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List of works by Mark Anthony Smith

4-Oxo-2-nonenal is both more neurotoxic and more protein reactive than 4-hydroxy-2-nonenal

scientific article published on August 2005

A clinical study of lupron depot in the treatment of women with Alzheimer's disease: preservation of cognitive function in patients taking an acetylcholinesterase inhibitor and treated with high dose lupron over 48 weeks

scientific article

A metabolic basis for Alzheimer disease

scientific article published on October 2003

A new model of oxidative stress in rat pups

scientific article

A novel approach to the identification and quantitative elemental analysis of amyloid deposits--insights into the pathology of Alzheimer's disease

scientific article published in March 2009

A novel endogenous indole protects rodent mitochondria and extends rotifer lifespan

scientific article

A novel origin for granulovacuolar degeneration in aging and Alzheimer's disease: parallels to stress granules

scientific article

A second look into the oxidant mechanisms in Alzheimer's disease

scientific article

A synergistic dysfunction of mitochondrial fission/fusion dynamics and mitophagy in Alzheimer's disease

scientific article

AGEs/RAGE complex upregulates BACE1 via NF-κB pathway activation

scientific article published on 17 July 2010

Aberrant expression of metabotropic glutamate receptor 2 in the vulnerable neurons of Alzheimer's disease

scientific article published on 11 February 2004

Aberrant localization of importin alpha1 in hippocampal neurons in Alzheimer disease

scientific article published on 27 October 2006

Abnormal iron metabolism and oxidative stress in mice expressing a mutant form of the ferritin light polypeptide gene

scientific article published on 30 March 2009

Abnormal mitochondrial dynamics and neurodegenerative diseases

scientific article published on 30 September 2009

Abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

scientific article

Abnormal mitochondrial dynamics--a novel therapeutic target for Alzheimer's disease?

scientific article published on 27 January 2010

Absence of cellular stress in brain after hypoxia induced by arousal from hibernation in Arctic ground squirrels

scientific article published on 23 June 2005

Accelerated alpha-synuclein aggregation after differentiation of SH-SY5Y neuroblastoma cells

scientific article published on July 2004

Accumulation of intraneuronal amyloid-β is common in normal brain.

scientific article

Activation of Akt by lithium: pro-survival pathways in aging

scientific article published on 3 January 2009

Activation of P38 kinase links π phosphorylation, oxidative stress and cell cycle-related events in Alzheimer disease

Activation of the extracellular signal-regulated kinase pathway contributes to the behavioral deficit of fragile x-syndrome

scientific article published on 27 March 2012

Adventiously-bound redox active iron and copper are at the center of oxidative damage in Alzheimer disease

scientific article

All-trans retinoic acid as a novel therapeutic strategy for Alzheimer's disease

scientific article

Altered redox balance in disease: Can we change the new equilibria?

Alzheimer Disease: Oxidative Stress and Compensatory Responses

article

Alzheimer disease and the role of free radicals in the pathogenesis of the disease

scientific article published on February 2008

Alzheimer disease pathology as a host response

scientific article published on June 2008

Alzheimer disease, the two-hit hypothesis: an update

scientific article published on 27 October 2006

Alzheimer disease: evidence for a central pathogenic role of iron-mediated reactive oxygen species

scientific article published on April 2004

Alzheimer's Disease: Advances for a New Century

scholarly article by George Perry et al published 27 December 2012 in Journal of Alzheimer's Disease

Alzheimer's disease and the cell cycle

scientific article published on January 2004

Alzheimer's disease: an intracellular movement disorder?

scientific article published in September 2005

Alzheimer's disease: cerebrovascular dysfunction, oxidative stress, and advanced clinical therapies

scientific article published on October 2008

Alzheimer's disease: diverse aspects of mitochondrial malfunctioning

scientific article

Alzheimer's disease: the two-hit hypothesis

scientific article published on April 2004

Alzheimer-specific epitopes of tau represent lipid peroxidation-induced conformations

scientific article

Alzheimers Disease and Oxidative Stress: The Old Problem Remains Unsolved

scholarly article published 1 March 2005

Amyloid beta: the alternate hypothesis

scientific article

Amyloid-beta and tau serve antioxidant functions in the aging and Alzheimer brain

scientific article

Amyloid-beta in Alzheimer's disease: the horse or the cart? Pathogenic or protective?

scientific article

Amyloid-beta vaccination: testing the amyloid hypothesis?: heads we win, tails you lose!

scientific article published on September 2006

Amyloid-beta, tau alterations and mitochondrial dysfunction in Alzheimer disease: the chickens or the eggs?

scientific article

Amyloid-beta-derived diffusible ligands cause impaired axonal transport of mitochondria in neurons

scientific article published on 13 February 2010

Amyloid-beta-induced toxicity of primary neurons is dependent upon differentiation-associated increases in tau and cyclin-dependent kinase 5 expression

scientific article published in February 2004

Amyloid-beta: a (life) preserver for the brain

scientific article published in November 2002

Amyloid-beta: a vascular sealant that protects against hemorrhage?

scientific article

Amyloid-β42 Interacts Mainly with Insoluble Prion Protein in the Alzheimer Brain ⬇️

scientific article published on March 10, 2011

Amyloids, Aggregates and Neuronal Inclusions: Good or Bad News for Neurons?

article

Amyotrophic lateral sclerosis: a novel hypothesis involving a gained 'loss of function' in the JNK/SAPK pathway

scientific article

Antibodies to potato virus Y bind the amyloid beta peptide: immunohistochemical and NMR studies

scientific article published on 27 May 2008

Antigen-antibody dissociation in Alzheimer disease: a novel approach to diagnosis

scientific article

Antigonadotropins: a novel strategy to halt Alzheimer's disease progression

scientific article

Antimicrobial peptide β-defensin-1 expression is upregulated in Alzheimer's brain

scientific article published on 18 October 2013

Antioxidant approaches for the treatment of Alzheimer's disease

scientific article published on July 2010

Antioxidant protection and neurodegenerative disease: the role of amyloid-beta and tau.

