

Correction to: Qualitative vs. Quantitative Methods in Psychiatric Research: Updated

scientific article published on 01 January 2019

Correction: Chronic Methamphetamine Effects on Brain Structure and Function in Rats.

scientific article published on 8 February 2017

Correction: Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics

scientific article published on 11 September 2015

Correction: Identification of Proteins Sensitive to Thermal Stress in Human Neuroblastoma and Glioma Cell Lines.

scientific article published on 26 November 2012

Coupling Neurogenetics (GARS™) and a Nutrigenomic Based Dopaminergic Agonist to Treat Reward Deficiency Syndrome (RDS): Targeting Polymorphic Reward Genes for Carbohydrate Addiction Algorithms

scientific article published on 24 June 2015

Depression-related improvement with vardenafil for erectile response

scientific article published on 01 August 2006

Distinct resting-state brain activities in heroin-dependent individuals ⬇️

scientific article published on May 30, 2011

Do dopaminergic gene polymorphisms affect mesolimbic reward activation of music listening response? Therapeutic impact on Reward Deficiency Syndrome (RDS).

scientific article

Dopamine D2 gene expression interacts with environmental enrichment to impact lifespan and behavior.

scientific article published on 15 March 2016

Dopamine and glucose, obesity, and reward deficiency syndrome

scientific article

Dopamine homeostasis: brain functional connectivity in reward deficiency syndrome

scientific article

Dopamine in the Brain: Hypothesizing Surfeit or Deficit Links to Reward and Addiction

scientific article published on 23 October 2015

Dopaminergic Neurogenetics of Sleep Disorders in Reward Deficiency Syndrome (RDS)

scientific article

Dysfunctional connectivity patterns in chronic heroin users: an fMRI study

scientific article published on 18 May 2009

Ecstasy toxicity: a comparison to methamphetamine and traumatic brain injury

scientific article published in January 2006

Educational intervention to improve secondhand smoke awareness, competency, and screening among health professions students.

scientific article published on 9 October 2012

Effect of Second-Hand Tobacco Smoke on the Nitration of Brain Proteins: A Systems Biology and Bioinformatics Approach

scientific article published on January 2017

Effects of baclofen and naltrexone, alone and in combination, on the consumption of palatable food in male rats.

scientific article published on 28 July 2014

Effects of environmental tobacco smoke on adult rat brain biochemistry

scientific article

Effects of sustained gamma-hydroxybutyrate treatments on spontaneous and evoked firing activity of locus coeruleus norepinephrine neurons

scientific article published in May 2004

Enhanced functional connectivity and volume between cognitive and reward centers of naïve rodent brain produced by pro-dopaminergic agent KB220Z.

scientific article

Enhancing Brain Pregnenolone May Protect Cannabis Intoxication but Should Not Be Considered as an Anti-addiction Therapeutic: Hypothesizing Dopaminergic Blockade and Promoting Anti-Reward

scientific article

Evoked Potentials and Memory/Cognition Tests Validate Brain Atrophy as Measured by 3T MRI (NeuroQuant) in Cognitively Impaired Patients

scientific article published on 5 August 2015

Exploration of Epigenetic State Hyperdopaminergia (Surfeit) and Genetic Trait Hypodopaminergia (Deficit) during Adolescent Brain Development

scientific article published in 2021

Fentanyl and propofol exposure in the operating room: sensitization hypotheses and further data

scientific article

Food Addiction and Cues in Prader-Willi Syndrome ⬇️

scientific article published on March 1, 2009

Food Addiction? ⬇️

scientific article published on March 1, 2009

Food addiction & obesity treatment development

scientific article published in January 2011

Food addiction and neuroimaging

scientific article

Food addiction and obesity: evidence from bench to bedside

scientific article

Food addiction: an evolving nonlinear science

scientific article

Food consumption and weight gain after cessation of chronic amphetamine administration

scientific article

Further developments in the neurobiology of food and addiction: Update on the state of the science ⬇️

scientific article published on February 3, 2012

Genetic Addiction Risk Score (GARS): molecular neurogenetic evidence for predisposition to Reward Deficiency Syndrome (RDS)

scientific article

Granger causality reveals a dominant role of memory circuit in chronic opioid dependence

scientific article

Gray matter deficits and resting-state abnormalities in abstinent heroin-dependent individuals

scientific article published on 16 July 2010

Hormonal and neural mechanisms of food reward, eating behaviour and obesity

scientific article

Human traumatic brain injury induces autoantibody response against glial fibrillary acidic protein and its breakdown products.

