List of works - Denis Serge François Biard

A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia ⬇️

scientific article published on June 1, 2011

A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation.

scientific article published on 6 July 2016

A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines.

scientific article

ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition

scientific article published on 22 January 2019

ARTEMIS nuclease facilitates apoptotic chromatin cleavage.

scientific article published on 6 October 2009

ATR contributes to telomere maintenance in human cells

scientific article

Breast cancer stem cell-like cells generated during TGFβ-induced EMT are radioresistant.

scientific article

Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients

scientific article published on 3 August 2015

Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation.

scientific article

Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.

scientific article published on July 1994

Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells.

scientific article published in June 2003

Development of new EBV-based vectors for stable expression of small interfering RNA to mimick human syndromes: application to NER gene silencing.

scientific article

Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells.

scientific article published on 14 June 2011

Differential expression of the Hs Kin17 protein during differentiation of in vitro reconstructed human skin ⬇️

scientific article published on July 1, 1997

Disruption of phactr-1 pathway triggers pro-inflammatory and pro-atherogenic factors: New insights in atherosclerosis development.

scientific article published on 9 September 2015

Ectopic expression of (Mm)Kin17 protein inhibits cell proliferation of human tumor-derived cells.

scientific article published on August 1999

Enhanced expression of the Kin17 protein immediately after low doses of ionizing radiation.

scientific article published on April 1997

Establishment of a human cell line for the detection of demethylating agents

scientific article

Flow cytometric detection of drugs altering the DNA methylation pattern.

scientific article published on October 1992

Forced extinction of CD24 stem-like breast cancer marker alone promotes radiation resistance through the control of oxidative stress

scientific article

Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.

scientific article published on 28 December 2013

HSP110 promotes colorectal cancer growth through STAT3 activation.

scientific article published on 7 November 2016

Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication

scientific article published on 20 April 2009

Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication

scientific article

Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stress

scientific article

Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

scientific article

Involvement of the Artemis protein in the relative biological efficiency observed with the 76-MeV proton beam used at the Institut Curie Proton Therapy Center in Orsay

scientific article published on September 2014

Long-term XPC silencing reduces DNA double-strand break repair.

scientific article

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.

scientific article published on 23 February 2017

NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon

scientific article

NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack.

scientific article published in April 2010

Novel anti-metastatic action of cidofovir mediated by inhibition of E6/E7, CXCR4 and Rho/ROCK signaling in HPV tumor cells.

scientific article

Overexpression of kin17 protein forms intranuclear foci in mammalian cells

scientific article published on 01 October 1997

PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility

scientific article

PARP-2 depletion results in lower radiation cell survival but cell line-specific differences in poly(ADP-ribose) levels

scientific article

PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage

scientific article published on 03 February 2014

Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes ⬇️

scientific article published on May 1, 2003

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy.

scientific article

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ

scientific article published on 01 November 2021

Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression

scientific article published on 25 October 2012

Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.

scientific article published on 16 July 2015

RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.

scientific article published on 2 April 2014

Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death.

scientific article

Radiation-induced mitotic catastrophe in PARG-deficient cells.

scientific article

Reactive oxygen species levels control NF-κB activation by low dose deferasirox in erythroid progenitors of low risk myelodysplastic syndromes

scientific article published on 6 November 2017

Regulation of the Escherichia coli lac operon expressed in human cells

scientific article published on February 1992

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome

scientific article published on 18 May 2015

Role of ATM in the telomere response to the G-quadruplex ligand 360A.

scientific article published on 7 February 2008

Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.

scientific article

Superoxide dismutase 2 (SOD2) contributes to genetic stability of native and T315I-mutated BCR-ABL expressing leukemic cells.

scientific article published on 14 March 2018

Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability

scientific article published on 19 September 2018

The cross talk between pathways in the repair of 8-oxo-7,8-dihydroguanine in mouse and human cells.

scientific article

The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins

scientific article

The mouse Kin-17 gene codes for a new protein involved in DNA transactions and is akin to the bacterial RecA protein

scientific article published on January 1995

The myofibroblast markers α-SM actin and β-actin are differentially expressed in 2 and 3-D culture models of fibrotic and normal skin.

scientific article published on January 1998

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.

scientific article

Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones.

scientific article

List of works by Denis Serge François Biard

A DNA-dependent stress response involving DNA-PK occurs in hypoxic cells and contributes to cellular adaptation to hypoxia ⬇️

A balanced pyrimidine pool is required for optimal Chk1 activation to prevent ultrafine anaphase bridge formation.

A new phosphorylated form of Ku70 identified in resistant leukemic cells confers fast but unfaithful DNA repair in cancer cell lines.

ALT cancer cells are specifically sensitive to lysine acetyl transferase inhibition

ARTEMIS nuclease facilitates apoptotic chromatin cleavage.

ATR contributes to telomere maintenance in human cells

Breast cancer stem cell-like cells generated during TGFβ-induced EMT are radioresistant.

Cdk5 promotes DNA replication stress checkpoint activation through RPA-32 phosphorylation, and impacts on metastasis free survival in breast cancer patients

Characterization of DNA ADP-ribosyltransferase activities of PARP2 and PARP3: new insights into DNA ADP-ribosylation.