scientific article

Antioxidant therapy in Alzheimer's disease: theory and practice

scientific article

Apoptosis in Alzheimer disease: a mathematical improbability

scientific article published on September 2006

Apoptotic and Oxidative Indicators in Alzheimer's Disease

scholarly article

Apoptotic promoters and inhibitors in Alzheimer's disease: Who wins out?

scientific article

Ascorbate distribution during hibernation is independent of ascorbate redox state

scientific article published in August 2004

Assembly in vitro of tau protein and its implications in Alzheimer's disease.

scientific article

Atherosclerotic lesions and mitochondria DNA deletions in brain microvessels: implication in the pathogenesis of Alzheimer's disease

scientific article published on January 2008

Autophagocytosis of mitochondria is prominent in Alzheimer disease

scientific article

Autophagy in Alzheimer's disease

scientific article published on July 2010

BRCA1 may modulate neuronal cell cycle re-entry in Alzheimer disease

scientific article published on 12 May 2007

Beyond estrogen: targeting gonadotropin hormones in the treatment of Alzheimer's disease

scientific article published in August 2004

Biomarkers in Alzheimer's disease: past, present and future

scientific article

CD3 in Lewy pathology: does the abnormal recall of neurodevelopmental processes underlie Parkinson's disease

scientific article

Call for Elan to publish Alzheimer's trial details.

scientific article published in April 2002

Carnosine: a versatile antioxidant and antiglycating agent

scientific article

Causes versus effects: the increasing complexities of Alzheimer's disease pathogenesis

scientific article

Cdk5 is a major regulator of p38 cascade: relevance to neurotoxicity in Alzheimer's disease

scientific article published on 14 March 2010

Cell cycle deregulation in the neurons of Alzheimer's disease

scientific article published on January 2011

Cell cycle proteins in Alzheimer's disease: plenty of wheels but no cycle.

scientific article published in June 2002

Cell cycle re-entry and mitochondrial defects in myc-mediated hypertrophic cardiomyopathy and heart failure

scientific article

Cell cycle re-entry mediated neurodegeneration and its treatment role in the pathogenesis of Alzheimer's disease

scientific article published on 09 December 2008

Cellular prion protein is essential for oligomeric amyloid-β-induced neuronal cell death

scientific article published on 18 November 2011

Cerebral amyloid angiopathy: major contributor or decorative response to Alzheimer's disease pathogenesis

scientific article published on May 2004

Cerebral hemorrhage and amyloid-beta

scientific article published in February 2003

Cerebrotendinous xanthomatosis: case report with evidence of oxidative stress

scientific article

Challenging the amyloid cascade hypothesis: senile plaques and amyloid-beta as protective adaptations to Alzheimer disease

scientific article published in June 2004

Chapter 19. Targeting Oxidative Mechanisms in Alzheimer Disease

Chapter 5 - Development of iron chelator-nanoparticle conjugates as potential therapeutic agents for Alzheimer disease

scientific article published on 08 December 2009

Chitin-like polysaccharides in Alzheimer's disease brains

scientific article

Cholesterol homeostasis markers are localized to mouse hippocampal pyramidal and granule layers

scientific article published on August 2010

Cholesterol, oxidative stress, and Alzheimer's disease: expanding the horizons of pathogenesis

scientific article

Chronic Leptin Supplementation Ameliorates Pathology and Improves Cognitive Performance in a Transgenic Mouse Model of Alzheimer's Disease

scientific article published in December 2009

Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease

scientific article published on February 2009

Chronic oxidative stress causes increased tau phosphorylation in M17 neuroblastoma cells

scientific article

Chronological primacy of oxidative stress in Alzheimer disease.

scientific article published in May 2005

Cleavage and conformational changes of tau protein follow phosphorylation during Alzheimer's disease

scientific article published in April 2008

Clinical benefit and preservation of flavonols in dark chocolate manufacturing

scientific article

Clusterin up-regulation following sub-lethal oxidative stress and lipid peroxidation in human neuroblastoma cells

scientific article published on 7 February 2006

Commentary: "Ceramide and cholesterol: possible connections between normal aging of the brain and Alzheimer's disease. Just hypotheses or molecular pathways to be identified?" by Claudio Costantini, Rekha M.K. Kolasani, and Luigi Puglielli.

scientific article published in July 2005

Comparative biology and pathology of oxidative stress in Alzheimer and other neurodegenerative diseases: beyond damage and response

scientific article

Compensatory responses induced by oxidative stress in Alzheimer disease

scientific article

Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease

scientific article published in July 2004

Copper Induces Apoptosis of Neuroblastoma Cells Via Post-translational Regulation of the Expression of Bcl-2-family Proteins and the tx Mouse is a Better Model of Hepatic than Brain Cu Toxicity

scientific article published on 20 January 2008

Copper mediates dityrosine cross-linking of Alzheimer's amyloid-beta

scientific article

Current approaches in the treatment of Alzheimer's disease

scientific article published on 17 March 2008

DLP1-dependent mitochondrial fragmentation mediates 1-methyl-4-phenylpyridinium toxicity in neurons: implications for Parkinson's disease

scientific article published on 14 June 2011

DNA damage induces cdk2 protein levels and histone H2B phosphorylation in SH-SY5Y neuroblastoma cells.

