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List of works by Nicolaas Franken

3D radiobiological evaluation of combined radiotherapy and hyperthermia treatments.

scientific article published on 17 October 2016

A Four-Inflow Construction to Ensure Thermal Stability and Uniformity during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Rats

scientific article published on 26 November 2020

A method for the selective irradiation of part of a genome

scientific article published on 01 January 2000

A short time interval between radiotherapy and hyperthermia reduces in-field recurrence and mortality in women with advanced cervical cancer

scientific article

Additive effect of concomitant multiple low-dose doxorubicin and thoracic irradiation on ex vivo cardiac performance of the rat heart

scientific article published on 01 January 1998

Analysis of enhancement at small and large radiation doses for effectiveness of inactivation in cultured cells by combining two agents with radiation.

scientific article published on 15 August 2016

Analysis of gene expression using gene sets discriminates cancer patients with and without late radiation toxicity

scientific article (publication date: October 2006)

Biological modelling of the radiation dose escalation effect of regional hyperthermia in cervical cancer

scientific article published on 2 February 2016

BrdUrd-induced radiosensitization of two human tumour cell lines at iso-levels of incorporation

scientific article published on 01 September 2000

Cell survival and radiosensitisation: modulation of the linear and quadratic parameters of the LQ model (Review).

scientific article published on 13 March 2013

Cellular response to pulsed low-dose rate irradiation in X-ray sensitive hamster mutant cell lines.

scientific article published in September 2004

Changes in cardiac performance and sympathetic stimulation during and after fractionated radiotherapy in a rat model

scientific article published on 01 January 1996

Changes in myocardial and circulating atrial natriuretic peptide following thorax irradiation in rat

scientific article published on 01 July 1996

Chromatin mobility is increased at sites of DNA double-strand breaks ⬇️

scientific article published on February 10, 2012

Chromosome aberrations detected by FISH and correlation with cell survival after irradiation at various dose-rates and after bromodeoxyuridine radiosensitization.

scientific article published on March 2002

Clonogenic assay of cells in vitro.

scientific article

Colour junctions as predictors of radiosensitivity: X-irradiation combined with gemcitabine in a lung carcinoma cell line.

scientific article published on 29 August 2003

Comparison of RBE values of high-LET α-particles for the induction of DNA-DSBs, chromosome aberrations and cell reproductive death.

scientific article

Comparison of in vivo cardiac function with ex vivo cardiac performance of the rat heart after thoracic irradiation

scientific article published on 01 October 1997

Correlation between cell reproductive death and chromosome aberrations assessed by FISH for low and high doses of radiation and sensitization by iodo-deoxyuridine in human SW-1573 cells

scientific article published on 01 March 1999

Cyclopentenylcytosine does not enhance cisplatin-induced radiosensitization in human lung tumour cells.

scientific article published on May 2010

Decay of γ-H2AX foci correlates with potentially lethal damage repair and P53 status in human colorectal carcinoma cells.

scientific article published on 23 December 2013

Decay of γ-H2AX foci correlates with potentially lethal damage repair in prostate cancer cells.

scientific article published on 26 March 2013

Dynamics of chromosomal aberrations, induction of apoptosis, BRCA2 degradation and sensitization to radiation by hyperthermia.

scientific article published on 27 May 2016

Effect of 41 degrees C and 43 degrees C on cisplatin radiosensitization in two human carcinoma cell lines with different sensitivities for cisplatin.

scientific article published on July 2007

Effect of hyperthermia on uptake and cytotoxicity of cisplatin in cultured murine mammary carcinoma cells.

scientific article published on August 2005

Effects of cisplatin and gamma-irradiation on cell survival, the induction of chromosomal aberrations and apoptosis in SW-1573 cells.

scientific article published on 30 September 2005

Effects of gemcitabine on cell survival and chromosome aberrations after pulsed low dose-rate irradiation.

scientific article published on March 2004

Effects of hyperthermia on DNA repair pathways: one treatment to inhibit them all.

