List of works by Mark Mattson

"Control" laboratory rodents are metabolically morbid: why it matters

scientific article

17Beta-estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron

scientific article published on 01 November 1997

2-Deoxy-D-glucose protects hippocampal neurons against excitotoxic and oxidative injury: evidence for the involvement of stress proteins

scientific article

3,6'-dithiothalidomide improves experimental stroke outcome by suppressing neuroinflammation ⬇️

scientific article published on 13 February 2013

3-Hydroxybutyrate regulates energy metabolism and induces BDNF expression in cerebral cortical neurons

scientific article published on 14 October 2016

3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress

scientific article

4-Hydroxynonenal induces dysfunction and apoptosis of cultured endothelial cells

scientific article published on 01 November 1999

4-Hydroxynonenal induces oxidative stress and death of cultured spinal cord neurons

scientific article published on 01 June 2000

4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes ⬇️

scientific article published on October 1, 1997

4-hydroxynonenal, a lipid peroxidation product, rapidly accumulates following traumatic spinal cord injury and inhibits glutamate uptake

scientific article published on 01 June 1997

4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, Impairs Signal Transduction Associated with Muscarinic Acetylcholine and Metabotropic Glutamate Receptors: Possible Action on Gαq/11 ⬇️

scientific article published on August 1, 1997

A Pilot Study of Exenatide Actions in Alzheimer's Disease

scientific article published on 01 January 2019

A controlled trial of reduced meal frequency without caloric restriction in healthy, normal-weight, middle-aged adults

scientific article

A high-fat diet and NAD(+) activate Sirt1 to rescue premature aging in cockayne syndrome

scientific article (publication date: 4 November 2014)

A ketone ester diet exhibits anxiolytic and cognition-sparing properties, and lessens amyloid and tau pathologies in a mouse model of Alzheimer's disease

scientific article

A link between maze learning and hippocampal expression of neuroleukin and its receptor gp78

scientific article (publication date: 2002)

A mechanism for the neuroprotective effect of apolipoprotein E: isoform-specific modification by the lipid peroxidation product 4-hydroxynonenal

scientific article published on 01 April 2000

A mitochondrial uncoupler prodrug protects dopaminergic neurons and improves functional outcome in a mouse model of Parkinson's disease

scientific article published on 26 September 2019

A neural signaling triumvirate that influences ageing and age-related disease: insulin/IGF-1, BDNF and serotonin

scientific article

A randomized pilot study comparing zero-calorie alternate-day fasting to daily caloric restriction in adults with obesity

scientific article published on September 2016

A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid beta-peptide

scientific article published in January 1997

A synthetic uric acid analog accelerates cutaneous wound healing in mice

scientific article

A targeted neuroglial reporter line generated by homologous recombination in human embryonic stem cells

scientific article published on August 2009

AGEMAP: a gene expression database for aging in mice

scientific article

ALS-linked Cu/Zn-SOD mutation impairs cerebral synaptic glucose and glutamate transport and exacerbates ischemic brain injury

scientific article published on 01 March 2000

ALS-linked Cu/Zn-SOD mutation increases vulnerability of motor neurons to excitotoxicity by a mechanism involving increased oxidative stress and perturbed calcium homeostasis

scientific article published on November 1999

Aberrant heart rate and brainstem brain-derived neurotrophic factor (BDNF) signaling in a mouse model of Huntington's disease

scientific article published on 31 December 2011

Aberrant stress response associated with severe hypoglycemia in a transgenic mouse model of Alzheimer's disease

scientific article

Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease ⬇️

scientific article published on October 13, 2010

Accelerated cognitive aging in diabetic rats is prevented by lowering corticosterone levels

scientific article published on 24 June 2008

Activation of NF-kappaB protects hippocampal neurons against oxidative stress-induced apoptosis: evidence for induction of manganese superoxide dismutase and suppression of peroxynitrite production and protein tyrosine nitration

scientific article published in September 1997

Activation of TRPML1 clears intraneuronal Aβ in preclinical models of HIV infection

scientific article

Activation of mitochondrial ATP-dependent potassium channels protects neurons against ischemia-induced death by a mechanism involving suppression of Bax translocation and cytochrome c release

scientific article published in April 2002

Activity-dependent neuronal Klotho enhances astrocytic aerobic glycolysis.

scientific article published in January 2018

Activity-induced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks.

scientific article

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

scientific article published on 28 November 2016

Adhesion- and migration-related side effects of phosphothioated CpG oligodeoxynucleotides

scientific article published on 08 July 2009

Adiponectin protects rat hippocampal neurons against excitotoxicity ⬇️

scientific article published on September 15, 2010

Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain

scientific article published in January 2002

Adverse stress, hippocampal networks, and Alzheimer's disease

scientific article

Age and energy intake interact to modify cell stress pathways and stroke outcome

scientific article

Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

scientific article

Age-associated alterations in the levels of cytotoxic lipid molecular species and oxidative stress in the murine thymus are reduced by growth hormone treatment

scientific article

Age-related impairment of cerebral blood flow response to KATP channel opener in Alzheimer's disease mice with presenilin-1 mutation

scientific article published on 17 November 2020

Age-related trends in gene expression in the chemosensory-nasal mucosae of senescence-accelerated mice

scientific article published in April 2003

Aging and longevity in the simplest animals and the quest for immortality

scientific article

Aging enhances release of exosomal cytokine mRNAs by Aβ1-42-stimulated macrophages

scientific article

Alteration in calcium channel properties is responsible for the neurotoxic action of a familial frontotemporal dementia tau mutation ⬇️

scientific article published on October 1, 2003

Alterations in Raft Lipid Metabolism in Aging and Neurodegenerative Disorders

Altered Extracellular Vesicle Concentration, Cargo, and Function in Diabetes

scientific article published on 02 May 2018

Altered calcium homeostasis and mitochondrial dysfunction in cortical synaptic compartments of presenilin-1 mutant mice

scientific article published in March 1999

Altered neuronal and microglial responses to excitotoxic and ischemic brain injury in mice lacking TNF receptors

scientific article published on 01 July 1996

Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma

scientific article published on 14 December 2006

Alternative Splicing of Neuronal Differentiation Factor TRF2 Regulated by HNRNPH1/H2

scientific article published on 20 April 2016

Alzheimer peptides perturb lipid-regulating enzymes

scientific article published in November 2005

Alzheimer's PS-1 mutation perturbs calcium homeostasis and sensitizes PC12 cells to death induced by amyloid beta-peptide.

scientific article published in December 1996

Alzheimer's amyloid beta-peptide enhances ATP/gap junction-mediated calcium-wave propagation in astrocytes

scientific article published in January 2003

Alzheimer's disease and neuronal network activity

scientific article

Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.

scientific article published in June 1997

Amyloid beta-peptide and oxidative cellular injury in Alzheimer's disease

scientific article published on June 1996

Amyloid beta-peptide disrupts carbachol-induced muscarinic cholinergic signal transduction in cortical neurons.

scientific article published on June 1996

Amyloid beta-peptide impairs glucose transport in hippocampal and cortical neurons: involvement of membrane lipid peroxidation

scientific article published on 01 February 1997

Amyloid beta-peptide impairs ion-motive ATPase activities: evidence for a role in loss of neuronal Ca2+ homeostasis and cell death ⬇️

scientific article published on September 1, 1995

Amyloid beta-peptide induces cell monolayer albumin permeability, impairs glucose transport, and induces apoptosis in vascular endothelial cells.