scientific article published on September 2005

Decline in mitochondrial bioenergetics underlies central insulin resistance in streptozocin-induced model of sporadic Alzheimer's disease

scholarly article by Sónia Correia et al published July 2011 in Alzheimer's and Dementia

Dementia and testosterone levels in men.

scientific article

Detection and localization of markers of oxidative stress by in situ methods: application in the study of Alzheimer disease

scientific article published in January 2010

Differential regulation of glutamate receptors in Alzheimer's disease

scientific article

Direct and indirect roles of cyclin-dependent kinase 5 as an upstream regulator in the c-Jun NH2-terminal kinase cascade: relevance to neurotoxic insults in Alzheimer's disease

scientific article

Dissociated Aβ antibody level in newly diagnosed Alzheimer's disease: A population-based study

article

Dissociated amyloid-beta antibody levels as a serum biomarker for the progression of Alzheimer's disease: a population-based study

scientific article

Disturbance in AMP-activated protein kinase (AMPK) signaling pathway in Alzheimer's disease

Divalent metal transporter, iron, and Parkinson's disease: a pathological relationship.

scientific article

Down-regulation of aminolevulinate synthase, the rate-limiting enzyme for heme biosynthesis in Alzheimer's disease

scientific article

Down-regulation of serum gonadotropins but not estrogen replacement improves cognition in aged-ovariectomized 3xTg AD female mice

scientific article

Down-regulation of serum gonadotropins is as effective as estrogen replacement at improving menopause-associated cognitive deficits

scientific article

Drug discovery for neurodegenerative diseases: challenges and novel biochemical targets dedicated to the memory of Mark A. Smith for his inspiring contribution to Alzheimer's disease

scientific article published in January 2011

Dysregulation of leptin signaling in Alzheimer disease: evidence for neuronal leptin resistance

scientific article published on 21 August 2013

Dysregulation of the hypothalamic-pituitary-gonadal axis with menopause and andropause promotes neurodegenerative senescence

scientific article

Early amyloid accumulation in the hippocampus of SAMP8 mice

scientific article published in January 2010

Early induction of c-Myc is associated with neuronal cell death ⬇️

scientific article published on October 8, 2011

Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity

scientific article

Ectopic expression of phospho-Smad2 in Alzheimer's disease: uncoupling of the transforming growth factor-beta pathway?

scientific article published in December 2006

Ectopic localization of FOXO3a protein in Lewy bodies in Lewy body dementia and Parkinson's disease

scientific article published on 23 July 2009

Ectopic localization of phosphorylated histone H3 in Alzheimer's disease: a mitotic catastrophe?

scientific article published on 26 February 2003

Effect of quinones on microtubule polymerization: a link between oxidative stress and cytoskeletal alterations in Alzheimer's disease

scientific article published on 13 December 2004

Effect of the lipid peroxidation product acrolein on tau phosphorylation in neural cells

scientific article published on March 2003

Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1-associated regulator of cyclin B, in Alzheimer's disease

scientific article

Elevated luteinizing hormone expression colocalizes with neurons vulnerable to Alzheimer's disease pathology

scientific article published in November 2002

Elevation of {beta}-amyloid 1-42 autoantibodies in the blood of amnestic patients with mild cognitive impairment

scientific article published in July 2010

Emerging evidence for the neuroprotective role of alpha-synuclein

scientific article

Estrogen bows to a new master: the role of gonadotropins in Alzheimer pathogenesis

scientific article

Evidence for Oxidative Damage in the Autistic Brain

article

Evidence for the novel expression of human kallikrein-related peptidase 3, prostate-specific antigen, in the brain.

scientific article published on 20 October 2008

Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease

scientific article published on April 2009

Evidence for the role of luteinizing hormone in Alzheimer disease

scientific article published on December 2007

Evidence of DNA damage in Alzheimer disease: phosphorylation of histone H2AX in astrocytes

scientific article published on 23 April 2008

Expression of CD74 is increased in neurofibrillary tangles in Alzheimer's disease

scientific article published on 11 September 2008

Feedback on a feedback loop: the hypothalamic-pituitary-gonadal axis.

scientific article

Ferric cycle activity and Alzheimer disease

scientific article

Food Antioxidants and Alzheimer’s Disease

article

Foreword: Apoptotic Mechanisms in Neurodegenerative Diseases

Formation of aberrant phosphotau fibrillar polymers in neural cultured cells

scientific article published in March 2002

From aging to Alzheimer's disease: unveiling "the switch" with the senescence-accelerated mouse model (SAMP8).

scientific article published on December 2008

Frontiers in Alzheimer's disease therapeutics

scientific article

Functional implications of antiestrogen induction of quinone reductase: inhibition of estrogen-induced deoxyribonucleic acid damage

scientific article

Gender differences in Alzheimer disease: the role of luteinizing hormone in disease pathogenesis

scientific article

Getting the iron out: phlebotomy for Alzheimer's disease?

scientific article published on 04 February 2009

Gonadotropins: a cohesive gender-based etiology of Alzheimer disease

scientific article published on 18 October 2006

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

scientific article

Heme catabolism and heme oxygenase in neurodegenerative disease

scientific article published in October 2004

Heme deficiency in Alzheimer's disease: a possible connection to porphyria

scientific article (publication date: 2006)

Heme-a, the heme prosthetic group of cytochrome c oxidase, is increased in Alzheimer's disease

scientific article published on 17 June 2009

Hibernation, a Model of Neuroprotection

High molecular weight neurofilament proteins are physiological substrates of adduction by the lipid peroxidation product hydroxynonenal

scientific article published on 3 December 2001

Hippocampal neurogenesis and PSA-NCAM expression following exposure to 56Fe particles mimics that seen during aging in rats

scientific article

Homocysteine and Alzheimer's disease: a modifiable risk?

