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List of works by Pilar Sanchez Blazquez

Activation of mu-opioid receptors transfers control of Galpha subunits to the regulator of G-protein signaling RGS9-2: role in receptor desensitization

scientific article

Administration of myr(+)-G(i2)alpha subunits prevents acute tolerance (tachyphylaxis) to mu-opioid effects in mice.

scientific article published in March 2001

Agonists determine the pattern of G-protein activation in mu-opioid receptor-mediated supraspinal analgesia.

scientific article

Antibodies and antisense oligodeoxynucleotides to mu-opioid receptors, selectively block the effects of mu-opioid agonists on intestinal transit and permeability in mice.

scientific article published on May 1999

Antibodies directed against alpha subunits of Gi, Gx/z, GO and GS transducer proteins reduced the morphine withdrawal syndrome in mice

scientific article published on 01 January 1994

Antibodies raised against the N-terminal sequence of delta opioid receptors blocked delta-mediated supraspinal antinociception in mice.

scientific article

Behavioral, neurochemical and morphological changes induced by the overexpression of munc18-1a in brain of mice: relevance to schizophrenia.

scientific article

Brain-specific Galphaz interacts with Src tyrosine kinase to regulate Mu-opioid receptor-NMDAR signaling pathway.

scientific article

Calcium/calmodulin-dependent protein kinase II supports morphine antinociceptive tolerance by phosphorylation of glycosylated phosducin-like protein.

scientific article

Calmodulin Supports TRPA1 Channel Association with Opioid Receptors and Glutamate NMDA Receptors in the Nervous Tissue

scientific article published on 28 December 2020

Cannabidiol enhances morphine antinociception, diminishes NMDA-mediated seizures and reduces stroke damage via the sigma 1 receptor

scientific article published on 17 September 2018

Cannabinoid receptors couple to NMDA receptors to reduce the production of NO and the mobilization of zinc induced by glutamate.

scientific article published on June 2013

Cholera toxin and pertussis toxin on opioid- and α2-mediated supraspinal analgesia in mice ⬇️

scientific article published on January 1, 1991

Chronic pain leads to concomitant noradrenergic impairment and mood disorders.

scientific article published on 31 July 2012

Detecting zinc release induced by mu-opioid receptor agonists in brain slices

scientific article published in January 2015

Different modes of opiate interaction in rat vas deferens

scientific article published on 01 October 1982

Direct association of Mu-opioid and NMDA glutamate receptors supports their cross-regulation: molecular implications for opioid tolerance.

scientific article published on September 2012

Dissimilar efficacy of opioids to produce mu-mediated analgesia: role of Gx/z and Gi2 transducer proteins.

scientific article published in January 1994

Dynorphin A: inhibitory effect on other opiate ligand bindings in the mouse brain.

scientific article published in August 1984

Dynorphin B-29: chemical synthesis and pharmacological properties in opioid systems in vitro.

scientific article published in September 1984

Dynorphin(1-10)amide: a potent and selective analog of dynorphin(1-13)

scientific article published on 01 October 1982

Dynorphin(1–13), a long-lasting inhibitor of opiate receptor binding ⬇️

scientific article published on October 18, 1982

Dynorphin1–13: interaction with other opiate ligand bindings in vitro ⬇️

scientific article published on June 8, 1984

Effect of intrathecal injection of pertussis toxin on substance P, norepinephrine and serotonin contents in various neural structures of arthritic rats

scientific article published on 01 January 1990

Effector antagonism by the regulators of G protein signalling (RGS) proteins causes desensitization of mu-opioid receptors in the CNS

scientific article (publication date: June 2005)

Endogenous opioid peptides: comparative evaluation of their receptor affinities in the mouse brain.

scientific article published in January 1983

Expression of neural RGS-R7 and Gbeta5 Proteins in Response to Acute and Chronic Morphine.

scientific article

Further characterization of alpha N-acetyl beta-endorphin-(1-31) regulatory activity, I: Effect on opioid- and alpha 2-mediated supraspinal antinociception in mice

scientific article published on January 1, 1992

G-receptor antagonists increased the activating effect of mastoparan on low Km GTPase of mouse PAG.

scientific article published on February 1995

GPCRs promote the release of zinc ions mediated by nNOS/NO and the redox transducer RGSZ2 protein.

scientific article published on 10 July 2012

GX/Z Is Regulated by μ But Not δ Opioid Receptors in the Stimulation of the Low Km GTPase Activity in Mouse Periaqueductal Grey Matter ⬇️

scientific article published on June 1, 1997

HINT1 protein cooperates with cannabinoid 1 receptor to negatively regulate glutamate NMDA receptor activity

scientific article published on 05 October 2013

HINT1 protein: a new therapeutic target to enhance opioid antinociception and block mechanical allodynia

scientific article published on February 2015

Impairment by apomorphine of one-trial passive avoidance learning in mice: The opposing roles of the dopamine and noradrenaline systems ⬇️

scientific article published on March 14, 1979

In vivo modulation of G proteins and opioid receptor function by antisense oligodeoxynucleotides.

