List of works by Massimo Levrero

"Anti-Ia reactivity in sera from patients with chronic active hepatitis (CAH)"

scientific article published on 01 October 1987

A global scientific strategy to cure hepatitis B

scientific article published on 10 April 2019

A p38-dependent pathway regulates DeltaNp63 DNA binding to p53-dependent promoters in UV-induced apoptosis of keratinocytes.

scientific article published in October 2005

A role of p73 in mitotic exit.

scientific article published on 28 June 2005

A second-generation hepatitis C virus confirmatory test for chronic hepatitis B virus infection.

scientific article published in January 1992

Accumulation of a cellular protein bearing c-myc-like antigenicity in hepatic and non-hepatic delta antigen expressing cells

scientific article published on 01 January 1993

Additional complexity in p73: induction by mitogens in lymphoid cells and identification of two new splicing variants ε and ζ

scientific article published on 01 May 1999

Adenosine deaminase, a key enzyme in DNA precursors control, is a new p73 target.

scientific article published on November 2003

Aiming for cure in HBV and HDV infection

scientific article

Alpha-interferon as maintenance drug after initial fludarabine therapy for patients with chronic lymphocytic leukemia and low-grade non-Hodgkin's lymphoma.

scientific article published in January 1994

Apoptotic, non-apoptotic, and anti-apoptotic pathways of tumor necrosis factor signalling

scientific article published on 01 October 1998

Binding of CDK9 to TRAF2

scientific article

ChIP-on-chip analysis of in vivo mutant p53 binding to selected gene promoters.

scientific article

Challenges to a Cure for HBV Infection.

scientific article

Characterization of effector cells in lymphocytotoxicity to autologous hepatocytes in HBsAg-positive and autoimmune chronic active hepatitis (CAH)

scientific article published on 01 February 1986

Characterization of the hepatitis B virus preS/S region encoded transcriptional transactivator

scientific article published on April 1, 1992

Chromatin dynamics of gene activation and repression in response to interferon alpha (IFN(alpha)) reveal new roles for phosphorylated and unphosphorylated forms of the transcription factor STAT2

scientific article

Chronic cryptogenic hepatitis in childhood is unrelated to hepatitis G virus.

scientific article published in April 1999

Circulating HBsAg/IgM complexes in acute and chronic hepatitis B

scientific article published on 01 October 1984

Clinical improvement and partial correction of the T cell defects of acquired immunodeficiency syndrome (AIDS) and lymphoadenopathy syndrome (LAS) by a calf thymus acid lysate

scientific article published on 01 April 1986

Combining amplicon sequencing and metabolomics in cirrhotic patients highlights distinctive microbiota features involved in bacterial translocation, systemic inflammation and hepatic encephalopathy.

scientific article

Control of cccDNA function in hepatitis B virus infection.

scientific article published on 10 June 2009

Control of hepatitis B virus replication by innate response of HepaRG cells.

scientific article published on January 2010

Current treatments for chronic hepatitis B virus infections

scientific article published on 15 June 2016

Cytotoxic T lymphocyte response to a wild type hepatitis B virus epitope in patients chronically infected by variant viruses carrying substitutions within the epitope.

scientific article

DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest.

scientific article

DNA damage-dependent acetylation of p73 dictates the selective activation of apoptotic target genes.

scientific article published in January 2002

DNp73α protects myogenic cells from apoptosis

scientific article published on 01 May 2006

Detection of the hepatitis B virus (HBV) covalently-closed-circular DNA (cccDNA) in mice transduced with a recombinant AAV-HBV vector

scientific article published on 11 July 2017

Differential regulation of E2F1 apoptotic target genes in response to DNA damage.

scientific article published in June 2003

Differential roles of p300 and PCAF acetyltransferases in muscle differentiation

scientific article

Direct-acting antiviral therapy decreases hepatocellular carcinoma recurrence rate in cirrhotic patients with chronic hepatitis C.

scientific article published on 19 April 2017

Distribution of three major hepatitis C virus genotypes in Italy. A multicentre study of 495 patients with chronic hepatitis C.

scientific article published in January 1995

Does the hepatitis C virus replicate in cells of the hematopoietic lineage?