scientific article

Hydroxynonenal adducts indicate a role for lipid peroxidation in neocortical and brainstem Lewy bodies in humans

scientific article published in February 2002

Hydroxynonenal, toxic carbonyls, and Alzheimer disease

scientific article

Hydroxynonenal-generated crosslinking fluorophore accumulation in Alzheimer disease reveals a dichotomy of protein turnover

scientific article published on 12 November 2011

Ill-fated amyloid-beta vaccine

scientific article

Impaired balance of mitochondrial fission and fusion in Alzheimer's disease

scientific journal article

Increased expression of p130 in Alzheimer disease

scientific article published on 28 September 2006

Increased expression of the remodeling- and tumorigenic-associated factor osteopontin in pyramidal neurons of the Alzheimer's disease brain

scientific article published in February 2007

Increased iron and free radical generation in preclinical Alzheimer disease and mild cognitive impairment

scientific article

Increased isoprostane and prostaglandin are prominent in neurons in Alzheimer disease

scientific article published on 22 January 2007

Increased p27, an essential component of cell cycle control, in Alzheimer's disease

scientific article published in April 2003

Increases in luteinizing hormone are associated with declines in cognitive performance

scientific article published on 6 February 2007

Indices of metabolic dysfunction and oxidative stress

scientific article published on 7 March 2007

Indoleamine 2,3-dioxygenase and 3-hydroxykynurenine modifications are found in the neuropathology of Alzheimer's disease

scientific article

Inhibition of Polo-like kinase 1 reduces beta-amyloid-induced neuronal cell death in Alzheimer's disease ⬇️

scientific article published on September 1, 2011

Insights into amyloid-beta-induced mitochondrial dysfunction in Alzheimer disease

scientific article published on 21 September 2007

Insights into cerebrovascular complications and Alzheimer disease through the selective loss of GRK2 regulation

scientific article published on 06 October 2008

Insulin and Insulin-Sensitizing Drugs in Neurodegeneration: Mitochondria as Therapeutic Targets

scientific article published on 23 December 2009

Insulin is a two-edged knife on the brain

scientific article published on January 2009

Insulin signaling, diabetes mellitus and risk of Alzheimer disease.

scientific article

Insulin-resistant brain state: the culprit in sporadic Alzheimer's disease?

scientific article

Intraneuronal amyloid beta accumulation and oxidative damage to nucleic acids in Alzheimer disease

scientific article

Involvement of Maillard reactions in Alzheimer disease

scientific article

Involvement of oxidative stress in Alzheimer disease

scientific article

Iron homeostasis is maintained in the brain, but not the liver, following mild hypoxia

scientific article published in January 2007

Iron, zinc and copper in the Alzheimer's disease brain: A quantitative meta-analysis. Some insight on the influence of citation bias on scientific opinion ⬇️

scientific article published on May 11, 2011

Iron: A Pathological Mediator of Alzheimer Disease? ⬇️

scientific article published on January 31, 2009

Iron: a pathological mediator of Alzheimer disease?

scientific article published in January 2002

Iron: the Redox-active center of oxidative stress in Alzheimer disease

scientific article published on 17 May 2007

Is Alzheimer's disease a mitochondrial disorder?

scientific article

Is Alzheimers Disease a Myth? When is Disease a Disease?

Is intraneuronal amyloid beta-peptide accumulation the trigger of Alzheimer's disease pathophysiology?

scientific article published in August 2004

Is nitric oxide a key target in the pathogenesis of brain lesions during the development of Alzheimer's disease?

scientific article published in July 2004

Is oxidative damage the fundamental pathogenic mechanism of Alzheimer's and other neurodegenerative diseases?

scientific article

Is the time dimension of the cell cycle re-entry in AD regulated by centromere cohesion dynamics?

scientific article published on January 2008

JKK1, an upstream activator of JNK/SAPK, is activated in Alzheimer's disease

scientific article published in April 2003

Klf15 orchestrates circadian nitrogen homeostasis

scientific article published in March 2012

LRRK2 in Parkinson's disease and dementia with Lewy bodies

scientific article

LRRK2 protein is a component of lewy bodies

LRRK2-mediated neurodegeneration and dysfunction of dopaminergic neurons in a Caenorhabditis elegans model of Parkinson's disease

scientific article

La función del estrés oxidativo en la patogénesis de la enfermedad de Alzheimer

Labeling of cerebral amyloid beta deposits in vivo using intranasal basic fibroblast growth factor and serum amyloid P component in mice

scientific article published in August 2002

Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and β-amyloid in neurons ⬇️

scientific article published on September 17, 2011

Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells

scientific article published on 25 March 2009

Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells

scientific article published on 16 September 2008

Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease

scientific article

Leptin: a novel therapeutic strategy for Alzheimer's disease

scientific article

Leucine-rich repeat kinase 2 colocalizes with alpha-synuclein in Parkinson's disease, but not tau-containing deposits in tauopathies

scientific article published on 06 March 2008

Lipid peroxidation and 4-hydroxy-2-nonenal formation by copper ion bound to amyloid-beta peptide

scientific article published on 29 August 2007

Lipoic acid and N-acetyl cysteine decrease mitochondrial-related oxidative stress in Alzheimer disease patient fibroblasts.

scientific article published on September 2007

Lipoic acid and N-acetyl cysteine protect against mitochondrial-related oxidative stress in fibroblasts from Alzheimer disease patients