scientific article

Incidence of morphine withdrawal and quasi-abstinence syndrome in a model of chronic pain in the rat

scientific article published on 01 October 1987

Influence of Gz and Gi2 transducer proteins in the affinity of opioid agonists to mu receptors.

scientific article published in August 1998

Intracerebroventricular N-ethylmaleimide differentially reduces supraspinal opioid analgesia in mice.

scientific article

Intracerebroventricular injection of antibodies directed against Gs alpha enhances the supraspinal antinociception induced by morphine, beta-endorphin and clonidine in mice

scientific article published on 01 January 1992

Intrathecal pertussis toxin attenuates the morphine withdrawal syndrome in normal but not in arthritic rats.

scientific article

LEU5enkephalin containing peptides derived from a common precursor: Evaluation of opioid activity in in vitro bioassays ⬇️

scientific article published on March 2, 1984

Local changes in GTP-binding protein immunoreactivities in human epileptogenic neocortex.

scientific article published in March 1998

Mastoparan reduces the supraspinal analgesia mediated by mu/delta-opioid receptors in mice.

scientific article

Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins

scientific article

Myr+-Gi2 alpha and Go alpha subunits restore the efficacy of opioids, clonidine and neurotensin giving rise to antinociception in G-protein knock-down mice.

scientific article

NMDAR-nNOS generated zinc recruits PKCgamma to the HINT1-RGS17 complex bound to the C terminus of Mu-opioid receptors.

scientific article

NO-released zinc supports the simultaneous binding of Raf-1 and PKCγ cysteine-rich domains to HINT1 protein at the mu-opioid receptor.

scientific article published on 27 March 2011

Opiates as antidepressants.

scientific article published on January 2009

Pertussis toxin differentially reduces the efficacy of opioids to produce supraspinal analgesia in the mouse

scientific article published on 01 August 1988

RGS-Rz and RGS9-2 proteins control mu-opioid receptor desensitisation in CNS: the role of activated Galphaz subunits

scientific article

RGS14 prevents morphine from internalizing Mu-opioid receptors in periaqueductal gray neurons.

scientific article

RGS9 proteins facilitate acute tolerance to mu-opioid effects

scientific article (publication date: February 2001)

RGSZ2 binds to the neural nitric oxide synthase PDZ domain to regulate mu-opioid receptor-mediated potentiation of the N-methyl-D-aspartate receptor-calmodulin-dependent protein kinase II pathway.

scientific article published on 19 May 2011

Stimulation of mu- and delta-opioid receptors enhances phosphoinositide metabolism in mouse spinal cord: evidence for subtypes of delta-receptors.

scientific article published in June 1999

Sumoylated RGS-Rz proteins act as scaffolds for Mu-opioid receptors and G-protein complexes in mouse brain.

scientific article published on 9 August 2006

The GBeta5 subunit that associates with the R7 subfamily of RGS proteins regulates mu-opioid effects.

scientific article

The Sigma 2 receptor promotes and the Sigma 1 receptor inhibits mu-opioid receptor-mediated antinociception

scientific article published on 11 November 2020

The Sigma-1 Receptor Antagonist, S1RA, Reduces Stroke Damage, Ameliorates Post-Stroke Neurological Deficits and Suppresses the Overexpression of MMP-9.

scientific article published on 05 August 2017

The cannabinoid receptor 1 associates with NMDA receptors to produce glutamatergic hypofunction: implications in psychosis and schizophrenia.

scientific article

The delta2-opioid receptor subtype stimulates phosphoinositide metabolism in mouse periaqueductal gray matter.

scientific article published in January 1998

The mu-opioid receptor and the NMDA receptor associate in PAG neurons: implications in pain control.

scientific article

The plasticity of the association between mu-opioid receptor and glutamate ionotropic receptor N in opioid analgesic tolerance and neuropathic pain.

scientific article published on 13 March 2013

The σ1 receptor engages the redox-regulated HINT1 protein to bring opioid analgesia under NMDA receptor negative control

scientific article published on 18 February 2015

Transport of CSF antibodies to Galpha subunits across neural membranes requires binding to the target protein and protein kinase C activity.

scientific article published in March 1999

Use of selective antagonists and antisense oligonucleotides to evaluate the mechanisms of BUBU antinociception

scientific article published on 01 October 1999

alpha N-acetyl derivatives of beta-endorphin-(1-31) and -(1-27) regulate the supraspinal antinociceptive activity of different opioids in mice

scientific article published on 01 January 1991

alpha N-acetyl human beta-endorphin-(1-31) alleviates the morphine withdrawal syndrome in rodents: a comparative study with clonidine

scientific article published on 01 January 1992

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