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List of works by Marco Giorgio

A Role for PML in Innate Immunity

scientific article

A cell- and developmental stage-specific promoter drives the expression of a truncated c-kit protein during mouse spermatid elongation.

scientific article published on April 1996

A novel neuroferritinopathy mouse model (FTL 498InsTC) shows progressive brain iron dysregulation, morphological signs of early neurodegeneration and motor coordination deficits.

scientific article

A p53-p66Shc signalling pathway controls intracellular redox status, levels of oxidation-damaged DNA and oxidative stress-induced apoptosis.

scientific article

Ablation of the gene encoding p66Shc protects mice against AGE-induced glomerulopathy by preventing oxidant-dependent tissue injury and further AGE accumulation.

scientific article

Angiogenesis inhibition by the maleimide-based small molecule GNX-686

scientific article published on 28 October 2011

Apoptosis and aging: role of p66Shc redox protein.

scientific article

Blood orange juice inhibits fat accumulation in mice.

scientific article published on 22 December 2009

Circulating cytochrome c as potential biomarker of impaired reperfusion in ST-segment elevation acute myocardial infarction.

scientific article

Cyclophilin D counteracts P53-mediated growth arrest and promotes Ras tumorigenesis

scientific article

Decreased superoxide production in macrophages of long-lived p66Shc knock-out mice.

scientific article

Deletion of p66Shc longevity gene protects against experimental diabetic glomerulopathy by preventing diabetes-induced oxidative stress

scientific article published on 01 June 2006

Deletion of the life span determinant p66Shc prevents age-dependent increases in emotionality and pain sensitivity in mice.

scientific article published on 30 June 2006

Deletion of the lifespan determinant p66(Shc) improves performance in a spatial memory task, decreases levels of oxidative stress markers in the hippocampus and increases levels of the neurotrophin BDNF in adult mice.

scientific article

Deletion of the p66Shc longevity gene reduces systemic and tissue oxidative stress, vascular cell apoptosis, and early atherogenesis in mice fed a high-fat diet.

scholarly article

Development of progressive kidney damage and myeloma kidney in interleukin-6 transgenic mice

article

Diabetes Promotes Cardiac Stem Cell Aging and Heart Failure, Which Are Prevented by Deletion of the p66 shc Gene

article

Diabetes causes bone marrow autonomic neuropathy and impairs stem cell mobilization via dysregulated p66Shc and Sirt1.

scientific article

Diabetes-Associated Myelopoiesis Drives Stem Cell Mobilopathy Through an OSM-p66Shc Signaling Pathway

scientific article published on 01 April 2019

Diagnostic and Prognostic Utility of Circulating Cytochrome c in Acute Myocardial Infarction.

scientific article

Dietary cyanidin 3-glucoside from purple corn ameliorates doxorubicin-induced cardiotoxicity in mice.

scientific article published on 21 February 2017

Electrochemical study of hydrogen peroxide formation in isolated mitochondria

scientific article published on 03 December 2011

Electron Transfer between Cytochrome c and p66Shc Generates Reactive Oxygen Species that Trigger Mitochondrial Apoptosis

article

Enrichment of tomato fruit with health-promoting anthocyanins by expression of select transcription factors.

scientific article

Epigenomic profiling of archived FFPE tissues by enhanced PAT-ChIP (EPAT-ChIP) technology

scientific article published on 16 November 2018

Erratum to: The p66Shc redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells

scientific article published on 01 November 2015

Gender-dependent resiliency to stressful and metabolic challenges following prenatal exposure to high-fat diet in the p66(Shc-/-) mouse.

scientific article published on 22 August 2014

Gene rearrangements in the molecular pathogenesis of acute promyelocytic leukemia ⬇️

scientific article published on November 1, 1997

Genetic inactivation of the p66 isoform of ShcA is neuroprotective in a murine model of multiple sclerosis.

scientific article published on 25 January 2012

Glucose and Lactate Miniaturized Biosensors for SECM-Based High-Spatial Resolution Analysis: A Comparative Study

scientific article

Greater resistance to inflammation at adulthood could contribute to extended life span of p66(Shc-/-) mice.

scientific article published on 18 January 2010

Hydrogen peroxide: a metabolic by-product or a common mediator of ageing signals?

scientific article

Insights into the beneficial effect of caloric/ dietary restriction for a healthy and prolonged life.

