List of works - Yasutoshi Koga

A case of chronic toluene intoxication with atrophy of cerebrum, cerebellum and brainstem on CT and MRI

scientific article published on 01 April 1992

A new diagnostic indication device of a biomarker GDF15 for mitochondrial diseases: from laboratory to automated inspection

scientific article published on 23 September 2020

A new sequence variant in mitochondrial DNA associated with high penetrance of Russian Leber hereditary optic neuropathy.

scientific article published in June 2005

ADHD-like behavior in a patient with hypothalamic hamartoma

scientific article

Arginine therapy in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes

scientific article published on 01 January 2020

Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene ⬇️

scientific article published on March 31, 2011

Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease

scientific article published on 07 February 2019

Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans

scientific journal article

Complex II

scientific article

Cytochrome c oxidase deficiency with acute onset and rapid recovery

scientific article published on 01 September 1990

Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA(Leu(UUR)) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes ⬇️

scientific article published on February 1, 1992

Developmental delay and failure to thrive in a 7-month-old baby boy with spontaneous transient Graves' thyrotoxicosis: a case report

scientific article published on 10 August 2016

Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase

scientific article (publication date: October 1992)

Early Onset of Diabetes Mellitus Accelerates Cognitive Decline in Japanese Patients with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes.

scientific article published in January 2016

Effect of L-arginine on synaptosomal mitochondrial function

scientific article

Effects of L-arginine on the acute phase of strokes in three patients with MELAS.

scientific article published in March 2002

Efficacy of pyruvate therapy in patients with mitochondrial disease: a semi-quantitative clinical evaluation study

scientific article published on 02 May 2014

Endothelial dysfunction in MELAS improved by l-arginine supplementation.

scientific article

Evaluation of systemic redox states in patients carrying the MELAS A3243G mutation in mitochondrial DNA

scientific article published on 14 March 2012

Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage.

scientific article

Findings in muscle in complex I (NADH coenzyme Q reductase) deficiency

scientific article published on 01 December 1988

Fine mapping of mitochondrial RNAs derived from the mtDNA region containing a point mutation associated with MELAS ⬇️

scientific article published on February 11, 1993

Focal cytochrome c oxidase deficiency in various neuromuscular diseases

scientific article published on 01 June 1989

GDF-15, a mitochondrial disease biomarker, is associated with the severity of multiple sclerosis

scientific article published on 22 August 2019

GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases

scientific article published on 01 November 2014

Glycogenic hepatopathy and non-alcoholic fatty liver disease in type 1 diabetes patients.

scientific article published in December 2013

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.

scientific article published on 14 October 2015

In vitro analysis of mutations causing myoclonus epilepsy with ragged-red fibers in the mitochondrial tRNA(Lys)gene: two genotypes produce similar phenotypes.

scientific article published on May 1995

Inhibition of mitochondrial functions by margosa oil: possible implications in the pathogenesis of Reye's syndrome

scientific article published on 01 August 1987

Inter- and/or intra-organ distribution of mitochondrial C3303T or A3243G mutation in mitochondrial cytopathy.

scientific article published in February 2001

L-Arginine intervention at hyper-acute phase protects the prolonged MRI abnormality in MELAS.

scientific article published on 22 June 2016

L-arginine improves the symptoms of strokelike episodes in MELAS.

scientific article

L-arginine therapy on MELAS

scientific article published in November 2008

Long-term analysis of differentiation in human myoblasts repopulated with mitochondria harboring mtDNA mutations.

scientific article

MELAS and L-arginine therapy

scientific article

MELAS and L-arginine therapy: pathophysiology of stroke-like episodes.

scientific article

MELAS exhibits dominant negative effects on mitochondrial RNA processing ⬇️

scientific article published on 01 June 1998

Maple syrup urine disease: Nutritional management by intravenous hyperalimentation and uneventful course after surgical repair of dislocation of the hip ⬇️

scientific article published on 01 April 1998

Marinesco-Sjogren syndrome: can the diagnosis be made prior to cataract formation?