scientific article published on July 1998

E1A stimulates FGF-2 release promoting differentiation of primary endothelial cells

scientific article published on 01 March 2000

EZH2, JMJD3, and UTX epigenetically regulate hepatic plasticity inducing retro-differentiation and proliferation of liver cells

scientific article published on 08 July 2019

Effect of 28 consecutive days lymphoblastoid interferon (alpha-IFN) administration on hepatitis B virus related chronic liver disease.

scientific article

Elevated serum levels of 90K/MAC-2 BP predict unresponsiveness to alpha-interferon therapy in chronic HCV hepatitis patients.

scientific article published on August 1996

Endothelial activation by angiotensin II through NFkappaB and p38 pathways: Involvement of NFkappaB-inducible kinase (NIK), free oxygen radicals, and selective inhibition by aspirin

scientific article (publication date: June 2003)

Erratum: The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells

scientific article published on 28 November 2016

Evaluation of the transfer and expression in mice of an enzyme-encoding gene using a human adenovirus vector

article

Genome-wide identification of direct HBx genomic targets

scientific article (publication date: 17 February 2017)

HBV cure: why, how, when?

scientific article

HBX causes cyclin D1 overexpression and development of breast cancer in transgenic animals that are heterozygous for p53.

scientific article published in May 2003

HBeAg/anti-HBe system and development of primary hepatocellular carcinoma in patients with HBsAg-positive liver cirrhosis

scientific article published on February 1, 1983

HCV core-mediated activation of latent TGF-β via thrombospondin drives the crosstalk between hepatocytes and stromal environment.

scientific article published on 6 August 2013

Hepatitis B

scientific article published on 20 September 2018

Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer-related gene transcription

scientific article published on 29 February 2020

Hepatitis B virus X gene product acts as a transactivator in vivo.

scientific article published in July 1994

Hepatitis B virus X protein is essential to initiate and maintain virus replication after infection.

scientific article published on 2 March 2011

Hepatitis B virus and hepatocellular carcinoma: a possible role for the viral transactivators

scientific article published on December 1, 1991

Hepatitis C virus (HCV) RNA determination after two weeks of induction interferon treatment is an accurate predictor of nonresponse: comparison of two treatment schedules.

scientific article published in November 2001

IL28B polymorphisms influence stage of fibrosis and spontaneous or interferon-induced viral clearance in thalassemia patients with hepatitis C virus infection

scientific article

IL6 Inhibits HBV Transcription by Targeting the Epigenetic Control of the Nuclear cccDNA Minichromosome

scientific article published on 18 November 2015

Immunoregulation of the in vitro anti-HBs antibody synthesis in chronic HBsAg carriers and in recently boosted anti-hepatitis B vaccine recipients

scientific article published on 01 May 1985

Immunoregulatory T cells in HBV-induced chronic liver disease as defined by monoclonal antibodies

scientific article published on 01 January 1983

Immunotherapy with interferon-alpha in patients affected by chronic hepatitis C induces an intercorrelated stimulation of the cytokine network and an increase in depressive and anxiety symptoms.

scientific article published in December 2001

In vitro induction of HBsAg-specific CD8 CD11 human suppressor T cells

scientific article published on 01 November 1987

In vivo activity of the hepatitis B virus core promoter: tissue specificity and temporal regulation.

scientific article published in September 1995

Infection of circulating and liver infiltrating T cells by hepatitis C virus of different subtypes.

scientific article published on January 1995

Intracellular localization of full-length and truncated hepatitis C virus core protein expressed in mammalian cells.

scientific article published on June 1994

Intrahepatic innate immune response pathways are downregulated in untreated chronic hepatitis B.

scientific article published on 30 December 2016

Long-lasting memory T cell responses following self-limited acute hepatitis B

scientific article published on September 1996

MEK1 inhibition sensitizes primary acute myelogenous leukemia to arsenic trioxide-induced apoptosis.

scientific article published on 7 February 2006

Mapping of B-cell epitopes of the human hepatitis B virus X protein ⬇️

scientific article published on June 1, 1990

Mechanism of action of ribavirin in anti-HCV regimens: new insights for an age-old question?

scientific article published on 9 May 2013

Mechanisms of HBV-induced hepatocellular carcinoma.

scientific article published on April 2016

Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities.

scientific article

Modulation of intracellular signal transduction pathways by the hepatitis B virus transactivator pX.

scientific article

Molecular and functional analysis of occult hepatitis B virus isolates from patients with hepatocellular carcinoma.