scientific article published in May 1997

An overview of APP processing enzymes and products

scientific article

Ancient viral protein enrages astrocytes in multiple sclerosis

scientific article published in October 2004

Anti-apoptotic role of telomerase in pheochromocytoma cells

scientific article published on 01 March 1999

Anti-death properties of TNF against metabolic poisoning: mitochondrial stabilization by MnSOD.

scientific article

Anticonvulsants attenuate amyloid beta-peptide neurotoxicity, Ca2+ deregulation, and cytoskeletal pathology

scientific article published on 01 March 1995

Antiparallel  -sheet architecture in Iowa-mutant  -amyloid fibrils

scientific article

Arachidonic acid increases choline acetyltransferase activity in spinal cord neurons through a protein kinase C-mediated mechanism.

scientific article published in August 2004

Arachidonic acid-induced oxidative injury to cultured spinal cord neurons

scientific article published on 01 August 1999

Are there roles for brain cell senescence in aging and neurodegenerative disorders?

scientific article

Assessing the involvement of telomerase in stem cell biology

scientific article published on 01 January 2002

Assessment of NAD+metabolism in human cell cultures, erythrocytes, cerebrospinal fluid and primate skeletal muscle

scientific article published on 27 February 2019

Astrocytic gap junctional communication decreases neuronal vulnerability to oxidative stress-induced disruption of Ca2+ homeostasis and cell death

scientific article

Autoantibodies to amyloid beta-peptide (Abeta) are increased in Alzheimer's disease patients and Abeta antibodies can enhance Abeta neurotoxicity: implications for disease pathogenesis and vaccine development

scientific article published on January 2003

BDNF and 5-HT: a dynamic duo in age-related neuronal plasticity and neurodegenerative disorders

scientific article published in October 2004

BDNF and exercise enhance neuronal DNA repair by stimulating CREB-mediated production of apurinic/apyrimidinic endonuclease 1.

scientific article published on 10 October 2013

Bacterial alkaloids mitigate seizure-induced hippocampal damage and spatial memory deficits

scientific article published in October 1996

Basic FGF attenuates amyloid beta-peptide-induced oxidative stress, mitochondrial dysfunction, and impairment of Na+/K+-ATPase activity in hippocampal neurons

scientific article published in May 1997

Basic FGF regulates the expression of a functional 71 kDa NMDA receptor protein that mediates calcium influx and neurotoxicity in hippocampal neurons

scientific article published on 01 November 1993

Basic fibroblast growth factor (bFGF) enhances functional recovery following severe spinal cord injury to the rat

scientific article published on 01 August 2000

Bcl-2 protects isolated plasma and mitochondrial membranes against lipid peroxidation induced by hydrogen peroxide and amyloid beta-peptide.

scientific article published in January 1998

Beneficial effects of dietary restriction on cerebral cortical synaptic terminals: preservation of glucose and glutamate transport and mitochondrial function after exposure to amyloid beta-peptide, iron, and 3-nitropropionic acid.

scientific article published on July 2000

Beneficial effects of intermittent fasting and caloric restriction on the cardiovascular and cerebrovascular systems

scientific article

Bidirectional metabolic regulation of neurocognitive function

scientific article

Bioenergetics of aging and calorie restriction.

scientific article

Biological sex and DNA repair deficiency drive Alzheimer's disease via systemic metabolic remodeling and brain mitochondrial dysfunction

scientific article published on 24 April 2020

Bone marrow transplantation reveals roles for brain macrophage/microglia TNF signaling and nitric oxide production in excitotoxic neuronal death

scientific article published on 01 January 2004

Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

scientific article published on 24 July 2020

Brain injury and tumor necrosis factors induce calbindin D-28k in astrocytes: evidence for a cytoprotective response

scientific article published on 01 October 1995

Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health

scientific article

Brain-derived neurotrophic factor mediates an excitoprotective effect of dietary restriction in mice

scientific article

CHD5, a brain-specific paralog of Mi2 chromatin remodeling enzymes, regulates expression of neuronal genes

scientific article

Calcium and reactive oxygen species mediate staurosporine-induced mitochondrial dysfunction and apoptosis in PC12 cells

scientific article published on 01 February 1998

Calcium dysregulation mediates mitochondrial and neurite outgrowth abnormalities in SOD2 deficient embryonic cerebral cortical neurons

scientific article published on 02 November 2018

Calcium orchestrates apoptosis.

scientific article

Calcium signaling in the ER: its role in neuronal plasticity and neurodegenerative disorders

scientific article

Calmodulin mediates brain-derived neurotrophic factor cell survival signaling upstream of Akt kinase in embryonic neocortical neurons

scientific article published on 17 December 2002

Caloric restriction and intermittent fasting alter spectral measures of heart rate and blood pressure variability in rats

scientific article

Caloric restriction and intermittent fasting: two potential diets for successful brain aging

scientific article

Caloric restriction increases neurotrophic factor levels and attenuates neurochemical and behavioral deficits in a primate model of Parkinson's disease

scientific article

Caloric restriction: impact upon pituitary function and reproduction

scientific article published on 07 February 2008

Calorie restriction up-regulates the plasma membrane redox system in brain cells and suppresses oxidative stress during aging

scholarly article

Cardioprotection by intermittent fasting in rats

scientific article published on 7 November 2005

Cardioprotective effect of intermittent fasting is associated with an elevation of adiponectin levels in rats

scientific journal article

Caspase-mediated degradation of AMPA receptor subunits: a mechanism for preventing excitotoxic necrosis and ensuring apoptosis

scientific article published on 01 May 2000

Caspase-mediated suppression of glutamate (AMPA) receptor channel activity in hippocampal neurons in response to DNA damage promotes apoptosis and prevents necrosis: implications for neurological side effects of cancer therapy and neurodegenerative

scientific article published on 01 April 2001

Catecholamines potentiate amyloid beta-peptide neurotoxicity: involvement of oxidative stress, mitochondrial dysfunction, and perturbed calcium homeostasis

scientific article published in October 1998

Cell cycle activation linked to neuronal cell death initiated by DNA damage

scientific article published in February 2004

Cell-extracellular matrix interactions regulate neural differentiation of human embryonic stem cells

scientific article

Cellular lifespan and senescence signaling in embryonic stem cells

scientific article

Cellular signaling roles of TGF beta, TNF alpha and beta APP in brain injury responses and Alzheimer's disease

scientific article published on 01 February 1997

Central mechanisms of HPA axis regulation by voluntary exercise.

scientific article

Ceramide protects hippocampal neurons against excitotoxic and oxidative insults, and amyloid beta-peptide toxicity

scientific article published in February 1996

Ceruloplasmin deficiency reduces levels of iron and BDNF in the cortex and striatum of young mice and increases their vulnerability to stroke

scientific article

Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF.

scientific article published on 24 November 2011

Chronic alternate-day fasting results in reduced diastolic compliance and diminished systolic reserve in rats

scientific article

Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease

scientific article published on 13 July 2013

Circulating brain-derived neurotrophic factor and indices of metabolic and cardiovascular health: data from the Baltimore Longitudinal Study of Aging

scientific article

Class II G protein-coupled receptors and their ligands in neuronal function and protection

scientific article

Clathrin assembly protein AP180 and CALM differentially control axogenesis and dendrite outgrowth in embryonic hippocampal neurons

scientific journal article

Clathrin assembly proteins AP180 and CALM in the embryonic rat brain

scientific article

Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA.