scientific article published on 01 July 1997

Mitochondrial diseases

Mitochondrial encephalomyopathies and cytochrome c oxidase deficiency: muscle culture study

scientific article published on 01 January 1991

Mitochondrial tRNA gene mutations in patients having mitochondrial disease with lactic acidosis.

scientific article

Molecular pathology of MELAS and l-arginine effects ⬇️

scientific article published on September 14, 2011

Muscle pathology in cytochrome c oxidase deficiency

scientific article published on 01 January 1988

New TRPM6 mutation and management of hypomagnesaemia with secondary hypocalcaemia

scientific article published on 28 June 2014

P1148A in fibrillin-1 is not a mutation leading to Shprintzen-Goldberg syndrome

scientific article published on 01 January 1997

Progressive cytochrome c oxidase deficiency in a case of Leigh's encephalomyelopathy

scientific article published on 01 January 1990

Pyruvate Improved Insulin Secretion Status in a Mitochondrial Diabetes Mellitus Patient.

scientific article published on 17 February 2016

Pyruvate therapy for Leigh syndrome due to cytochrome c oxidase deficiency.

scientific article published on 17 July 2009

Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA.

scientific article published in February 1990

Successful Glycemic Control Decreases the Elevated Serum FGF21 Level without Affecting Normal Serum GDF15 Levels in a Patient with Mitochondrial Diabetes.

scientific article published in January 2016

Successful treatment of infantile-onset ACAD9-related cardiomyopathy with a combination of sodium pyruvate, beta-blocker, and coenzyme Q10

scientific article published on 01 October 2019

Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial.

scientific article published on 17 April 2018

The mitochondrial DNA C3303T mutation can cause cardiomyopathy and/or skeletal myopathy

scientific article published on 01 August 1999

The mitochondrial tRNA(Leu)(UUR)) mutation in MELAS: a model for pathogenesis

scientific article published on July 17, 1992

Therapeutic potential of pyruvate therapy for mitochondrial diseases.

scientific article

Therapeutic regimen of L-arginine for MELAS: 9-year, prospective, multicenter, clinical research

scientific article published on 29 September 2018

Tissue specificity in cytochrome c oxidase deficient myopathy

scientific article published on 01 September 1989

Use of single strand conformation polymorphism analysis to detect point mutations in human mitochondrial DNA

scientific article published on 01 September 1992

[A case of complex I deficiency with episodic respiratory distress]

scientific article published in July 1990

[Complex III]

scientific article published on 01 April 2002

[Diagnosis and treatment of mitochondrial myopathy--update review]

scientific article published in March 2010

[Migraine headache and mitochondrial DNA abnormality]

scientific article published on 01 October 2005

List of works by Yasutoshi Koga

A case of chronic toluene intoxication with atrophy of cerebrum, cerebellum and brainstem on CT and MRI

A new diagnostic indication device of a biomarker GDF15 for mitochondrial diseases: from laboratory to automated inspection

A new sequence variant in mitochondrial DNA associated with high penetrance of Russian Leber hereditary optic neuropathy.

ADHD-like behavior in a patient with hypothalamic hamartoma

Arginine therapy in mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes

Beneficial effect of pyruvate therapy on Leigh syndrome due to a novel mutation in PDH E1α gene ⬇️

Biomarkers and clinical rating scales for sodium pyruvate therapy in patients with mitochondrial disease

Cdk5rap1-mediated 2-methylthio modification of mitochondrial tRNAs governs protein translation and contributes to myopathy in mice and humans

Complex II

Cytochrome c oxidase deficiency with acute onset and rapid recovery

Defects in mitochondrial protein synthesis and respiratory chain activity segregate with the tRNA(Leu(UUR)) mutation associated with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes ⬇️

Developmental delay and failure to thrive in a 7-month-old baby boy with spontaneous transient Graves' thyrotoxicosis: a case report

Differential expression of genes specifying two isoforms of subunit VIa of human cytochrome c oxidase

Early Onset of Diabetes Mellitus Accelerates Cognitive Decline in Japanese Patients with Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, and Stroke-Like Episodes.

Effect of L-arginine on synaptosomal mitochondrial function

Effects of L-arginine on the acute phase of strokes in three patients with MELAS.