Low-dose pterostilbene, but not resveratrol, is a potent neuromodulator in aging and Alzheimer's disease

scientific article published on 7 October 2011

Luteinizing hormone modulates cognition and amyloid-beta deposition in Alzheimer APP transgenic mice

scientific article published on 13 February 2006

Luteinizing hormone, a reproductive regulator that modulates the processing of amyloid-beta precursor protein and amyloid-beta deposition

scientific article

MAPKs are differentially modulated in arctic ground squirrels during hibernation

scientific article published in June 2005

Malignant glioma progression and nitric oxide

scientific article published on 12 September 2006

Mathematical modeling of microtubule dynamics: insights into physiology and disease

scientific article

Melatonin exhibits antioxidant properties in a mouse brain slice model of excitotoxicity

scientific article

Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease

scientific article published in June 2003

Memantine: "hypothesis testing" not "disease modifying" in Alzheimer's disease

scientific article

Menopause, estrogen, and gonadotropins in Alzheimer's disease

scientific article published on January 2008

Metal Homeostasis and Its Relation to Oxidative Stress in Alzheimer’s Disease

Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence

scientific article published in March 2003

Metal chelators coupled with nanoparticles as potential therapeutic agents for Alzheimer's disease

scientific article published on June 2009

Metal ions and oxidative protein modification in neurological disease.

scientific article

Microbial origin of glutamate, hibernation and tissue trauma: an in vivo microdialysis study

scientific article published in September 2002

Microglial activation and amyloid-beta clearance induced by exogenous heat-shock proteins

scientific article published in April 2002

Microtubule Reduction in Alzheimer's Disease and Aging Is Independent of τ Filament Formation ⬇️

scientific article published on May 1, 2003

Mislocalization of CDK11/PITSLRE, a regulator of the G2/M phase of the cell cycle, in Alzheimer disease

scientific article

Mitochondria DNA deletions in atherosclerotic hypoperfused brain microvessels as a primary target for the development of Alzheimer's disease

scientific article published on 23 December 2004

Mitochondria and Neurodegenerative Diseases

Mitochondria and vascular lesions as a central target for the development of Alzheimer's disease and Alzheimer disease-like pathology in transgenic mice

scientific article published on September 2003

Mitochondria as a primary target for vascular hypoperfusion and oxidative stress in Alzheimer's disease

scientific article

Mitochondria: a therapeutic target in neurodegeneration

scientific article published on 21 October 2009

Mitochondria: the missing link between preconditioning and neuroprotection

scientific article

Mitochondrial DNA oxidative damage and repair in aging and Alzheimer's disease

scientific article published on 7 December 2012

Mitochondrial Drugs for Alzheimer Disease

scientific article

Mitochondrial abnormalities and oxidative imbalance in Alzheimer disease.

scientific article published on July 2006

Mitochondrial abnormalities and oxidative imbalance in neurodegenerative disease.

scientific article published on 16 October 2002

Mitochondrial abnormalities in a streptozotocin-induced rat model of sporadic Alzheimer's disease

scientific article published in May 2013

Mitochondrial dynamics in Alzheimer's disease: opportunities for future treatment strategies

scientific article

Mitochondrial dysfunction is a trigger of Alzheimer's disease pathophysiology

scientific article published on 21 October 2009

Mitochondrial failures in Alzheimer's disease

scientific article

Mitochondrial importance in Alzheimer's, Huntington's and Parkinson's diseases

scientific article published on January 2012

Mitochondrial preconditioning: a potential neuroprotective strategy

scientific article published on 26 August 2010

Mitogen- and stress-activated protein kinase 1: convergence of the ERK and p38 pathways in Alzheimer's disease

scientific article published in February 2005

Modeling cholesterol metabolism by gene expression profiling in the hippocampus

scientific article published on 30 March 2011

Modeling the heterogeneity in risk of progression to Alzheimer's disease across cognitive profiles in mild cognitive impairment

scientific article published on 06 March 2013

Modification of amyloid-β1-42 fibril structure by methionine-35 oxidation

scientific article published in January 2013

Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats

scientific article

Molecular neuropathogenesis of Alzheimer's disease: an interaction model stressing the central role of oxidative stress

scientific article

Molecular pathogenesis of Alzheimer's disease: reductionist versus expansionist approaches

scientific article published on 26 March 2009

NMR studies of zinc, copper, and iron binding to histidine, the principal metal ion complexing site of amyloid-beta peptide

scientific article published in January 2010

Nanoparticle and iron chelators as a potential novel Alzheimer therapy

scientific article

Nanoparticle and other metal chelation therapeutics in Alzheimer disease

scientific article

Nanoparticle delivery of transition-metal chelators to the brain: Oxidative stress will never see it coming!

scientific article

Nanoparticle iron chelators: a new therapeutic approach in Alzheimer disease and other neurologic disorders associated with trace metal imbalance

scientific article published on 21 August 2006

Nanoparticle-chelator conjugates as inhibitors of amyloid-beta aggregation and neurotoxicity: a novel therapeutic approach for Alzheimer disease

scientific article published on 25 March 2009

Nanoparticle-iron Chelator Conjugates as Multifunctional Disease-modifying Drugs for Prevention and Treatment of Alzheimer’s Disease

Natural Oxidant Balance in Parkinson Disease

scholarly article by George Perry et al published 1 December 2009 in Archives of Neurology

Neurodegenerative diseases: mechanisms and therapies

scientific article published in January 2006

Neurodegenerative processes in Alzheimer’s disease: an overview of pathogenesis with strategic biomarker potential

Neuroendocrinology-based therapy for Alzheimer's disease

scientific article published on 22 March 2012

Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer’s Disease

article

Neurofilamentopathy in neurodegenerative diseases

scientific article published on 26 August 2011

Neurogenesis in Alzheimer’s Disease

Neurogenesis in Human Hippocampus: Implications for Alzheimer Disease Pathogenesis

