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List of works by Domenico Lio

1267 HSP70-2 polymorphism as a risk factor for carotid plaque rupture and cerebral ischaemia in old type 2 diabetes-atherosclerotic patients.

scientific article published on 18 April 2005

A Typical Immune T/B Subset Profile Characterizes Bicuspid Aortic Valve: In an Old Status?

scientific article

A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people.

scientific article published on 19 August 2009

A genetically determined high setting of TNF-alpha influences immunologic parameters of HLA-B8,DR3 positive subjects: implications for autoimmunity.

scientific article published in July 2001

A methodological strategy for PAH genotyping in populations with a marked molecular heterogeneity of hyperphenylalaninemia.

scientific article published in February 2001

A pilot study on prostate cancer risk and pro-inflammatory genotypes: pathophysiology and therapeutic implications.

scientific article published in January 2010

A study of serum immunoglobulin levels in elderly persons that provides new insights into B cell immunosenescence

scientific article published on 01 November 2006

Acute phase response in oldest-old individuals after surgical stress

scientific article published on 01 March 2006

Age- and gender-related values of lymphocyte subsets in subjects from Northern and Southern Italy

scientific article published in January 2002

Age-related changes in the expression of CD95 (APO1/FAS) on blood lymphocytes.

scientific article published in August 1999

Age-related inflammation: the contribution of different organs, tissues and systems. How to face it for therapeutic approaches.

scientific article published on January 2010

Alpha1-antitrypsin heterozygosity plays a positive role in attainment of longevity

scientific article published on 20 September 2006

Analysis of HLA-DRB1, DQA1, DQB1 haplotypes in Sardinian centenarians.

scientific article published on 04 July 2007

Analysis of IL-6, IL-10 and IL-17 genetic polymorphisms as risk factors for sepsis development in burned patients.

scientific article published on 12 November 2011

Analysis of candidate genes in celiac disease: a tool to identify life-threatening associated genes?

scientific article published on 01 January 2006

Analysis of hemochromatosis gene mutations in the Sicilian population: implications for survival and longevity

scientific article published on 01 January 2002

Analysis of polymorphisms Leiden Factor V G1691A and prothrombin G20210A as risk factors for acute myocardial infarction

scientific article published on 15 September 2011

Apolipoprotein E Genotypic Frequencies Among Down Syndrome Patients Imply Early Unsuccessful Aging for ApoE4 Carriers

scientific article published on 01 September 2007

Are Endothelial Progenitor Cells the Real Solution for Cardiovascular Diseases? Focus on Controversies and Perspectives

scientific article

Are the leukocyte telomere length attrition and telomerase activity alteration potential predictor biomarkers for sporadic TAA in aged individuals?

scientific article published on 17 August 2014

Association between +1059G/C CRP polymorphism and acute myocardial infarction in a cohort of patients from Sicily: a pilot study.

scientific article published on May 2006

Association between C1019T polymorphism of connexin37 and acute myocardial infarction: a study in patients from Sicily.

scientific article

Association between HFE mutations and acute myocardial infarction: a study in patients from Northern and Southern Italy

scientific article published on 01 July 2003

Association between longevity and cytokine gene polymorphisms. A study in Sardinian centenarians

scientific article published on 01 June 2004

Association between platelet endothelial cellular adhesion molecule 1 (PECAM-1/CD31) polymorphisms and acute myocardial infarction: a study in patients from Sicily.

scientific article published in August 2004

Association between the HFE mutations and longevity: a study in Sardinian population.

scientific article published in April 2003

Association between the HLA-A2 allele and Alzheimer disease

scientific article published on 01 January 2006

Association between the polymorphism of CCR5 and Alzheimer's disease: results of a study performed on male and female patients from Northern Italy.

scientific article published in November 2006

Association between the polymorphisms of TLR4 and CD14 genes and Alzheimer's disease.

scientific article published in January 2008

B cells in the aged: CD27, CD5, and CD40 expression ⬇️

scientific article published on April 1, 2003

Biological Basis of the HLA-B8,DR3-Associated Progression of Acquired Immune Deficiency Syndrome ⬇️

scientific article published on January 1, 1998

Biology of longevity: role of the innate immune system.

scientific article

CCR5 receptor: biologic and genetic implications in age-related diseases.

