List of works - Margaret Harnett

A role for phospholipase D activation in B cell activation

scientific article published on 01 November 1993

Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms.

scientific article published in March 1998

Analysis of G-proteins regulating signal transduction pathways

scientific article published on 01 January 1994

Antigen receptor-mediated phosphoinositide hydrolysis in murine T cells is not initiated via G-protein activation

scientific article published on 01 July 1991

Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation

scientific article published on 01 March 1996

Assay of protein kinases and protein phosphorylation

scientific article published on 01 January 1994

B cell receptor-stimulated mitochondrial phospholipase A2 activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells.

scientific article published in January 2001

CD40 signalling in B cell apoptosis and rescue.

scientific article published on May 1997

Changes in the activities and cellular localisation of phospholipases in differentiating HL-60 cells.

scientific article published on November 1993

Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries

scientific article published on 01 July 2001

Cross-talk between B cell surface immunoglobulin and interleukin 4 receptors: the role of protein kinase C and Ca2(+)-mediated signals

scientific article published on 01 October 1990

Cross-talk between surface immunoglobulin and interleukin-4 receptors on murine B-lymphocytes.

scientific article

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62.

scientific article

Differential roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and CD40-mediated rescue of WEHI-231 immature B cells

scientific article published on 01 April 2002

Differentiation dependent switch in signalling pathways initiated by Fc gamma RI

scientific article published on 01 May 1997

Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcgammaRIIb.

scientific article published on October 2002

Direct quantitation of T cell signaling by laser scanning cytometry.

scientific article

Dissection of the signalling mechanisms underlying FcgammaRIIB-mediated apoptosis of mature B-cells.

scientific article published in December 2004

Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels.

scientific article published on May 2011

FcgammaRI activation of phospholipase Cgamma1 and protein kinase C in dibutyryl cAMP-differentiated U937 cells is dependent solely on the tyrosine-kinase activated form of phosphatidylinositol-3-kinase

scientific article published on 01 September 1999

FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3'-inositol phosphatase, PTEN.

scientific article

Fluorescence-based assays as tools for understanding immunologic processes.

scientific article

Functional coupling of FcgammaRI to nicotinamide adenine dinucleotide phosphate (reduced form) oxidative burst and immune complex trafficking requires the activation of phospholipase D1.

scientific article

G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells

scientific article published on 01 May 1988

IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62.

scientific article

IL-4 promotes anti-Ig-mediated protein kinase C translocation and reverses phorbol ester-mediated protein kinase C down-regulation in murine B cells

scientific article published on 01 December 1991

Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus.

scientific article published on 28 May 2012

Immunology. B cells spread and gather.

scientific article

Introduction to immune cell signalling.

scientific article

Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4+ T cells in vitro and in vivo.

scientific article published in December 2007

Laser scanning cytometry: capturing the immune system in situ.

scientific article

Laser scanning cytometry: understanding the immune system in situ.

scientific article

Lipid signalling in lymphocyte activation and cell death.

scientific article published on May 1997

Murine B-cell activation via CD38 and protein tyrosine phosphorylation

scientific article published on 01 December 1994

Protein kinase C activators inhibit the antigen receptor-coupled polyphosphoinositide phosphodiesterase in murine B lymphocytes

scientific article published on 01 November 1988

Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.

scientific article published on February 1996

Regulation of surface IgM- and IgD-mediated inositol phosphate formation and Ca2+ mobilization in murine B lymphocytes

scientific article published on 01 October 1989

Regulation of the polyphosphoinositide-specific phosphodiesterase in B lymphocytes

scientific article published on 01 January 1989

Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool.

scientific article

Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

scientific article published in February 2018

Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

scientific article published on 08 November 2021

The antigen receptors on mature and immature T lymphocytes are coupled to phosphatidylcholine-specific phospholipase D activation

scientific article published on 01 February 1997

The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing

scientific article published on 12 March 2020

The role of G-proteins versus protein tyrosine kinases in the regulation of lymphocyte activation.

scientific article published on December 1992

Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases

scientific article published on 01 January 1998

List of works by Margaret Harnett

A role for phospholipase D activation in B cell activation

Aggregation of the human high affinity immunoglobulin G receptor (FcgammaRI) activates both tyrosine kinase and G protein-coupled phosphoinositide 3-kinase isoforms.