Neuronal RNA oxidation is a prominent feature of dementia with Lewy bodies

scientific article published in November 2002

Neuronal RNA oxidation is a prominent feature of familial Alzheimer's disease

scientific article published in October 2004

Neuronal Survival and Death in Alzheimer Disease

Neuronal cell cycle re-entry markers are altered in the senescence accelerated mouse P8 (SAMP8).

scientific article published in January 2012

Neuronal failure in Alzheimer's disease: a view through the oxidative stress looking-glass

scientific article

Neuronal leptin resistance in Alzheimer's disease

scholarly article by David Bonda et al published July 2013 in Alzheimer's and Dementia

Neuronal mitochondrial amelioration by feeding acetyl-L-carnitine and lipoic acid to aged rats

scientific article published on 28 March 2008

Neuropathology and treatment of Alzheimer disease: did we lose the forest for the trees?

scientific article published on May 2007

Neuropathology in Alzheimer's disease: awaking from a hundred-year-old dream

scientific article published on 3 May 2006

Neuropathology of Alzheimer disease: pathognomonic but not pathogenic

scientific article

Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress

scientific article

Neuroprotective effect of cocoa flavonoids on in vitro oxidative stress

Neuroprotective effects of SB-415286 on hydrogen peroxide-induced cell death in B65 rat neuroblastoma cells and neurons

scientific article

Neuroprotective effects of caffeine against complex I inhibition-induced apoptosis are mediated by inhibition of the Atm/p53/E2F-1 path in cerebellar granule neurons

scientific article

Neuroprotective properties of Bcl-w in Alzheimer disease

scientific article

Neurotoxic dopamine quinone facilitates the assembly of tau into fibrillar polymers

scientific article published in October 2005

New insights into the mechanisms of mitochondrial preconditioning-triggered neuroprotection

scientific article published on January 2011

Novel therapeutics for Alzheimer's disease: an update

scientific article

Nuclear and mitochondrial DNA oxidation in Alzheimer's disease

scientific article published on 23 January 2012

Nucleic acid oxidation in Alzheimer disease

scientific article published on 18 January 2008

O2-04-07 Elevated expression of a regulator of the G2/M phase of the cell cycle, neuronal CIP-1 associated regulator of cyclin B, in Alzheimer disease

Overexpression of GRK2 in Alzheimer disease and in a chronic hypoperfusion rat model is an early marker of brain mitochondrial lesions

scientific article published in August 2006

Oxidative Damage and Antioxidant Responses in Alzheimer's Disease

article

Oxidative Stress Mechanisms and Potential Therapeutic Modalities in Alzheimer Disease

Oxidative Stress and Alzheimer Disease: Mechanisms and Therapeutic Opportunities

Oxidative Stress and Balance in Neurodegenerative Diseases

Oxidative Stress and Neurodegeneration: An Inevitable Consequence of Aging? Implications for Therapy

article

Oxidative Stress and its Implications for Future Treatments and Management of Alzheimer Disease

scientific article

Oxidative Stress in Alzheimer’s Disease: A Critical Appraisal of the Causes and the Consequences

Oxidative Stress in Parkinson`s Disease

scholarly article by Avi L. Friedlich et al published 20 May 2009 in The open pathology journal

Oxidative damage and Alzheimer's disease: are antioxidant therapies useful?

scientific article

Oxidative damage in cultured human olfactory neurons from Alzheimer's disease patients

scientific article published on February 2004

Oxidative damage in the olfactory system in Alzheimer's disease

scientific article

Oxidative damage is present in the fatal brain edema of diabetic ketoacidosis ⬇️

scientific article published on October 30, 2010

Oxidative damage to RNA in aging and neurodegenerative disorders

scientific article published on 06 June 2012

Oxidative damage to RNA in neurodegenerative diseases

scientific article published in January 2006

Oxidative damage to nucleic acids in human prion disease

scientific article published in April 2002

Oxidative imbalance in Alzheimer's disease

scientific article

Oxidative stress activates a positive feedback between the gamma- and beta-secretase cleavages of the beta-amyloid precursor protein ⬇️

scientific article

Oxidative stress and iron imbalance in Alzheimer disease: how rust became the fuss!

scientific article published on January 2006

Oxidative stress and neurodegeneration

scientific article

Oxidative stress and neuronal adaptation in Alzheimer disease: the role of SAPK pathways

scientific article published on October 2003

Oxidative stress and neurotoxicity

scientific article published on 04 December 2007

Oxidative stress and redox-active iron in Alzheimer's disease

scientific article published on March 2004

Oxidative stress in Alzheimer disease: a possibility for prevention

scientific article published on 13 April 2010

Oxidative stress in diabetes and Alzheimer's disease

scientific article published on January 2009

Oxidative stress increases expression and activity of BACE in NT2 neurons

scientific article published in August 2002

Oxidative stress is an early event in hydrostatic pressure induced retinal ganglion cell damage

scientific article

Oxidative stress signalling in Alzheimer's disease

scientific article published on March 2004

Oxidative stress: the old enemy in Alzheimer's disease pathophysiology

scientific article

P1-266 The critical role of the ERK pathway in the pathogenesis of Alzheimer's disease

scholarly article by Xiongwei Zhu et al published July 2004 in Neurobiology of Aging

P1-351: A novel approach to diagnosis: Antigen-antibody disassociation in Alzheimer's disease

scholarly article by Mark A. Smith et al published July 2008 in Alzheimer's and Dementia

P3-219 Acetylation: a novel posttranslational modification in Alzheimer disease

P3-306 Differential expression of metabotrophic glutamate receptors (MGlurs) in Alzheimer disease