scientific article published on 07 August 2015

Effects of in vivo heart irradiation on myocardial energy metabolism in rats

scientific article published on 01 April 1993

Enhanced activity of deoxycytidine kinase after pulsed low dose rate and single dose gamma irradiation.

scientific article published on January 2006

Enhancement of radiation effectiveness by hyperthermia and incorporation of halogenated pyrimidines at low radiation doses as compared with high doses: implications for mechanisms.

scientific article published on 19 March 2014

Enhancing radiosensitisation of BRCA2-proficient and BRCA2-deficient cell lines with hyperthermia and PARP1-i.

scientific article

Enhancing synthetic lethality of PARP-inhibitor and cisplatin in BRCA-proficient tumour cells with hyperthermia

scientific article

Enhancing the abscopal effect of radiation and immune checkpoint inhibitor therapies with magnetic nanoparticle hyperthermia in a model of metastatic breast cancer

scientific article published on 01 November 2019

HyCHEED System for Maintaining Stable Temperature Control during Preclinical Irreversible Electroporation Experiments at Clinically Relevant Temperature and Pulse Settings

scientific article published on 31 October 2020

Hyperthermia Selectively Targets Human Papillomavirus in Cervical Tumors via p53-Dependent Apoptosis.

scientific article published on 16 November 2015

Hyperthermia and incorporation of halogenated pyrimidines: Radiosensitization in cultured rodent and human tumor cells ⬇️

scientific article published on September 1, 1997

Hyperthermia, cisplatin and radiation trimodality treatment: a promising cancer treatment? A review from preclinical studies to clinical application.

scientific article published on June 2007

Hyperthermia: The Optimal Treatment to Overcome Radiation Resistant Hypoxia

scientific article published on 09 January 2019

In regard to Ohri N et al

scientific article published on 01 July 2013

Inactivation of p53 and of pRb protects human colorectal carcinoma cells against hyperthermia-induced cytotoxicity and apoptosis.

scientific article published on October 1999

Increased chromosome exchange frequencies in iodo-deoxyuridine-sensitized human SW-1573 cells after gamma-irradiation

scientific article published on 01 January 1999

Increased uptake of doxorubicin by cells undergoing heat stress does not explain its synergistic cytotoxicity with hyperthermia

scientific article published on 01 January 2019

Induction of the early response protein EGR-1 in human tumour cells after ionizing radiation is correlated with a reduction of repair of lethal lesions and an increase of repair of sublethal lesions.

scientific article published on April 2004

Inhibition of homologous recombination by hyperthermia shunts early double strand break repair to non-homologous end-joining ⬇️

scientific article published on December 11, 2012

Measurement and analysis of the impact of time-interval, temperature and radiation dose on tumour cell survival and its application in thermoradiotherapy plan evaluation.

scientific article published on 9 May 2017

Medical and biological consequences of nuclear disasters

scientific article published in January 2012

Mild hyperthermia inhibits homologous recombination, induces BRCA2 degradation, and sensitizes cancer cells to poly (ADP-ribose) polymerase-1 inhibition.

scientific article

Mismatch repair proficiency is not required for radioenhancement by gemcitabine.

scientific article

Modification of potentially lethal damage in irradiated Chinese hamster V79 cells after incorporation of halogenated pyrimidines

scientific article published on 01 July 1997

Muscle wasting after radiotherapy in young and adult rats

scientific article published on 01 September 2001

Myocardial enzyme activities in plasma after whole-heart irradiation in rats

scientific article published on 01 January 2000

Neurological complications after 434 MHz microwave hyperthermia of the rat lumbar region including the spinal cord

scientific article published on 01 August 1992

Neurological observations after local irradiation and hyperthermia of rat lumbosacral spinal cord.

scientific article

Non-Invasive Imaging and Scoring of Peritoneal Metastases in Small Preclinical Animal Models Using Ultrasound: A Preliminary Trial

scientific article published in 2022

PCC and COBRA-FISH a new tool to characterize primary cervical carcinomas: to assess hall-marks and stage specificity.

