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List of works by Louis Charles Gerstenfeld

A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo

scientific article

AMPK downregulates ALK2 via increasing the interaction between Smurf1 and Smad6, leading to inhibition of osteogenic differentiation.

scientific article published on 25 August 2017

Absence of mouse pleiotrophin does not affect bone formation in vivo.

scientific article published in December 2004

Acute Phosphate Restriction Impairs Bone Formation and Increases Marrow Adipose Tissue in Growing Mice

scientific article published on 21 June 2016

Acute phosphate restriction leads to impaired fracture healing and resistance to BMP-2.

scientific article

Advanced glycation end products stimulate osteoblast apoptosis via the MAP kinase and cytosolic apoptotic pathways.

scientific article published on 24 October 2006

Anabolic role of lysyl oxidase like-2 in cartilage of knee and temporomandibular joints with osteoarthritis

scientific article published on 2 August 2017

Analysis of fracture healing by large-scale transcriptional profile identified temporal relationships between metalloproteinase and ADAMTS mRNA expression

scientific article published on 06 March 2006

Autogenous regulation of a network of bone morphogenetic proteins (BMPs) mediates the osteogenic differentiation in murine marrow stromal cells.

scientific article published on 12 January 2007

BMP treatment of C3H10T1/2 mesenchymal stem cells induces both chondrogenesis and osteogenesis.

scientific article

BMP2 activity, although dispensable for bone formation, is required for the initiation of fracture healing.

scientific article published on 12 November 2006

BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing

scientific article published on 18 March 2016

Bone formation during distraction osteogenesis is dependent on both VEGFR1 and VEGFR2 signaling.

scientific article published on May 2008

Bone marrow lesions from osteoarthritis knees are characterized by sclerotic bone that is less well mineralized.

scientific article published on 26 January 2009

Cell density and estradiol modulation of procollagen type III in cultured calf smooth muscle cells

scientific article published on 01 October 1982

Cell-free translation of calf type III collagen. Effect of magnesium on ribosome movement during elongation

scientific article published on 01 October 1983

Characterization of an Avian Bone Sialoprotein (BSP) cDNA: Comparisons to Mammalian BSP and Identification of Conserved Structural Domains ⬇️

scientific article published on April 1, 1995

Characterization of demineralized bone matrix-induced osteogenesis in rat calvarial bone defects: III. Gene and protein expression

scientific article published on 01 October 2000

Characterization of structural sequences in the chicken osteocalcin gene: expression of osteocalcin by maturing osteoblasts and by hypertrophic chondrocytes in vitro.

scientific article published in January 1995

Characterization of the Major Non-collagenous Proteins of Chicken Bone: Identification of a Novel 60-kDa Non-collagenous Phosphoprotein

scientific article published on 01 March 1995

Characterization of the chicken osteopontin-encoding gene.

scientific article published on March 1994

Chondrocytes provide morphogenic signals that selectively induce osteogenic differentiation of mesenchymal stem cells.

scientific article published in February 2002

Chondrogenic potential of skeletal cell populations: selective growth of chondrocytes and their morphogenesis and development in vitro

scientific article published on 01 October 1998

Colloidal-gold immunocytochemical localization of osteopontin in avian eggshell gland and eggshell.

scientific article published on 5 February 2008

Combined effects of recombinant human BMP-7 (rhBMP-7) and parathyroid hormone (1-34) in metaphyseal bone healing.

scientific article

Comparative morphological and biochemical analysis of hypertrophic, non-hypertrophic and 1,25(OH)2D3 treated non-hypertrophic chondrocytes

scientific article published on 01 January 1990

Comparison of effects of the bisphosphonate alendronate versus the RANKL inhibitor denosumab on murine fracture healing.

scientific article

Comparison of two phosphoproteins in chicken bone and their similarities to the mammalian bone proteins, osteopontin and bone sialoprotein II ⬇️

scientific article published on November 30, 1990

Correlation between RUST assessments of fracture healing to structural and biomechanical properties

scientific article

Development of avian tibial dyschondroplasia: gene expression and protein synthesis

scientific article published on 01 December 1998

Developmental aspects of fracture healing and the use of pharmacological agents to alter healing

scientific article published on 01 December 2003

Developmental restriction of embryonic calvarial cell populations as characterized by their in vitro potential for chondrogenic differentiation.