P3-317: Failure in the control of cell cycle causes neurodegeneration

P3-375

P38 activation mediates amyloid-beta cytotoxicity

scientific article published on June 2005

P4-162

P4-166: Overexpression of amyloid precursor protein causes abnormal mitochondrial dynamics via differential modulation of mitochondrial fission/fusion proteins

PKC inhibition is involved in trichosanthin-induced apoptosis in human chronic myeloid leukemia cell line K562.

scientific article published on 26 July 2006

Paraffin-embedded tissue (PET) blot method: application to Alzheimer disease

scientific article

Pathological implications of cell cycle re-entry in Alzheimer disease

scientific article

Pathology's new role: defining disease process and protective responses.

scientific article published in January 2008

Perspectives on the amyloid-beta cascade hypothesis

scientific article published on April 2004

Phosphorylated tau: toxic, protective, or none of the above

scientific article published on August 2008

Physiological regulation of tau phosphorylation during hibernation

scientific article published on June 2008

Possible involvement of Wiskott-Aldrich syndrome protein family in aberrant neuronal sprouting in Alzheimer's disease

scientific article

Predicting the failure of amyloid-beta vaccine.

scientific article published in May 2002

Premature centromere division of metaphase chromosomes in peripheral blood lymphocytes of Alzheimer's disease patients: relation to gender and age.

scientific article

Premature centromere division of the X chromosome in neurons in Alzheimer's disease

scientific article published on 09 July 2008

Presenilin 1 overexpressions in Chinese hamster ovary (CHO) cells decreases the phosphorylation of retinoblastoma protein: relevance for neurodegeneration.

scientific article published in June 2002

Presenilin mutation: a deadly first hit in Alzheimer disease. A commentary on "aging sensitizes towards ROS formation and lipid peroxidation in PS1M146L transgenic mice".

scientific article published on 19 January 2006

Prevention and treatment of Alzheimer disease and aging: antioxidants

scientific article published on February 2007

Prion disease and Alzheimer's disease: pathogenic overlap

scientific article

Protein Misfolding in Alzheimer's Disease

scholarly article published 3 December 2007

Protein Modification by Dicarbonyl Molecular Species in Neurodegenerative Diseases ⬇️

scientific article published on March 14, 2011

Proton magnetic resonance imaging and spectroscopy identify metabolic changes in the striatum in the MPTP feline model of parkinsonism

scientific article

R-_-Lipoic Acid as a Potent Agent of Mitochondrial Protectionin Alzheimer’s Disease

RNA oxidation in Alzheimer disease and related neurodegenerative disorders

scientific article published on 07 March 2009

Redox Active Iron at the Center of Oxidative Stress in Alzheimer Disease

article published in 2005

Redox metals and oxidative abnormalities in human prion diseases

scientific article published on 11 August 2005

Reduced homocysteine-thiolactonase activity in Alzheimer's disease

scientific article published in January 2010

Reduction of inclusion body pathology in ApoE-deficient mice fed a combination of antioxidants

scientific article published in April 2003

Reexamining Alzheimer's disease: evidence for a protective role for amyloid-beta protein precursor and amyloid-beta

scientific article

Regulation of glycogen synthase kinase-3beta by products of lipid peroxidation in human neuroblastoma cells

scientific article published on June 2004

Resveratrol and neurodegenerative diseases: activation of SIRT1 as the potential pathway towards neuroprotection

scientific article published on February 2009

Retinoblastoma protein phosphorylation at multiple sites is associated with neurofibrillary pathology in Alzheimer disease.

scientific article published on January 2008

Ribosomal RNA in Alzheimer disease is oxidized by bound redox-active iron

scientific article

Role of Oxidative Insult and Neuronal Survival in Alzheimer’s and Parkinson’s Diseases

scholarly article

Role of high mobility group protein-1 (HMG1) in amyloid-beta homeostasis

scientific article published in February 2003

Role of metal dyshomeostasis in Alzheimer's disease

scientific article

Role of mitochondrial dysfunction in Alzheimer's disease

scientific article

Role of mitochondrial-mediated signaling pathways in Alzheimer disease and hypoxia

scientific article published on October 2009

Role of vascular hypoperfusion-induced oxidative stress and mitochondria failure in the pathogenesis of Azheimer disease

scientific article published on January 2003

S4-02-01 Alzheimer disease: the two hit hypothesis

Senile plaque composition and posttranslational modification of amyloid-beta peptide and associated proteins

scientific article

Sequestration of p27 within the cytoplasm of cardiac myocytes in chronic ischemic heart disease: pathogenic implications for ischemic cardiomyopathy

scientific article published on March 2006

Signal Transduction in Alzheimer’s Disease

article published in 2002

Signal transduction cascades associated with oxidative stress in Alzheimer's disease

scientific article published on May 2007

Signaling effect of amyloid-beta(42) on the processing of AbetaPP

scientific article

Soluble amyloid beta-protein is increased in frontotemporal dementia with tau gene mutations.

scientific article published in February 2004

Specific reaction of Met 35 in amyloid beta peptide with hypochlorous acid

scientific article published in July 2010

Staying connected: synapses in Alzheimer disease

scientific article

Steroidogenic acute regulatory protein (StAR): evidence of gonadotropin-induced steroidogenesis in Alzheimer disease

scientific article

Subcellular and metabolic examination of amyloid-beta peptides in Alzheimer disease pathogenesis: evidence for Abeta(25-35).

scientific article published on 12 September 2009

Sublethal RNA oxidation as a mechanism for neurodegenerative disease

scientific article published on 20 May 2008

Systemic increase of oxidative nucleic acid damage in Parkinson's disease and multiple system atrophy

scientific article published in March 2002

Targeting gonadotropins: an alternative option for Alzheimer disease treatment

scientific article

Tau modifiers as therapeutic targets for Alzheimer's disease

scientific article

Tau phosphorylation and assembly.