scientific article

Predicting Radiosensitivity with Gamma-H2AX Foci Assay after Single High-Dose-Rate and Pulsed Dose-Rate Ionizing Irradiation.

scientific article published on 20 January 2016

Prof. Johan Broerse 1934-2017.

scientific article published on 29 August 2017

Prostate Cancer Patients with Late Radiation Toxicity Exhibit Reduced Expression of Genes Involved in DNA Double-Strand Break Repair and Homologous Recombination

scientific article published on 20 January 2017

Protection of myocytes against free radical-induced damage by accelerated turnover of the glutathione redox cycle

scientific article published on 01 April 1995

Quantification of the contribution of hyperthermia to results of cervical cancer trials: in regard to Plataniotis and Dale (Int J Radiat Oncol Biol Phys 2009;73:1538-1544)

scientific article published on 01 October 2009

Quantifying the combined effect of radiation therapy and hyperthermia in terms of equivalent dose distributions

scientific article published on 08 January 2014

Radiosensitization by Hyperthermia: The Effects of Temperature, Sequence, and Time Interval in Cervical Cell Lines

scientific article published on 03 March 2020

Radiosensitization by bromodeoxyuridine and hyperthermia: analysis of linear and quadratic parameters of radiation survival curves of two human tumor cell lines.

scientific article

Radiosensitization by iodo-deoxyuridine in cultured SW-1573 human lung tumor cells

scientific article published on 01 September 1997

Radiosensitizing effect of the histone acetyltransferase inhibitor anacardic acid on various mammalian cell lines.

scientific article published on July 2010

Reduced activity of double-strand break repair genes in prostate cancer patients with late normal tissue radiation toxicity

scientific article published on 8 January 2014

Relative biological effectiveness of high linear energy transfer α-particles for the induction of DNA-double-strand breaks, chromosome aberrations and reproductive cell death in SW-1573 lung tumour cells ⬇️

scientific article published on December 21, 2011

Scintimetric detection of choroidal malignant melanoma with [123I]-5-iodo-2-thiouracil

scientific article published on 01 January 1986

Sensitivity to ionizing radiation and chemotherapeutic agents in gemcitabine-resistant human tumor cell lines.

scientific article published on September 2002

Sensitizing thermochemotherapy with a PARP1-inhibitor.

scientific article published on 19 August 2016

Targeting DNA double strand break repair with hyperthermia and DNA-PKcs inhibition to enhance the effect of radiation treatment

scientific article published on September 2016

Targeting therapy-resistant cancer stem cells by hyperthermia

scientific article

The Temperature-Dependent Effectiveness of Platinum-Based Drugs Mitomycin-C and 5-FU during Hyperthermic Intraperitoneal Chemotherapy (HIPEC) in Colorectal Cancer Cell Lines

scientific article published on 25 July 2020

The clinical benefit of hyperthermia in pancreatic cancer: a systematic review.

scientific article published on 23 November 2017

The effect of time interval between radiotherapy and hyperthermia on planned equivalent radiation dose

scientific article published on 11 May 2018

The use of equivalent radiation dose in the evaluation of late effects after childhood cancer treatment.

scientific article published on 14 June 2014

Thermoradiotherapy planning: Integration in routine clinical practice.

scientific article published on 15 December 2015

Time dependent changes in myocardial norepinephrine concentration and adrenergic receptor density following X-irradiation of the rat heart

scientific article published on 01 January 1992

Transient inhibition of Calyculin A induced premature chromosome condensation by hyperthermia.

scientific article

Variation in Clinical Application of Hyperthermic Intraperitoneal Chemotherapy: A Review

scientific article published on 11 January 2019

Wild-type p53-function is not required for hyperthermia-enhanced cytotoxicity of cisplatin

scientific article published on 01 July 2001

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