scientific article published on 18 October 2016

Combination Therapy with Low-Dose IVIG and a C1-esterase Inhibitor Ameliorates Brain Damage and Functional Deficits in Experimental Ischemic Stroke

scientific article published on 3 January 2018

Concentration- and cell type-specific effects of calbindin D28k on vulnerability of hippocampal neurons to seizure-induced injury

scientific article published on 01 January 2000

Conserved and differential effects of dietary energy intake on the hippocampal transcriptomes of females and males

scientific article

Contributions of impaired hippocampal plasticity and neurodegeneration to age-related deficits in hormonal pulsatility

scientific article published on 05 January 2008

Controlled meal frequency without caloric restriction alters peripheral blood mononuclear cell cytokine production

scientific article

Corrigendum to “Alternate day calorie restriction improves clinical findings and reduces markers of oxidative stress and inflammation in overweight adults with moderate asthma” [Free Radic. Biol. Med. 42 (2007) 665–674]

article

Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease

scientific article published in June 2001

Cross-species transcriptional profiles establish a functional portrait of embryonic stem cells

scientific article published on 19 October 2006

Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus

scientific article published on 24 March 2008

Cyclooxygenase-1 inhibition reduces amyloid pathology and improves memory deficits in a mouse model of Alzheimer's disease.

scientific article

Cytochalasins Protect Hippocampal Neurons Against Amyloid β‐Peptide Toxicity: Evidence that Actin Depolymerization Suppresses Ca2+ Influx ⬇️

scientific article published on September 1, 1995

DJ-1 is essential for long-term depression at hippocampal CA1 synapses

scientific article

DNA base excision repair activities in mouse models of Alzheimer's disease

scientific article published on 18 April 2008

DNA immunization with HBsAg-based particles expressing a B cell epitope of amyloid β-peptide attenuates disease progression and prolongs survival in a mouse model of Alzheimer's disease.

scientific article published on 14 January 2012

DNA polymerase β decrement triggers death of olfactory bulb cells and impairs olfaction in a mouse model of Alzheimer's disease

scientific article published on 30 September 2016

DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes

scientific article

Decline in daily running distance presages disease onset in a mouse model of ALS.

scientific article published on 06 May 2009

Defective DNA base excision repair in brain from individuals with Alzheimer's disease and amnestic mild cognitive impairment

scientific article

Defects of immune regulation in the presenilin-1 mutant knockin mouse.

scientific article published in January 2007

Deficiency of Toll-like receptors 2, 3 or 4 extends life expectancy in Huntington's disease mice.

scientific article published on 18 January 2018

Deletion in the N-terminal half of olfactomedin 1 modifies its interaction with synaptic proteins and causes brain dystrophy and abnormal behavior in mice

scientific article

Deuterated polyunsaturated fatty acids reduce brain lipid peroxidation and hippocampal amyloid β-peptide levels, without discernable behavioral effects in an APP/PS1 mutant transgenic mouse model of Alzheimer's disease.

scientific article published on 5 March 2018

Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons

scientific article

Diet-induced elevations in serum cholesterol are associated with alterations in hippocampal lipid metabolism and increased oxidative stress

scientific article

Diet-induced insulin resistance impairs hippocampal synaptic plasticity and cognition in middle-aged rats.

scientific article published on January 2008

Dietary energy intake modifies brainstem autonomic dysfunction caused by mutant α-synuclein

scientific article

Dietary folate deficiency and elevated homocysteine levels endanger dopaminergic neurons in models of Parkinson's disease

scientific article published in January 2002

Dietary restriction and 2-deoxyglucose administration improve behavioral outcome and reduce degeneration of dopaminergic neurons in models of Parkinson's disease

scientific article

Dietary restriction enhances neurotrophin expression and neurogenesis in the hippocampus of adult mice

scientific article published in February 2002

Dietary restriction mitigates cocaine-induced alterations of olfactory bulb cellular plasticity and gene expression, and behavior

scientific article

Dietary restriction normalizes glucose metabolism and BDNF levels, slows disease progression, and increases survival in huntingtin mutant mice

scholarly article

Dietary restriction selectively decreases glucocorticoid receptor expression in the hippocampus and cerebral cortex of rats.

scientific article published in December 2000

Dietary supplement creatine protects against traumatic brain injury

scientific article published on 01 November 2000

Dietary supplementation with 2-deoxy-D-glucose improves cardiovascular and neuroendocrine stress adaptation in rats

scientific article

Different amyloidogenic peptides share a similar mechanism of neurotoxicity involving reactive oxygen species and calcium

scientific article published on 01 April 1995

Differential effects of BDNF, ADNF9, and TNFalpha on levels of NMDA receptor subunits, calcium homeostasis, and neuronal vulnerability to excitotoxicity

scientific article published on 01 February 2000

Direct cleavage of AMPA receptor subunit GluR1 and suppression of AMPA currents by caspase-3: implications for synaptic plasticity and excitotoxic neuronal death

scientific article published in January 2002

Disease progression after bone marrow transplantation in a model of multiple sclerosis is associated with chronic microglial and glial progenitor response

scientific article

Disrupted energy metabolism and neuronal circuit dysfunction in cognitive impairment and Alzheimer's disease

scientific article

Disruption of neurogenesis by amyloid beta-peptide, and perturbed neural progenitor cell homeostasis, in models of Alzheimer's disease

scientific article published in December 2002

Disruption of neurogenesis in the subventricular zone of adult mice, and in human cortical neuronal precursor cells in culture, by amyloid beta-peptide: implications for the pathogenesis of Alzheimer's disease

scientific article published in January 2002

Distinguishing features of progenitor cells in the late embryonic and adult hippocampus

scientific article published in March 2003

Do apoptotic mechanisms regulate synaptic plasticity and growth-cone motility?

scientific article

Dual effects of ATP on rat hippocampal synaptic plasticity

scientific article published in March 2004

Dysregulation of cellular calcium homeostasis in Alzheimer's disease: bad genes and bad habits

scientific article

Early involvement of lysosome dysfunction in the degeneration of cerebral cortical neurons caused by the lipid peroxidation product 4-hydroxynonenal

scientific article published on 17 January 2017

Eating less suppresses microRNA assassins in the brain

scientific article published on March 2011

Effects of a dietary ketone ester on hippocampal glycolytic and tricarboxylic acid cycle intermediates and amino acids in a 3xTgAD mouse model of Alzheimer's disease

scientific article published on 18 January 2017

Effects of amyloid precursor protein derivatives and oxidative stress on basal forebrain cholinergic systems in Alzheimer's disease

scientific article

Effects of cerebral ischemia in mice deficient in Persephin

scientific article

Electroconvulsive shock ameliorates disease processes and extends survival in huntingtin mutant mice.

scientific article

Electrophysiological and cerebrovascular effects of the alpha-secretase-derived form of amyloid precursor protein in young and middle-aged rats

scientific article published on 8 December 2006

Elevated hepatic and depressed renal cytochrome P450 activity in the Tg2576 transgenic mouse model of Alzheimer's disease

scientific article published in February 2002

Elongation factor 2 diphthamide is critical for translation of two IRES-dependent protein targets, XIAP and FGF2, under oxidative stress conditions.