scientific article published on January 2004

Tau phosphorylation in Alzheimer's disease: pathogen or protector?

scientific article (publication date: April 2005)

Tau--an inhibitor of deacetylase HDAC6 function

scientific article

Telomeres and telomerase in Alzheimer's disease: epiphenomena or a new focus for therapeutic strategy?

scientific article

Temporal Primacy of Oxidative Stress in the Pathological Cascade of Alzheimer Disease

The "Down's" side of mitochondria

scientific article

The (un)balance between metabolic and oxidative abnormalities and cellular compensatory responses in Alzheimer disease

scientific article

The Key Role of Oxidative Stress in Alzheimer's Disease

scholarly article published 2007

The Potential Application of Antioxidant Agents in Alzheimer Disease Therapeutics

The X-chromosome instability phenotype in Alzheimer's disease: a clinical sign of accelerating aging?

scientific article published on 31 July 2009

The application of microarray technology to neuropathology: cutting edge tool with clinical diagnostics potential or too much information?

scientific article published on November 2006

The blood-brain barrier in Alzheimer's disease: novel therapeutic targets and nanodrug delivery

scientific article published on January 2012

The cell cycle and hormonal fluxes in Alzheimer disease: a novel therapeutic target

scientific article

The cell cycle hypothesis of Alzheimer's disease: suggestions for drug development

scientific article published on 13 December 2006

The cell cycle in Alzheimer disease: a unique target for neuropharmacology

scientific article

The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies

scientific article

The contribution of luteinizing hormone to Alzheimer disease pathogenesis

scientific article

The earliest stage of cognitive impairment in transition from normal aging to Alzheimer disease is marked by prominent RNA oxidation in vulnerable neurons

scientific article published on March 2012

The effect of mGluR2 activation on signal transduction pathways and neuronal cell survival

scientific article

The essential role of ERK in 4-oxo-2-nonenal-mediated cytotoxicity in SH-SY5Y human neuroblastoma cells

scientific article published on 13 January 2009

The estrogen myth: potential use of gonadotropin-releasing hormone agonists for the treatment of Alzheimer's disease

scientific article

The fallacy of amyloid and cognition in Alzheimer's disease

scientific article published in January 2006

The gonadotropin connection in Alzheimer's disease

scientific article

The mitochondrial dynamics of Alzheimer's disease and Parkinson's disease offer important opportunities for therapeutic intervention

scientific article published on January 2011

The neuronal expression of MYC causes a neurodegenerative phenotype in a novel transgenic mouse

scientific article published on 22 January 2009

The neuroprotective activities of melatonin against the Alzheimer beta-protein are not mediated by melatonin membrane receptors

scientific article

The p38 pathway is activated in Pick disease and progressive supranuclear palsy: a mechanistic link between mitogenic pathways, oxidative stress, and tau.

scientific article published in September 2002

The role of E2F1 in the development of hypertrophic cardiomyopathy ⬇️

scientific article published on June 7, 2011

The role of abnormal mitochondrial dynamics in the pathogenesis of Alzheimer's disease

scientific article published on May 2009

The role of iron and copper in the aetiology of neurodegenerative disorders: therapeutic implications

scientific article

The role of mitogen-activated protein kinase pathways in Alzheimer's disease

scientific article

The role of novel chitin-like polysaccharides in Alzheimer disease

scientific article published on December 2007

The role of oxidative stress in the pathophysiology of cerebrovascular lesions in Alzheimer's disease

scientific article

The sirtuin pathway in ageing and Alzheimer disease: mechanistic and therapeutic considerations

scientific article

The state versus amyloid-beta: the trial of the most wanted criminal in Alzheimer disease

scientific article

The up-regulation of BACE1 mediated by hypoxia and ischemic injury: role of oxidative stress and HIF1alpha

scientific article

Therapeutic opportunities in Alzheimer disease: one for all or all for one?

scientific article

Therapeutic options in Alzheimer's disease

scientific article published on June 2006

Therapeutic potential of c-Myc inhibition in the treatment of hypertrophic cardiomyopathy ⬇️

scientific article published on March 1, 2011

Therapeutic potential of oxidant mechanisms in Alzheimer's disease

scientific article

Thinking Outside the Box in Alzheimer Disease Treatment

Three histidine residues of amyloid-beta peptide control the redox activity of copper and iron

scientific article published on 11 October 2007

Three-dimensional tomographic imaging and characterization of iron compounds within Alzheimer's plaque core material

scientific article published in June 2008

Tipping the apoptotic balance in Alzheimer's disease: the abortosis concept

scientific article published on January 2003

Transgenic Mouse Models of Alzheimer's Disease

article

Treating the lesions, not the disease

scientific article published on May 2007

Treatment advances in Alzheimer's disease based on the oxidative stress model

scientific article

Two Hits and You’re Out? A Novel Mechanistic Hypothesis of Alzheimer Disease

Up-regulation of astrocyte metabotropic glutamate receptor 5 by amyloid-β peptide

scientific article published on 18 January 2009

Vascular oxidative stress in Alzheimer disease

scientific article

Widespread distribution of reticulon-3 in various neurodegenerative diseases

scientific article

Will Preventing Protein Aggregates Live Up to Its Promise as Prophylaxis Against Neurodegenerative Diseases?

article

Will preventing protein aggregates live up to its promise as prophylaxis against neurodegenerative diseases?

scientific article published on October 2003

c-Jun phosphorylation in Alzheimer disease

scientific article

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