scientific article published in December 1997

Device for the application of a dynamic biaxially uniform and isotropic strain to a flexible cell culture membrane

scientific article published on 01 September 1994

Diabetes causes decreased osteoclastogenesis, reduced bone formation, and enhanced apoptosis of osteoblastic cells in bacteria stimulated bone loss

scientific article published on 02 October 2003

Diabetes causes the accelerated loss of cartilage during fracture repair which is reversed by insulin treatment.

scientific article published on 29 October 2008

Diabetes interferes with the bone formation by affecting the expression of transcription factors that regulate osteoblast differentiation

scientific article published on 01 January 2003

Diabetes reduces mesenchymal stem cells in fracture healing through a TNFα-mediated mechanism

scientific article

Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing

scientific article published on 01 March 2002

Diminished bone formation during diabetic fracture healing is related to the premature resorption of cartilage associated with increased osteoclast activity

scientific article

Direct percutaneous gene delivery to enhance healing of segmental bone defects

article

Downregulation of cell growth and cell cycle regulated genes during chick osteoblast differentiation with the reciprocal expression of histone gene variants.

scientific article published in June 1989

Earliest phases of chondrogenesis are dependent upon angiogenesis during ectopic bone formation in mice.

scientific article published on 12 April 2017

Effect of 1,25-dihydroxyvitamin D3 on induction of chondrocyte maturation in culture: extracellular matrix gene expression and morphology

scientific article published on 01 March 1990

Effect of caffeine on parameters of osteoblast growth and differentiation of a mineralized extracellular matrix in vitro

scientific article published on 01 October 1991

Effect of protein-hydroxyethylmethacrylate hydrogels on cultured endothelial cells

scientific article published on 01 January 1983

Effects of 17 beta-estradiol on the biosynthesis of collagen in cultured bovine aortic smooth muscle cells

scientific article published on 01 April 1981

Effects of fixation and demineralization on the retention of bone phosphoprotein and other matrix components as evaluated by biochemical analyses and quantitative immunocytochemistry.

scientific article

Effects of the local mechanical environment on vertebrate tissue differentiation during repair: does repair recapitulate development?

scientific article published on 01 July 2003

Enhancement of Experimental Fracture-Healing by Systemic Administration of Recombinant Human Parathyroid Hormone (PTH 1-34)

Erratum to: Overview of Skeletal Repair (Fracture Healing and Its Assessment)

scientific article published on 01 January 2014

Erratum: "BMPR1A antagonist differentially affects cartilage and bone formation during fracture healing" [J Orthop Res. Vol 34, 2096-2105 (2016)]

scientific article published on 20 September 2017

Experimental use of fibrin glue to induce site-directed osteogenesis from cultured periosteal cells

scientific article published on 01 March 2000

Experiments with osteoblasts cultured under hypergravity conditions

scientific article published on 01 January 2004

Expression and role of interleukin-6 in distraction osteogenesis.

scientific article

Expression and ultrastructural immunolocalization of a major 66 kDa phosphoprotein synthesized by chicken osteoblasts during mineralization in vitro.

scientific article published in September 1990

Expression of differentiated function by mineralizing cultures of chicken osteoblasts

scientific article published on 01 July 1987

Expression of osteoprotegerin, receptor activator of NF-kappaB ligand (osteoprotegerin ligand) and related proinflammatory cytokines during fracture healing.

scientific article published in June 2001

Expression of smooth muscle actin in cells involved in distraction osteogenesis in a rat model.

scientific article

Expression of smooth muscle actin in connective tissue cells participating in fracture healing in a murine model.

scientific article

Expression of type I and III collagen genes during differentiation of embryonic chicken myoblasts in culture.

scientific article published on August 1984

FOXO1 modulates osteoblast differentiation ⬇️

scientific article published on January 28, 2011

Factors that promote progressive development of the osteoblast phenotype in cultured fetal rat calvaria cells

scientific article published on 01 May 1990

Fibronectin gene expression, synthesis and accumulation during in vitro differentiation of chicken osteoblasts.

scientific article published in December 1995

Fidelity of Runx2 activity in breast cancer cells is required for the generation of metastases-associated osteolytic disease.

scientific article published on July 2004

Formation of phalanges and small joints by tissue-engineering

scientific article

Fracture healing as a post-natal developmental process: molecular, spatial, and temporal aspects of its regulation.

scientific article

Fracture healing: mechanisms and interventions

scientific article

From the Cover: Tributyltin Alters the Bone Marrow Microenvironment and Suppresses B Cell Development.