scientific article

CD14 C (-260)T polymorphism, atherosclerosis, elderly: Role of cytokines and metallothioneins

scientific article published on 13 November 2006

CYTOKINE SERUM PROFILE IN A GROUP OF SICILIAN NONAGENARIANS

scientific article published on 01 January 2012

Can the TLR-4-mediated signaling pathway be "a key inflammatory promoter for sporadic TAA"?

scientific article

Centenarian offspring: a model for understanding longevity.

scientific article published in January 2014

Characterization of two alternative Interleukin(IL)-10 5'UTR mRNA sequences, induced by lipopolysaccharide (LPS) stimulation of peripheral blood mononuclear cells.

scientific article published on 27 May 2009

Connexin37 1019 gene polymorphism in myocardial infarction patients and centenarians

article

Consumption of wheat foodstuffs not a risk for celiac disease occurrence in burkina faso.

scientific article published in August 2002

Correlation between clinical response and urinary interleukin levels using different doses and intravesical administration schedules of interferon-alpha-2b combined with epirubicin: a pilot study

scientific article published on 01 January 1993

Cytokine gene polymorphisms and breast cancer susceptibility

scientific article published on 01 November 2006

Cytokine genotyping (TNF and IL-10) in patients with celiac disease and selective IgA deficiency

scientific article published on 01 April 2003

Cytokine profile of breast cell lines after different radiation doses

scientific article

DVWA gene polymorphisms and osteoarthritis

scientific article

Does Down's syndrome support the homocysteine theory of atherogenesis? Experience in elderly subjects with trisomy 21.

scientific article published on 14 March 2006

Double-rosetting technique for the detection of Fc gamma receptor-positive T lymphocytes

scientific article published on 01 January 1983

Enumeration of TG lymphocytes in B-chronic lymphocytic leukaemia (B-CLL) by a rapid double-rosetting technique

scientific article published on 01 January 1984

Evaluation of cytokine polymorphisms (TNFα, IFNγ and IL-10) in Down patients with coeliac disease

scientific article published on 22 September 2005

Evidences of +896 A/G TLR4 polymorphism as an indicative of prevalence of complications in T2DM patients

scientific article published on 02 April 2014

Frequency of Polymorphisms of Signal Peptide of TGF-beta1 and -1082G/A SNP at the Promoter Region of Il-10 Gene in Patients with Carotid Stenosis

article

Frequency of the HFE gene mutations in five Italian populations.

scientific article

G-protein-coupled receptor kinase 5 polymorphism and Takotsubo cardiomyopathy.

scientific article

Gamma/delta T lymphocytes are affected in the elderly.

scientific article

Gender-related immune-inflammatory factors, age-related diseases, and longevity.

scientific article published on April 2010

Genetic control of C3 production by the S region of the mouse MHC

scientific article published on 01 October 1988

Genetic control of immune response in carriers of ancestral haplotype 8.1: the study of chemotaxis

scientific article published on 01 November 2006

Genetic risk profiles for Alzheimer's disease: integration of APOE genotype and variants that up-regulate inflammation.

scientific article published on 22 August 2006

Genetics of inflammation in age-related atherosclerosis: its relevance to pharmacogenomics.

scientific article published on April 2007

Genetics of longevity. data from the studies on Sicilian centenarians

scientific article

Genotype frequencies of the +874T-->A single nucleotide polymorphism in the first intron of the interferon-gamma gene in a sample of Sicilian patients affected by tuberculosis.

scientific article

Gluten Stimulation Induces an in vitro Expansion of Peripheral Blood Tγδ Cells from HLA-DQ2-Positive Subjects of Families of Patients with Celiac Disease ⬇️

scientific article published on January 1, 1998

HLA and sprue: a study of Sicilian families with celiac disease

scientific article published on 01 July 1990

HLA-DR phenotypes and blood levels of T cell subsets

scientific article published on 01 November 1984

Hemostasis and ageing.

scientific article

Hypothesis: interleukin-5 production impairment can be a key point in the pathogenesis of the MHC-linked selective IgA deficiency.

scientific article published in January 1998

IL-10 and TNF-alpha polymorphisms in a sample of Sicilian patients affected by tuberculosis: implication for ageing and life span expectancy.