scientific article

Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics

scientific article

Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics

scientific article (publication date: July 2015)

Hypothesizing Darkness Induced Alcohol Intake Linked to Dopaminergic Regulation of Brain Function

scientific article

Hypothesizing dopaminergic genetic antecedents in schizophrenia and substance seeking behavior

scientific article

Hypothesizing that designer drugs containing cathinones ("bath salts") have profound neuro-inflammatory effects and dangerous neurotoxic response following human consumption

scientific article published on 8 July 2013

Identification of proteins sensitive to thermal stress in human neuroblastoma and glioma cell lines

scientific article

Identification of tyrosine nitration in UCH-L1 and GAPDH.

scientific article published in June 2011

Improving naltrexone compliance and outcomes with putative pro- dopamine regulator KB220, compared to treatment as usual

scientific article published on 01 May 2020

Increased assessment and monitoring needed for patients receiving methadone

scientific article published on 01 May 2008

Interaction of satiety and reward response to food stimulation.

scientific article published in January 2004

Investigating the effects of low dose alcohol on neural timing using functional MRI.

scientific article published on 16 September 2011

Lifetime psychiatric and substance use disorders among impaired physicians in a physicians health program: comparison to a general treatment population: psychopathology of impaired physicians.

scientific article published on March 2013

Low dopamine function in attention deficit/hyperactivity disorder: should genotyping signify early diagnosis in children?

scientific article

Methadone- and heroin-related deaths in Florida

scientific article published on January 2008

Methamphetamine- and trauma-induced brain injuries: comparative cellular and molecular neurobiological substrates

scientific article

Methods in drug abuse models: comparison of different models of methamphetamine paradigms

scientific article published in January 2012

Methods in drug abuse neuroproteomics: methamphetamine psychoproteome

scientific journal article

Methods in systems biology of experimental methamphetamine drug abuse

scientific article published on January 2010

Methods in tobacco abuse: proteomic changes following second-hand smoke exposure

scientific article published in January 2012

Middle-age initiation of alcohol consumption unlikely to cause addiction

scientific article published in September 2008

Molecular Genetic Testing in Reward Deficiency Syndrome (RDS): Facts and Fiction

scientific article published on January 2015

Molecular neurological correlates of endorphinergic/dopaminergic mechanisms in reward circuitry linked to endorphinergic deficiency syndrome (EDS)

scientific article published on 14 February 2020

Molecular role of dopamine in anhedonia linked to reward deficiency syndrome (RDS) and anti- reward systems

scientific article published in March 2018

NIDA-Drug Addiction Treatment Outcome Study (DATOS) Relapse as a Function of Spirituality/Religiosity

scientific article published on January 2015

Neuro-Genetics of Reward Deficiency Syndrome (RDS) as the Root Cause of "Addiction Transfer": A New Phenomenon Common after Bariatric Surgery

scientific article published on December 2011

Neuro-chemical activation of brain reward meso-limbic circuitry is associated with relapse prevention and drug hunger: A hypothesis ⬇️

scientific article published on April 1, 2011

Neuro-psychopharmacogenetics and Neurological Antecedents of Posttraumatic Stress Disorder: Unlocking the Mysteries of Resilience and Vulnerability ⬇️

scientific article published on December 1, 2010

Neurobiological mechanisms in addictive and psychiatric disorders

scientific article

Neurogenetic and epigenetic correlates of adolescent predisposition to and risk for addictive behaviors as a function of prefrontal cortex dysregulation

scientific article published on 28 April 2015

Neurogenetics and Epigenetics in Impulsive Behaviour: Impact on Reward Circuitry

scientific article

Neurogenetics and gene therapy for reward deficiency syndrome: are we going to the Promised Land?