scientific article published on 7 April 2017

Gene expression and extracellular matrix ultrastructure of a mineralizing chondrocyte cell culture system

scientific article published on February 1991

Generation of closed transverse fractures in small animals.

scientific article published on January 2014

Genetic variation in the structural pattern of osteoclast activity during post-natal growth of mouse femora.

scientific article published on 21 February 2010

Growth factor regulation of fracture repair.

scientific article

Healing of segmental bone defects by direct percutaneous gene delivery: effect of vector dose

article

Identification and characterization of the major chicken bone phosphoprotein. Analysis of its synthesis by cultured embryonic chick osteoblasts

scientific article published on 01 January 1990

Identification of the In Vivo Phosphorylated Sites of Secreted Osteopontin from Cultured Chicken Osteoblasts

scientific article published on 01 April 1995

Identification of the Phosphorylated Sites of Metabolically32P-Labeled Osteopontin from Cultured Chicken Osteoblasts

scientific article published in Journal of Biological Chemistry

Impaired fracture healing in the absence of TNF-alpha signaling: the role of TNF-alpha in endochondral cartilage resorption.

scientific article published in September 2003

Impaired intranuclear trafficking of Runx2 (AML3/CBFA1) transcription factors in breast cancer cells inhibits osteolysis in vivo.

scientific article

Increased VEGF expression in the epiphyseal cartilage after ischemic necrosis of the capital femoral epiphysis

scientific article published on 20 September 2004

Induction of a neoarthrosis by precisely controlled motion in an experimental mid-femoral defect

scientific article published on 01 May 2002

Induction of apoptosis in chondrocytes by tumor necrosis factor-alpha

scientific article published on 01 September 2001

Induction of bone-related proteins, osteocalcin and osteopontin, and their matrix ultrastructural localization with development of chondrocyte hypertrophy in vitro

scientific article published on 01 June 1993

Interactions of cisplatin with calcium phosphate nanoparticles: in vitro controlled adsorption and release.

scientific article published on July 2004

Intrinsic Sex-Linked Variations in Osteogenic and Adipogenic Differentiation Potential of Bone Marrow Multipotent Stromal Cells

scientific article

Lysyl oxidase-like-2 (LOXL2) is a major isoform in chondrocytes and is critically required for differentiation

scientific journal article

MRT letter: Contrast-enhanced computed tomographic imaging of soft callus formation in fracture healing.

scientific article published on 28 October 2011

Mechanical microenvironments and protein expression associated with formation of different skeletal tissues during bone healing.

scientific article published on 31 March 2015

Mechanical stimulation alters tissue differentiation and molecular expression during bone healing

scientific journal article

Mechanism of action and morphologic changes in the alveolar bone in response to selective alveolar decortication-facilitated tooth movement.

scientific article published in April 2011

Micro-computed tomography assessment of fracture healing: relationships among callus structure, composition, and mechanical function.

scientific article

Molecular mechanisms controlling bone formation during fracture healing and distraction osteogenesis

scientific article

Mouse models of bone healing: fracture, marrow ablation, and distraction osteogenesis.

scientific article published on 2 March 2015

Osteoblast cytoskeletal modulation in response to mechanical strain in vitro.

scientific article published in March 1998

Osteoblast-related transcription factors Runx2 (Cbfa1/AML3) and MSX2 mediate the expression of bone sialoprotein in human metastatic breast cancer cells

scientific article (publication date: 15 May 2003)

Osteoblasts induce osteopontin expression in response to attachment on fibronectin: demonstration of a common role for integrin receptors in the signal transduction processes of cell attachment and mechanical stimulation.

scientific article

Osteogenic potential of murine osteosarcoma cells: comparison of bone-specific gene expression in in vitro and in vivo conditions.

scientific article published on May 1996

Osteopontin in skeletal tissue homeostasis: An emerging picture of the autocrine/paracrine functions of the extracellular matrix

scientific article published on 01 June 1999

Overview of biological mechanisms and applications of three murine models of bone repair: closed fracture with intramedullary fixation, distraction osteogenesis, and marrow ablation by reaming

scientific article

Overview of skeletal repair (fracture healing and its assessment).