Analysis of G-proteins regulating signal transduction pathways

Antigen receptor-mediated phosphoinositide hydrolysis in murine T cells is not initiated via G-protein activation

Antigen receptors on immature, but not mature, B and T cells are coupled to cytosolic phospholipase A2 activation: expression and activation of cytosolic phospholipase A2 correlate with lymphocyte maturation

Assay of protein kinases and protein phosphorylation

B cell receptor-stimulated mitochondrial phospholipase A2 activation and resultant disruption of mitochondrial membrane potential correlate with the induction of apoptosis in WEHI-231 B cells.

CD40 signalling in B cell apoptosis and rescue.

Changes in the activities and cellular localisation of phospholipases in differentiating HL-60 cells.

Chronic hypoxia induces constitutive p38 mitogen-activated protein kinase activity that correlates with enhanced cellular proliferation in fibroblasts from rat pulmonary but not systemic arteries

Cross-talk between B cell surface immunoglobulin and interleukin 4 receptors: the role of protein kinase C and Ca2(+)-mediated signals

Cross-talk between surface immunoglobulin and interleukin-4 receptors on murine B-lymphocytes.

Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62.

Differential roles for extracellularly regulated kinase-mitogen-activated protein kinase in B cell antigen receptor-induced apoptosis and CD40-mediated rescue of WEHI-231 immature B cells

Differentiation dependent switch in signalling pathways initiated by Fc gamma RI

Differentiation of the human monocyte cell line, U937, with dibutyryl cyclicAMP induces the expression of the inhibitory Fc receptor, FcgammaRIIb.

Direct quantitation of T cell signaling by laser scanning cytometry.

Dissection of the signalling mechanisms underlying FcgammaRIIB-mediated apoptosis of mature B-cells.

Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels.

FcgammaRI activation of phospholipase Cgamma1 and protein kinase C in dibutyryl cAMP-differentiated U937 cells is dependent solely on the tyrosine-kinase activated form of phosphatidylinositol-3-kinase

FcgammaRIIb-mediated negative regulation of BCR signalling is associated with the recruitment of the MAPkinase-phosphatase, Pac-1, and the 3'-inositol phosphatase, PTEN.

Fluorescence-based assays as tools for understanding immunologic processes.

Functional coupling of FcgammaRI to nicotinamide adenine dinucleotide phosphate (reduced form) oxidative burst and immune complex trafficking requires the activation of phospholipase D1.

G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells

IL-33/ST2 signalling and crosstalk with FcεRI and TLR4 is targeted by the parasitic worm product, ES-62.

IL-4 promotes anti-Ig-mediated protein kinase C translocation and reverses phorbol ester-mediated protein kinase C down-regulation in murine B cells

Immune complex-mediated co-ligation of the BCR with FcγRIIB results in homeostatic apoptosis of B cells involving Fas signalling that is defective in the MRL/Lpr model of systemic lupus erythematosus.

Immunology. B cells spread and gather.

Introduction to immune cell signalling.

Inverse Rap1 and phospho-ERK expression discriminate the maintenance phase of tolerance and priming of antigen-specific CD4+ T cells in vitro and in vivo.

Laser scanning cytometry: capturing the immune system in situ.

Laser scanning cytometry: understanding the immune system in situ.

Lipid signalling in lymphocyte activation and cell death.

Murine B-cell activation via CD38 and protein tyrosine phosphorylation

Protein kinase C activators inhibit the antigen receptor-coupled polyphosphoinositide phosphodiesterase in murine B lymphocytes

Rapid regulation of PDE-2 and PDE-4 cyclic AMP phosphodiesterase activity following ligation of the T cell antigen receptor on thymocytes: analysis using the selective inhibitors erythro-9-(2-hydroxy-3-nonyl)-adenine (EHNA) and rolipram.

Regulation of surface IgM- and IgD-mediated inositol phosphate formation and Ca2+ mobilization in murine B lymphocytes

Regulation of the polyphosphoinositide-specific phosphodiesterase in B lymphocytes

Rewiring of CD40 is necessary for delivery of rescue signals to B cells in germinal centres and subsequent entry into the memory pool.

Small Molecule Analogues of the parasitic worm product ES-62 interact with the TIR domain of MyD88 to inhibit pro-inflammatory signalling

Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts

The antigen receptors on mature and immature T lymphocytes are coupled to phosphatidylcholine-specific phospholipase D activation

The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing

The role of G-proteins versus protein tyrosine kinases in the regulation of lymphocyte activation.

Upregulation of cAMP-specific PDE-4 activity following ligation of the TCR complex on thymocytes is blocked by selective inhibitors of protein kinase C and tyrosyl kinases