Efficacy of pyruvate therapy in patients with mitochondrial disease: a semi-quantitative clinical evaluation study

Endothelial dysfunction in MELAS improved by l-arginine supplementation.

Evaluation of systemic redox states in patients carrying the MELAS A3243G mutation in mitochondrial DNA

Evidence of ROS generation by mitochondria in cells with impaired electron transport chain and mitochondrial DNA damage.

Findings in muscle in complex I (NADH coenzyme Q reductase) deficiency

Fine mapping of mitochondrial RNAs derived from the mtDNA region containing a point mutation associated with MELAS ⬇️

Focal cytochrome c oxidase deficiency in various neuromuscular diseases

GDF-15, a mitochondrial disease biomarker, is associated with the severity of multiple sclerosis

GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases

Glycogenic hepatopathy and non-alcoholic fatty liver disease in type 1 diabetes patients.

Growth differentiation factor 15 as a useful biomarker for mitochondrial disorders.

In vitro analysis of mutations causing myoclonus epilepsy with ragged-red fibers in the mitochondrial tRNA(Lys)gene: two genotypes produce similar phenotypes.

Inhibition of mitochondrial functions by margosa oil: possible implications in the pathogenesis of Reye's syndrome

Inter- and/or intra-organ distribution of mitochondrial C3303T or A3243G mutation in mitochondrial cytopathy.

L-Arginine intervention at hyper-acute phase protects the prolonged MRI abnormality in MELAS.

L-arginine improves the symptoms of strokelike episodes in MELAS.

L-arginine therapy on MELAS

Long-term analysis of differentiation in human myoblasts repopulated with mitochondria harboring mtDNA mutations.

MELAS and L-arginine therapy

MELAS and L-arginine therapy: pathophysiology of stroke-like episodes.

MELAS exhibits dominant negative effects on mitochondrial RNA processing ⬇️

Maple syrup urine disease: Nutritional management by intravenous hyperalimentation and uneventful course after surgical repair of dislocation of the hip ⬇️

Marinesco-Sjogren syndrome: can the diagnosis be made prior to cataract formation?

Mitochondrial diseases

Mitochondrial encephalomyopathies and cytochrome c oxidase deficiency: muscle culture study

Mitochondrial tRNA gene mutations in patients having mitochondrial disease with lactic acidosis.

Molecular pathology of MELAS and l-arginine effects ⬇️

Muscle pathology in cytochrome c oxidase deficiency

New TRPM6 mutation and management of hypomagnesaemia with secondary hypocalcaemia

P1148A in fibrillin-1 is not a mutation leading to Shprintzen-Goldberg syndrome

Progressive cytochrome c oxidase deficiency in a case of Leigh's encephalomyelopathy

Pyruvate Improved Insulin Secretion Status in a Mitochondrial Diabetes Mellitus Patient.

Pyruvate therapy for Leigh syndrome due to cytochrome c oxidase deficiency.

Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA.

Successful Glycemic Control Decreases the Elevated Serum FGF21 Level without Affecting Normal Serum GDF15 Levels in a Patient with Mitochondrial Diabetes.

Successful treatment of infantile-onset ACAD9-related cardiomyopathy with a combination of sodium pyruvate, beta-blocker, and coenzyme Q10

Taurine supplementation for prevention of stroke-like episodes in MELAS: a multicentre, open-label, 52-week phase III trial.

The mitochondrial DNA C3303T mutation can cause cardiomyopathy and/or skeletal myopathy

The mitochondrial tRNA(Leu)(UUR)) mutation in MELAS: a model for pathogenesis

Therapeutic potential of pyruvate therapy for mitochondrial diseases.

Therapeutic regimen of L-arginine for MELAS: 9-year, prospective, multicenter, clinical research

Tissue specificity in cytochrome c oxidase deficient myopathy

Use of single strand conformation polymorphism analysis to detect point mutations in human mitochondrial DNA

[A case of complex I deficiency with episodic respiratory distress]

[Complex III]

[Diagnosis and treatment of mitochondrial myopathy--update review]

[Migraine headache and mitochondrial DNA abnormality]

[The treatment of mitochondrial disorders, present and future]