scientific article published on 14 May 2015

Neurogenetics of acute and chronic opiate/opioid abstinence: treating symptoms and the cause.

scientific article published on March 2017

Neurogenetics of dopaminergic receptor supersensitivity in activation of brain reward circuitry and relapse: proposing "deprivation-amplification relapse therapy" (DART).

scientific article published on November 2009

Neurological and Neuropsychological Changes Associated with SARS-CoV-2 Infection: New Observations, New Mechanisms

scientific article published on 03 January 2021

Neurological correlates of brain reward circuitry linked to opioid use disorder (OUD): Do homo sapiens acquire or have a reward deficiency syndrome?

scientific article published on 15 September 2020

Obesity: pathophysiology and intervention

scientific article

Opioid treatment for chronic back pain and its association with addiction

scientific article published on 01 September 2007

Opioid use disorder: current trends and potential treatments

scholarly article

Our evolved unique pleasure circuit makes humans different from apes: Reconsideration of data derived from animal studies

scientific article published on 28 February 2018

Overlaps in the Nosology of Substance Abuse and Overeating: The Translational Implications of “Food Addiction” ⬇️

scientific article published on September 1, 2011

PATHOS: a brief screening application for assessing sexual addiction

scientific article published on March 2012

Performance enhancing, non-prescription use of Ritalin: a comparison with amphetamines and cocaine.

scientific article published on January 2007

Physicians and drug screening

scientific article published on 01 August 2006

Physicians' experiences with impaired colleagues

Pilot clinical observations between food and drug seeking derived from fifty cases attending an eating disorder clinic

scientific article published on 09 August 2016

Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study

scientific article

Prescription opioid abuse and dependence among physicians: hypotheses and treatment

scientific article published on May 2008

Prescription opioids and overdose deaths

scientific article published on 01 May 2009

Prevalence of drug and alcohol use in urban Afghanistan: epidemiological data from the Afghanistan National Urban Drug Use Study (ANUDUS).

scientific article

Problem doctors: is there a system-level solution?

scientific article published on 01 June 2006

Psychiatric research: psychoproteomics, degradomics and systems biology

scientific article published on April 2008

Psychoproteomic analysis of rat cortex following acute methamphetamine exposure

scientific journal article

Psychostimulant use disorder emphasizing methamphetamine and the opioid -dopamine connection: Digging out of a hypodopaminergic ditch

scientific article published on 28 November 2020

Putative COVID- 19 Induction of Reward Deficiency Syndrome (RDS) and Associated Behavioral Addictions with Potential Concomitant Dopamine Depletion: Is COVID-19 Social Distancing a Double Edged Sword?

scientific article published on 22 September 2020

Putative dopamine agonist (KB220Z) attenuates lucid nightmares in PTSD patients: role of enhanced brain reward functional connectivity and homeostasis redeeming joy.

scientific article published in June 2015

Qualitative versus quantitative methods in psychiatric research

scientific article published in January 2012

Qualitative vs. Quantitative Methods in Psychiatric Research: Updated

scientific article published on 01 January 2019

Randomized fMRI Trial of the Central Effects of Acute Acupuncture on Glucose Levels and Core Body Temperature in “Overweight” Males

Rapid Anti-Depressant Relief by Ketamine: Exploring A Complex Mechanism of Action

scholarly article

Recent updates on drug abuse analyzed by neuroproteomics studies: Cocaine, Methamphetamine and MDMA

article published in 2014

Reduced responses to heroin-cue-induced craving in the dorsal striatum: effects of long-term methadone maintenance treatment

scientific article published on 23 August 2014

Regarding "Is cigarette smoking a gateway to alcohol and illicit drug use disorders? A study of youths with and without attention deficit hyperactivity disorder"

scientific article published on 28 July 2006

Response to "Comorbid psychiatric diagnoses and their association with cocaine-induced psychosis in cocaine-dependent subjects".