scientific article published on 17 October 2013

Elusive roles for astrocytes in neurodegenerative disorders

scientific article published on 01 May 1996

Enantioselective inhibition of d-serine transport by (S)-ketamine

scientific article published on 3 July 2015

Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice

scientific article

Endoplasmic reticulum D-myo-inositol 1,4,5-trisphosphate-sensitive stores regulate nuclear factor-kappaB binding activity in a calcium-independent manner

scientific article

Endoplasmic reticulum calcium release is modulated by actin polymerization

scientific article published in August 2002

Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders

scientific article

Energy intake and amyotrophic lateral sclerosis

scientific article

Energy restriction negates NMDA receptor antagonist efficacy in ischemic stroke

scientific article published on 10 June 2011

Enhancing the GLP-1 receptor signaling pathway leads to proliferation and neuroprotection in human neuroblastoma cells

scientific article

Essential role for integrin linked kinase in Akt-mediated integrin survival signaling in hippocampal neurons

scientific article

Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons

scientific article published on 01 May 1996

Estrogens stabilize mitochondrial function and protect neural cells against the pro-apoptotic action of mutant presenilin-1

scientific article published on 01 December 1997

Evidence That Actin Depolymerization Protects Hippocampal Neurons against Excitotoxicity by Stabilizing [Ca2+]i ⬇️

scientific article published on 01 June 1995

Evidence for a developmental role for TLR4 in learning and memory

scientific article

Evidence for altered Numb isoform levels in Alzheimer's disease patients and a triple transgenic mouse model.

scientific article

Evidence for caspase-mediated cleavage of AMPA receptor subunits in neuronal apoptosis and Alzheimer's disease

scientific article

Evidence for miR-181 involvement in neuroinflammatory responses of astrocytes

scientific article

Evidence for synaptic apoptosis

scientific article published in September 1998

Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis.

scientific article published in July 1997

Evidence that BDNF regulates heart rate by a mechanism involving increased brainstem parasympathetic neuron excitability

scientific article

Evidence that OGG1 glycosylase protects neurons against oxidative DNA damage and cell death under ischemic conditions.

scientific article

Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis

scientific article published in October 2002

Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death

scientific article

Evidence that brain-derived neurotrophic factor is required for basal neurogenesis and mediates, in part, the enhancement of neurogenesis by dietary restriction in the hippocampus of adult mice.

scientific article

Evidence that caspase-1 is a negative regulator of AMPA receptor-mediated long-term potentiation at hippocampal synapses

scientific article published on 29 March 2006

Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke.

scientific article published on 16 October 2013

Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease.

scientific article

Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes

scientific article

Evolutionarily conserved transcriptional co-expression guiding embryonic stem cell differentiation

scientific article

Exacerbation of damage and altered NF-kappaB activation in mice lacking tumor necrosis factor receptors after traumatic brain injury.

scientific article

Excitotoxic and Excitoprotective Mechanisms: Abundant Targets for the Prevention and Treatment of Neurodegenerative Disorders ⬇️

scientific article published on January 1, 2003

Excitotoxic and Radiation Stress Increase TERT Levels in the Mitochondria and Cytosol of Cerebellar Purkinje Neurons

scientific article published on 15 September 2015

Exendin-4 ameliorates motor neuron degeneration in cellular and animal models of amyotrophic lateral sclerosis

scientific article

Exendin-4 improves glycemic control, ameliorates brain and pancreatic pathologies, and extends survival in a mouse model of Huntington's disease

scientific article

Exercise and BDNF reduce Aβ production by enhancing α-secretase processing of APP.

scientific article published on 6 April 2017

Exposure to polychlorinated biphenyls causes endothelial cell dysfunction

scientific article published on 01 August 1995

Extension of lifespan in C. elegans by naphthoquinones that act through stress hormesis mechanisms

scientific article (publication date: 2011)

Extracellular Vesicle-Associated Aβ Mediates Trans-Neuronal Bioenergetic and Ca2+-Handling Deficits in Alzheimer's Disease Models

scientific article

Extracellular vesicle-depleted fetal bovine and human sera have reduced capacity to support cell growth

scientific article

Flipping the Metabolic Switch: Understanding and Applying the Health Benefits of Fasting.

scientific article published on 31 October 2017

Folate and homocysteine metabolism: therapeutic targets in cardiovascular and neurodegenerative disorders

scientific article

Folate deficiency inhibits proliferation of adult hippocampal progenitors

scientific article published in July 2005

Folic acid and homocysteine in age-related disease

scientific article

Folic acid deficiency and homocysteine impair DNA repair in hippocampal neurons and sensitize them to amyloid toxicity in experimental models of Alzheimer's disease.

scientific article published in March 2002

Food restriction reduces brain damage and improves behavioral outcome following excitotoxic and metabolic insults

scientific article

Functional role of soluble receptor for advanced glycation end products in stroke

scientific article published on 3 January 2013

GLP-1 receptor stimulation depresses heart rate variability and inhibits neurotransmission to cardiac vagal neurons.

scientific article

GLP-1 receptor stimulation preserves primary cortical and dopaminergic neurons in cellular and rodent models of stroke and Parkinsonism

scholarly article

GLP-1 receptor stimulation reduces amyloid-beta peptide accumulation and cytotoxicity in cellular and animal models of Alzheimer's disease.

scientific article

Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke.

scientific article published on 7 May 2006

Gap junctional communication is required to maintain mouse cortical neural progenitor cells in a proliferative state

scientific article published in August 2004

Gene expression atlas of the mouse central nervous system: impact and interactions of age, energy intake and gender

scientific article

Genome wide profiling of human embryonic stem cells (hESCs), their derivatives and embryonal carcinoma cells to develop base profiles of U.S. Federal government approved hESC lines

scientific article

Ghrelin augments murine T-cell proliferation by activation of the phosphatidylinositol-3-kinase, extracellular signal-regulated kinase and protein kinase C signaling pathways

scientific article

Glucagon-like peptide-1 decreases endogenous amyloid-beta peptide (Abeta) levels and protects hippocampal neurons from death induced by Abeta and iron.

scientific article published in June 2003

Glucagon‐like peptide 1 modulates calcium responses to glutamate and membrane depolarization in hippocampal neurons ⬇️

scientific article published on December 1, 2003

Glucose metabolic crosstalk and regulation in brain function and diseases

scientific article published in 2021

Gonadal transcriptome alterations in response to dietary energy intake: sensing the reproductive environment

scientific article

Good and Bad Amyloid Antibodies ⬇️

scientific article published on September 26, 2003

Growth factors protect neurons against excitotoxic/ischemic damage by stabilizing calcium homeostasis

scientific article published on 01 December 1993

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

scientific article

Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

scientific article

HIV-1 protein Tat induces apoptosis of hippocampal neurons by a mechanism involving caspase activation, calcium overload, and oxidative stress

scientific article published in December 1998

Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States.

scientific article published in June 2018

Hepatic cytochrome P-450 expression in tumor necrosis factor-alpha receptor (p55/p75) knockout mice after endotoxin administration

scientific article published on 01 March 1999

Herp stabilizes neuronal Ca2+ homeostasis and mitochondrial function during endoplasmic reticulum stress

scientific article

Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice

scientific article

Hold the salt: vasopressor role for BDNF.