scientific article published in February 2007

Molecular mechanisms of HBV-associated hepatocarcinogenesis.

scientific article published on May 2013

Monitoring of NK-1 and NK-15 subsets and natural killer activity in kidney transplant recipients receiving cyclosporine

scientific article published on 01 January 1985

Mutant p53 enhances nuclear factor kappaB activation by tumor necrosis factor alpha in cancer cells

scientific article published on 01 March 2007

Mutant p53 exerts its gain of function through activation of the NF-κB pathway.

scientific article

MyoD prevents cyclinA/cdk2 containing E2F complexes formation in terminally differentiated myocytes.

scientific article published on March 1997

Non-Coding RNAs and Hepatitis C Virus-Induced Hepatocellular Carcinoma

scientific article published on 30 October 2018

Non-invasive biomarkers for chronic hepatitis B virus infection management

scientific article published on 06 July 2019

Normalization of depressed natural killer activity after interferon-alpha therapy is associated with a low frequency of relapse in patients with chronic hepatitis C

scientific article published on 01 January 1993

Nuclear HBx binds the HBV minichromosome and modifies the epigenetic regulation of cccDNA function.

scientific article

Occult hepatitis B virus infection.

scientific article

PRMT5 restricts hepatitis B virus replication through epigenetic repression of covalently closed circular DNA transcription and interference with pregenomic RNA encapsidation.

scientific article published on 25 February 2017

PTPS-03EPIGENETIC SILENCING OF β-ARRESTIN1 AND ITS INTRAGENIC miR-326 CONTROLS MEDULLOBLASTOMA GROWTH.

scientific article

Perspectives and limitations for nucleo(t)side analogs in future HBV therapies

scientific article published on 16 May 2018

Physical interaction with human tumor-derived p53 mutants inhibits p63 activities.

scientific article

Prevalence and genomic variability of transfusion transmitted virus in Italian cryptogenic chronic liver disease and healthy blood donors.

scientific article

Primary effusion Burkitt's lymphoma with t(8;22) in a patient with hepatitis C virus-related cirrhosis.

scientific article published in January 1997

Reactive Oxygen Intermediates Mediate Angiotensin II-induced c-Jun•c-Fos Heterodimer DNA Binding Activity and Proliferative Hypertrophic Responses in Myogenic Cells ⬇️

scientific article published on September 22, 1995

Reactive oxygen intermediates (ROIs) are involved in the intracellular transduction of angiotensin II signal in C2C12 cells.

scientific article published on March 1995

Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus

scientific article published on 07 August 2017

Recombinant immunoblot assay for hepatitis C virus antibody in chronic hepatitis

scientific article published on January 1, 1992

Regulation of E2F4 mitogenic activity during terminal differentiation by its heterodimerization partners for nuclear translocation

scientific article published on 01 April 1998

Regulation of the p300 HAT domain via a novel activation loop.

scientific article published on 7 March 2004

RelA/NF-kappaB recruitment on the bax gene promoter antagonizes p73-dependent apoptosis in costimulated T cells.

scientific article published on 23 November 2007

Relationship between T cell subsets and suppressor cell activity in chronic hepatitis B virus (HBV) infection.

scientific article published in August 1983

Replicative and transcriptional activities of hepatitis B virus in patients coinfected with hepatitis B and hepatitis delta viruses.

scientific article

Ribavirin restores IFNα responsiveness in HCV-infected livers by epigenetic remodelling at interferon stimulated genes

scientific article published on 16 June 2015

Risk management of HBsAg or anti-HCV positive healthcare workers in hospital.

scientific article published in December 2001

Serum hepatitis B core-related antigen (HBcrAg) correlates with covalently closed circular DNA transcriptional activity in chronic hepatitis B patients

scientific article published on 07 December 2018

Structure, function and regulation of p63 and p73.

scientific article

Suppressor T cells role in the unresponsiveness to Candida albicans in chronic mucocutaneous candidiasis

scientific article published on 01 January 1985

Suppressor cell activity and T-cell subsets in multiple sclerosis

scientific article published on 01 June 1987

Sustained activation of the Raf/MEK/Erk pathway in response to EGF in stable cell lines expressing the Hepatitis C Virus (HCV) core protein.

scientific article

TP63 and TP73 in cancer, an unresolved "family" puzzle of complexity, redundancy and hierarchy

scientific article

Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways.