Concomitant p53 gene mutation and increased radiosensitivity in rat lung embryo epithelial cells during neoplastic development.

Depletion of KIN17, a human DNA replication protein, increases the radiosensitivity of RKO cells.

Development of new EBV-based vectors for stable expression of small interfering RNA to mimick human syndromes: application to NER gene silencing.

Differential contribution of XPC, RAD23A, RAD23B and CENTRIN 2 to the UV-response in human cells.

Differential expression of the Hs Kin17 protein during differentiation of in vitro reconstructed human skin ⬇️

Disruption of phactr-1 pathway triggers pro-inflammatory and pro-atherogenic factors: New insights in atherosclerosis development.

Ectopic expression of (Mm)Kin17 protein inhibits cell proliferation of human tumor-derived cells.

Enhanced expression of the Kin17 protein immediately after low doses of ionizing radiation.

Establishment of a human cell line for the detection of demethylating agents

Flow cytometric detection of drugs altering the DNA methylation pattern.

Forced extinction of CD24 stem-like breast cancer marker alone promotes radiation resistance through the control of oxidative stress

Gap-filling and bypass at the replication fork are both active mechanisms for tolerance of low-dose ultraviolet-induced DNA damage in the human genome.

HSP110 promotes colorectal cancer growth through STAT3 activation.

Human DNA polymerase eta is required for common fragile site stability during unperturbed DNA replication

Human kin17 protein directly interacts with the simian virus 40 large T antigen and inhibits DNA replication

Interaction with OGG1 is required for efficient recruitment of XRCC1 to base excision repair and maintenance of genetic stability after exposure to oxidative stress

Interplay between Cernunnos-XLF and nonhomologous end-joining proteins at DNA ends in the cell.

Involvement of the Artemis protein in the relative biological efficiency observed with the 76-MeV proton beam used at the Institut Curie Proton Therapy Center in Orsay

Long-term XPC silencing reduces DNA double-strand break repair.

Mammary adipocytes stimulate breast cancer invasion through metabolic remodeling of tumor cells.

NADPH oxidase 1 modulates WNT and NOTCH1 signaling to control the fate of proliferative progenitor cells in the colon

NER factors are recruited to active promoters and facilitate chromatin modification for transcription in the absence of exogenous genotoxic attack.

Novel anti-metastatic action of cidofovir mediated by inhibition of E6/E7, CXCR4 and Rho/ROCK signaling in HPV tumor cells.

Overexpression of kin17 protein forms intranuclear foci in mammalian cells

PARP inhibition versus PARP-1 silencing: different outcomes in terms of single-strand break repair and radiation susceptibility

PARP-2 depletion results in lower radiation cell survival but cell line-specific differences in poly(ADP-ribose) levels

PARP1-TDP1 coupling for the repair of topoisomerase I-induced DNA damage

Participation of kin17 protein in replication factories and in other DNA transactions mediated by high molecular weight nuclear complexes ⬇️

Patients with colorectal tumors with microsatellite instability and large deletions in HSP110 T17 have improved response to 5-fluorouracil–based chemotherapy.

Phospho-Ku70 induced by DNA damage interacts with RNA Pol II and promotes the formation of phospho-53BP1 foci to ensure optimal cNHEJ

Poly (ADP-ribose) glycohydrolase regulates retinoic acid receptor-mediated gene expression

Pyrimidine Pool Disequilibrium Induced by a Cytidine Deaminase Deficiency Inhibits PARP-1 Activity, Leading to the Under Replication of DNA.

RAD50 phosphorylation promotes ATR downstream signaling and DNA restart following replication stress.

Rad51 and DNA-PKcs are involved in the generation of specific telomere aberrations induced by the quadruplex ligand 360A that impair mitotic cell progression and lead to cell death.

Radiation-induced mitotic catastrophe in PARG-deficient cells.

Reactive oxygen species levels control NF-κB activation by low dose deferasirox in erythroid progenitors of low risk myelodysplastic syndromes

Regulation of the Escherichia coli lac operon expressed in human cells

Reversal of mitochondrial defects with CSB-dependent serine protease inhibitors in patient cells of the progeroid Cockayne syndrome

Role of ATM in the telomere response to the G-quadruplex ligand 360A.

Role of the ubiquitin-binding domain of Polη in Rad18-independent translesion DNA synthesis in human cell extracts.

Superoxide dismutase 2 (SOD2) contributes to genetic stability of native and T315I-mutated BCR-ABL expressing leukemic cells.

Targeting nonsense-mediated mRNA decay in colorectal cancers with microsatellite instability

The cross talk between pathways in the repair of 8-oxo-7,8-dihydroguanine in mouse and human cells.

The human stress-activated protein kin17 belongs to the multiprotein DNA replication complex and associates in vivo with mammalian replication origins

The mouse Kin-17 gene codes for a new protein involved in DNA transactions and is akin to the bacterial RecA protein

The myofibroblast markers α-SM actin and β-actin are differentially expressed in 2 and 3-D culture models of fibrotic and normal skin.

Translesion synthesis mechanisms depend on the nature of DNA damage in UV-irradiated human cells.

Untangling the relationships between DNA repair pathways by silencing more than 20 DNA repair genes in human stable clones.