scientific article

IL-10 and TNF-α polymorphisms and the recovery from HCV infection

scientific article published on 01 July 2003

IL-5 enhances in vitro and in vivo antigen-specific IgA production in MHC genetically determined low IL-5 responder mice

scientific article published on 01 July 1995

Identification of three particular morphological phenotypes in sporadic thoracic aortic aneurysm: phenotype III as sporadic thoracic aortic aneurysm biomarker in aged individuals

scientific article published on 08 April 2014

IgD serum levels are influenced by HLA-DR phenotype

scientific article published on 01 March 1992

Immunogenetics of longevity. Is major histocompatibility complex polymorphism relevant to the control of human longevity? A review of literature data.

scientific article

Immunogenetics, gender, and longevity.

scientific article published on November 2006

Immunoglobulin heavy chain allotypes in a sample of Sicilian patients with celiac disease

scientific article published on 01 January 1991

Immunoglobulin heavy-chain allotypes play a role in the clinical history of celiac disease

scientific article published on 01 January 1991

Immunological and immunogenetic markers in sporadic Alzheimer's disease.

scientific article

Immunosenescence and anti-immunosenescence therapies: the case of probiotics.

scientific article published on April 2008

Impact of CMV and EBV seropositivity on CD8 T lymphocytes in an old population from West-Sicily.

scientific article published on 23 May 2007

Impairment of gamma/delta T lymphocytes in elderly: implications for immunosenescence

scientific article published on 01 October 2004

In vitro treatment with interleukin-2 normalizes type-1 cytokine production by lymphocytes from elderly.

scientific article published in May 2000

Induction of contact sensitivity by cell-associated immunocomplexes requires activation of the early complement components ⬇️

scientific article published on December 1, 1992

Inflammation, ageing and cancer.

scientific article published on 10 July 2008

Inflammation, genes and zinc in Alzheimer's disease.

scientific article published on 08 December 2007

Inflammation, genes and zinc in ageing and age-related diseases.

scientific article published on October 2006

Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 -1082 promoter SNP and its interaction with TNF-alpha -308 promoter SNP.

scientific article published in April 2003

Inflammation, longevity, and cardiovascular diseases: role of polymorphisms of TLR4.

scientific article

Interleukin-10 promoter polymorphism in sporadic Alzheimer's disease.

scientific article

Interleukin-12 release by mitogen-stimulated mononuclear cells in the elderly.

scientific article published in May 1998

Interleukin-6 gene polymorphism is an age-dependent risk factor for myocardial infarction in men

article

Involvement of −308 TNF-α and 1267 Hsp70-2 polymorphisms and zinc status in the susceptibility of coronary artery disease (CAD) in old patients

scientific article published on 01 October 2006

Is human immunosenescence clinically relevant? Looking for ‘immunological risk phenotypes’

scientific article published on 01 July 2002

Laboratory parameters in centenarians of Italian ancestry

article

Lymphocyte subsets in hereditary angioedema

scientific article published on 01 November 1982

Major histocompatibility complex and sporadic Alzheimer's disease: a critical reappraisal.

scientific article published on April 2004

Major histocompatibility complex regulation of interleukin-5 production in the mouse

scientific article published on 01 November 1993

Modification of cytokine patterns in subjects bearing the HLA-B8,DR3 phenotype: implications for autoimmunity

scientific article published on December 1, 1997

Modification of peripheral blood T-lymphocyte surface receptors and Langerhans cell numbers in hereditary angioedema

scientific article published on 01 March 1986

NF-κB pathway activators as potential ageing biomarkers: targets for new therapeutic strategies.

scientific article published on 20 June 2013

OKT4+ and OKT8+ cell subset values and HLA-DR phenotypes

scientific article published on 01 February 1985

Opposite effects of interleukin 10 common gene polymorphisms in cardiovascular diseases and in successful ageing: genetic background of male centenarians is protective against coronary heart disease.

scientific article published on October 2004

Opposite role of pro-inflammatory alleles in acute myocardial infarction and longevity: results of studies performed in a Sicilian population.

scientific article published on May 2006

PECAM-1/CD31 in infarction and longevity.

scientific article published in April 2007

Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: a genetically determined defect of C4 influences immunological parameters of healthy carriers of the haplotype

scientific article published on 01 September 2003

Pathogenesis of autoimmune diseases associated with 8.1 ancestral haplotype: effect of multiple gene interactions.