scientific article published in April 2015

Homeostatic disinhibition in the aging brain and Alzheimer's disease

scientific article

Homocysteic acid induces intraneuronal accumulation of neurotoxic Abeta42: implications for the pathogenesis of Alzheimer's disease

scientific article published in June 2005

Homocysteine and Folate Deficiency Sensitize Oligodendrocytes to the Cell Death-Promoting Effects of a Presenilin-1 Mutation and Amyloid β-Peptide ⬇️

scientific article published on January 1, 2003

Hormesis/preconditioning mechanisms, the nervous system and aging.

scientific article

Hormetic dietary phytochemicals

scientific article published on 10 June 2008

How does the brain control lifespan?

scientific article

HuD regulates coding and noncoding RNA to induce APP→Aβ processing

scientific article

Hydroxyurea attenuates oxidative, metabolic, and excitotoxic stress in rat hippocampal neurons and improves spatial memory in a mouse model of Alzheimer's disease

scientific article published on 29 August 2018

Impact of Coffee and Cacao Purine Metabolites on Neuroplasticity and Neurodegenerative Disease

scientific article published on 8 February 2018

Impact of aging on stress-responsive neuroendocrine systems

scientific article

Impact of energy intake and expenditure on neuronal plasticity

scientific article published on 10 June 2008

Impact of intermittent fasting on health and disease processes

scientific article published on 31 October 2016

Impact of lysosome status on extracellular vesicle content and release

scientific article

Impact of reduced meal frequency without caloric restriction on glucose regulation in healthy, normal-weight middle-aged men and women

scientific article published in December 2007

Impaired attention in the 3xTgAD mouse model of Alzheimer's disease: rescue by donepezil (Aricept).

scientific article

Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit

scientific journal article

Impaired mitochondrial function, oxidative stress and altered antioxidant enzyme activities following traumatic spinal cord injury.

scientific article published in August 1997

Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid beta-peptide: role of the lipid peroxidation product 4-hydroxynonenal

scientific article published in July 1997

Impulsivity is associated with uric acid: evidence from humans and mice

scientific article

Increased vulnerability of ApoE4 neurons to HIV proteins and opiates: protection by diosgenin and L-deprenyl.

scientific article

Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice

scientific article

Incretin Mimetics as Rational Candidates for the Treatment of Traumatic Brain Injury

scientific article published on 11 February 2019

Induction of neuroprotective kappa B-dependent transcription by secreted forms of the Alzheimer's beta-amyloid precursor.

scientific article

Inhibition of notch signalling ameliorates experimental inflammatory arthritis.

scientific article published on 19 November 2013

Interactive effects of excitotoxic injury and dietary restriction on microgliosis and neurogenesis in the hippocampus of adult mice

scientific article published on January 2003

Intercellular transfer of pathogenic α-synuclein by extracellular vesicles is induced by the lipid peroxidation product 4-hydroxynonenal

scientific article published on 22 September 2017

Interferon-gamma is up-regulated in the hippocampus in response to intermittent fasting and protects hippocampal neurons against excitotoxicity

scientific article published in June 2006

Interferon-gamma promotes differentiation of neural progenitor cells via the JNK pathway

scientific article published on 6 April 2007

Intermittent fasting and caloric restriction ameliorate age-related behavioral deficits in the triple-transgenic mouse model of Alzheimer's disease

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Intermittent fasting and dietary supplementation with 2‐deoxy‐D‐glucose improve functional and metabolic cardiovascular risk factors in rats ⬇️

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Intermittent fasting attenuates inflammasome activity in ischemic stroke

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Intermittent fasting dissociates beneficial effects of dietary restriction on glucose metabolism and neuronal resistance to injury from calorie intake

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Intermittent food deprivation improves cardiovascular and neuroendocrine responses to stress in rats

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Intermittent metabolic switching, neuroplasticity and brain health

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Interrogation of brain miRNA and mRNA expression profiles reveals a molecular regulatory network that is perturbed by mutant huntingtin

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Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage

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Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death

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Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways

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Invaginating Presynaptic Terminals in Neuromuscular Junctions, Photoreceptor Terminals, and Other Synapses of Animals

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Invaginating Structures in Mammalian Synapses.

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Invertebrates as workhorses for aging and intervention studies

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Involvement of Fc receptors in disorders of the central nervous system

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Involvement of Notch signaling in hippocampal synaptic plasticity

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Involvement of mitochondrial K+ release and cellular efflux in ischemic and apoptotic neuronal death

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Involvement of notch signaling in wound healing

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Involvement of oxidative stress-induced abnormalities in ceramide and cholesterol metabolism in brain aging and Alzheimer's disease

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Ischemic and excitotoxic brain injury is enhanced in mice lacking the p55 tumor necrosis factor receptor

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K+ channel openers protect hippocampal neurons against oxidative injury and amyloid beta-peptide toxicity

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Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells

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Knockdown of FABP5 mRNA decreases cellular cholesterol levels and results in decreased apoB100 secretion and triglyceride accumulation in ARPE-19 cells

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L-type Ca2+ currents at CA1 synapses, but not CA3 or dentate granule neuron synapses, are increased in 3xTgAD mice in an age-dependent manner

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Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization

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Lifelong running reduces oxidative stress and degenerative changes in the testes of mice.

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Linoleic acid activates nuclear transcription factor-kappa B (NF-kappa B) and induces NF-kappa B-dependent transcription in cultured endothelial cells.

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Linoleic acid and TNF-alpha cross-amplify oxidative injury and dysfunction of endothelial cells

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Live longer sans the AT1A receptor

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Loss of NEIL1 causes defects in olfactory function in mice

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Low plasma N-3 fatty acids and dementia in older persons: the InCHIANTI study

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Lowering corticosterone levels reinstates hippocampal brain-derived neurotropic factor and Trkb expression without influencing deficits in hypothalamic brain-derived neurotropic factor expression in leptin receptor-deficient mice

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Lysophosphatidic acid decreases glutamate and glucose uptake by astrocytes

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Lysophosphatidic acid induces a sustained elevation of neuronal intracellular calcium

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Lysophosphatidic acid induces necrosis and apoptosis in hippocampal neurons

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MMP-7 cleaves the NR1 NMDA receptor subunit and modifies NMDA receptor function

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Massively parallel signature sequencing profiling of fetal human neural precursor cells

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Meal size and frequency affect neuronal plasticity and vulnerability to disease: cellular and molecular mechanisms

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Medium Chain Triglycerides induce mild ketosis and may improve cognition in Alzheimer's disease. A systematic review and meta-analysis of human studies

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Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats

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Mitochondria and Neuroplasticity ⬇️

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Mitochondria in cell death: novel targets for neuroprotection and cardioprotection

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Mitochondria in neuroplasticity and neurological disorders

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Mitochondrial DNA damage and repair in neurodegenerative disorders

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Mitochondrial DNA in extracellular vesicles declines with age

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Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges

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Mitochondrial UCP4 mediates an adaptive shift in energy metabolism and increases the resistance of neurons to metabolic and oxidative stress

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Mitochondrial function in human neuroblastoma cells is up-regulated and protected by NQO1, a plasma membrane redox enzyme

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Mitochondrial potassium channels and uncoupling proteins in synaptic plasticity and neuronal cell death ⬇️

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Mitochondrial superoxide production negatively regulates neural progenitor proliferation and cerebral cortical development

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Mitochondrial uncoupling protein-4 regulates calcium homeostasis and sensitivity to store depletion-induced apoptosis in neural cells.