scientific article published on January 2014

Phosphorylation of Osteopontin by Golgi Kinases

scientific article published on 01 April 1995

Processing of procollagen types III and I in cultured bovine smooth muscle cells

scientific article published on 01 July 1984

Protein Kinases of Cultured Chicken Osteoblasts That Phosphorylate Extracellular Bone Proteins

scientific article published on 01 January 1996

Protein kinases of cultured osteoblasts: Selectivity for the extracellular matrix proteins of bone and their catalytic competence for osteopontin

scientific article published on 01 October 1996

Qualitative and quantitative differences between bone graft obtained from the medullary canal (with a Reamer/Irrigator/Aspirator) and the iliac crest of the same patient.

scientific article

Role of Fas and Treg cells in fracture healing as characterized in the fas-deficient (lpr) mouse model of lupus.

scientific article

Role of hypoxia inducible factor-1 alpha pathway in bone regeneration.

scientific article published on October 2008

Selective adhesion of osteoblastic cells to different integrin ligands induces osteopontin gene expression.

scientific article

Selective and Nonselective Cyclooxygenase-2 Inhibitors and Experimental Fracture-Healing

scientific article published on 01 January 2007

Selective extractability of noncollagenous proteins from chicken bone

scientific article published on 01 September 1994

Serum proteomic assessment of the progression of fracture healing.

scientific article published on 2 October 2017

Sex-Linked Skeletal Phenotype of Lysyl Oxidase Like-1 Mutant Mice.

scientific article published on 5 November 2015

Signal transduction of mechanical stimuli is dependent on microfilament integrity: identification of osteopontin as a mechanically induced gene in osteoblasts.

scientific article published in October 1997

Skeletal trauma generates systemic BMP2 activation that is temporally related to the mobilization of CD73+ cells

scientific article

Structural analysis and characterization of tissue and hormonal responsive expression of the avian bone sialoprotein (BSP) gene

scientific article published on 01 January 1997

Structure, composition, and maturation of newly deposited calcium-phosphate crystals in chicken osteoblast cell cultures

article

TNF-alpha mediates diabetes-enhanced chondrocyte apoptosis during fracture healing and stimulates chondrocyte apoptosis through FOXO1.

scientific article published on July 2010

TNFα contributes to diabetes impaired angiogenesis in fracture healing.

scientific article published on 8 March 2017

Tendon regeneration and scar formation: The concept of scarless healing

scientific article (publication date: 27 April 2015)

The hypoxia-inducible factor alpha pathway couples angiogenesis to osteogenesis during skeletal development.

scientific article published on June 2007

The nuclear factor of activated T cells (NFAT) transcription factor NFATp (NFATc2) is a repressor of chondrogenesis

scientific article

The role of angiogenesis in a murine tibial model of distraction osteogenesis.

scientific article

The transcriptome of fracture healing defines mechanisms of coordination of skeletal and vascular development during endochondral bone formation.

scientific article

Three-dimensional reconstruction of fracture callus morphogenesis.

scientific article published on 24 July 2006

Transcriptional analysis of fracture healing and the induction of embryonic stem cell-related genes

scientific article

Transcriptional profiling and biochemical analysis of mechanically induced cartilaginous tissues in a rat model

scientific article

Transcriptional regulation restricting bone sialoprotein gene expression to both hypertrophic chondrocytes and osteoblasts

scientific article published on 01 January 2002

Transient chondrogenic phase in the intramembranous pathway during normal skeletal development.

scientific article published in March 2000

Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells

scientific article published on 13 May 2015

Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice.

scientific article published on 30 January 2018

Tumor necrosis factor alpha (TNF-alpha) coordinately regulates the expression of specific matrix metalloproteinases (MMPS) and angiogenic factors during fracture healing.

scientific article published in February 2005

Tumor necrosis factor alpha activation of the apoptotic cascade in murine articular chondrocytes is associated with the induction of metalloproteinases and specific pro-resorptive factors

scientific article published on 01 October 2003

Urine matrix metalloproteinases (MMPs) as biomarkers for the progression of fracture healing

scientific article

Use of cultured embryonic chicken osteoblasts as a model of cellular differentiation and bone mineralization.

scientific article published in January 1989

Use of genetically modified muscle and fat grafts to repair defects in bone and cartilage

scientific article

VEGF and bone cell signalling: an essential vessel for communication?

scientific article

Vascular tissues are a primary source of BMP2 expression during bone formation induced by distraction osteogenesis

scientific article published on 25 February 2012

runt homology domain transcription factors (Runx, Cbfa, and AML) mediate repression of the bone sialoprotein promoter: evidence for promoter context-dependent activity of Cbfa proteins

scientific article

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