scientific article published in May 2008

Retraction: Hypersexuality Addiction and Withdrawal: Phenomenology, Neurogenetics and Epigenetics

scientific article published on 6 October 2015

Reward Circuitry Dopaminergic Activation Regulates Food and Drug Craving Behavior ⬇️

scientific article published on January 1, 2011

Reward Deficiency Syndrome (RDS): A Cytoarchitectural Common Neurobiological Trait of All Addictions

scientific article published in 2021

Reward Deficiency Syndrome: Attentional/Arousal Subtypes, Limitations of Current Diagnostic Nosology, and Future Research

scientific article

Second-hand and third-hand drug exposures in the operating room: a factor in anesthesiologists' dependency on fentanyl

scientific article published on July 2010

Sensitivity to Alcohol in Obese Patients: A Possible Role for Food Addiction ⬇️

scientific article published on September 1, 2011

Setting the standard for recovery: Physicians' Health Programs

scientific article published in March 2009

Severe deficit in brain reward function associated with fentanyl withdrawal in rats

scientific article published on 19 September 2005

Sex, Drugs, and Rock ‘N’ Roll: Hypothesizing Common Mesolimbic Activation as a Function of Reward Gene Polymorphisms ⬇️

scientific article published on January 1, 2012

Should the United States Government Repeal Restrictions on Buprenorphine/Naloxone Treatment?

scientific article published on 27 July 2016

Smoking cessation and the risk for type 2 diabetes mellitus.

scientific article published in June 2010

Speed, cocaine, and other psychostimulants death rates

scientific article published on 8 June 2007

Substance use disorder a bio-directional subset of reward deficiency syndrome

scientific article published in June 2017

Symptoms of ADHD or marijuana use?

scientific article published on 01 June 2007

Systematic evaluation of "compliance" to prescribed treatment medications and "abstinence" from psychoactive drug abuse in chemical dependence programs: data from the comprehensive analysis of reported drugs

scientific article

The DRD2 Taq1A A1 Allele May Magnify the Risk of Alzheimer's in Aging African-Americans.

scientific article published on 30 September 2017

The Effect of Chronic Methamphetamine Exposure on the Hippocampal and Olfactory Bulb Neuroproteomes of Rats

scientific article

The Food and Drug Addiction Epidemic: Targeting Dopamine Homeostasis

scientific article published on 22 August 2017

The Mirage of Impairing Drug Concentration Thresholds: A Rationale for Zero Tolerance Per Se Driving under the Influence of Drugs Laws ⬇️

scientific article published on June 1, 2012

The Molecular Neurobiology of Twelve Steps Program & Fellowship: Connecting the Dots for Recovery

scientific article

The Psychoactive Designer Drug and Bath Salt Constituent MDPV Causes Widespread Disruption of Brain Functional Connectivity

scientific article published on 21 March 2016

The effects of buprenorphine on fentanyl withdrawal in rats

scientific article published on 9 January 2007

The next generation of obesity treatments: beyond suppressing appetite

scientific article published on 9 October 2013

The therapeutic potential of exercise for neuropsychiatric diseases: A review

scientific article published on 04 March 2020

Tossing the baby out with the bathwater after a brief rinse? The potential downside of dismissing food addiction based on limited data

scientific article published on 20 June 2012

Traumatic brain injury and methamphetamine: A double-hit neurological insult

scientific article published on 30 January 2020

Using the Neuroadaptagen KB200z™ to Ameliorate Terrifying, Lucid Nightmares in RDS Patients: the Role of Enhanced, Brain-Reward, Functional Connectivity and Dopaminergic Homeostasis

scientific article published on January 2015

Why are we consuming so much sugar despite knowing too much can harm us?

scientific article published on 01 January 2015

rsfMRI effects of KB220Z™ on neural pathways in reward circuitry of abstinent genotyped heroin addicts

scientific article published on 16 December 2014

Paulina is supported by:

About Paulina

Help