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Mitophagy and Alzheimer's Disease: Cellular and Molecular Mechanisms.

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Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer's disease

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Molecular changes in brain aging and Alzheimer's disease are mirrored in experimentally silenced cortical neuron networks

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Molecular control of the amount, subcellular location, and activity state of translation elongation factor 2 in neurons experiencing stress

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Molecular targeting of TRF2 suppresses the growth and tumorigenesis of glioblastoma stem cells

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Monoamine oxidases regulate telencephalic neural progenitors in late embryonic and early postnatal development

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Morin attenuates tau hyperphosphorylation by inhibiting GSK3β.

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Multifunctional tellurium molecule protects and restores dopaminergic neurons in Parkinson's disease models

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Mutant SPTLC1 dominantly inhibits serine palmitoyltransferase activity in vivo and confers an age-dependent neuropathy

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Mutant presenilin 1 increases the expression and activity of BACE1

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NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

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NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

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NAD+ in Aging: Molecular Mechanisms and Translational Implications

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NAD+ in Brain Aging and Neurodegenerative Disorders

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NAD+ supplementation normalizes key Alzheimer's features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency

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NF-kappa B as a therapeutic target in neurodegenerative diseases

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Neural progenitor cells grown on hydrogel surfaces respond to the product of the transgene of encapsulated genetically engineered fibroblasts

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Neurodegeneration: nicked to death

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Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses

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Neuronal expression of familial Parkinson's disease A53T α-synuclein causes early motor impairment, reduced anxiety and potential sleep disturbances in mice

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Neurons efficiently repair glutamate-induced oxidative DNA damage by a process involving CREB-mediated up-regulation of apurinic endonuclease 1.

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Neuroprotection by the PGE2 EP2 receptor in permanent focal cerebral ischemia

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Neuroprotection provided by dietary restriction in rats is further enhanced by reducing glucocortocoids.

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Neuroprotective action of cycloheximide involves induction of bcl-2 and antioxidant pathways

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Neuroprotective actions of a histidine analogue in models of ischemic stroke

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Neuroprotective and neurorestorative signal transduction mechanisms in brain aging: modification by genes, diet and behavior.

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Neurotrophic factors attenuate glutamate-induced accumulation of peroxides, elevation of intracellular Ca2+ concentration, and neurotoxicity and increase antioxidant enzyme activities in hippocampal neurons

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Neutralization of transthyretin reverses the neuroprotective effects of secreted amyloid precursor protein (APP) in APPSW mice resulting in tau phosphorylation and loss of hippocampal neurons: support for the amyloid hypothesis.

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New Therapeutic Strategies and Drug Candidates for Neurodegenerative Diseases: p53 and TNF-  Inhibitors, and GLP-1 Receptor Agonists

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Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

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Nicotinamide prevents NAD+ depletion and protects neurons against excitotoxicity and cerebral ischemia: NAD+ consumption by SIRT1 may endanger energetically compromised neurons

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Nicotine attenuates arachidonic acid-induced overexpression of nitric oxide synthase in cultured spinal cord neurons

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Nicotine protects against arachidonic-acid-induced caspase activation, cytochrome c release and apoptosis of cultured spinal cord neurons

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Nitric oxide acts in a positive feedback loop with BDNF to regulate neural progenitor cell proliferation and differentiation in the mammalian brain

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Nontelomeric TRF2-REST interaction modulates neuronal gene silencing and fate of tumor and stem cells

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Nontelomeric splice variant of telomere repeat-binding factor 2 maintains neuronal traits by sequestering repressor element 1-silencing transcription factor

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Nordihydroguaiaretic acid protects hippocampal neurons against amyloid beta-peptide toxicity, and attenuates free radical and calcium accumulation

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Notch signaling and neuronal death in stroke.

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Notch1 deficiency decreases hepatic lipid accumulation by induction of fatty acid oxidation

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Notch: from neural development to neurological disorders

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Novel RNA- and FMRP-binding protein TRF2-S regulates axonal mRNA transport and presynaptic plasticity

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Novel p53 inactivators with neuroprotective action: syntheses and pharmacological evaluation of 2-imino-2,3,4,5,6,7-hexahydrobenzothiazole and 2-imino-2,3,4,5,6,7-hexahydrobenzoxazole derivatives.

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Nuclear DNA damage signalling to mitochondria in ageing

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Numb endocytic adapter proteins regulate the transport and processing of the amyloid precursor protein in an isoform-dependent manner: implications for Alzheimer disease pathogenesis

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Numb isoforms containing a short PTB domain promote neurotrophic factor-induced differentiation and neurotrophic factor withdrawal-induced death of PC12 Cells

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Numb modifies neuronal vulnerability to amyloid beta-peptide in an isoform-specific manner by a mechanism involving altered calcium homeostasis: implications for neuronal death in Alzheimer's disease

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Nutritional strategies to optimise cognitive function in the aging brain.

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Olfactory bulbectomy protects hippocampal pyramidal neurons against excitotoxic death

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Opposing Actions of Thrombin and Protease Nexin‐1 on Amyloid β‐Peptide Toxicity and on Accumulation of Peroxides and Calcium in Hippocampal Neurons ⬇️

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Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease.

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Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein ⬇️

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Oxidative stress mediates monocrotaline-induced alterations in tenascin expression in pulmonary artery endothelial cells ⬇️

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Oxidized low density lipoproteins induce a pathologic response by retinal pigmented epithelial cells

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PDGFs protect hippocampal neurons against energy deprivation and oxidative injury: evidence for induction of antioxidant pathways.

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PTEN regulates Akt kinase activity in hippocampal neurons and increases their sensitivity to glutamate and apoptosis

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Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death.

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Par-4: an emerging pivotal player in neuronal apoptosis and neurodegenerative disorders

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Paroxetine retards disease onset and progression in Huntingtin mutant mice

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Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice

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Participation of gene expression in the protection against amyloid beta-peptide toxicity by the beta-amyloid precursor protein.

scientific article published in January 1996

Participation of par-4 in the degeneration of striatal neurons induced by metabolic compromise with 3-nitropropionic acid

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Patterns of laminins and integrins in the embryonic ventricular zone of the CNS.

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Permeability transition pore-mediated mitochondrial superoxide flashes mediate an early inhibitory effect of amyloid beta1-42 on neural progenitor cell proliferation

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Permeability transition pore-mediated mitochondrial superoxide flashes regulate cortical neural progenitor differentiation

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Perturbation of sphingolipid metabolism and ceramide production in HIV-dementia

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Phenformin suppresses calcium responses to glutamate and protects hippocampal neurons against excitotoxicity

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Phosphatidylinositol-3-kinase-Akt kinase and p42/p44 mitogen-activated protein kinases mediate neurotrophic and excitoprotective actions of a secreted form of amyloid precursor protein

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Phosphothioated oligodeoxynucleotides induce nonspecific effects on neuronal cell adhesion in a growth substrate-dependent manner

scientific article published in June 2009

Phytochemicals in Ischemic Stroke

scientific article published on 18 May 2016

Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke

scientific article published on 21 October 2009

Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits

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Plasma BDNF is associated with age-related white matter atrophy but not with cognitive function in older, non-demented adults

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Plasma membrane sphingomyelin hydrolysis increases hippocampal neuron excitability by sphingosine-1-phosphate mediated mechanisms

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Playtime prevents obesity by brain-mediated fat browning

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Plumbagin promotes the generation of astrocytes from rat spinal cord neural progenitors via activation of the transcription factor Stat3.