scientific article published on 26 June 2008

Targeting a phospho-STAT3-miRNAs pathway improves vesicular hepatic steatosis in an in vitro and in vivo model

scientific article published in Scientific Reports

Targeting mitochondrial dysfunction can restore antiviral activity of exhausted HBV-specific CD8 T cells in chronic hepatitis B.

scientific article published on 6 February 2017

The HMGA1 protoncogene frequently deregulated in cancer is a transcriptional target of E2F1.

scientific article published on 2 March 2012

The hepatitis B virus (HBV) pX transactivates the c-fos promoter through multiple cis-acting elements.

scientific article

The hepatitis B virus HBx protein inhibits caspase 3 activity

scientific article published in 2013

The hepatitis B virus HBx protein inhibits caspase 3 activity.

scientific article published on December 1998

The hepatitis B virus X protein up-regulates tumor necrosis factor alpha gene expression in hepatocytes.

scientific article published on October 1998

The histone deacetylase inhibiting drug Entinostat induces lipid accumulation in differentiated HepaRG cells

scientific article published on 20 June 2016

The molecular basis of myocardial hypertrophy.

scientific article published on July 1994

The novel HBx mutation F30V correlates with hepatocellular carcinoma in vivo, reduces hepatitis B virus replicative efficiency and enhances anti-apoptotic activity of HBx N terminus in vitro

scientific article published on 23 November 2018

The p53 family protein p73 provides new insights into cancer chemosensitivity and targeting.

scientific article published on 27 October 2009

The p53/p63/p73 family of transcription factors: overlapping and distinct functions.

scientific article

The post-genomic era: workshop on chromatin immunoprecipitation-related techniques

scientific article published on 18 May 2007

The sodium/iodide symporter NIS is a transcriptional target of the p53-family members in liver cancer cells.

scientific article published on 19 September 2013

The transcriptional coactivator Yes-associated protein drives p73 gene-target specificity in response to DNA Damage.

scientific article

The tyrosine kinase c-Abl regulates p73 in apoptotic response to cisplatin-induced DNA damage

scientific article

Towards an HBV cure: state-of-the-art and unresolved questions--report of the ANRS workshop on HBV cure.

scientific article

Trans-activation of epidermal growth factor receptor gene by the hepatitis B virus X-gene product.

scientific article published on October 1993

Treatment of chronic hepatitis B: update of the recommendations from the 2007 Italian Workshop.

scientific article published on 26 January 2011

Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells.

scientific article

Truncated pre-S/S proteins transactivate multiple target sequences

scientific article published on 01 January 1992

Two new p73 splice variants, gamma and delta, with different transcriptional activity.

scientific article

Ultrasound detection of abdominal lymphadenomegaly in subjects with hepatitis C virus infection and persistently normal transaminases: a predictive index of liver histology severity.

scientific article published in April 1998

Update of the statements on biology and clinical impact of occult hepatitis B virus infection

scientific article published on 18 April 2019

Vav-1 and the IKK alpha subunit of I kappa B kinase functionally associate to induce NF-kappa B activation in response to CD28 engagement.

scientific article published on March 2003

Viral determinants and host immune responses in the pathogenesis of HBV infection.

scientific article

Viral hepatitis and liver cancer: the case of hepatitis C.

scientific article

Vitamin D levels and IL28B polymorphisms are related to rapid virological response to standard of care in genotype 1 chronic hepatitis C.

scientific article published on 13 April 2012

[Hepatitis delta virus replication and the role of the small hepatitis delta protein S-HDAg]

scientific article published on 01 October 2018

[Immunosuppressive therapy of chronic active hepatitis: results of a long-term follow-up]

scientific article published on 01 June 1983

[The behavior of the HBeAg-anti-HBe system in chronic hepatitis]

scientific article published on 01 January 1983

miRNA let-7c promotes granulocytic differentiation in acute myeloid leukemia.

scientific article published on 10 September 2012

p300 is required for MyoD-dependent cell cycle arrest and muscle-specific gene transcription

scientific article

p53-paralog DNp73 oncogene is repressed by IFNα/STAT2 through the recruitment of the Ezh2 polycomb group transcriptional repressor. ⬇️

scientific article

p73 is regulated by phosphorylation at the G2/M transition.

scientific article published on 13 August 2003

Paulina is supported by:

About Paulina

Help