scientific article

Interplay among H3K9-editing enzymes SUV39H1, JMJD2C and SRC-1 drives p66Shc transcription and vascular oxidative stress in obesity.

scientific article published on 25 October 2017

Low oxygen tension maintains multipotency, whereas normoxia increases differentiation of mouse bone marrow stromal cells

scientific article published on 22 January 2013

Maternal Care Determinant of Longevity?

scientific article

Medullary thyroid carcinomas in transgenic mice expressing a Polyoma carboxyl-terminal truncated middle-T and wild type small-T antigens

scientific article published on 01 April 1999

Mitochondria and vascular pathology.

scientific article published on January 2009

Mitochondrial DNA copy number is regulated by cellular proliferation: a role for Ras and p66(Shc)

scientific article published on 25 May 2006

Mitochondrial pathways for ROS formation and myocardial injury: the relevance of p66(Shc) and monoamine oxidase.

scientific article published on 26 February 2009

Mitochondrial redox signalling by p66Shc mediates ALS-like disease through Rac1 inactivation

scientific article published on 09 August 2011

Modelling the p53/p66Shc Aging Pathway in the Shortest Living Vertebrate Nothobranchius Furzeri

scientific article published on 10 March 2015

Moro orange juice prevents fatty liver in mice

scientific article

New aspects of p66Shc in ischaemia reperfusion injury and other cardiovascular diseases

scientific article published on 15 March 2016

Oxidative stress activates a specific p53 transcriptional response that regulates cellular senescence and aging.

scientific article published on 27 March 2013

Oxidative stress and the unfulfilled promises of antioxidant agents

scientific article (publication date: 2015)

P66SHC deletion improves fertility and progeric phenotype of late-generation TERC-deficient mice but not their short lifespan

scientific article published on 10 March 2016

Protein kinase C beta and prolyl isomerase 1 regulate mitochondrial effects of the life-span determinant p66Shc

scientific article published on 01 February 2007

Ras-dependent carbon metabolism and transformation in mouse fibroblasts

scientific article published on 10 April 2006

Recognition efficiency of the hepatitis B virus polyadenylation signals is tissue specific in transgenic mice.

scientific article published on November 1992

Reduced mitochondrial Ca(2+) transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase.

scientific article

Regulatory effects of the mitochondrial energetic status on mitochondrial p66Shc.

scientific article published on October 2006

Role of PML in cell growth and the retinoic acid pathway

scientific journal article

The P66Shc/mitochondrial permeability transition pore pathway determines neurodegeneration.

scientific article published on 15 May 2013

The Shc locus regulates insulin signaling and adiposity in mammals ⬇️

scientific article published on November 15, 2010

The cellular prion protein counteracts cardiac oxidative stress

scientific article

The influence of Shc proteins on life span in mice.

scientific article

The life span determinant p66Shc localizes to mitochondria where it associates with mitochondrial heat shock protein 70 and regulates trans-membrane potential.

scientific article published on 12 April 2004

The mitochondrial reactive oxygen species regulator p66Shc controls PDGF-induced signaling and migration through protein tyrosine phosphatase oxidation

scientific article published on 27 December 2013

The mitochondrial translation machinery as a therapeutic target in Myc-driven lymphomas

scientific article published on 31 August 2016

The p53-p66Shc apoptotic pathway is dispensable for tumor suppression whereas the p66Shc-generated oxidative stress initiates tumorigenesis.

scientific article published in January 2013

The p66(Shc) redox adaptor protein is induced by saturated fatty acids and mediates lipotoxicity-induced apoptosis in pancreatic beta cells.

scientific article

The redox enzyme p66Shc contributes to diabetes and ischemia-induced delay in cutaneous wound healing.

scientific article

Therapeutic synergy between tigecycline and venetoclax in a preclinical model of MYC/BCL2 double-hit B cell lymphoma.

scientific article published in January 2018

p53 and aging: role of p66Shc.

scientific article published on July 2013

p66SHC promotes T cell apoptosis by inducing mitochondrial dysfunction and impaired Ca2+ homeostasis

scientific article published on 23 June 2006

p66Shc deletion or deficiency protects from obesity but not metabolic dysfunction in mice and humans

scientific article published on 30 June 2015

p66Shc, mitochondria, and the generation of reactive oxygen species.

scientific article

p66Shc-generated oxidative signal promotes fat accumulation

scientific article published on 06 October 2008

p66ShcA modulates tissue response to hindlimb ischemia.

scientific article

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