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Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia

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Possible angiogenic roles for claudin-4 in ovarian cancer

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Postnatal TLR2 activation impairs learning and memory in adulthood.

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Pregabalin suppresses calcium-mediated proteolysis and improves stroke outcome ⬇️

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Presenilin mutations and calcium signaling defects in the nervous and immune systems

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Presenilin-1 mutation impairs cholinergic modulation of synaptic plasticity and suppresses NMDA currents in hippocampus slices

scientific article published on 20 February 2008

Presenilin-1 mutation sensitizes oligodendrocytes to glutamate and amyloid toxicities, and exacerbates white matter damage and memory impairment in mice

scientific article published in January 2003

Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons

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Presenilin-1 mutations sensitize neurons to DNA damage-induced death by a mechanism involving perturbed calcium homeostasis and activation of calpains and caspase-12

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Presenilins and APP in neuritic and synaptic plasticity: implications for the pathogenesis of Alzheimer's disease

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Presenilins, the endoplasmic reticulum, and neuronal apoptosis in Alzheimer's disease.

scientific article published on January 1998

Preventing NAD(+) depletion protects neurons against excitotoxicity: bioenergetic effects of mild mitochondrial uncoupling and caloric restriction

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Probing extracellular Sonic hedgehog in neurons

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Prophylactic activation of neuroprotective stress response pathways by dietary and behavioral manipulations

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Prophylactic treatment with paroxetine ameliorates behavioral deficits and retards the development of amyloid and tau pathologies in 3xTgAD mice

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Protease nexin-1 and thrombin modulate neuronal Ca2+ homeostasis and sensitivity to glucose deprivation-induced injury ⬇️

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Protection and reversal of excitotoxic neuronal damage by glucagon-like peptide-1 and exendin-4.

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Protein kinase C iota protects neural cells against apoptosis induced by amyloid beta-peptide.

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Protein twists and turns in Alzheimer disease

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Publisher Correction: Intermittent metabolic switching, neuroplasticity and brain health

scientific article published on 30 June 2020

Purine Biosynthesis Enzymes in Hippocampal Neurons

scientific article published on 2 September 2017

Quiescence and activation of stem and precursor cell populations in the subependymal zone of the mammalian brain are associated with distinct cellular and extracellular matrix signals

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RNA interference in biology and medicine

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Reciprocal inhibition of p53 and nuclear factor-kappaB transcriptional activities determines cell survival or death in neurons.

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Reduced energy intake: the secret to a long and healthy life?

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Reduction of AP180 and CALM produces defects in synaptic vesicle size and density

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Region-specific regulation of glucocorticoid receptor/HSP90 expression and interaction in brain

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Resveratrol inhibits the proliferation of neural progenitor cells and hippocampal neurogenesis

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Reversal of Behavioral and Metabolic Abnormalities, and Insulin Resistance Syndrome, by Dietary Restriction in Mice Deficient in Brain-Derived Neurotrophic Factor ⬇️

scientific article published on June 1, 2003

Revisiting the astrocyte-oligodendrocyte relationship in the adult CNS.

scientific article published on 18 March 2007

Role of cyclic GMP in the regulation of neuronal calcium and survival by secreted forms of beta-amyloid precursor

scientific article published on 01 May 1995

Role of dietary iron restriction in a mouse model of Parkinson's disease

scientific article published in December 2004

Role of glutathione redox cycle in TNF-alpha-mediated endothelial cell dysfunction

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Roles for dysfunctional sphingolipid metabolism in Alzheimer's disease neuropathogenesis

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Roles of nuclear factor kappaB in neuronal survival and plasticity

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S100 beta protects hippocampal neurons from damage induced by glucose deprivation

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SDF1alpha/CXCR4 signaling stimulates beta-catenin transcriptional activity in rat neural progenitors

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SDF1alpha/CXCR4 signaling, via ERKs and the transcription factor Egr1, induces expression of a 67-kDa form of glutamic acid decarboxylase in embryonic hippocampal neurons

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SIRT3 Haploinsufficiency Aggravates Loss of GABAergic Interneurons and Neuronal Network Hyperexcitability in an Alzheimer's Disease Model

scientific article published on 09 December 2019

SIRT3 mediates hippocampal synaptic adaptations to intermittent fasting and ameliorates deficits in APP mutant mice

scientific article published on 23 April 2019

Secreted beta-amyloid precursor protein counteracts the proapoptotic action of mutant presenilin-1 by activation of NF-kappaB and stabilization of calcium homeostasis

scientific article published on 01 May 1998

Secreted form of amyloid precursor protein enhances basal glucose and glutamate transport and protects against oxidative impairment of glucose and glutamate transport in synaptosomes by a cyclic GMP-mediated mechanism

scientific article published on August 1999

Secreted form of β-amyloid precursor protein shifts the frequency dependency for induction of LTD, and enhances LTP in hippocampal slices ⬇️

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Seizures and tissue injury induce telomerase in hippocampal microglial cells

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Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer's disease

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Self-propagating, molecular-level polymorphism in Alzheimer's beta-amyloid fibrils

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Self-renewal and differentiation capabilities are variable between human embryonic stem cell lines I3, I6 and BG01V

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Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer's disease model

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Sex-dependent metabolic, neuroendocrine, and cognitive responses to dietary energy restriction and excess

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Silencing survival data

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Simultaneous single neuron recording of O2 consumption, [Ca2+]i and mitochondrial membrane potential in glutamate toxicity.

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Sleep disturbances in Alzheimer's and Parkinson's diseases

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Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice

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Sonic Hedgehog Signaling and Hippocampal Neuroplasticity

scientific article published on 16 November 2016

Sonic hedgehog expression in the postnatal brain

Sonic hedgehog promotes autophagy in hippocampal neurons

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Sphingolipid metabolism regulates development and lifespan in Caenorhabditis elegans

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Squelching glioblastoma stem cells by targeting REST for proteasomal degradation

scientific article published on 11 September 2009

Stage-dependent Olig2 expression in motor neurons and oligodendrocytes differentiated from embryonic stem cells

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Staurosporine, K-252a, and K-252b stabilize calcium homeostasis and promote survival of CNS neurons in the absence of glucose.

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Stroke and T-cells

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Stromal factors SDF1α, sFRP1, and VEGFD induce dopaminergic neuron differentiation of human pluripotent stem cells

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Structure, Distribution, and Function of Neuronal/Synaptic Spinules and Related Invaginating Projections

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Subcellular localization of Patched and Smoothened, the receptors for Sonic hedgehog signaling, in the hippocampal neuron

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Superoxide flashes in single mitochondria

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Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.