scientific article

Pathological implications of Th1/Th2 cytokine genetic variants in Behçet's disease: Data from a pilot study in a Sicilian population.

scientific article

Pathophysiology of age-related diseases

scientific article

Plasma cytokine profiles in patients with celiac disease and selective IgA deficiency.

scientific article published in August 2003

Polymorphisms of pro-inflammatory genes and Alzheimer's disease risk: a pharmacogenomic approach.

scientific article published on 20 November 2006

Portrait of inflammatory response to ionizing radiation treatment.

scientific article

Prevalence of non organ-specific autoantibodies in healthy centenarians

scientific article published on 01 January 2002

Pro-inflammatory genetic background and zinc status in old atherosclerotic subjects.

scientific article published on 19 June 2008

Production of T suppressor factor specific for the hapten picryl chloride requires both T suppressor cells and an antigen-specific, genetically restricted second signal

scientific article published on 01 November 1987

Prostate cancer: from the pathophysiologic implications of some genetic risk factors to translation in personalized cancer treatments

scientific article published on 10 January 2014

Regulatory cytokine gene polymorphisms and risk of colorectal carcinoma

scientific article published on 01 November 2006

Reversible inhibition of mononuclear cell Fc receptors by sera from breast cancer patients.

scientific article published on May 1984

Role of TGF-β pathway polymorphisms in sporadic thoracic aortic aneurysm: rs900 TGF-β2 is a marker of differential gender susceptibility.

scientific article published on 24 February 2014

Role of Toll-like receptor 4 in acute myocardial infarction and longevity

scientific article published on 01 November 2004

Role of environmental and genetic factor interaction in age-related disease development: the gastric cancer paradigm

scientific article published on 01 April 2008

Role of proinflammatory alleles in longevity and atherosclerosis: results of studies performed on -1562C/T MMP-9 in centenarians and myocardial infarction patients from Sicily

scientific article published on 01 November 2006

Role of prothrombotic polymorphisms in successful or unsuccessful aging

scientific article published on 19 March 2011

Role of the pyrin M694V (A2080G) allele in acute myocardial infarction and longevity: a study in the Sicilian population.

scientific article

Search for genetic factors associated with susceptibility to multiple sclerosis

scientific article published on 01 May 2006

Sharing pathogenetic mechanisms between acute myocardial infarction and Alzheimer's disease as shown by partially overlapping of gene variant profiles

article

Suppression of contact sensitivity by a plastic adherent T-cell, induced in mice infected with Newcastle disease virus (NDV).

scientific article published on October 1987

Susceptibility to Heart Defects in Down Syndrome Is Associated with Single Nucleotide Polymorphisms in HAS 21 Interferon Receptor Cluster and VEGFA Genes

scientific article published on 28 November 2020

Systemic immune responses in Alzheimer's disease: in vitro mononuclear cell activation and cytokine production

scientific article published on 01 January 2010

TLR2 and age-related diseases: potential effects of Arg753Gln and Arg677Trp polymorphisms in acute myocardial infarction

scientific article published on 01 April 2008

Taking advantage of viral immune evasion: virus-derived proteins represent novel biopharmaceuticals.

scientific article

The molecular basis of the low hemolytic activity of C4 molecules from low-C4 mice with IgM-coated erythrocytes

scientific article published on 01 September 1989

The nACHR4 594C/T polymorphism in Alzheimer disease.

scientific article published in January 2006

The role of IL-1 gene cluster in longevity: a study in Italian population

scientific article published on 01 April 2003

Trafficking phenotype and production of granzyme B by double negative B cells (IgG(+)IgD(-)CD27(-)) in the elderly

scientific article published on 2 January 2014

Tumor necrosis factor-α−308A/G polymorphism is associated with age at onset of Alzheimer's disease

scientific article published on 03 March 2006

Viral antibody titers are influenced by HLA-DR2 phenotype.

scientific article published in January 1994

[An experimental in-vitro evaluation of membrane antigen expression and of interleukin production by monocytes exposed to magnetic resonance]

scientific article published on 01 March 1996

[Characterization of cell suspensions adhering to nylon obtained from mononuclear cells in toto or depleted of monocytes]

scientific article published on 01 December 1984

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