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Suppression of brain aging and neurodegenerative disorders by dietary restriction and environmental enrichment: molecular mechanisms

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Suppression of uracil-DNA glycosylase induces neuronal apoptosis

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Synthesis and evaluation of neuroprotective alpha,beta-unsaturated aldehyde scavenger histidyl-containing analogues of carnosine

scientific article published on September 2005

TERT suppresses apoptotis at a premitochondrial step by a mechanism requiring reverse transcriptase activity and 14-3-3 protein-binding ability

scientific article published on 19 February 2003

TLR2 activation inhibits embryonic neural progenitor cell proliferation

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TLR4-dependent metabolic changes are associated with cognitive impairment in an animal model of type 1 diabetes

scientific article published on 14 December 2013

TNF-α Differentially Regulates Synaptic Plasticity in the Hippocampus and Spinal Cord by Microglia-Dependent Mechanisms after Peripheral Nerve Injury.

scientific article published on January 2017

TRF2 dysfunction elicits DNA damage responses associated with senescence in proliferating neural cells and differentiation of neurons.

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Tamoxifen protects against acute tumor necrosis factor alpha-induced cardiac injury via improving mitochondrial functions.

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Targeting TNF-alpha receptors for neurotherapeutics

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Targeting ischemic brain injury with intravenous immunoglobulin

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Taxol stabilizes [Ca2+]i and protects hippocampal neurons against excitotoxicity

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Tellurium compound AS101 ameliorates experimental autoimmune encephalomyelitis by VLA-4 inhibition and suppression of monocyte and T cell infiltration into the CNS

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Telomerase mediates the cell survival-promoting actions of brain-derived neurotrophic factor and secreted amyloid precursor protein in developing hippocampal neurons.

scientific article published in December 2002

Telomere neurobiology.

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Telomere protection mechanisms change during neurogenesis and neuronal maturation: newly generated neurons are hypersensitive to telomere and DNA damage

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Telomere shortening in neurological disorders: an abundance of unanswered questions

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Testing the product of slopes in related regressions

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The AAA+ ATPase Thorase regulates AMPA receptor-dependent synaptic plasticity and behavior

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The DNA damaging agent etoposide activates a cell survival pathway involving alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors and mitogen-activated protein kinases in hippocampal neurons

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The KATP Channel Activator Diazoxide Ameliorates Amyloid-β and Tau Pathologies and Improves Memory in the 3xTgAD Mouse Model of Alzheimer's Disease ⬇️

scientific article published on January 1, 2010

The PTEN phosphatase is essential for long-term depression of hippocampal synapses

scientific article published in January 2006

The Role of Uric Acid and Methyl Derivatives in the Prevention of Age-Related Neurodegenerative Disorders

scientific article published on 10 June 2015

The actin-severing protein gelsolin modulates calcium channel and NMDA receptor activities and vulnerability to excitotoxicity in hippocampal neurons.

scientific article published in November 1997

The adversities of aging

scientific article published on August 2006

The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons

scientific article published on 19 October 2016

The canonical Notch pathway effector RBP-J regulates neuronal plasticity and expression of GABA transporters in hippocampal networks

scientific article published on 27 March 2015

The clathrin assembly protein AP180 regulates the generation of amyloid-beta peptide

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The effect of intermittent energy and carbohydrate restriction v. daily energy restriction on weight loss and metabolic disease risk markers in overweight women

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The endoplasmic reticulum stress-responsive protein GRP78 protects neurons against excitotoxicity and apoptosis: suppression of oxidative stress and stabilization of calcium homeostasis

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The excitatory neurotransmitter glutamate stimulates DNA repair to increase neuronal resiliency

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The homocysteine-inducible endoplasmic reticulum (ER) stress protein Herp counteracts mutant α-synuclein-induced ER stress via the homeostatic regulation of ER-resident calcium release channel proteins

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The identity and regulation of the mitochondrial permeability transition pore: where the known meets the unknown

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The lipid peroxidation product 4-hydroxynonenal facilitates opening of voltage-dependent Ca2+ channels in neurons by increasing protein tyrosine phosphorylation

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The long and the short of TRF2 in neurogenesis

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The microenvironment of the embryonic neural stem cell: lessons from adult niches?

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The mitochondrial uncoupler DNP triggers brain cell mTOR signaling network reprogramming and CREB pathway up-regulation

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The neuronal death protein par-4 mediates dopaminergic synaptic plasticity

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The organotellurium compound ammonium trichloro(dioxoethylene-0,0') tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice.

scientific article published on 30 April 2007

The plasma membrane redox enzyme NQO1 sustains cellular energetics and protects human neuroblastoma cells against metabolic and proteotoxic stress

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The plasma membrane redox system in aging

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The plasma membrane redox system is impaired by amyloid β-peptide and in the hippocampus and cerebral cortex of 3xTgAD mice.

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The prostate apoptosis response-4 protein participates in motor neuron degeneration in amyotrophic lateral sclerosis

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The therapeutic potential of microRNAs in nervous system damage, degeneration, and repair.

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Therapeutic perspectives for the treatment of Huntington's disease: treating the whole body

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Thidoredxin-2 overexpression fails to rescue chronic high calorie diet induced hippocampal dysfunction.

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Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis.

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Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation

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Toll-like receptor 4 mediates fat, sugar, and umami taste preference and food intake and body weight regulation

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Toll-like receptor signaling in neural plasticity and disease

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Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal

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Toll-like receptors 2 and 4 modulate autonomic control of heart rate and energy metabolism

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Toll-like receptors in neurodegeneration.

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Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway

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Topoisomerase 3β knockout mice show transcriptional and behavioural impairments associated with neurogenesis and synaptic plasticity

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Transcriptome Analysis Reveals Intermittent Fasting-Induced Genetic Changes in Ischemic Stroke

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Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke.

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Transcriptome coexpression map of human embryonic stem cells

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Transferrin fusion technology: a novel approach to prolonging biological half-life of insulinotropic peptides

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Transient improvement in cognitive function and synaptic plasticity in rats following cancer chemotherapy.

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Truncated tyrosine kinase B brain-derived neurotrophic factor receptor directs cortical neural stem cells to a glial cell fate by a novel signaling mechanism

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Tumor necrosis factor-alpha-induced neutral sphingomyelinase-2 modulates synaptic plasticity by controlling the membrane insertion of NMDA receptors

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Tumor necrosis factors alpha and beta protect neurons against amyloid beta-peptide toxicity: evidence for involvement of a kappa B-binding factor and attenuation of peroxide and Ca2+ accumulation.

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Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis

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Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria.

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Uric acid enhances longevity and endurance and protects the brain against ischemia

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Urocortin, but not urocortin II, protects cultured hippocampal neurons from oxidative and excitotoxic cell death via corticotropin-releasing hormone receptor type I

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Vasoactive intestinal peptide-null mice demonstrate enhanced sweet taste preference, dysglycemia, and reduced taste bud leptin receptor expression

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Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals

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Voluntary exercise and caloric restriction enhance hippocampal dendritic spine density and BDNF levels in diabetic mice.

scientific article published on October 2009

Walking speed decline in older adults is associated with elevated pro-BDNF in plasma extracellular vesicles

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Whole-Body Vibration Mimics the Metabolic Effects of Exercise in Male Leptin Receptor-Deficient Mice.

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XRCC1 protects against the lethality of induced oxidative DNA damage in nondividing neural cells

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